公开(公告)号：US20090214223A1

公开(公告)日：2009-08-27

申请号：US12035677

申请日：2008-02-22

申请人： Young-Kai Chen ,  Sanjay Patel ,  Mahmoud Rasras ,  Kun-Yii Tu

发明人： Young-Kai Chen ,  Sanjay Patel ,  Mahmoud Rasras ,  Kun-Yii Tu

IPC分类号： H04B10/04

CPC分类号： H04B10/00 ,  H04B2210/006

摘要： According to one embodiment, a microwave photonic band-stop (MPBS) filter uses an electrical input signal to drive an optical Mach-Zehnder modulator. A modulated optical carrier produced by the modulator is applied to an optical filter having at least two tunable spectral attenuation bands that are located substantially symmetrically on either side of the carrier frequency. The resulting filtered optical signal is applied to an optical-to-electrical (O/E) converter to produce an electrical output signal.

摘要翻译： 根据一个实施例，微波光子带阻（MPBS）滤波器使用电输入信号来驱动光学马赫 - 曾德尔调制器。 由调制器产生的调制光载波被应用于具有至少两个可调频谱衰减频带的滤光器，该衰减频带基本对称地位于载波频率的任一侧上。 所得到的经滤波的光信号被施加到光电（O / E）转换器以产生电输出信号。

公开(公告)号：US08014676B2

公开(公告)日：2011-09-06

申请号：US12035677

申请日：2008-02-22

申请人： Young-Kai Chen ,  Sanjay Patel ,  Mahmoud Rasras ,  Kun-Yii Tu

发明人： Young-Kai Chen ,  Sanjay Patel ,  Mahmoud Rasras ,  Kun-Yii Tu

IPC分类号： H04B10/04 ,  H04J14/02

CPC分类号： H04B10/00 ,  H04B2210/006

摘要： According to one embodiment, a microwave photonic band-stop (MPBS) filter uses an electrical input signal to drive an optical Mach-Zehnder modulator. A modulated optical carrier produced by the modulator is applied to an optical filter having at least two tunable spectral attenuation bands that are located substantially symmetrically on either side of the carrier frequency. The resulting filtered optical signal is applied to an optical-to-electrical (O/E) converter to produce an electrical output signal.

摘要翻译： 根据一个实施例，微波光子带阻（MPBS）滤波器使用电输入信号来驱动光学马赫 - 曾德尔调制器。 由调制器产生的调制光载波被应用于具有至少两个可调频谱衰减频带的滤光器，该衰减频带基本对称地位于载波频率的任一侧上。 所得到的经滤波的光信号被施加到光电（O / E）转换器以产生电输出信号。

公开(公告)号：US09223721B2

公开(公告)日：2015-12-29

申请号：US13603280

申请日：2012-09-04

申请人： Sanjay Patel ,  Ranjit Joseph Rozario

发明人： Sanjay Patel ,  Ranjit Joseph Rozario

IPC分类号： G06F12/10 ,  G06F12/14

CPC分类号： G06F9/45558 ,  G06F12/1036 ,  G06F12/109 ,  G06F12/145 ,  G06F12/1475 ,  G06F2009/45587

摘要： A method includes assigning unique guest identifications to different guests, specifying an address region and permissions for the different guests and controlling a guest jump from one physical memory segment to a second physical memory segment through operational permissions defined in a root memory management unit that supports guest isolation and protection.

摘要翻译： 一种方法包括为不同的访客分配唯一的访客标识，为不同的客人指定地址区域和权限，并通过在支持访客的根内存管理单元中定义的操作权限来控制来宾从一个物理内存段跳转到第二个物理内存段 隔离和保护。

公开(公告)号：US09095503B2

公开(公告)日：2015-08-04

申请号：US13430662

申请日：2012-03-26

申请人： Mir Imran ,  Mir Hashim ,  Glen McLaughlin ,  Huma Arastu ,  Rekha Vaidyanathan ,  Joel Harris ,  Radhika Korupolu ,  Andrew Mangogna ,  Chang Ong ,  Sanjay Patel ,  Lu Wang ,  Timothy Williams

