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61 条记录 (耗时 0.054 秒)

    Dosage Form for Time-Varying Patterns of Drug Delivery
    11.
    发明申请
    Dosage Form for Time-Varying Patterns of Drug Delivery 审中-公开
    药物递送时间变化模式的剂型

    公开(公告)号：US20070207204A1

    公开(公告)日：2007-09-06

    申请号：US11744999

    申请日：2007-05-07

    申请人： David Edgren ,  Patrick Wong ,  Shu Li

    发明人： David Edgren ,  Patrick Wong ,  Shu Li

    IPC分类号： A61K9/66

    CPC分类号： A61K9/0004 ,  A61K31/277

    摘要： The present invention provides a multi-release oral drug delivery system that initiates drug release following an initial drug-free release interval, after administration to a subject, and a second drug-free release period before release of another dose of drug. The system has (1) inner compartments enclosed within a semipermeable membrane, and (2) a drug coating on the exterior of the semipermeable membrane surrounded by a microporous membrane, which microporous membrane is permeable to fluid and drug. The drug coating is released after the initial drug-free release interval. An inner compartment drug is released after a second drug-free release interval provided by a drug-free inner compartment.

    摘要翻译： 本发明提供一种多次释放的口服药物递送系统，其在给予受试者之后，在初始无药物释放间隔之后启动药物释放，以及释放另一剂量药物之前的第二无药物释放期。 该系统具有（1）封闭在半透膜内的内隔室，（2）由微孔膜包围的半透膜外部的药物涂层，该微孔膜可渗透流体和药物。 药物涂层在初始无药物释放间隔后释放。 在由无药物的内隔室提供的第二无药物释放间隔后释放内室药物。

    Dosage forms for low solubility and or low dissolution rate free acid pharmaceutical agents
    12.
    发明申请
    Dosage forms for low solubility and or low dissolution rate free acid pharmaceutical agents 审中-公开
    用于低溶解度或低溶解度游离酸药剂的剂型

    公开(公告)号：US20050287213A1

    公开(公告)日：2005-12-29

    申请号：US11148679

    申请日：2005-06-08

    申请人： Patrick Wong ,  Noymi Yam ,  Sherry Li

    发明人： Patrick Wong ,  Noymi Yam ,  Sherry Li

    IPC分类号： A61K9/00 ,  A61K9/24 ,  A61K9/64 ,  A61K31/19 ,  A61K31/35 ,  A61K31/522

    CPC分类号： A61K9/0004

    摘要： An osmotic controlled release dosage form is described comprising a core comprising a first drug composition, wherein the first drug composition comprises topiramate and/or its pharmaceutically acceptable salt; a semi-permeable wall surrounding the core; and an exit orifice through the semi-permeable wall for releasing the first drug composition from the dosage form over a prolonged period of time.

    摘要翻译： 描述渗透控制释放剂型，其包含包含第一药物组合物的核心，其中所述第一药物组合物包含托吡酯和/或其药学上可接受的盐; 围绕芯的半透壁; 以及通过半透壁的出口孔，用于在长时间内从剂型释放第一药物组合物。

    Gastric retention dosage form having multiple layers
    13.
    发明申请
    Gastric retention dosage form having multiple layers 审中-公开
    具有多层的胃滞留剂型

    公开(公告)号：US20050019409A1

    公开(公告)日：2005-01-27

    申请号：US10914486

    申请日：2004-08-09

    申请人： David Edgren ,  Francisco Jao ,  Patrick Wong

    发明人： David Edgren ,  Francisco Jao ,  Patrick Wong

    IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K9/24 ,  A61K31/00 ,  A61K47/00

    CPC分类号： A61K9/0065 ,  Y10S424/06 ,  Y10S514/836 ,  Y10S514/866 ,  Y10S514/884 ,  Y10S514/909 ,  Y10S514/96 ,  Y10S514/961 ,  Y10S514/965

    摘要： The present invention is directed to a multilayered dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of an active agent to a fluid environment of use. The active agent dosage form is a multilayer core, often bilayer, formed of polymer matrices that swell upon contact with the fluids of the stomach. At least one layer of the multilayered dosage form includes an active agent. A portion of the polymer matrices are surrounded by a band of insoluble material that prevents the covered portion of the polymer matrices from swelling and provides a segment of the dosage form that is of sufficient rigidity to withstand the contractions of the stomach and delay expulsion of the dosage form from the stomach until substantially all of the active agent has been dispensed.

