公开(公告)号：US20220000844A1

公开(公告)日：2022-01-06

申请号：US17296601

申请日：2019-12-02

Applicant: Merck Sharp & Dohme Corp.

Inventor： Christopher J. Bungard ,  Helen Y. Chen ,  Jason M. Cox ,  Liangqin Guo ,  Michael J. Kelly, III ,  Ronald M. Kim ,  Mark E. Layton ,  Hong Liu ,  Jian Liu ,  Mehul F. Patel ,  James J. Perkins ,  Deping Wang ,  Walter Won ,  Younong Yu ,  Ting Zhang

IPC: A61K31/433 ,  C07D285/08 ,  C07D417/12 ,  C07D239/42 ,  A61K31/4439 ,  A61K31/505 ,  A61K31/5377 ,  A61K31/167

Abstract: Disclosed are compounds of Formula (I), Formula (II), or a salt thereof: Formula (I) Formula (II) which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula (I), Formula (II) or their salts, and methods of treating pain disorders, cough, and itch using the same.

公开(公告)号：US10351558B2

公开(公告)日：2019-07-16

申请号：US15550862

申请日：2016-02-12

Applicant: Merck Sharp & Dohme Corp. ,  Dongfang Meng ,  Hong Li ,  Meng Yang ,  Manuel de Lera Ruiz ,  Sunita V. Dewnani ,  Tianying Jian ,  Dann L. Parker, Jr. ,  Ting Zhang ,  Louis-Charles Campeau ,  Harold B. Wood ,  Jiayi Xu ,  Richard Berger ,  Jane Yang Wu ,  Robert K. Orr ,  Shawn P. Walsh ,  Bart Harper

Inventor： Dongfang Meng ,  Hong Li ,  Meng Yang ,  Manuel de Lera Ruiz ,  Sunita V. Dewnani ,  Tianying Jian ,  Dann L. Parker, Jr. ,  Ting Zhang ,  Louis-Charles Campeau ,  Harold B. Wood ,  Jiayi Xu ,  Richard Berger ,  Jane Yang Wu ,  Robert K. Orr ,  Shawn P. Walsh ,  Bart Harper

IPC: C07D471/04 ,  C07D403/12 ,  C07D417/14 ,  A61P9/00 ,  C07D413/14 ,  C07D471/14 ,  C07D498/04 ,  C07D513/04

Abstract: The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.

公开(公告)号：US20190092738A1

公开(公告)日：2019-03-28

申请号：US16086654

申请日：2017-03-17

Applicant: Merck Sharp & Dohme Corp.

Inventor： Anthony J. Roecker ,  Mark E. Layton ,  Thomas J. Greshock ,  Joseph E. Pero ,  Michael J. Kelly, III ,  Ting Zhang

IPC: C07D277/52 ,  C07D285/08 ,  A61K31/635 ,  A61K45/06

CPC classification number: C07D277/52 ,  A61K31/18 ,  A61K31/426 ,  A61K31/427 ,  A61K31/433 ,  A61K31/635 ,  A61K45/06 ,  C07D285/08 ,  C07F7/0812 ,  A61K2300/00

Abstract: Disclosed are compounds of Formula A-1, or a salt thereof: Formula A-1, where J, K, Q and R1 are as defined herein, which compounds have properties for inhibiting sodium ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A-1 or their salts, and methods of treating pain (e.g. chronic pain), or cough or itch disorders using the same.

公开(公告)号：US10189819B2

公开(公告)日：2019-01-29

申请号：US15534029

申请日：2015-12-07

Applicant: MERCK SHARP & DOHME CORP. ,  MOCHIDA PHARMACEUTICAL CO., LTD

Inventor： Ting Zhang ,  Yi-Heng Chen ,  Liangqin Guo ,  Alan Hruza ,  Tianying Jian ,  Bing Li ,  Dongfang Meng ,  Dann L. Parker ,  Edward C. Sherer ,  Harold B. Wood ,  Isao Sakurada

IPC: C07D403/12 ,  C07D401/14 ,  C07D401/12 ,  C07D471/04 ,  C07D413/14 ,  C07D413/12 ,  C07D417/12

Abstract: The present invention provides a compound of Formula I, and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.

公开(公告)号：US20180022747A1

公开(公告)日：2018-01-25

申请号：US15550862

申请日：2016-02-12

Applicant: Dongfang MENG ,  Hong LI ,  Meng YANG ,  Manuel de Lera RUIZ ,  Sunita V. DEWNANI ,  Tianying JIAN ,  Dann L. PARKER, JR. ,  Ting ZHANG ,  Louis-Charles CAMPEAU ,  Bart HARPER ,  Harold B. WOOD ,  Jiayi XU ,  Richard BERGER ,  Jane Yang WU ,  Robert K. ORR ,  Shawn P. WALSH ,  Merck Sharp & Dohme Corp.

Inventor： Dongfang Meng ,  Hong Li ,  Meng Yang ,  Manuel de Lera Ruiz ,  Sunita V. Dewnani ,  Tianying Jian ,  Dann L. Parker, Jr. ,  Ting Zhang ,  Louis-Charles Campeau ,  Harold B. Wood ,  Jiayi Xu ,  Richard Berger ,  Jane Yang Wu ,  Robert K. Orr ,  Shawn P. Walsh ,  Bart Harper

IPC: C07D471/04 ,  C07D403/12 ,  C07D498/04 ,  C07D417/14 ,  C07D513/04 ,  C07D471/14 ,  C07D413/14

CPC classification number: C07D471/04 ,  A61P9/00 ,  C07D403/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/14 ,  C07D498/04 ,  C07D513/04

Abstract: The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.

