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    DRUG ELUTING COCHLEAR IMPLANTS
    11.
    发明申请
    DRUG ELUTING COCHLEAR IMPLANTS 有权
    药物涂抹胶印

    公开(公告)号：US20120283666A1

    公开(公告)日：2012-11-08

    申请号：US13284287

    申请日：2011-10-28

    申请人： Thomas Lenarz ,  Klaus-Peter Schmitz ,  Detlef Behrend ,  Katrin Sternberg ,  Simon Williams ,  David Martin

    发明人： Thomas Lenarz ,  Klaus-Peter Schmitz ,  Detlef Behrend ,  Katrin Sternberg ,  Simon Williams ,  David Martin

    IPC分类号： A61M31/00 ,  A61N1/05

    CPC分类号： A61L27/34 ,  A61K9/0024 ,  A61L27/54 ,  A61L31/08 ,  A61L31/10 ,  A61L2300/258 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/416 ,  A61M31/002 ,  A61N1/36036 ,  C08L67/04

    摘要： Drug delivery systems and biocompatible coatings for use with implantable stimulation devices such as cochlear implants have been developed. These drug delivery systems and coatings comprise polyhydroxyalkanoate (PHA) polymers and copolymers. The drug delivery systems may be used to deliver pharmacologically active substances, for example, directly from a cochlear implant to the inner ear. The coatings can impart lubricity to cochlear devices for ease of insertion of the electrodes. In the preferred embodiment, the drug delivery system comprises a polyhydroxyalkanoate polymer, and in the most preferred embodiment, the PHA polymer comprises poly(4-hydroxybutyrate) (P(4HB)) or copolymer thereof. A particularly preferred embodiment is where the silicone sheath of the cochlear implant electrodes has been surface modified, and coated with P(4HB), and the P(4HB) either contains a pharmacologically active substance or has been coated with such a substance.

    摘要翻译： 已经开发了用于植入式刺激装置如耳蜗植入物的药物递送系统和生物相容性涂层。 这些药物递送系统和涂层包含聚羟基链烷酸酯（PHA）聚合物和共聚物。 药物递送系统可以用于将药理活性物质例如直接从耳蜗植入物递送到内耳。 涂层可以赋予耳蜗装置润滑性，便于插入电极。 在优选的实施方案中，药物递送系统包含聚羟基链烷酸酯聚合物，并且在最优选的实施方案中，PHA聚合物包含聚（4-羟基丁酸酯）（P（4HB））或其共聚物。 一个特别优选的实施方案是其中耳蜗植入电极的硅氧烷鞘被表面改性并且涂覆有P（4HB），并且P（4HB）含有药理学活性物质或已被这种物质包被。

    POLYMERIC, DEGRADABLE DRUG-ELUTING STENTS AND COATINGS
    14.
    发明申请
    POLYMERIC, DEGRADABLE DRUG-ELUTING STENTS AND COATINGS 有权
    聚合，可降解药水和涂层

    公开(公告)号：US20090012604A1

    公开(公告)日：2009-01-08

    申请号：US12188113

    申请日：2008-08-07

    申请人： Klaus-Peter Schmitz ,  Detlef Behrend ,  Katrin Sternberg ,  Niels Grabow ,  David P. Martin ,  Simon F. Williams

    发明人： Klaus-Peter Schmitz ,  Detlef Behrend ,  Katrin Sternberg ,  Niels Grabow ,  David P. Martin ,  Simon F. Williams

    IPC分类号： A61F2/06

    CPC分类号： A61L31/18 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/606 ,  A61L2420/08 ,  C08L67/04

    摘要： Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delaminating and can be used as a coating matrix for drug incorporation.

    摘要翻译： 可吸收支架和可吸收支架涂层已经开发出具有改进的性能。 这些装置优选包含4-羟基丁酸酯和任选的聚-L-乳酸和其它可吸收的聚合物和添加剂的生物相容性共聚物或均聚物。 这些材料的组合物可用于制造提供有利的径向强度，抵抗反冲和蠕变的可吸收支架，可以在球囊导管上塑性膨胀，并且可以在体内迅速部署。 衍生自这些材料的支架涂层提供生物相容性均匀的延展性涂层，并且可以在没有涂层开裂和/或分层的情况下扩展，并且可以用作药物掺入的涂层基质。

    Polymeric, degradable drug-eluting stents and coatings
    15.
    发明授权
    Polymeric, degradable drug-eluting stents and coatings 有权
    聚合，可降解的药物洗脱支架和涂层

    公开(公告)号：US09592325B2

    公开(公告)日：2017-03-14

    申请号：US12188113

    申请日：2008-08-07

    申请人： Klaus-Peter Schmitz ,  Detlef Behrend ,  Katrin Sternberg ,  Niels Grabow ,  David Martin ,  Simon Williams

    发明人： Klaus-Peter Schmitz ,  Detlef Behrend ,  Katrin Sternberg ,  Niels Grabow ,  David Martin ,  Simon Williams

    IPC分类号： A61F2/82 ,  A61L31/18 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16

    CPC分类号： A61L31/18 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/606 ,  A61L2420/08 ,  C08L67/04

    摘要： Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delaminating and can be used as a coating matrix for drug incorporation.

    摘要翻译： 可吸收支架和可吸收支架涂层已经开发出具有改进的性能。 这些装置优选包含4-羟基丁酸酯和任选的聚-L-乳酸和其它可吸收的聚合物和添加剂的生物相容性共聚物或均聚物。 这些材料的组合物可用于制造提供有利的径向强度，抵抗反冲和蠕变的可吸收支架，可以在球囊导管上塑性膨胀，并且可以在体内迅速部署。 衍生自这些材料的支架涂层提供生物相容性均匀的延展性涂层，并且可以在没有涂层开裂和/或分层的情况下扩展，并且可以用作药物掺入的涂层基质。