发明人： Mir Imran ,  Mir Hashim ,  Glen McLaughlin ,  Huma Arastu ,  Rekha Vaidyanathan ,  Joel Harris ,  Radhika Korupolu ,  Andrew Mangogna ,  Chang Ong ,  Sanjay Patel ,  Lu Wang ,  Timothy Williams

IPC分类号： A61N1/30 ,  A61K9/00 ,  A61N1/04 ,  A61K31/4178 ,  A61K31/4468 ,  A61K31/454 ,  A61K31/5415 ,  A61N1/32

CPC分类号： A61N1/325 ,  A61K9/0009 ,  A61K9/0014 ,  A61K31/4178 ,  A61K31/4468 ,  A61K31/454 ,  A61K31/5415 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/0448 ,  A61N1/30 ,  A61N1/303

摘要： Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.

摘要翻译： 各种实施方案提供了用于治疗剂的双相离子电渗透皮递送的方法和系统。 用于这种传送的方法的实施例包括将至少一个电极组件定位成与患者的皮肤电连通。 组合件包括包含被动地扩散入皮肤的治疗剂的溶液。 使用具有例如极性和大小的特性的第一电流，在第一时段期间，将剂量的药剂从组合物输送到皮肤中，以将药剂排斥出组合体。 在第二时段期间，使用具有吸引剂的特性的第二电流将试剂保持在组合中，使得药剂递送到皮肤中最小化。 可以根据患者的输入要求递送剂量。 实施方案可以用于递送由不希望的被动扩散引起不利影响的试剂。

公开(公告)号：US09086906B2

公开(公告)日：2015-07-21

申请号：US13436654

申请日：2012-03-30

申请人： Sanjay Patel ,  Ranjit Joseph Rozario

发明人： Sanjay Patel ,  Ranjit Joseph Rozario

IPC分类号： G06F9/455

CPC分类号： G06F9/4555

摘要： A computer readable storage medium includes executable instructions to define a processor with guest mode control registers supporting guest mode operating behavior defined by guest context specified in the guest mode control registers. The guest mode control registers include a control bit to specify a guest access blocked register state and a shared register state. Root mode control registers support root mode operating behavior defined by root context specified in the root mode control registers. The root mode control registers include control bits to enable replicated register state access and shared register state access. The guest context and the root context support virtualization of hardware resources such that multiple operating systems supporting multiple applications are executed by the hardware resources.

摘要翻译： 计算机可读存储介质包括可执行指令，以定义具有访客模式控制寄存器的处理器，所述访客模式控制寄存器支持由访客模式控制寄存器中指定的访客上下文定 访客模式控制寄存器包括一个控制位，用于指定访客阻止寄存器状态和共享寄存器状态。 根模式控制寄存器支持在根模式控制寄存器中指定的根上下文定义的根模式操作行为。 根模式控制寄存器包括用于启用复制寄存器状态访问和共享寄存器状态访问的控制位。 访客环境和根本环境支持硬件资源的虚拟化，使得支持多个应用的​​多个操作系统由硬件资源执行。

公开(公告)号：US08524720B2

公开(公告)日：2013-09-03

申请号：US12651639

申请日：2010-01-04

申请人： David Bebbington ,  Hayley Binch ,  Ronald Knegtel ,  Julian M.C. Golec ,  Sanjay Patel ,  Jean-Damien Charrier ,  David Kay ,  Robert Davies ,  Pan Li ,  Marion Wannamaker ,  Cornelia Forster ,  Albert Pierce

发明人： David Bebbington ,  Hayley Binch ,  Ronald Knegtel ,  Julian M.C. Golec ,  Sanjay Patel ,  Jean-Damien Charrier ,  David Kay ,  Robert Davies ,  Pan Li ,  Marion Wannamaker ,  Cornelia Forster ,  Albert Pierce

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/00 ,  A61P25/28 ,  A61P3/10

CPC分类号： C07D401/14 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D473/16 ,  C07D487/04 ,  C07D491/04 ,  C07D491/10 ,  C07D493/04 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04

摘要： This invention describes novel pyrazole compounds of formula IV: wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are independently selected from T-R3, or taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-8 membered ring having 1-3 ring heteroatoms selected from oxygen, sulfur, or nitrogen; and R2, R2′, T, and R3 are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.