    摘要翻译： 本发明涉及一种多层剂型，其适于保留在胃中并且可用于将活性剂延长递送至使用的流体环境。 活性剂剂型是由与胃液接触时膨胀的聚合物基质形成的多层芯，通常是双层的。 至少一层多层剂型包括活性剂。 聚合物基质的一部分被不溶性材料带包围，其阻止聚合物基质的被覆盖部分膨胀，并且提供具有足够刚度以抵抗胃收缩和延迟排出 剂型，直到基本上所有的活性剂已被分配。

    Dosage forms and layered deposition processes for fabricating dosage forms
    19.
    发明申请
    Dosage forms and layered deposition processes for fabricating dosage forms 审中-公开
    用于制备剂型的剂量形式和分层沉积方法

    公开(公告)号：US20050118246A1

    公开(公告)日：2005-06-02

    申请号：US10976589

    申请日：2004-10-29

    申请人： Patrick Wong ,  B. Silber

    发明人： Patrick Wong ,  B. Silber

    IPC分类号： A61K9/00 ,  A61K9/70 ,  A61K9/14

    CPC分类号： A61K9/0065 ,  A61F2013/0296 ,  A61K9/703 ,  A61K9/7084 ,  A61K9/7092

    摘要： Disclosed are transdermal or transmucosal dosage forms which include a matrix and a drug where the total amount of drug present in the dosage form exceeds the solubility limit of the drug in the matrix. Also disclosed are transdermal or transmucosal dosage forms which include two or more drug-containing layers and one or more intervening hydrophilic layers where the two or more drug-containing layers being separated from one another by the one or more intervening hydrophilic layers. Methods for delaying release and delivery of an active from an active layer disposed in a transdermal or transmucosal dosage form are also disclosed, as well as methods for manufacturing transdermal or transmucosal dosage forms by providing a substrate and disposing at least one transdermal or transmucosal dosage form layer on the substrate using a printing process.

    摘要翻译： 公开了透皮或透粘膜剂型，其包括基质和药物，其中存在于剂型中的药物的总量超过药物在基质中的溶解度极限。 还公开了透皮或透粘膜剂型，其包括两个或更多个药物含有层和一个或多个中间亲水层，其中两个或更多个药物含有层通过一个或多个中间亲水层彼此分离。 还公开了延缓活性物质从透皮或经粘膜剂型形成的活性层的释放和递送的方法，以及通过提供底物和设置至少一种透皮或透粘膜剂型形成透皮或经粘膜剂型的方法 使用印刷方法在基板上。

    Method and device for enhancing transdermal agent flux
    20.
    发明申请
    Method and device for enhancing transdermal agent flux 审中-公开
    增强透皮剂通量的方法和装置

    公开(公告)号：US20050031676A1

    公开(公告)日：2005-02-10

    申请号：US10910889

    申请日：2004-08-03

    申请人： Patrick Wong ,  Peter Daddona

    发明人： Patrick Wong ,  Peter Daddona

    IPC分类号： A61B10/00 ,  A61B17/20 ,  A61M37/00 ,  A61K38/19 ,  A61L15/16

    CPC分类号： A61M37/0015 ,  A61B10/0064 ,  A61B17/205 ,  A61B2010/0009 ,  A61M2037/003 ,  A61M2037/0053

    摘要： A porous microprojection member for insertion into biological tissue surrounded by interstitial fluid having a wall that includes interior and exterior surfaces, the exterior surface substantially enclosing the interior surface; and a biocompatible coating disposed on the interior surface, the microprojection member being adapted to substantially restrict contact of the coating with the tissue during insertion of the microprojection member into the tissue, the microprojection member having sufficient porosity to allow migration of the interstitial fluid through the wall of the microprojection member.

    摘要翻译： 一种用于插入由间隙液包围的生物组织的多孔微突出构件，其具有包括内表面和外表面的壁，所述外表面基本上包围所述内表面; 以及设置在所述内表面上的生物相容性涂层，所述微突出物构件适于基本上限制所述涂层与所述组织在所述微突出物构件插入所述组织期间的接触，所述微突出物构件具有足够的孔隙率以允许所述间质液体通过 微突起构件的壁。