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    Drug eluting cochlear implants
    1.
    发明授权
    Drug eluting cochlear implants 有权
    药物洗脱耳蜗植入物

    公开(公告)号：US09162010B2

    公开(公告)日：2015-10-20

    申请号：US13284287

    申请日：2011-10-28

    申请人： Thomas Lenarz ,  Klaus-Peter Schmitz ,  Detlef Behrend ,  Katrin Sternberg ,  Simon Williams ,  David Martin

    发明人： Thomas Lenarz ,  Klaus-Peter Schmitz ,  Detlef Behrend ,  Katrin Sternberg ,  Simon Williams ,  David Martin

    IPC分类号： A61K9/00 ,  A61L31/10 ,  A61L27/34 ,  A61L27/54 ,  A61N1/36 ,  A61M31/00 ,  A61L31/08

    CPC分类号： A61L27/34 ,  A61K9/0024 ,  A61L27/54 ,  A61L31/08 ,  A61L31/10 ,  A61L2300/258 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/416 ,  A61M31/002 ,  A61N1/36036 ,  C08L67/04

    摘要： Drug delivery systems and biocompatible coatings for use with implantable stimulation devices such as cochlear implants have been developed. These drug delivery systems and coatings comprise polyhydroxyalkanoate (PHA) polymers and copolymers. The drug delivery systems may be used to deliver pharmacologically active substances, for example, directly from a cochlear implant to the inner ear. The coatings can impart lubricity to cochlear devices for ease of insertion of the electrodes. In the preferred embodiment, the drug delivery system comprises a polyhydroxyalkanoate polymer, and in the most preferred embodiment, the PHA polymer comprises poly(4-hydroxybutyrate) (P(4HB)) or copolymer thereof. A particularly preferred embodiment is where the silicone sheath of the cochlear implant electrodes has been surface modified, and coated with P(4HB), and the P(4HB) either contains a pharmacologically active substance or has been coated with such a substance.

    摘要翻译： 已经开发了用于植入式刺激装置如耳蜗植入物的药物递送系统和生物相容性涂层。 这些药物递送系统和涂层包含聚羟基链烷酸酯（PHA）聚合物和共聚物。 药物递送系统可以用于将药理活性物质例如直接从耳蜗植入物递送到内耳。 涂层可以赋予耳蜗装置润滑性，便于插入电极。 在优选的实施方案中，药物递送系统包含聚羟基链烷酸酯聚合物，并且在最优选的实施方案中，PHA聚合物包含聚（4-羟基丁酸酯）（P（4HB））或其共聚物。 一个特别优选的实施方案是其中耳蜗植入电极的硅氧烷鞘被表面改性并且涂覆有P（4HB），并且P（4HB）含有药理学活性物质或已被这种物质包被。

    DRUG ELUTING COCHLEAR IMPLANTS
    2.
    发明申请
    DRUG ELUTING COCHLEAR IMPLANTS 有权
    药物涂抹胶印

    公开(公告)号：US20120283666A1

    公开(公告)日：2012-11-08

    申请号：US13284287

    申请日：2011-10-28

    申请人： Thomas Lenarz ,  Klaus-Peter Schmitz ,  Detlef Behrend ,  Katrin Sternberg ,  Simon Williams ,  David Martin

    发明人： Thomas Lenarz ,  Klaus-Peter Schmitz ,  Detlef Behrend ,  Katrin Sternberg ,  Simon Williams ,  David Martin

    IPC分类号： A61M31/00 ,  A61N1/05

    CPC分类号： A61L27/34 ,  A61K9/0024 ,  A61L27/54 ,  A61L31/08 ,  A61L31/10 ,  A61L2300/258 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/416 ,  A61M31/002 ,  A61N1/36036 ,  C08L67/04

    摘要： Drug delivery systems and biocompatible coatings for use with implantable stimulation devices such as cochlear implants have been developed. These drug delivery systems and coatings comprise polyhydroxyalkanoate (PHA) polymers and copolymers. The drug delivery systems may be used to deliver pharmacologically active substances, for example, directly from a cochlear implant to the inner ear. The coatings can impart lubricity to cochlear devices for ease of insertion of the electrodes. In the preferred embodiment, the drug delivery system comprises a polyhydroxyalkanoate polymer, and in the most preferred embodiment, the PHA polymer comprises poly(4-hydroxybutyrate) (P(4HB)) or copolymer thereof. A particularly preferred embodiment is where the silicone sheath of the cochlear implant electrodes has been surface modified, and coated with P(4HB), and the P(4HB) either contains a pharmacologically active substance or has been coated with such a substance.

