公开(公告)号：US20160328991A1

公开(公告)日：2016-11-10

申请号：US15148976

申请日：2016-05-06

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Robert J. Boock ,  David DeRenzy ,  Laura J. Dunn ,  Matthew Lawrence Johnson ,  Katherine Yerre Koehler ,  Apurv Ullas Kamath ,  Andrew Attila Pal ,  David Price ,  Eli Reihman ,  Mark Wu

IPC: G09B19/00 ,  A61B5/145

Abstract: Provided are systems and methods using which users may learn and become familiar with the effects of various aspects of their lifestyle on their health, e.g., users may learn about how food and/or exercise affects their glucose level and other physiological parameters, as well as overall health. In some cases the user selects a program to try; in other cases, a computing environment embodying the system suggests programs to try, including on the basis of pattern recognition, i.e., by the computing environment determining how a user could improve a detected pattern in some way. In this way, users such as type II diabetics or even users who are only prediabetic or non-diabetic may learn healthy habits to benefit their health.

公开(公告)号：US20160073939A1

公开(公告)日：2016-03-17

申请号：US14952317

申请日：2015-11-25

Applicant: DexCom, Inc.

Inventor： Robert J. Boock ,  Monica A. Rixman ,  Huashi Zhang ,  Michael J. Estes ,  Kristina Lawrence

IPC: A61B5/1486 ,  A61B5/145

CPC classification number: C12Q1/002 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1486 ,  A61B5/14865 ,  C12Q1/006

Abstract: Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.

公开(公告)号：US20150090589A1

公开(公告)日：2015-04-02

申请号：US14567293

申请日：2014-12-11

Applicant: DexCom, Inc.

Inventor： Michael J. Estes ,  Jennifer Blackwell ,  Sebastian Bohm ,  Robert J. Boock ,  Jack Pryor ,  Peter C. Simpson ,  Matthew D. Wightlin

IPC: G01N27/403

Abstract: Systems and methods for compensating for effects of temperature on implantable sensors are provided. In some embodiments, systems and methods are provided for measuring a temperature to determine a change in temperature in a sensor environment. In certain embodiments, a temperature compensation factor is determined based on a change in temperature of the sensor environment. The temperature compensation factor can be used in processing raw data of an analyte signal to report a more accurate analyte concentration.

Abstract translation: 提供了用于补偿温度对植入式传感器的影响的系统和方法。 在一些实施例中，提供了用于测量温度以确定传感器环境中的温度变化的系统和方法。 在某些实施例中，基于传感器环境的温度变化来确定温度补偿系数。 温度补偿因子可用于处理分析物信号的原始数据，以报告更准确的分析物浓度。

公开(公告)号：US20140088389A1

公开(公告)日：2014-03-27

申请号：US13789371

申请日：2013-03-07

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Sebastian Bohm ,  Robert J. Boock ,  Matthew D. Wightlin ,  Huashi Zhang

IPC: A61B5/1486

CPC classification number: A61B5/1486 ,  A61B5/14532 ,  A61B5/14865 ,  A61B2562/125 ,  C12Q1/002

Abstract: In one embodiment, a continuous analyte sensor having more than one working electrode, and configured to reduce or eliminate crosstalk between the working electrodes. In another embodiment, a continuous analyte sensor having more than one working electrode, and configured so that a membrane system has equal thicknesses over each of the electrodes, despite having differing numbers of layers over each of the electrodes. In another embodiment, a configuration for connecting a continuous analyte sensor to sensor electronics. In another embodiment, methods for forming precise windows in an insulator material on a multi-electrode assembly. In another embodiment, a contact assembly for a continuous analyte sensor having more than one working electrode.

Abstract translation: 在一个实施例中，连续分析物传感器具有多于一个的工作电极，并被配置为减少或消除工作电极之间的串扰。 在另一个实施方案中，连续的分析物传感器具有多于一个的工作电极，并且被配置为使得膜系统在每个电极上具有相同的厚度，尽管在每个电极上具有不同数量的层。 在另一个实施例中，用于将连续分析物传感器连接到传感器电子器件的配置。 在另一个实施例中，用于在多电极组件上形成绝缘体材料中的精确窗口的方法。 在另一个实施例中，用于具有多于一个工作电极的连续分析物传感器的接触组件。

公开(公告)号：US20140005508A1

公开(公告)日：2014-01-02

申请号：US13747746

申请日：2013-01-23

Applicant: DEXCOM, INC.

Inventor： Michael J. Estes ,  Jennifer Blackwell ,  Sebastian Bohm ,  Robert J. Boock ,  Jack Pryor ,  Peter C. Simpson ,  Matthew D. Wightlin

IPC: A61B5/145

CPC classification number: G01N27/403 ,  A61B5/14532 ,  A61B5/14865 ,  A61B5/1495

Abstract: Systems and methods for compensating for effects of temperature on implantable sensors are provided. In some embodiments, systems and methods are provided for measuring a temperature to determine a change in temperature in a sensor environment. In certain embodiments, a temperature compensation factor is determined based on a change in temperature of the sensor environment. The temperature compensation factor can be used in processing raw data of an analyte signal to report a more accurate analyte concentration.

