摘要:
A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
摘要:
Methods of making coated implantable medical devices are provided. The methods include positioning a first layer comprising a bioactive on at least a portion of a structure, and positioning at least one porous layer over the first layer. The at least one porous layer has a thickness adequate to provide a controlled release of the bioactive.
摘要:
Endovascular filter (10) including a plurality of struts (14) with distal ends (18) adapted to anchor the filter to the vessel wall after deployment, such as by having barbs (20), the filter being adapted to be retrieved if desired. Strut distal ends (18) are coated with an antiproliferative agent (40) that inhibits the ingrowth of tissue around the filter, thereby permitting the filter to be retrieved and removed atraumatically after a prolonged period of time, thus extending the useful life of the retrievable filter. Optionally, the proximal end (22) of the filter may also be so coated, or the entire filter.
摘要:
Bioactive-coated medical devices are provided, including coated vascular stents. The medical device coating can include a coating layer posited over at least a portion of the medical device surface, and can include a butyl methacrylate polymer or an ethylene-vinyl acetate copolymer in combination with a bioactive material that can function as both an immunosuppressive agent and an antiproliferative agent. Optionally, multilayer coatings can further include an adhesion promoting layer comprising parylene positioned between the coating layer and the medical device surface, a porous layer comprising butyl methacrylate positioned over at least a portion of the coating layer, or both. The coating layer preferably comprises between about 0.5 and 2.0 μg/mm2 of the bioactive material on the outer surface of the medical device. The bioactive material can be absorbed into the coating layer, which can have a thickness of between about 0.5 μm to about 5 μm.
摘要:
Methods of making coated implantable medical devices are provided. The methods include positioning a first layer comprising a bioactive on at least a portion of a structure, and positioning at least one porous layer over the first layer. The at least one porous layer has a thickness adequate to provide a controlled release of the bioactive.
摘要:
A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
摘要:
A self-expanding or otherwise expandable artificial valve prostheses for deployment within a body passageway, such as a vessel or duct of a patient. The valve prostheses include a support structure having an outer frame, a supporting member and a valve leaflet. The portion of the valve leaflet is supported by the supporting member and is positioned away from the wall of the body passageway when the device is deployed within the body passageway.
摘要:
Methods and associated structure for utilizing multiple ports or PHYs comprising a SAS wide port to improve transmission bandwidth utilization for a single large I/O request. In one aspect hereof, a large I/O request is broken into a plurality of smaller I/O requests to be distributed over multiple PHYs or ports of a configured wide SAS port. The number of smaller I/O requests may be any number up to the maximum number of PHYs or ports comprising the SAS wide port. In another aspect hereof, the size of a large I/O request may be compared against a threshold value to determine whether the large request should be broken into smaller requests. The threshold value may be determined in accordance with features and aspects hereof either statically or dynamically based on workloads assigned to, and utilization of, the configured SAS wide port.
摘要:
Improved methods and structures for testing of SAS components, in situ, in a SAS domain. A first SAS component is adapted to generate stimuli such as error conditions to elicit a response to the error condition from a second SAS component coupled to the first in the intended SAS domain configuration. In one aspect, a SAS device controller generates stimuli applied to a SAS expander coupled thereto and verifies proper response from the SAS expander. In another aspect, a SAS expander generates stimuli applied to a SAS device controller coupled thereto and verifies proper response from the SAS device controller. Stimuli may be generated by custom circuits or firmware/software within the first component. Vendor specific SAS SMP transactions may be used to cause the first component to enter the special verification mode.
摘要:
A multi-chip module (MCM) designed using standard die SAS expander components for rapidly designing a customized SAS expander having a predetermined number of ports. A number of standard expander die circuit components are selected and disposed on a MCM design. Each expander die circuit has a predetermined number of internal ports within the MCM and a predetermined number of ports for coupling to SAS devices external to the MCM. An internal fabric is disposed on the MCM and selectively coupled to internal ports of the SAS expanders to provide the desired number of external ports with desired routing therebetween. The internal fabric may be statically configured or dynamically programmed. The internal fabric routing may provide wide port routes as well as standard port connections.