公开(公告)号：US09808445B2

公开(公告)日：2017-11-07

申请号：US15303322

申请日：2015-04-10

Applicant: Merck Sharp & Dohme Corp. ,  Mochida Pharmaceutical Co., Ltd.

Inventor： Isao Sakurada ,  Tomokazu Hirabayashi ,  Yoshitaka Maeda ,  Hiroshi Nagasue ,  Takashi Mizuno ,  Jiayi Xu ,  Ting Zhang ,  Cameron Smith ,  Dann Parker

IPC: A61K31/501 ,  A61K31/439 ,  C07D413/14 ,  C07D261/20 ,  C07D413/04 ,  C07D498/04 ,  C07D209/52 ,  C07D519/00 ,  A61K31/444 ,  A61K31/506 ,  A61K45/06

CPC classification number: A61K31/439 ,  A61K31/444 ,  A61K31/501 ,  A61K31/506 ,  A61K45/06 ,  C07D209/52 ,  C07D261/20 ,  C07D413/04 ,  C07D413/14 ,  C07D498/04 ,  C07D519/00

Abstract: In its many embodiments, the present invention provides a novel class of benzamide compounds represented by Formula (I) or pharmaceutically acceptable salts or solvates thereof, or pharmaceutical compositions comprising one or more said compounds or pharmaceutically acceptable salts or solvates thereof, and methods for using said compounds or pharmaceutically acceptable salts or solvates thereof for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.

公开(公告)号：US10221167B2

公开(公告)日：2019-03-05

申请号：US15378465

申请日：2016-12-14

Applicant: Merck Sharp & Dohme Corp.

Inventor： Thomas J. Greshock ,  James Mulhearn ,  Junying Zheng ,  Ronald M. Kim ,  Ting Zhang ,  Anthony J. Roecker ,  Walter Won ,  Philippe Nantermet ,  Rajan Anand ,  Gang Zhou ,  Deping Wang ,  Liangqin Guo

IPC: C07D417/12 ,  C07D285/08 ,  C07D277/52 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/4168 ,  A61K31/426 ,  A61K31/427 ,  A61K31/433 ,  A61K31/551 ,  A61K45/06

Abstract: Disclosed are compounds of Formula A, or a salt thereof: wherein R1, R2, and E are defined herein, which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating pain disorders, cough, and itch using the same.

公开(公告)号：US09914727B2

公开(公告)日：2018-03-13

申请号：US14652174

申请日：2013-12-16

Applicant: Merck Sharp & Dohme Corp. ,  Mochida Pharmaceutical Co., Ltd.

Inventor： Cameron James Smith ,  John Qiang Tan ,  Ting Zhang ,  James Balkovec ,  William John Greenlee ,  Liangqin Guo ,  Yi-Heng Chen ,  Yili Chen ,  Samuel Chackalamannil ,  Tomokazu Hirabayashi ,  Mika Sekioka

IPC: C07D413/14 ,  C07D413/12 ,  C07D513/04

CPC classification number: C07D413/14 ,  C07D413/12 ,  C07D513/04

Abstract: The present invention provides compounds of Formula (I) and pharmaceutical compositions comprising compounds of Formula I, and methods for using compounds of Formula I for treating or preventing thromboses, embolisms, hypercoaguability or fibrotic changes.

公开(公告)号：US20180030036A1

公开(公告)日：2018-02-01

申请号：US15534029

申请日：2015-12-07

Applicant: Ting ZHANG ,  Yi-Heng CHEN ,  Liangqin GUO ,  Alan HARUZA ,  Tianying JIAN ,  Bing LI ,  Dongfang MENG ,  Dann L. PARKER, JR. ,  Edward C. SHERER ,  Harold B. WOOD ,  Isao SAKURADA ,  MERCK SHARP & DOHME CORP. ,  MOCHIDA PHARMACEUTICAL CO., LTD

Inventor： Ting Zhang ,  Yi-Heng Chen ,  Liangqin Guo ,  Alan Hruza ,  Tianying Jian ,  Bing Li ,  Dongfang Meng ,  Dann L. Parker ,  Edward C. Sherer ,  Harold B. Wood ,  Isao Sakurada

IPC: C07D403/12 ,  C07D401/14 ,  C07D401/12 ,  C07D471/04

CPC classification number: C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04

Abstract: The present invention provides a compound of Formula I, and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.

公开(公告)号：US10968210B2

公开(公告)日：2021-04-06

申请号：US16345913

申请日：2017-11-13

Applicant: Merck Sharp & Dohme Corp. ,  Thomas J. Greshock ,  James Mulhearn ,  Anthony J. Roecker ,  Tianying Jian ,  Gang Zhou ,  Liangqin Guo ,  Walter Won ,  Ting Zhang ,  Rajan Anand ,  John E. Stelmach ,  Deping Wang ,  Ronald M. Kim ,  Mark E. Layton ,  Christopher S. Burgey ,  Philippe G. Nantermet

Inventor： Thomas J. Greshock ,  James Mulhearn ,  Anthony J. Roecker ,  Tianying Jian ,  Gang Zhou ,  Liangqin Guo ,  Walter Won ,  Ting Zhang ,  Rajan Anand ,  John E. Stelmach ,  Deping Wang ,  Ronald M. Kim ,  Mark E. Layton ,  Christopher S. Burgey ,  Philippe G. Nantermet

IPC: C07D417/12 ,  C07D417/14 ,  C07D277/52 ,  C07D471/04 ,  C07D487/10 ,  C07D401/12 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08

Abstract: Disclosed are compounds of Formula A, or a salt thereof: Formula (A), wherein: Het, Q and R1A to R4A are defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating cough, itch, acute pain and neuropathic pain disorders using the same.