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公开(公告)号：US20190233406A1
公开(公告)日：2019-08-01
申请号：US16246068
申请日：2019-01-11
发明人： Thomas J. Greshock , James Mulhearn , Junying Zheng , Ronald M. Kim , Ting Zhang , Anthony J. Roecker , Walter Won , Philippe Nantermet , Rajan Anand , Gang Zhou , Deping Wang , Liangqin Guo
IPC分类号： C07D417/12 , A61K31/426 , A61K31/433 , A61K31/427 , A61K31/551 , C07D277/52 , C07D285/08 , A61K45/06
CPC分类号： C07D417/12 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/551 , A61K45/06 , C07D277/52 , C07D285/08 , A61K2300/00
摘要： Disclosed are compounds of Formula A, or a salt thereof: wherein R1, R2, and E are defined herein, which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating pain disorders, cough, and itch using the same.
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2.发明授权Substituted benzamides and substituted pyridinecarboxamides as Btk inhibitors 有权取代的苯甲酰胺和取代的吡啶甲酰胺作为Btk抑制剂公开(公告)号：US09481682B2
公开(公告)日：2016-11-01
申请号：US14762954
申请日：2014-01-22
发明人： Ronald M. Kim , Jian Liu , Xiaolei Gao , Sobhana Babu Boga , Deodialsingh Guiadeen , Joseph A. Kozlowski , Wensheng Yu , Rajan Anand , Younong Yu , Oleg B. Selyutin , Ying-Duo Gao , Hao Wu , Shilan Liu , Chundao Yang , Hongjian Wang
IPC分类号： A61K31/4985 , A61K31/4427 , C07D241/38 , C07D213/81 , C07D491/048 , A61K31/497 , A61K31/519 , C07D487/04 , C07D519/00 , A61K31/506 , A61K31/5365 , A61K31/5383 , A61K45/06 , C07D455/02 , C07D471/04 , C07D498/04
CPC分类号： C07D491/048 , A61K31/497 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/5365 , A61K31/5383 , A61K45/06 , C07D455/02 , C07D471/04 , C07D487/04 , C07D498/04 , C07D519/00 , Y02A50/411 , Y02A50/463
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.
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公开(公告)号：US20220000844A1
公开(公告)日：2022-01-06
申请号：US17296601
申请日：2019-12-02
发明人： Christopher J. Bungard , Helen Y. Chen , Jason M. Cox , Liangqin Guo , Michael J. Kelly, III , Ronald M. Kim , Mark E. Layton , Hong Liu , Jian Liu , Mehul F. Patel , James J. Perkins , Deping Wang , Walter Won , Younong Yu , Ting Zhang
IPC分类号： A61K31/433 , C07D285/08 , C07D417/12 , C07D239/42 , A61K31/4439 , A61K31/505 , A61K31/5377 , A61K31/167
摘要： Disclosed are compounds of Formula (I), Formula (II), or a salt thereof: Formula (I) Formula (II) which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula (I), Formula (II) or their salts, and methods of treating pain disorders, cough, and itch using the same.
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公开(公告)号：US10221167B2
公开(公告)日：2019-03-05
申请号：US15378465
申请日：2016-12-14
发明人： Thomas J. Greshock , James Mulhearn , Junying Zheng , Ronald M. Kim , Ting Zhang , Anthony J. Roecker , Walter Won , Philippe Nantermet , Rajan Anand , Gang Zhou , Deping Wang , Liangqin Guo
IPC分类号： C07D417/12 , C07D285/08 , C07D277/52 , A61K31/4178 , A61K31/4196 , A61K31/4168 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/551 , A61K45/06
摘要： Disclosed are compounds of Formula A, or a salt thereof: wherein R1, R2, and E are defined herein, which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating pain disorders, cough, and itch using the same.
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公开(公告)号：US09446130B2
公开(公告)日：2016-09-20
申请号：US14762929
申请日：2014-01-17
发明人： Ronald M. Kim , Jian Liu , Hao Wu , Shilan Liu , Chundao Yang , Shuling Zheng
IPC分类号： C07D487/04 , C07D473/34 , A61K31/519 , A61K31/4985 , A61P19/02 , A61K45/06 , C07D519/00
CPC分类号： A61K45/06 , A61K31/4985 , A61K31/519 , C07D473/34 , C07D487/04 , C07D519/00
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or pharmaceutically acceptable salts thereof. Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.
