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    Rapid-exchange balloon catheter shaft and method
    11.
    发明授权
    Rapid-exchange balloon catheter shaft and method 有权
    快速交换球囊导管轴和方法

    公开(公告)号：US08454673B2

    公开(公告)日：2013-06-04

    申请号：US12906976

    申请日：2010-10-18

    Applicant: Laila Al-Marashi ,  David Grewe ,  Stephen Griffin ,  Elaine Lim ,  David Majercak ,  Roger Stevens

    Inventor： Laila Al-Marashi ,  David Grewe ,  Stephen Griffin ,  Elaine Lim ,  David Majercak ,  Roger Stevens

    IPC: A61F2/84

    CPC classification number: A61M25/10 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/91558 ,  A61F2230/0054 ,  A61F2250/0018 ,  A61M25/0054 ,  A61M2025/0183

    Abstract: A balloon catheter or stent delivery system for medical treatment of a patient has a proximal hub, a balloon, and an improved shaft design. The catheter shaft has a rapid-exchange configuration, and a tubular outer body that includes a hypotube extending from the catheter proximal end to a position at or near a proximal leg of the balloon. An inner tubular body defines a guidewire lumen extending from a distal guidewire port at the catheter distal end to a proximal port located at a position between the balloon and the hub. A distal leg of the balloon is directly or indirectly affixed to the inner body, and a proximal leg of the balloon is affixed to the distal end of the outer body. The hypotube has an aperture for accepting the inner body proximal end, and a circumferential cut pattern. The cut pattern adds flexibility, and may extend from the hypotube distal end to a position proximal of the proximal guidewire port. The cut pattern may have any desired shape, including a spiral, a helical undulating path, or an overlapping serpentine path with inflection points, for example. The hypotube has a fluid-tight covering such as a heat-shrink polymer, so the outer body supports pressure of an inflation medium. The proximal guidewire port may be positioned on or between the individual portions of the cut pattern, or at a position beyond the cut pattern.

    Abstract translation: 用于患者医疗的球囊导管或支架输送系统具有近端毂，球囊和改进的轴设计。 导管轴具有快速交换构造，以及管状外体，其包括从导管近端延伸到球囊的近端腿处或附近的位置的海波管。 内部管状体限定从导管远端处的远端导丝端口延伸到位于气囊和轮毂之间的位置的近端口的导丝管腔。 球囊的远端腿直接或间接地固定到内体上，并且气球的近端腿固定到外体的远端。 海波管具有用于接纳内体近端的孔和圆周切割图案。 切割图案增加了柔性，并且可以从海波管远端延伸到近端导丝端口的近端。 切割图案可以具有任何期望的形状，例如包括螺旋形，螺旋形起伏路径或具有拐点的重叠蛇形路径。 海波管具有流体密封的覆盖物，例如热收缩聚合物，因此外壳支撑膨胀介质的压力。 近端导丝端口可以定位在切割图案的各个部分之间或之间，或位于切割图案之外的位置。

    MANUFACTURING METHODS FOR COVERING ENDOLUMINAL PROSTHESES
    12.
    发明申请
    MANUFACTURING METHODS FOR COVERING ENDOLUMINAL PROSTHESES 有权
    用于覆盖内膜前列腺的制造方法

    公开(公告)号：US20110135806A1

    公开(公告)日：2011-06-09

    申请号：US12959023

    申请日：2010-12-02

    Applicant: David Grewe ,  Blayne Roeder ,  Steven Charlebois ,  Adam Griebel

    Inventor： David Grewe ,  Blayne Roeder ,  Steven Charlebois ,  Adam Griebel

    IPC: B05D1/16

    CPC classification number: B05D1/007 ,  D01D5/0069 ,  D01D5/0076

    Abstract: The disclosure relates to a method for coating a target. The method includes providing a target and an electrospinning apparatus. The target comprises a first surface and an opposing second surface. The electrospinning apparatus comprises a mandrel, a mask including an aperture, a reservoir loaded with a solution, and an orifice fluidly coupled to the reservoir. The mandrel is located adjacent the target second surface. The orifice is located at a distance from the target first surface. The mask is located intermediate the orifice and the target first surface. The solution is electrospun through the mask aperture onto the target first surface. In one example the target is an endoluminal prosthesis.