    摘要翻译： 已经开发了用于植入式刺激装置如耳蜗植入物的药物递送系统和生物相容性涂层。 这些药物递送系统和涂层包含聚羟基链烷酸酯（PHA）聚合物和共聚物。 药物递送系统可以用于将药理活性物质例如直接从耳蜗植入物递送到内耳。 涂层可以赋予耳蜗装置润滑性，便于插入电极。 在优选的实施方案中，药物递送系统包含聚羟基链烷酸酯聚合物，并且在最优选的实施方案中，PHA聚合物包含聚（4-羟基丁酸酯）（P（4HB））或其共聚物。 一个特别优选的实施方案是其中耳蜗植入电极的硅氧烷鞘被表面改性并且涂覆有P（4HB），并且P（4HB）含有药理学活性物质或已被这种物质包被。

    Polymeric, degradable drug-eluting stents and coatings
    3.
    发明授权
    Polymeric, degradable drug-eluting stents and coatings 有权
    聚合，可降解的药物洗脱支架和涂层

    公开(公告)号：US09592325B2

    公开(公告)日：2017-03-14

    申请号：US12188113

    申请日：2008-08-07

    申请人： Klaus-Peter Schmitz ,  Detlef Behrend ,  Katrin Sternberg ,  Niels Grabow ,  David Martin ,  Simon Williams

    发明人： Klaus-Peter Schmitz ,  Detlef Behrend ,  Katrin Sternberg ,  Niels Grabow ,  David Martin ,  Simon Williams

    IPC分类号： A61F2/82 ,  A61L31/18 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16

    CPC分类号： A61L31/18 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/606 ,  A61L2420/08 ,  C08L67/04

    摘要： Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delaminating and can be used as a coating matrix for drug incorporation.

    摘要翻译： 可吸收支架和可吸收支架涂层已经开发出具有改进的性能。 这些装置优选包含4-羟基丁酸酯和任选的聚-L-乳酸和其它可吸收的聚合物和添加剂的生物相容性共聚物或均聚物。 这些材料的组合物可用于制造提供有利的径向强度，抵抗反冲和蠕变的可吸收支架，可以在球囊导管上塑性膨胀，并且可以在体内迅速部署。 衍生自这些材料的支架涂层提供生物相容性均匀的延展性涂层，并且可以在没有涂层开裂和/或分层的情况下扩展，并且可以用作药物掺入的涂层基质。

    POLYMERIC, DEGRADABLE DRUG-ELUTING STENTS AND COATINGS
    6.
    发明申请
    POLYMERIC, DEGRADABLE DRUG-ELUTING STENTS AND COATINGS 有权
    聚合，可降解药水和涂层

    公开(公告)号：US20110190866A1

    公开(公告)日：2011-08-04

    申请号：US13057974

    申请日：2009-07-17

    申请人： Klaus-Peter Schmitz ,  Detlef Behrend ,  Katrin Sternberg ,  Niels Grabow ,  David P. Martin ,  Simon F. Williams

    发明人： Klaus-Peter Schmitz ,  Detlef Behrend ,  Katrin Sternberg ,  Niels Grabow ,  David P. Martin ,  Simon F. Williams

    IPC分类号： A61F2/84 ,  A61F2/82 ,  B05D7/00

    CPC分类号： A61L31/18 ,  A61F2/82 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/606 ,  C08L67/04

    摘要： Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delarmnating and can be used as a coating matrix for drug incorporation.

    摘要翻译： 可吸收支架和可吸收支架涂层已经开发出具有改进的性能。 这些装置优选包含4-羟基丁酸酯和任选的聚-L-乳酸和其它可吸收的聚合物和添加剂的生物相容性共聚物或均聚物。 这些材料的组合物可用于制造提供有利的径向强度，抵抗反冲和蠕变的可吸收支架，可以在球囊导管上塑性膨胀，并且可以在体内迅速部署。 衍生自这些材料的支架涂层提供生物相容性均匀的延展性涂层，并且可以在没有涂层开裂和/或脱胶的情况下扩展，并且可以用作药物掺入的涂层基质。