摘要翻译： 本发明描述了式IV的新型吡唑化合物：其中环D是5-7元单环或选自芳基，杂芳基，杂环基或碳环基的8-10元双环; R x和R y独立地选自T-R 3，或与它们的插入原子一起形成具有1-3个选自氧，硫或氮的环杂原子的稠合的，不饱和的或部分不饱和的5-8元环; R2，R2'，T和R3如说明书中所述。 这些化合物可用作蛋白激酶抑制剂，特别是作为用于治疗诸如癌症，糖尿病和阿尔茨海默病的疾病的极光-2和GSK-3的抑制剂。

公开(公告)号：US20120177700A1

公开(公告)日：2012-07-12

申请号：US13338210

申请日：2011-12-27

申请人： Mir A. Imran ,  Mir Hashim ,  Lu Wang ,  Sanjay Patel ,  Joel M. Harris ,  Phil Morgan

发明人： Mir A. Imran ,  Mir Hashim ,  Lu Wang ,  Sanjay Patel ,  Joel M. Harris ,  Phil Morgan

IPC分类号： A61K9/00 ,  A61K33/42 ,  B82Y5/00

CPC分类号： A61K9/14 ,  A61K33/26

摘要： Embodiments of the invention provide nanonized iron compositions for treatment of iron deficiency such as iron deficiency anemia. Many embodiments provide nanonized iron compositions which are sized to minimize adverse reaction such as immune response, adverse GI reaction and allergic reaction to iron compound included in the composition. The nanonized iron compositions can be used in a variety of drug delivery forms, including an oral dosage form, a transdermal patch, in an intravenous solution or in a dialysate for treatment of a patient with chronic kidney disease (CKD). Embodiments of the invention also provide methods of using the nanonized iron compositions for the treatment of iron deficiency in a patient in need thereof including patients with iron deficiency anemia and CKD.

摘要翻译： 本发明的实施方案提供了用于治疗铁缺乏症（例如缺铁性贫血）的纳米铁组合物。 许多实施方案提供纳米级铁组合物，其尺寸设定成使包括在组合物中的铁化合物的不良反应如免疫应答，不良GI反应和过敏反应最小化。 纳米铁组合物可以以各种药物递送形式使用，包括口服剂型，透皮贴剂，静脉内溶液或用于治疗慢性肾脏病（CKD）患者的透析液。 本发明的实施方案还提供了使用纳米铁组合物治疗需要其的患者缺铁的方法，包括缺铁性贫血和CKD患者。

公开(公告)号：US08195883B2

公开(公告)日：2012-06-05

申请号：US12694877

申请日：2010-01-27

申请人： Prashant Jain ,  Yoganand Chillarige ,  Sandip Das ,  Shukur Moulali Pathan ,  Srinivasan R. Iyengar ,  Sanjay Patel

发明人： Prashant Jain ,  Yoganand Chillarige ,  Sandip Das ,  Shukur Moulali Pathan ,  Srinivasan R. Iyengar ,  Sanjay Patel

IPC分类号： G06F13/00

CPC分类号： G06F12/0811 ,  G06F12/0813

摘要： A processor may include several processor cores, each including a respective higher-level cache; a lower-level cache including several tag units each including several controllers, where each controller corresponds to a respective cache bank configured to store data, and where the controllers are concurrently operable to access their respective cache banks; and an interconnect network configured to convey data between the cores and the lower-level cache. The controllers may share access to an interconnect egress port coupled to the interconnect network, and may generate multiple concurrent requests to convey data via the shared port, where each of the requests is destined for a corresponding core, and where a datapath width of the port is less than a combined width of the multiple requests. The given tag unit may arbitrate among the controllers for access to the shared port, such that the requests are transmitted to corresponding cores serially rather than concurrently.

