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公开(公告)号：US20220305035A1
公开(公告)日：2022-09-29
申请号：US17615769
申请日：2020-06-08
申请人： Anthony J. ROECKER , Mark E. LAYTON , Deping WANG , Xiu WANG , Xuanjia PENG , Merck Sharp & Dohme Corp.
发明人： Anthony J. Roecker , Mark E. Layton , Deping Wang , Xiu Wang , Xuanjia Peng
IPC分类号： A61K31/635 , C07D417/12 , C07D417/14
摘要： Disclosed are compounds of Formula A, or a salt thereof: Wherein “A1”, R1, R2, R3, R6, and R7 are as defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating cough, itch and neuropathic pain disorders using the same.
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12.发明申请公开(公告)号：US20190185462A1
公开(公告)日：2019-06-20
申请号：US16309390
申请日：2017-06-19
发明人： Abbas Walji , Richard Berger , Craig A. Stump , Kelly Ann S. Schlegel , James J. Mulhearn , Thomas J. Greshock , Deping Wang , Mark E. Fraley , Kristen G. Jones
IPC分类号： C07D413/10 , C07D413/14 , C07D413/04 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/052 , C07D498/04 , C07D513/04 , C07D271/06 , C07D471/14 , A61P25/28 , A61P25/18 , A61P29/00 , A61P11/06 , A61P3/10 , A61P35/00 , A61P37/02
CPC分类号： C07D413/10 , A61K45/06 , A61P3/10 , A61P9/00 , A61P11/06 , A61P25/18 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/02 , C07D271/06 , C07D271/113 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/14 , C07D487/04 , C07D491/048 , C07D491/052 , C07D498/04 , C07D513/04 , C07F7/0807
摘要： The present invention is directed to substituted 5-trifluoromethyl oxadiazole compounds of generic formula (I) or a pharmaceutically acceptable salt thereof. In particular, the invention is directed to a class of aryl and heteroaryl substituted 5-trifluoromethyl oxadiazole compounds of formula I which may be useful as HDAC6 inhibitors for treating cellular proliferative diseases, including cancer, neurodegenerative diseases, such as schizophrenia and stroke, as well as other diseases.
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公开(公告)号：US20220064147A1
公开(公告)日：2022-03-03
申请号：US17413882
申请日：2019-12-13
发明人： Antonella Converso , Abdellatif El Marrouni , Ashley Forster , Jessica L. Frie , David N. Hunter , Scott D. Kuduk , Helen J. Mitchell , Philippe Nantermet , Deyou Sha , William Daniel Shipe , Cheng Wang , Deping Wang
IPC分类号： C07D403/06 , A61K45/06
摘要： The present disclosure is directed to pyrimidone derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV nave cells, and for the treatment or prophylaxis of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC).
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公开(公告)号：US10287269B2
公开(公告)日：2019-05-14
申请号：US15559284
申请日：2016-03-21
发明人： Dong-Ming Shen , Jonathan E. Wilson , Meng Yang , Dann Parker , Zack Zhiqiang Guo , Alejandro Crespo , Deping Wang , Troy McCracken
IPC分类号： C07D403/04 , C07D401/14 , C07D405/14
摘要： The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
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公开(公告)号：US10221167B2
公开(公告)日：2019-03-05
申请号：US15378465
申请日：2016-12-14
发明人： Thomas J. Greshock , James Mulhearn , Junying Zheng , Ronald M. Kim , Ting Zhang , Anthony J. Roecker , Walter Won , Philippe Nantermet , Rajan Anand , Gang Zhou , Deping Wang , Liangqin Guo
IPC分类号： C07D417/12 , C07D285/08 , C07D277/52 , A61K31/4178 , A61K31/4196 , A61K31/4168 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/551 , A61K45/06
摘要： Disclosed are compounds of Formula A, or a salt thereof: wherein R1, R2, and E are defined herein, which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating pain disorders, cough, and itch using the same.
