公开(公告)号：US10722356B2

公开(公告)日：2020-07-28

申请号：US15796147

申请日：2017-10-27

Applicant: Edwards Lifesciences Corporation

Inventor： Brian S. Conklin ,  Derrick Johnson

IPC: A61F2/24 ,  A61B17/00 ,  A61F2/95

Abstract: Valve holders and introducers for delivering a prosthetic heart valve to an implant site are in various embodiments configured to facilitate insertion of prosthetic valves through small incisions or access sites on a patient's body. The valve holders can also be configured to reduce or eliminate the occurrence of suture looping or other damage to the prosthetic valve during implantation. A valve holder according to embodiments of the invention includes features that reduce or eliminate mistakes during implantation of the prosthetic valves, for example, a removable activator dial and a removable handle that prevent implantation of the valve prior to proper deployment or adjustment of the holder. An introducer is provided which can facilitate passing of a prosthetic valve between adjacent ribs of a patient. Valve holders and introducers according to the various embodiments can be used in minimally invasive procedures, such as thoracotomy procedures.

公开(公告)号：US10667904B2

公开(公告)日：2020-06-02

申请号：US15452617

申请日：2017-03-07

Applicant: Edwards Lifesciences Corporation

Inventor： Salvador Marquez ,  Da-Yu Chang ,  Cindy Woo ,  Hao-Chung Yang ,  Lynn T. Dang ,  Javier A. Sanguinetti ,  Alexander H. Siemons ,  Yaron Keidar ,  Virginia Qi Lin ,  Brian S. Conklin ,  Donald E. Bobo, Jr.

IPC: A61F2/24 ,  A61B5/026 ,  A61B5/00

Abstract: Sensor-integrated prosthetic valves that can comprise a variety of features, including a plurality of valve leaflets, a frame assembly configured to support the plurality of valve leaflets and define a plurality of commissure supports terminating at an outflow end of the prosthetic valve, a sensor device associated with the frame assembly and configured to generate a sensor signal, for example, a sensor signal indicating deflection of one or more of the plurality of commissure supports, and a transmitter assembly configured to receive the sensor signal from the sensor device and wirelessly transmit a transmission signal that is based at least in part on the sensor signal.

公开(公告)号：US20200069426A1

公开(公告)日：2020-03-05

申请号：US16549957

申请日：2019-08-23

Applicant: Edwards Lifesciences Corporation

Inventor： Brian S. Conklin ,  Maria L. Saravia ,  Adam J. Yestrepsky ,  Derrick Johnson ,  Rodolfo Rodriguez ,  Sai Prasad Uppalapati ,  Louis A. Campbell

IPC: A61F2/24

Abstract: Systems, apparatuses, and methods disclosed herein are provided for medical treatment, including transcatheter medical treatments and/or for treatment of dilated hearts (e.g., dilated left ventricle) or functional mitral valve regurgitation within a human heart. The systems, apparatuses, and methods disclosed herein may include applying one or more heart splints to the patient's heart to apply pressure to the heart to reshape the heart. Anchors disclosed herein may be utilized in plugs for treating openings in a septum between two chambers of a heart, e.g., ventricular septal defects (VSD), atrial septal defects (ASD), and patent foramen ovale (PFO). In addition, the anchors disclosed herein may be utilized to reshape an annulus of a patient's heart valve, including a tricuspid valve of a patient's heart. The anchors disclosed herein may also be utilized to reposition a heart valve leaflet to reduce heart valve leaflet prolapse.

公开(公告)号：US20190224009A1

公开(公告)日：2019-07-25

申请号：US16252140

申请日：2019-01-18

Applicant: Edwards Lifesciences Corporation

Inventor： Brian S. Conklin

IPC: A61F2/24

Abstract: Valve holders and introducers for delivering a prosthetic heart valve to an implant site are configured to facilitate insertion of prosthetic valves through small incisions or access sites on a patient's body. The valve holders can also be configured to reduce or eliminate the occurrence of suture looping or other damage to the prosthetic valve during implantation. A valve holder according to embodiments of the invention includes features that reduce or eliminate mistakes during implantation of the prosthetic valves, such as a handle that prevents implantation of the valve prior to proper deployment or adjustment of the holder. An introducer is provided which can facilitate temporary deformation of a nitinol prosthetic valve to pass between adjacent ribs of a patient without rib spreading. Valves are provided having a wireform and stiffener band made of materials that exhibit superelastic properties. Valve holders, introducers, and valves according to the various embodiments can be used in minimally invasive procedures, such as thoracotomy procedures.

公开(公告)号：US20190201200A1

公开(公告)日：2019-07-04

申请号：US16297187

申请日：2019-03-08

Applicant: Edwards Lifesciences Corporation

Inventor： Brian S. Conklin

IPC: A61F2/24 ,  A61F2/02

CPC classification number: A61F2/2445 ,  A61F2/02 ,  A61F2/24 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/2442 ,  A61F2/2457 ,  A61F2/2463 ,  A61F2220/0008 ,  A61F2230/0054 ,  A61F2230/0069 ,  A61F2250/0018

Abstract: A method and device for anchoring a prosthetic heart valve or annuloplasty ring to a valve annulus in a heart and a method of implanting same is disclosed. The device can include a prosthetic valve or annuloplasty ring with one or more anchors configured to be threaded or otherwise passed underneath a native leaflet and/or subvalvular tissue to secure the device at the native annulus.