摘要翻译： 处理器可以包括几个处理器核心，每个处理器核心包括相应的更高级别的高速缓存; 包括几个标签单元的低级缓存，每个标签单元包括多个控制器，其中每个控制器对应于被配置为存储数据的相应缓存组，并且其中控制器同时可操作以访问其各自的高速缓存存储体; 以及被配置为在所述核和所述下级缓存之间传送数据的互连网络。 控制器可以共享对耦合到互连网络的互连出口端口的访问，并且可以生成多个并发请求以经由共享端口传送数据，其中每个请求去往相应的核心，并且其中端口的数据路径宽度 小于多个请求的组合宽度。 给定标签单元可以在控制器之间仲裁以访问共享端口，使得请求被串行地发送到相应的核心而不是同时发送。

公开(公告)号：US08117896B2

公开(公告)日：2012-02-21

申请号：US11836736

申请日：2007-08-09

申请人： Jonathan Day Lucas ,  Manna Leon Warburton ,  Todd Mlsna ,  Sanjay Patel ,  Stephen Terrence Hobson

发明人： Jonathan Day Lucas ,  Manna Leon Warburton ,  Todd Mlsna ,  Sanjay Patel ,  Stephen Terrence Hobson

IPC分类号： G01N30/08

CPC分类号： G01N30/08 ,  G01N2030/085 ,  G01N2030/126

摘要： Apparatus, systems and methods are described for preconcentrators, chemical sensing systems and gas chromatographs. A preconcentrator is described that comprises a hollow enclosure containing a sorbent material. The enclosure may be a capillary tube that can be formed in to a desired shape and that may be heated. Heating may be accomplished by passing an electrical current through the capillary or other hollow enclosure form. The sorbent material can be a liquid, a solid, a porous ceramic material and/or a chemiselective polymer. The sorbent material can be coated to the inner wall of the enclosure. The hollow enclosure may be maintained in an insulated chamber. The preconcentrator acts to concentrate a vapor passed through the preconcentrator to a chemical sensing array that can detect chemicals present in the vapor. A gas passed through the hollow enclosure can provide a chemically concentrated input to a chromatographic column.

公开(公告)号：US20090089809A1

公开(公告)日：2009-04-02

申请号：US11862205

申请日：2007-09-27

申请人： Amod Dattatray Deshpande ,  Sanjay Patel

发明人： Amod Dattatray Deshpande ,  Sanjay Patel

IPC分类号： G06F9/44 ,  G06F7/00

CPC分类号： G06F9/5027 ,  G06F9/547 ,  G06F2209/509 ,  G06F2209/541

摘要： A system and method for automatic generation of parallelizable application units is disclosed. In one embodiment, a method includes executing application binaries and dependencies having a hooked application method on a computer node of a cluster of a network, receiving a context of the hooked application method from a client of the network upon reaching a hook of the hooked application method during execution of the application binaries and the dependencies, executing the context of the hooked application method on the computer node, and generating results of the hooked application method on the computer node. The method may further include serializing the results on the computer node, and transmitting, via the network, the serialized results to the client. In addition, the method may include executing two or more hooked application methods in parallel.

摘要翻译： 公开了一种用于自动生成可并行化应用单元的系统和方法。 在一个实施例中，一种方法包括在网络的集群的计算机节点上执行具有挂钩应用方法的应用二进制文件和依赖关系，在到达钩挂应用程序的钩子时从网络的客户端接收挂钩的应用方法的上下文 在执行应用程序二进制程序和依赖关系期间执行方法，在计算机节点上执行挂接应用程序的上下文，以及在计算机节点上生成挂钩应用程序的结果。 该方法还可以包括在计算机节点上串行化结果，以及经由网络将序列化结果发送给客户端。 此外，该方法可以包括并行地执行两个或更多个挂钩的应用方法。