Abstract translation: 提供了用于补偿温度对植入式传感器的影响的系统和方法。 在一些实施例中，提供了用于测量温度以确定传感器环境中的温度变化的系统和方法。 在某些实施例中，基于传感器环境的温度变化来确定温度补偿系数。 温度补偿因子可用于处理分析物信号的原始数据，以报告更准确的分析物浓度。

公开(公告)号：US20240180462A1

公开(公告)日：2024-06-06

申请号：US18405518

申请日：2024-01-05

Applicant: Dexcom, Inc.

Inventor： James H Brauker ,  Robert J. Boock ,  Monica Rixman Swinney ,  Peter C. Simpson ,  Mark C. Brister ,  Mark Shults

IPC: A61B5/1486 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1473 ,  C12Q1/00 ,  G01N33/543 ,  G01N33/66

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/411 ,  A61B5/6848 ,  C12Q1/006 ,  G01N33/54366 ,  G01N33/66 ,  A61B5/1473 ,  A61B5/418 ,  A61B2562/08 ,  Y02A50/30

Abstract: Biointerface membranes are provided which can be utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device incorporating such membranes are provided.

公开(公告)号：US11864891B2

公开(公告)日：2024-01-09

申请号：US17394690

申请日：2021-08-05

Applicant: DexCom, Inc.

Inventor： Robert J. Boock ,  Chris W. Dring

IPC: A61B5/1486 ,  A61B5/145

CPC classification number: A61B5/14865 ,  A61B5/1486 ,  A61B5/14532 ,  A61B5/14546

Abstract: Devices are provided for measurement of an analyte concentration, e.g., glucose in a host. The device can include a sensor configured to generate a signal associated with a concentration of an analyte; and a sensing membrane located over the sensor. The sensing membrane comprises a diffusion resistance domain configured to control a flux of the analyte therethrough. The diffusion resistance domain comprises one or more zwitterionic compounds and a base polymer comprising both hydrophilic and hydrophobic regions.

公开(公告)号：US20230138407A1

公开(公告)日：2023-05-04

申请号：US18091658

申请日：2022-12-30

Applicant: DexCom, Inc.

Inventor： Jiong Zou ,  Robert J. Boock ,  Andrew Trinin Dennis ,  Ted Tang Lee ,  Jeff T. Suri ,  David Sze ,  Mark A. Tapsak ,  Huashi Zhang ,  Shanger Wang

IPC: G01N27/327 ,  C12N11/089 ,  C12N11/093 ,  C12N11/08 ,  C08L39/06 ,  C08L69/00 ,  C08L75/04 ,  C12Q1/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  G01N33/66 ,  A61K31/045 ,  A61K31/137 ,  A61K31/46 ,  A61K31/465 ,  A61K31/485 ,  A61K31/515 ,  A61K31/56 ,  A61K33/00 ,  A61K36/185 ,  A61K38/28 ,  A61B5/1473

Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The enzyme layer protects the enzyme and prevents it from leaching from the sensing membrane into a host or deactivating.

公开(公告)号：US20220214300A1

公开(公告)日：2022-07-07

申请号：US17560566

申请日：2021-12-23

Applicant: DEXCOM, INC.

Inventor： Shanger Wang ,  Robert J. Boock ,  Andrew Trinin Dennis ,  Ted Tang Lee ,  Jeff T. Suri ,  David Sze ,  Mark A. Tapsak ,  Huashi Zhang ,  Jiong Zou

IPC: G01N27/327 ,  C08G18/08 ,  C08G18/48 ,  C08G18/40 ,  C08G18/38 ,  C08G18/12 ,  C08G18/44 ,  C08G18/75 ,  C12N11/089 ,  C12N11/093 ,  C12N11/08 ,  C08L39/06 ,  C08L69/00 ,  C08L75/04 ,  C12Q1/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  G01N33/66 ,  A61K31/045 ,  A61K31/137 ,  A61K31/46 ,  A61K31/465 ,  A61K31/485 ,  A61K31/515 ,  A61K31/56 ,  A61K33/00 ,  A61K36/185 ,  A61K38/28 ,  A61B5/1473

Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer can comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise a diffusion-resistance layer, which can comprise a base polymer having a lowest Tg of greater than −50 C.

公开(公告)号：US11179079B2

公开(公告)日：2021-11-23

申请号：US16721675

申请日：2019-12-19

Applicant: DexCom, Inc.

Inventor： Robert J. Boock ,  Chris W. Dring

IPC: A61B5/1486 ,  A61B5/145

Abstract: Devices are provided for measurement of an analyte concentration, e.g., glucose in a host. The device can include a sensor configured to generate a signal associated with a concentration of an analyte; and a sensing membrane located over the sensor. The sensing membrane comprises a diffusion resistance domain configured to control a flux of the analyte therethrough. The diffusion resistance domain comprises one or more zwitterionic compounds and a base polymer comprising both hydrophilic and hydrophobic regions.