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    Manufacturing methods for covering endoluminal prostheses
    1.
    发明授权
    Manufacturing methods for covering endoluminal prostheses 有权
    用于覆盖腔内假体的制造方法

    公开(公告)号：US08637109B2

    公开(公告)日：2014-01-28

    申请号：US12959023

    申请日：2010-12-02

    Applicant: David Grewe ,  Blayne Roeder ,  Steven Charlebois ,  Adam Griebel

    Inventor： David Grewe ,  Blayne Roeder ,  Steven Charlebois ,  Adam Griebel

    IPC: B05D1/32 ,  B05D1/16

    CPC classification number: B05D1/007 ,  D01D5/0069 ,  D01D5/0076

    Abstract: The disclosure relates to a method for coating a target. The method includes providing a target and an electrospinning apparatus. The target comprises a first surface and an opposing second surface. The electrospinning apparatus comprises a mandrel, a mask including an aperture, a reservoir loaded with a solution, and an orifice fluidly coupled to the reservoir. The mandrel is located adjacent the target second surface. The orifice is located at a distance from the target first surface. The mask is located intermediate the orifice and the target first surface. The solution is electrospun through the mask aperture onto the target first surface. In one example the target is an endoluminal prosthesis.

    Abstract translation: 本公开涉及涂覆靶的方法。 该方法包括提供靶和静电纺丝装置。 靶包括第一表面和相对的第二表面。 静电纺丝装置包括心轴，包括孔的掩模，装有溶液的储存器和流体耦合到储存器的孔。 心轴位于目标第二表面附近。 孔口位于离目标第一表面一定距离处。 掩模位于孔口和目标第一表面之间。 该溶液通过掩模孔电纺到目标第一表面上。 在一个示例中，目标是腔内假体。

    Eluting, implantable medical device
    3.
    发明申请
    Eluting, implantable medical device 审中-公开
    洗脱，植入式医疗器械

    公开(公告)号：US20070073385A1

    公开(公告)日：2007-03-29

    申请号：US11523797

    申请日：2006-09-18

    Applicant: Darin Schaeffer ,  David Grewe ,  Patrick Ruane

    Inventor： Darin Schaeffer ,  David Grewe ,  Patrick Ruane

    IPC: A61F2/90

    CPC classification number: A61L31/082 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/30322 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2230/0054 ,  A61F2250/0023 ,  A61F2250/0026 ,  A61F2250/0068 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/416

    Abstract: An intraluminal device is provided with a porous structure. The porous structure may be loaded with a bioactive substance to treat surrounding tissues after the intraluminal device has been implanted. The porous structure may be made by depositing a metal film on a foam structure using chemical vapor deposition. Porous structures may also be made by sintering or applying a ceramic layer to the intraluminal device. An intraluminal device is also provided with a ceramic material applied to generally straight portions of the device structure but not to portions adapted to bend. One advantage is that the ceramic material is less likely to fracture since it is applied to regions that experience less strain.

    Abstract translation: 管腔内装置具有多孔结构。 在植入腔内装置之后，多孔结构可装载生物活性物质以治疗周围组织。 多孔结构可以通过使用化学气相沉积在金属泡沫结构上沉积金属膜来制造。 也可以通过烧结或将陶瓷层施加到腔内装置来制造多孔结构。 管腔内装置还设置有施加到装置结构的大致直线部分的陶瓷材料，但是不适于弯曲的部分。 一个优点是陶瓷材料不太可能破裂，因为它被应用于经历较小应变的区域。

    RAPID-EXCHANGE BALLOON CATHETER SHAFT AND METHOD
    4.
    发明申请
    RAPID-EXCHANGE BALLOON CATHETER SHAFT AND METHOD 有权
    快速交换气囊导管轴和方法

    公开(公告)号：US20110034989A1

    公开(公告)日：2011-02-10

    申请号：US12906976

    申请日：2010-10-18

    Applicant: Laila Al-Marashi ,  David Grewe ,  Stephen Griffin ,  Elaine Lim ,  David Majercak ,  Roger Stevens

    Inventor： Laila Al-Marashi ,  David Grewe ,  Stephen Griffin ,  Elaine Lim ,  David Majercak ,  Roger Stevens

    IPC: A61F2/84

    CPC classification number: A61M25/10 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/91558 ,  A61F2230/0054 ,  A61F2250/0018 ,  A61M25/0054 ,  A61M2025/0183

    Abstract: A balloon catheter or stent delivery system for medical treatment of a patient has a proximal hub, a balloon, and an improved shaft design. The catheter shaft has a rapid-exchange configuration, and a tubular outer body that includes a hypotube extending from the catheter proximal end to a position at or near a proximal leg of the balloon. An inner tubular body defines a guidewire lumen extending from a distal guidewire port at the catheter distal end to a proximal port located at a position between the balloon and the hub. A distal leg of the balloon is directly or indirectly affixed to the inner body, and a proximal leg of the balloon is affixed to the distal end of the outer body. The hypotube has an aperture for accepting the inner body proximal end, and a circumferential cut pattern. The cut pattern adds flexibility, and may extend from the hypotube distal end to a position proximal of the proximal guidewire port. The cut pattern may have any desired shape, including a spiral, a helical undulating path, or an overlapping serpentine path with inflection points, for example. The hypotube has a fluid-tight covering such as a heat-shrink polymer, so the outer body supports pressure of an inflation medium. The proximal guidewire port may be positioned on or between the individual portions of the cut pattern, or at a position beyond the cut pattern.

