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    Polymeric, degradable drug-eluting stents and coatings
    1.
    发明授权
    Polymeric, degradable drug-eluting stents and coatings 有权
    聚合，可降解的药物洗脱支架和涂层

    公开(公告)号：US09592325B2

    公开(公告)日：2017-03-14

    申请号：US12188113

    申请日：2008-08-07

    申请人： Klaus-Peter Schmitz ,  Detlef Behrend ,  Katrin Sternberg ,  Niels Grabow ,  David Martin ,  Simon Williams

    发明人： Klaus-Peter Schmitz ,  Detlef Behrend ,  Katrin Sternberg ,  Niels Grabow ,  David Martin ,  Simon Williams

    IPC分类号： A61F2/82 ,  A61L31/18 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16

    CPC分类号： A61L31/18 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/606 ,  A61L2420/08 ,  C08L67/04

    摘要： Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delaminating and can be used as a coating matrix for drug incorporation.

    摘要翻译： 可吸收支架和可吸收支架涂层已经开发出具有改进的性能。 这些装置优选包含4-羟基丁酸酯和任选的聚-L-乳酸和其它可吸收的聚合物和添加剂的生物相容性共聚物或均聚物。 这些材料的组合物可用于制造提供有利的径向强度，抵抗反冲和蠕变的可吸收支架，可以在球囊导管上塑性膨胀，并且可以在体内迅速部署。 衍生自这些材料的支架涂层提供生物相容性均匀的延展性涂层，并且可以在没有涂层开裂和/或分层的情况下扩展，并且可以用作药物掺入的涂层基质。

    Drug eluting cochlear implants
    3.
    发明授权
    Drug eluting cochlear implants 有权
    药物洗脱耳蜗植入物

    公开(公告)号：US09162010B2

    公开(公告)日：2015-10-20

    申请号：US13284287

    申请日：2011-10-28

    申请人： Thomas Lenarz ,  Klaus-Peter Schmitz ,  Detlef Behrend ,  Katrin Sternberg ,  Simon Williams ,  David Martin

    发明人： Thomas Lenarz ,  Klaus-Peter Schmitz ,  Detlef Behrend ,  Katrin Sternberg ,  Simon Williams ,  David Martin

    IPC分类号： A61K9/00 ,  A61L31/10 ,  A61L27/34 ,  A61L27/54 ,  A61N1/36 ,  A61M31/00 ,  A61L31/08

    CPC分类号： A61L27/34 ,  A61K9/0024 ,  A61L27/54 ,  A61L31/08 ,  A61L31/10 ,  A61L2300/258 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/416 ,  A61M31/002 ,  A61N1/36036 ,  C08L67/04

    摘要： Drug delivery systems and biocompatible coatings for use with implantable stimulation devices such as cochlear implants have been developed. These drug delivery systems and coatings comprise polyhydroxyalkanoate (PHA) polymers and copolymers. The drug delivery systems may be used to deliver pharmacologically active substances, for example, directly from a cochlear implant to the inner ear. The coatings can impart lubricity to cochlear devices for ease of insertion of the electrodes. In the preferred embodiment, the drug delivery system comprises a polyhydroxyalkanoate polymer, and in the most preferred embodiment, the PHA polymer comprises poly(4-hydroxybutyrate) (P(4HB)) or copolymer thereof. A particularly preferred embodiment is where the silicone sheath of the cochlear implant electrodes has been surface modified, and coated with P(4HB), and the P(4HB) either contains a pharmacologically active substance or has been coated with such a substance.

    摘要翻译： 已经开发了用于植入式刺激装置如耳蜗植入物的药物递送系统和生物相容性涂层。 这些药物递送系统和涂层包含聚羟基链烷酸酯（PHA）聚合物和共聚物。 药物递送系统可以用于将药理活性物质例如直接从耳蜗植入物递送到内耳。 涂层可以赋予耳蜗装置润滑性，便于插入电极。 在优选的实施方案中，药物递送系统包含聚羟基链烷酸酯聚合物，并且在最优选的实施方案中，PHA聚合物包含聚（4-羟基丁酸酯）（P（4HB））或其共聚物。 一个特别优选的实施方案是其中耳蜗植入电极的硅氧烷鞘被表面改性并且涂覆有P（4HB），并且P（4HB）含有药理学活性物质或已被这种物质包被。

    DRUG ELUTING COCHLEAR IMPLANTS
    4.
    发明申请
    DRUG ELUTING COCHLEAR IMPLANTS 有权
    药物涂抹胶印

    公开(公告)号：US20120283666A1

    公开(公告)日：2012-11-08

    申请号：US13284287

    申请日：2011-10-28

    申请人： Thomas Lenarz ,  Klaus-Peter Schmitz ,  Detlef Behrend ,  Katrin Sternberg ,  Simon Williams ,  David Martin