    Abstract translation: 本公开涉及涂覆靶的方法。 该方法包括提供靶和静电纺丝装置。 靶包括第一表面和相对的第二表面。 静电纺丝装置包括心轴，包括孔的掩模，装有溶液的储存器和流体耦合到储存器的孔。 心轴位于目标第二表面附近。 孔口位于离目标第一表面一定距离处。 掩模位于孔口和目标第一表面之间。 该溶液通过掩模孔电纺到目标第一表面上。 在一个示例中，目标是腔内假体。

    Expandable stent
    14.
    发明申请
    Expandable stent 审中-公开
    可扩展支架

    公开(公告)号：US20070185560A1

    公开(公告)日：2007-08-09

    申请号：US11604573

    申请日：2006-11-27

    Applicant: Blayne Roeder ,  Richard Swift ,  David Grewe

    Inventor： Blayne Roeder ,  Richard Swift ,  David Grewe

    IPC: A61F2/06

    CPC classification number: A61F2/885

    Abstract: An expandable stent for medical implantation is described which has a generally cylindrical structure with a central longitudinal axis. At least a portion of the generally cylindrical structure is formed from an arrangement of circumferentially curved structural members. The portion expands from a compressed state to an expanded state by a spiraling motion of each of the structural members about the central longitudinal axis. In the compressed state, each of the structural members may nest within an open region formed by segments composing the structural member, such that the portion of the generally cylindrical structure has no overlapping regions. A ratio of a circumferential length of each structural member to a spacing between adjacent structural members may be in the range of about 1.8 to about 2.3.

    Abstract translation: 描述了用于医学植入的可扩张支架，其具有具有中心纵向轴线的大致圆柱形结构。 大致圆柱形结构的至少一部分由周向弯曲的结构构件的布置形成。 通过每个结构构件围绕中心纵向轴线的螺旋运动，该部分从压缩状态膨胀到膨胀状态。 在压缩状态下，每个结构构件可以嵌套在由构成结构构件的段形成的开放区域内，使得大致圆柱形结构的部分没有重叠区域。 每个结构构件的圆周长度与相邻结构构件之间的间隔的比率可以在约1.8至约2.3的范围内。

    RAPID-EXCHANGE BALLOON CATHETER SHAFT AND METHOD
    16.
    发明申请
    RAPID-EXCHANGE BALLOON CATHETER SHAFT AND METHOD 有权
    快速交换气囊导管轴和方法

    公开(公告)号：US20110034989A1

    公开(公告)日：2011-02-10

    申请号：US12906976

    申请日：2010-10-18

    Applicant: Laila Al-Marashi ,  David Grewe ,  Stephen Griffin ,  Elaine Lim ,  David Majercak ,  Roger Stevens

    Inventor： Laila Al-Marashi ,  David Grewe ,  Stephen Griffin ,  Elaine Lim ,  David Majercak ,  Roger Stevens

    IPC: A61F2/84

    CPC classification number: A61M25/10 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/91558 ,  A61F2230/0054 ,  A61F2250/0018 ,  A61M25/0054 ,  A61M2025/0183

    Abstract: A balloon catheter or stent delivery system for medical treatment of a patient has a proximal hub, a balloon, and an improved shaft design. The catheter shaft has a rapid-exchange configuration, and a tubular outer body that includes a hypotube extending from the catheter proximal end to a position at or near a proximal leg of the balloon. An inner tubular body defines a guidewire lumen extending from a distal guidewire port at the catheter distal end to a proximal port located at a position between the balloon and the hub. A distal leg of the balloon is directly or indirectly affixed to the inner body, and a proximal leg of the balloon is affixed to the distal end of the outer body. The hypotube has an aperture for accepting the inner body proximal end, and a circumferential cut pattern. The cut pattern adds flexibility, and may extend from the hypotube distal end to a position proximal of the proximal guidewire port. The cut pattern may have any desired shape, including a spiral, a helical undulating path, or an overlapping serpentine path with inflection points, for example. The hypotube has a fluid-tight covering such as a heat-shrink polymer, so the outer body supports pressure of an inflation medium. The proximal guidewire port may be positioned on or between the individual portions of the cut pattern, or at a position beyond the cut pattern.