    Ocular implant
    8.
    发明授权
    Ocular implant 有权
    眼部植入

    公开(公告)号：US08206333B2

    公开(公告)日：2012-06-26

    申请号：US12524719

    申请日：2008-01-25

    申请人： Wolfram Schmidt ,  Katrin Sternberg ,  Detlef Behrend ,  Rudolf Guthoff ,  Klaus-Peter Schmitz

    发明人： Wolfram Schmidt ,  Katrin Sternberg ,  Detlef Behrend ,  Rudolf Guthoff ,  Klaus-Peter Schmitz

    IPC分类号： A61M5/00

    CPC分类号： A61F9/00781

    摘要： The present invention relates to an ocular implant, particularly a glaucoma stent.It is the object of the present invention to devise an ocular implant which allows the ocular eye pressure to be regulated, i.e., to be maintained at a desired level, while preventing the flow resistance from increasing over time, for example due to fibrosis.In order to achieve this object, the ocular implant according to the invention comprises a small tube (5), the wall surface (3) of which encloses a hollow duct that is open on both sides in the longitudinal direction of the hollow duct, wherein a first opening (1) allowing ocular humor to flow in and a second opening (2) allowing the ocular humor to be discharged is provided, and wherein the wall surface (3) is formed by a liquid-tight material, and wherein at least one pressure-controlled valve (4) is disposed in the area of the wall surface (3).

    摘要翻译： 本发明涉及眼部植入物，特别是青光眼支架。 本发明的目的是设计一种允许眼睛压力被调节，即保持在期望水平的眼部植入物，同时防止流动阻力随时间增加，例如由于纤维化。 为了实现该目的，根据本发明的眼部植入物包括小管（5），其壁表面（3）围绕中空管道，中空管道在中空管道的纵向两侧敞开，其中 提供允许眼睛流入的第一开口（1）和允许眼睛被排出的第二开口（2），并且其中壁表面（3）由液体密封材料形成，并且其中至少 一个压力控制阀（4）设置在壁表面（3）的区域中。

    Electrode arrangement and measuring device for measuring the electrical activity in an electrically active tissue
    10.
    发明授权
    Electrode arrangement and measuring device for measuring the electrical activity in an electrically active tissue 有权
    用于测量电活性组织中的电活动的电极装置和测量装置

    公开(公告)号：US08725227B2

    公开(公告)日：2014-05-13

    申请号：US12601156

    申请日：2008-06-04

    申请人： Detlef Behrend ,  Klaus-Peter Schmitz ,  Hans Wilhelm Pau ,  Katrin Sternberg ,  Wolfram Schmidt

    发明人： Detlef Behrend ,  Klaus-Peter Schmitz ,  Hans Wilhelm Pau ,  Katrin Sternberg ,  Wolfram Schmidt

    IPC分类号： A61B5/0492 ,  A61F11/00

    CPC分类号： A61B5/6817 ,  A61B5/0492 ,  A61B5/121 ,  A61B5/6815 ,  A61B5/6838 ,  A61B5/6848 ,  A61N1/0541 ,  A61N1/36036

    摘要： The invention relates to an electrode arrangement and a measuring device for measuring the action flow and/or the action potential of an electrically active tissue. The aim of the invention is to provide a simple and economically producible electrode for measuring action flows and/or action potentials in electrically active tissues (preferably the stapedius muscle tissue), ensuring that the electrode is fixed securely, but reversibly, in the muscle tissue and that the muscle tissue is disturbed as little as possible. The electrode arrangement according to the invention comprises a first electrode (2) and a fixing element (3), the first electrode (2) being connected to a first, long electrical line (4) and consisting of a long base body (6) comprising a first end (7) and a second end (8). The first electrical line (4) is connected to the base body (6) in the region of the second end (8) thereof, and means are provided for reversibly fixing the fixing element (3) to the first electrode (2).

    摘要翻译： 本发明涉及一种用于测量电活性组织的作用流和/或动作电位的电极装置和测量装置。 本发明的目的是提供一种用于测量电活动组织（优选吻合肌肉组织）中的作用流动和/或动作电位的简单且经济地生产的电极，确保电极在肌肉组织中可靠地可逆地固定 并且尽可能少地扰乱肌肉组织。 根据本发明的电极装置包括第一电极（2）和固定元件（3），所述第一电极（2）连接到第一长电线（4）并由长基体（6）组成， 包括第一端（7）和第二端（8）。 第一电线（4）在其第二端（8）的区域中连接到基体（6），并且设置用于将固定元件（3）可逆地固定到第一电极（2）的装置。