    发明人： Thomas Lenarz ,  Klaus-Peter Schmitz ,  Detlef Behrend ,  Katrin Sternberg ,  Simon Williams ,  David Martin

    IPC分类号： A61M31/00 ,  A61N1/05

    CPC分类号： A61L27/34 ,  A61K9/0024 ,  A61L27/54 ,  A61L31/08 ,  A61L31/10 ,  A61L2300/258 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/416 ,  A61M31/002 ,  A61N1/36036 ,  C08L67/04

    摘要： Drug delivery systems and biocompatible coatings for use with implantable stimulation devices such as cochlear implants have been developed. These drug delivery systems and coatings comprise polyhydroxyalkanoate (PHA) polymers and copolymers. The drug delivery systems may be used to deliver pharmacologically active substances, for example, directly from a cochlear implant to the inner ear. The coatings can impart lubricity to cochlear devices for ease of insertion of the electrodes. In the preferred embodiment, the drug delivery system comprises a polyhydroxyalkanoate polymer, and in the most preferred embodiment, the PHA polymer comprises poly(4-hydroxybutyrate) (P(4HB)) or copolymer thereof. A particularly preferred embodiment is where the silicone sheath of the cochlear implant electrodes has been surface modified, and coated with P(4HB), and the P(4HB) either contains a pharmacologically active substance or has been coated with such a substance.

    摘要翻译： 已经开发了用于植入式刺激装置如耳蜗植入物的药物递送系统和生物相容性涂层。 这些药物递送系统和涂层包含聚羟基链烷酸酯（PHA）聚合物和共聚物。 药物递送系统可以用于将药理活性物质例如直接从耳蜗植入物递送到内耳。 涂层可以赋予耳蜗装置润滑性，便于插入电极。 在优选的实施方案中，药物递送系统包含聚羟基链烷酸酯聚合物，并且在最优选的实施方案中，PHA聚合物包含聚（4-羟基丁酸酯）（P（4HB））或其共聚物。 一个特别优选的实施方案是其中耳蜗植入电极的硅氧烷鞘被表面改性并且涂覆有P（4HB），并且P（4HB）含有药理学活性物质或已被这种物质包被。

    Polyhydroxyalkanoates for In Vivo Applications
    5.
    发明申请
    Polyhydroxyalkanoates for In Vivo Applications 有权
    聚羟基链烷酸酯用于体内应用

    公开(公告)号：US20070280899A1

    公开(公告)日：2007-12-06

    申请号：US11748723

    申请日：2007-05-15

    申请人： Simon Williams ,  David Martin ,  Tillman Gerngross ,  Daniel Horowitz

    发明人： Simon Williams ,  David Martin ,  Tillman Gerngross ,  Daniel Horowitz

    IPC分类号： A61K31/765

    CPC分类号： C12P7/625 ,  A61B17/06166 ,  A61B42/00 ,  A61K47/593 ,  A61K47/6957 ,  A61L15/26 ,  A61L17/10 ,  A61L27/18 ,  A61L27/34 ,  A61L29/06 ,  A61L31/06 ,  C08G63/06 ,  C08G63/6852 ,  C08G63/6882 ,  C08G63/912 ,  C12N5/0068 ,  C12N2533/30 ,  Y10S977/775 ,  Y10T428/139 ,  C08L67/04

    摘要： Polyhydroxyalkanoates (PHAs) from which pyrogen has been removed are provided for use in numerous biomedical applications. PHAs which have been chemically modified to enhance physical and/or chemical properties, for targeting or to modify biodegradability or clearance by the reticuloendothelial system (RES), are described. Methods for depyrogenating PHA polymers prepared by bacterial fermentation processes are also provided, wherein pyrogens are removed from the polymers without adversely impacting the polymers' inherent chemical structures and physical properties. PHAs with advantageous processing characteristics, including low melting points and/or solubility in non-toxic solvents, are also described. PHAs are provided which are suitable for use in vivo applications such as in tissue coatings, stents, sutures, tubing, bone and other prostheses, bone or tissue cements, tissue regeneration devices, wound dressings, drug delivery, and for diagnostic and prophylactic uses. Properties which are selected for include degradability, elasticity, inclusion of functional groups or derivatized groups, which can in turn be used to attach targeting agents, and bioadhesion.