    Abstract translation: 用于患者医疗的球囊导管或支架输送系统具有近端毂，球囊和改进的轴设计。 导管轴具有快速交换构造，以及管状外体，其包括从导管近端延伸到球囊的近端腿处或附近的位置的海波管。 内部管状体限定从导管远端处的远端导丝端口延伸到位于气囊和轮毂之间的位置的近端口的导丝管腔。 球囊的远端腿直接或间接地固定到内体上，并且气球的近端腿固定到外体的远端。 海波管具有用于接纳内体近端的孔和圆周切割图案。 切割图案增加了柔性，并且可以从海波管远端延伸到近端导丝端口的近端。 切割图案可以具有任何期望的形状，例如包括螺旋形，螺旋形起伏路径或具有拐点的重叠蛇形路径。 海波管具有流体密封的覆盖物，例如热收缩聚合物，因此外壳支撑膨胀介质的压力。 近端导丝端口可以定位在切割图案的各个部分之间或之间，或位于切割图案之外的位置。

    Rapid-exchange balloon catheter shaft and method
    17.
    发明授权
    Rapid-exchange balloon catheter shaft and method 有权
    快速交换球囊导管轴和方法

    公开(公告)号：US07815600B2

    公开(公告)日：2010-10-19

    申请号：US12008509

    申请日：2008-01-11

    Applicant: Laila Al-Marashi ,  David Grewe ,  Stephen Griffin ,  Elaine Lim ,  David Majercak ,  Roger Stevens

    Inventor： Laila Al-Marashi ,  David Grewe ,  Stephen Griffin ,  Elaine Lim ,  David Majercak ,  Roger Stevens

    IPC: A61M31/00

    CPC classification number: A61M25/10 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/91558 ,  A61F2230/0054 ,  A61F2250/0018 ,  A61M25/0054 ,  A61M2025/0183

    Abstract: A rapid-exchange balloon catheter or stent delivery system, for medically treating a patient, has a proximal hub, a balloon, and an improved shaft design. The catheter shaft has a tubular outer body that includes a hypotube extending from the catheter proximal end to a position at or near the proximal leg of the balloon. An inner tubular body defines a guidewire lumen and extends from a distal guidewire port at the catheter distal end to proximal guidewire port located between the balloon and the proximal hub. The hypotube has an aperture for accepting the inner body proximal end and a circumferential cut pattern. The cut pattern adds flexibility and may have any desired shape, including a spiral, a helical undulating path, or an overlapping serpentine path with inflection points, for example. The proximal guidewire port may be positioned on or in between the individual portions of the cut pattern.

    Abstract translation: 用于医疗治疗患者的快速交换气囊导管或支架输送系统具有近端毂，球囊和改进的轴设计。 导管轴具有管状外体，其包括从导管近端延伸到球囊近端腿处或附近的位置的海波管。 内管状体限定了导丝内腔，并且从导管远端处的远端导丝端口延伸到位于气囊和近端毂之间的近端导丝端口。 海波管具有用于接纳内体近端和圆周切割图案的孔。 切割图案增加了柔性，并且可以具有任何期望的形状，例如包括螺旋形，螺旋形波形路径或具有拐点的重叠蛇形路径。 近端导丝端口可以定位在切割图案的各个部分之间或之中。

    Coated implantable medical device
    20.
    发明申请
    Coated implantable medical device 有权
    涂层可植入医疗器械

    公开(公告)号：US20070050010A1

    公开(公告)日：2007-03-01

    申请号：US11515395

    申请日：2006-09-01

    Applicant: Brian Bates ,  Anthony Ragheb ,  Neal Fearnot ,  William Voorhees ,  Thomas Kozma ,  David Grewe ,  Darin Schaeffer

    Inventor： Brian Bates ,  Anthony Ragheb ,  Neal Fearnot ,  William Voorhees ,  Thomas Kozma ,  David Grewe ,  Darin Schaeffer

    IPC: A61F2/86 ,  A61F2/06

    CPC classification number: A61F2/91 ,  A61F2/24 ,  A61F2/82 ,  A61F2/885 ,  A61F2250/0068 ,  A61K51/1282 ,  A61L27/306 ,  A61L27/54 ,  A61L29/085 ,  A61L29/106 ,  A61L29/16 ,  A61L31/088 ,  A61L31/10 ,  A61L31/16 ,  A61L33/022 ,  A61L2300/256 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61N5/1002 ,  C08L65/04

    Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.

    Abstract translation: 涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 和至少一层生物活性物质的层18位于涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。 此外，至少一个多孔层20可以放置在生物活性材料层18上方，其中多孔层包括聚合物并提供生物活性材料通过其控制释放。 优选地，结构12是冠状动脉支架。 多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。 特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。

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