    Abstract translation: 用于患者医疗的球囊导管或支架输送系统具有近端毂，球囊和改进的轴设计。 导管轴具有快速交换构造，以及管状外体，其包括从导管近端延伸到球囊的近端腿处或附近的位置的海波管。 内部管状体限定从导管远端处的远端导丝端口延伸到位于气囊和轮毂之间的位置的近端口的导丝管腔。 球囊的远端腿直接或间接地固定到内体上，并且气球的近端腿固定到外体的远端。 海波管具有用于接纳内体近端的孔和圆周切割图案。 切割图案增加了柔性，并且可以从海波管远端延伸到近端导丝端口的近端。 切割图案可以具有任何期望的形状，例如包括螺旋形，螺旋形起伏路径或具有拐点的重叠蛇形路径。 海波管具有流体密封的覆盖物，例如热收缩聚合物，因此外壳支撑膨胀介质的压力。 近端导丝端口可以定位在切割图案的各个部分之间或之间，或位于切割图案之外的位置。

    Rapid-exchange balloon catheter shaft and method
    5.
    发明授权
    Rapid-exchange balloon catheter shaft and method 有权
    快速交换球囊导管轴和方法

    公开(公告)号：US07815600B2

    公开(公告)日：2010-10-19

    申请号：US12008509

    申请日：2008-01-11

    Applicant: Laila Al-Marashi ,  David Grewe ,  Stephen Griffin ,  Elaine Lim ,  David Majercak ,  Roger Stevens

    Inventor： Laila Al-Marashi ,  David Grewe ,  Stephen Griffin ,  Elaine Lim ,  David Majercak ,  Roger Stevens

    IPC: A61M31/00

    CPC classification number: A61M25/10 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/91558 ,  A61F2230/0054 ,  A61F2250/0018 ,  A61M25/0054 ,  A61M2025/0183

    Abstract: A rapid-exchange balloon catheter or stent delivery system, for medically treating a patient, has a proximal hub, a balloon, and an improved shaft design. The catheter shaft has a tubular outer body that includes a hypotube extending from the catheter proximal end to a position at or near the proximal leg of the balloon. An inner tubular body defines a guidewire lumen and extends from a distal guidewire port at the catheter distal end to proximal guidewire port located between the balloon and the proximal hub. The hypotube has an aperture for accepting the inner body proximal end and a circumferential cut pattern. The cut pattern adds flexibility and may have any desired shape, including a spiral, a helical undulating path, or an overlapping serpentine path with inflection points, for example. The proximal guidewire port may be positioned on or in between the individual portions of the cut pattern.

    Abstract translation: 用于医疗治疗患者的快速交换气囊导管或支架输送系统具有近端毂，球囊和改进的轴设计。 导管轴具有管状外体，其包括从导管近端延伸到球囊近端腿处或附近的位置的海波管。 内管状体限定了导丝内腔，并且从导管远端处的远端导丝端口延伸到位于气囊和近端毂之间的近端导丝端口。 海波管具有用于接纳内体近端和圆周切割图案的孔。 切割图案增加了柔性，并且可以具有任何期望的形状，例如包括螺旋形，螺旋形波形路径或具有拐点的重叠蛇形路径。 近端导丝端口可以定位在切割图案的各个部分之间或之中。

    Coated implantable medical device
    8.
    发明申请
    Coated implantable medical device 有权
    涂层可植入医疗器械

    公开(公告)号：US20070050010A1

    公开(公告)日：2007-03-01

    申请号：US11515395

    申请日：2006-09-01

    Applicant: Brian Bates ,  Anthony Ragheb ,  Neal Fearnot ,  William Voorhees ,  Thomas Kozma ,  David Grewe ,  Darin Schaeffer

    Inventor： Brian Bates ,  Anthony Ragheb ,  Neal Fearnot ,  William Voorhees ,  Thomas Kozma ,  David Grewe ,  Darin Schaeffer

    IPC: A61F2/86 ,  A61F2/06

    CPC classification number: A61F2/91 ,  A61F2/24 ,  A61F2/82 ,  A61F2/885 ,  A61F2250/0068 ,  A61K51/1282 ,  A61L27/306 ,  A61L27/54 ,  A61L29/085 ,  A61L29/106 ,  A61L29/16 ,  A61L31/088 ,  A61L31/10 ,  A61L31/16 ,  A61L33/022 ,  A61L2300/256 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61N5/1002 ,  C08L65/04

    Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.

    Abstract translation: 涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 和至少一层生物活性物质的层18位于涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。 此外，至少一个多孔层20可以放置在生物活性材料层18上方，其中多孔层包括聚合物并提供生物活性材料通过其控制释放。 优选地，结构12是冠状动脉支架。 多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。 特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。

    Intraluminal device with a hollow structure
    9.
    发明申请
    Intraluminal device with a hollow structure 审中-公开
    具有中空结构的管腔内装置

    公开(公告)号：US20070043423A1

    公开(公告)日：2007-02-22

    申请号：US11502589

    申请日：2006-08-10

    Applicant: David Grewe

    Inventor： David Grewe

    IPC: A61F2/06

    CPC classification number: A61F2/885 ,  A61F2/90 ,  A61F2250/0068

    Abstract: Intraluminal devices are provided with an inner cavity. The inner cavity may be loaded with a bioactive substance. Fenestrations extend between an outer surface and the inner cavity. Thus, the bioactive substance may be released from the intraluminal device through the fenestrations.

    Abstract translation: 腔内装置设置有内腔。 内腔可以装载生物活性物质。 开窗在外表面和内腔之间延伸。 因此，生物活性物质可以通过开窗从管腔内装置释放。

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