    摘要翻译： 已经除去热原的聚羟基链烷酸酯（PHA）被提供用于许多生物医学应用。 已经化学改性以增强物理和/或化学性质的PHA用于通过网状内皮系统（RES）靶向或修饰生物降解性或清除的PHA。 还提供了通过细菌发酵方法制备的去氢原位PHA聚合物的方法，其中热原从聚合物中除去而不会不利地影响聚合物固有的化学结构和物理性质。 还描述了具有有利处理特性的PHA，包括低熔点和/或在无毒溶剂中的溶解度。 提供适用于体内应用的PHA，例如在组织包衣，支架，缝线，管，骨和其他假体，骨或组织水泥，组织再生装置，伤口敷料，药物递送以及诊断和预防用途中。 选择的性质包括降解性，弹性，包含官能团或衍生基团，其又可用于附着靶向剂，以及生物粘附。

    Medical Devices and Applications of Polyhydroxyalkanoate Polymers
    9.
    发明申请
    Medical Devices and Applications of Polyhydroxyalkanoate Polymers 有权
    聚羟基链烷酸酯聚合物的医疗器械及其应用

    公开(公告)号：US20080095823A1

    公开(公告)日：2008-04-24

    申请号：US11925635

    申请日：2007-10-26

    申请人： Simon Williams ,  David Martin ,  Frank Skraly

    发明人： Simon Williams ,  David Martin ,  Frank Skraly

    IPC分类号： A61F2/82

    CPC分类号： A61L27/58 ,  A61F2/07 ,  A61F2210/0004 ,  A61K31/715 ,  A61L17/12 ,  A61L27/18 ,  A61L31/06 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00 ,  C08G63/06 ,  C08J9/26 ,  C08J2201/0444 ,  C08J2201/0482 ,  C08J2367/04 ,  C08K5/0033 ,  C08L67/04 ,  C12P7/625 ,  Y10S606/911

    摘要： Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.

    摘要翻译： 由生物相容性聚羟基链烷酸酯形成或包括生物相容性聚羟基链烷酸酯的设备具有受控的降解速率，优选在生理条件下小于一年。 优选的装置包括缝线，缝线紧固件，弯液面修复装置，铆钉，钉，钉，螺钉（包括干涉螺钉），骨板和骨电镀系统，外科手术网，修复贴片，吊索，心血管贴片，矫形针 材料），粘附屏障，支架，引导组织修复/再生装置，关节软骨修复装置，神经导管，肌腱修复装置，房间隔缺损修复装置，心包块，填充剂和填充剂，静脉瓣，骨髓支架，半月板再生 装置，韧带和腱移植物，眼细胞植入物，脊髓融合笼，皮肤替代物，硬脑膜替代物，骨移植物替代物，骨榫，伤口敷料和止血剂。 聚羟基链烷酸酯可以含有由单体的混合物形成的添加剂，或者在其主链中包括侧基或修饰，或者可以化学改性，以改变降解速率。 聚羟基链烷酸酯组合物还在生理条件下的期望时间范围内提供有利的机械性能，生物相容性和降解时间。

    Medical Devices and Applications of Polyhydroxyalkanoate Polymers
    10.
    发明申请
    Medical Devices and Applications of Polyhydroxyalkanoate Polymers 有权
    聚羟基链烷酸酯聚合物的医疗器械及其应用

    公开(公告)号：US20070135929A1

    公开(公告)日：2007-06-14

    申请号：US11623593

    申请日：2007-01-16

    申请人： Simon Williams ,  David Martin ,  Frank Skraly

    发明人： Simon Williams ,  David Martin ,  Frank Skraly

    IPC分类号： A61F2/02

    CPC分类号： A61L27/58 ,  A61F2/07 ,  A61F2210/0004 ,  A61K31/715 ,  A61L17/12 ,  A61L27/18 ,  A61L31/06 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00 ,  C08G63/06 ,  C08J9/26 ,  C08J2201/0444 ,  C08J2201/0482 ,  C08J2367/04 ,  C08K5/0033 ,  C08L67/04 ,  C12P7/625 ,  Y10S606/911

    摘要： Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, would dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rats. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.

    摘要翻译： 由生物相容性聚羟基链烷酸酯形成或包括生物相容性聚羟基链烷酸酯的设备具有受控的降解速率，优选在生理条件下小于一年。 优选的装置包括缝线，缝线紧固件，弯液面修复装置，铆钉，钉，钉，螺钉（包括干涉螺钉），骨板和骨电镀系统，外科手术网，修复贴片，吊索，心血管贴片，矫形针 材料），粘附屏障，支架，引导组织修复/再生装置，关节软骨修复装置，神经导管，肌腱修复装置，房间隔缺损修复装置，心包块，填充剂和填充剂，静脉瓣，骨髓支架，半月板再生 器械，韧带和腱移植物，眼细胞植入物，脊髓融合笼，皮肤替代物，硬脑膜替代物，骨移植物替代物，骨榫，敷料和止血剂。 聚羟基链烷酸酯可以含有由单体混合物形成的添加剂，或者包括其主链中的侧基或修饰，或者可以化学改性，以改变降解大鼠。 聚羟基链烷酸酯组合物还在生理条件下的期望时间范围内提供有利的机械性能，生物相容性和降解时间。