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公开(公告)号：US20180057480A1
公开(公告)日：2018-03-01
申请号：US15559284
申请日：2016-03-21
发明人： Dong-Ming Shen , Jonathan E. Wilson , Meng Yang , Dann Parker , Zack Zhiqiang Guo , Alejandro Crespo , Deping Wang , Troy McCracken
IPC分类号： C07D403/04 , C07D405/14 , C07D401/14
CPC分类号： C07D403/04 , C07D401/14 , C07D405/14
摘要： The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
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公开(公告)号：US20170174674A1
公开(公告)日：2017-06-22
申请号：US15378465
申请日：2016-12-14
发明人： Thomas J. Greshock , James Mulhearn , Junying Zheng , Ronald M. Kim , Ting Zhang , Anthony J. Roecker , Walter Won , Philippe Nantermet , Rajan Anand , Gang Zhou , Deping Wang , Liangqin Guo
IPC分类号： C07D417/12 , C07D277/52 , A61K31/551 , A61K31/427 , A61K31/433 , A61K31/426 , C07D285/08 , A61K45/06
CPC分类号： C07D417/12 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/551 , A61K45/06 , C07D277/52 , C07D285/08 , A61K2300/00
摘要： Disclosed are compounds of Formula A, or a salt thereof: wherein R1, R2, and E are defined herein, which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating pain disorders, cough, and itch using the same.
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公开(公告)号：US20190233406A1
公开(公告)日：2019-08-01
申请号：US16246068
申请日：2019-01-11
发明人： Thomas J. Greshock , James Mulhearn , Junying Zheng , Ronald M. Kim , Ting Zhang , Anthony J. Roecker , Walter Won , Philippe Nantermet , Rajan Anand , Gang Zhou , Deping Wang , Liangqin Guo
IPC分类号： C07D417/12 , A61K31/426 , A61K31/433 , A61K31/427 , A61K31/551 , C07D277/52 , C07D285/08 , A61K45/06
CPC分类号： C07D417/12 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/551 , A61K45/06 , C07D277/52 , C07D285/08 , A61K2300/00
摘要： Disclosed are compounds of Formula A, or a salt thereof: wherein R1, R2, and E are defined herein, which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating pain disorders, cough, and itch using the same.
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公开(公告)号：US20180256575A1
公开(公告)日：2018-09-13
申请号：US15573858
申请日：2016-05-10
发明人： Dong-Ming Shen , Deping Wang , XiaoXia Qian , Bart Harper , Meng Yang , Yingjian Bo
CPC分类号： A61K31/513 , A61P25/06 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/28 , C07D239/38 , C07D239/42 , C07D239/52 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D487/04
摘要： The present invention is directed to pyrimidinone amide compounds which may be useful as therapeutic agents for the treatment of central nervous system and/or peripheral disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Alzheimer's, cognitive impairment, anxiety, depression, migraines, or Huntington's disease, Parkinson's disease, Parkinson's disease dementia (PDD), and other diseases associated with striatal hypofunction or basal ganglia dysfunction.
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公开(公告)号：US20220000844A1
公开(公告)日：2022-01-06
申请号：US17296601
申请日：2019-12-02
发明人： Christopher J. Bungard , Helen Y. Chen , Jason M. Cox , Liangqin Guo , Michael J. Kelly, III , Ronald M. Kim , Mark E. Layton , Hong Liu , Jian Liu , Mehul F. Patel , James J. Perkins , Deping Wang , Walter Won , Younong Yu , Ting Zhang
IPC分类号： A61K31/433 , C07D285/08 , C07D417/12 , C07D239/42 , A61K31/4439 , A61K31/505 , A61K31/5377 , A61K31/167
摘要： Disclosed are compounds of Formula (I), Formula (II), or a salt thereof: Formula (I) Formula (II) which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula (I), Formula (II) or their salts, and methods of treating pain disorders, cough, and itch using the same.
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