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公开(公告)号：US10968210B2
公开(公告)日：2021-04-06
申请号：US16345913
申请日：2017-11-13
申请人： Merck Sharp & Dohme Corp. , Thomas J. Greshock , James Mulhearn , Anthony J. Roecker , Tianying Jian , Gang Zhou , Liangqin Guo , Walter Won , Ting Zhang , Rajan Anand , John E. Stelmach , Deping Wang , Ronald M. Kim , Mark E. Layton , Christopher S. Burgey , Philippe G. Nantermet
发明人： Thomas J. Greshock , James Mulhearn , Anthony J. Roecker , Tianying Jian , Gang Zhou , Liangqin Guo , Walter Won , Ting Zhang , Rajan Anand , John E. Stelmach , Deping Wang , Ronald M. Kim , Mark E. Layton , Christopher S. Burgey , Philippe G. Nantermet
IPC分类号： C07D417/12 , C07D417/14 , C07D277/52 , C07D471/04 , C07D487/10 , C07D401/12 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08
摘要： Disclosed are compounds of Formula A, or a salt thereof: Formula (A), wherein: Het, Q and R1A to R4A are defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating cough, itch, acute pain and neuropathic pain disorders using the same.
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公开(公告)号：US10519147B2
公开(公告)日：2019-12-31
申请号：US16061815
申请日：2016-12-15
申请人： Merck Sharp & Dohme Corp. , Thomas J. Greshock , James Mulhearn , Liangqin Guo , Ting Zhang , Deping Wang , Ronald M. Kim , Mark E. Layton , Michael J. Kelly, III , Rajan Anand , Philippe Nantermet , Tianying Jian , Anthony J. Roecker , Walter Won , Gang Zhou
发明人： Thomas J. Greshock , James Mulhearn , Liangqin Guo , Ting Zhang , Deping Wang , Ronald M. Kim , Mark E. Layton , Michael J. Kelly, III , Rajan Anand , Philippe Nantermet , Tianying Jian , Anthony J. Roecker , Walter Won , Gang Zhou
IPC分类号： C07D417/12 , A61K45/06 , C07D277/52 , C07D285/135 , A61P25/02 , A61P25/04 , A61P11/14 , A61P17/04
摘要： Disclosed are compounds of Formula A, or a salt thereof, where Q, X, R1 and R2 are as defined herein, which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating pain (acute, post-operative, neuropathic), or cough or itch disorders using the same.
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公开(公告)号：US10011595B2
公开(公告)日：2018-07-03
申请号：US15532602
申请日：2015-12-14
发明人： Ronald M. Kim , Scott D. Kuduk , Nigel Liverton , Gang Zhou
IPC分类号： C07D213/84 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D413/12 , A61K31/44 , A61K31/4439 , A61K31/506
CPC分类号： C07D413/12 , C07D213/84 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12
摘要： The present invention is directed to ethyldiamne compounds which are antagonists of orexin receptors. Such compounds are of the general structural formula I: The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.
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公开(公告)号：US09834554B2
公开(公告)日：2017-12-05
申请号：US15105354
申请日：2014-12-16
发明人： Jian Liu , Ronald M. Kim , Joseph Kozlowski , Deodialsingh Guiadeen , Arto D. Krikorian , Younong Yu
IPC分类号： A61K31/437 , A61K31/5377 , C07D487/04 , C07D519/00 , C07D471/04 , A61K45/06
CPC分类号： C07D471/04 , A61K45/06 , C07D519/00
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or pharmaceutically acceptable salts thereof. Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.
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公开(公告)号：US09637486B2
公开(公告)日：2017-05-02
申请号：US15105370
申请日：2014-12-16
发明人： Jian Liu , Ronald M. Kim , Joseph Kozlowski , Arto D. Krikorian , Rajan Anand
IPC分类号： C07D471/04 , C07D519/00 , A61K31/4375 , A61K31/4545 , A61K45/06
CPC分类号： C07D471/04 , A61K31/4375 , A61K31/4545 , A61K45/06 , C07D519/00
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or pharmaceutically acceptable salts thereof. Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.
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