公开(公告)号：US20180318075A1

公开(公告)日：2018-11-08

申请号：US15990332

申请日：2018-05-25

Applicant: Edwards Lifesciences Corporation

Inventor： Hengchu Cao ,  Brian S. Conklin ,  Paul A. Schmidt ,  Grace M. Kim ,  James A. Davidson ,  Hoa T. Tran ,  Kristy L. Tam

IPC: A61F2/24

CPC classification number: A61F2/2427 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2415

Abstract: Disclosed prosthetic valves can comprise a sewing ring configured to secure the valve to an implantation site. Some disclosed valves comprise a resiliently collapsible frame having a neutral configuration and a collapsed deployment configuration. Some disclosed frames can self-expand to the neutral configuration when released from the collapsed deployment configuration. Collapsing a disclosed valve can provide convenient access to the sewing ring, such as for securing the valve to the implantation site, as well as for the insertion of the valve through relatively small surgical incisions.

公开(公告)号：US09968451B2

公开(公告)日：2018-05-15

申请号：US15295912

申请日：2016-10-17

Applicant: Edwards Lifesciences Corporation

Inventor： Salvador Marquez ,  Brian S. Conklin ,  Manouchehr A. Miraki ,  Yoon H. Kwon

IPC: A61F2/24 ,  A61B17/04 ,  A61B17/02

CPC classification number: A61F2/2445 ,  A61B17/02 ,  A61B17/0487 ,  A61B2017/0237 ,  A61B2017/0488 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2448

Abstract: A cardiac implant system including a cardiac implant such as an annuloplasty ring, a prosthetic heart valve, or a valved conduit pre-assembled at the time of manufacture with devices for securing the implant to a heart valve annulus using knotless suture fasteners. The knotless suture fasteners may be embedded within a pliant sealing edge of the cardiac implant, or they may be positioned adjacent to the sealing edge. The knotless suture fasteners are spring-biased so as to grip onto annulus anchoring sutures pass to therethrough upon removal of a restraining device, such as a hypotube inserted within the suture fasteners. Guide tubes are assembled in line with the suture fasteners to permit introduction of suture snares that pass through the suture fasteners and through the sealing edge to facilitate capture of the pre-installed annulus anchoring sutures.

公开(公告)号：US20180125644A1

公开(公告)日：2018-05-10

申请号：US15864992

申请日：2018-01-08

Applicant: Edwards Lifesciences Corporation

Inventor： Brian S. Conklin

IPC: A61F2/24

CPC classification number: A61F2/243 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0036 ,  A61F2250/006 ,  A61F2250/0071

Abstract: A prosthetic heart valve can include a valve frame having a wireform portion and a stent portion. The wireform and stent portions can be undetachably coupled together via a plurality of upright struts so as to form a one-piece prosthetic heart valve frame. Alternatively, a self-expanding wireform portion and a balloon-expandable stent portion can be coupled together via one or more leaflets and a subassembly having a flexible leaflet support stent and a sealing ring. The wireform portion can include cusps and commissures configured to support a plurality of leaflets. The prosthetic valve can be radially collapsible for minimally invasive and/or transcatheter delivery techniques. Disclosed embodiments can also provide flexion of the wireform portion (e.g., of the commissures) in response to physiologic pulsatile loading when the valve is implanted in a patient's native valve annulus. Methods of making and using prosthetic heart valves are also disclosed.

公开(公告)号：US20170000603A1

公开(公告)日：2017-01-05

申请号：US15199743

申请日：2016-06-30

Applicant: Edwards Lifesciences Corporation

Inventor： Brian S. Conklin ,  Qinggang Zeng

IPC: A61F2/24

Abstract: A hybrid prosthetic heart valve configured to replace a native heart valve and having a support frame configured to be expanded post implant in order to receive and/or support an expandable prosthetic heart valve therein (a valve-in-valve procedure). The prosthetic heart valve may be configured to have a generally rigid and/or expansion-resistant configuration when initially implanted to replace a native valve (or other prosthetic heart valve), but to assume a generally expanded form when subjected to an outward force such as that provided by a dilation balloon or other mechanical expander. An inflow stent frame is expandable for anchoring the valve in place, and may have an outflow end that is collapsible for delivery and expandable post-implant to facilitate a valve-in-valve procedure.

Abstract translation: 一种混合式假体心脏瓣膜，其构造成替代原生心脏瓣膜并具有支撑框架，所述支撑框架被配置为在植入物之后扩张，以便在其中接收和/或支撑可扩张的假体心脏瓣膜（阀门过程）。 假体心脏瓣膜可以被构造成当最初植入时具有大致刚性和/或抗膨胀的构造，以替代天然瓣膜（或其他假体心脏瓣膜），但是当受到向外的力（例如， 由膨胀气球或其他机械膨胀机提供。 流入支架框架是可扩张的，用于将阀固定在适当位置，并且可具有用于输送和可扩展的植入后可折叠的流出端，以便于阀门过程。

公开(公告)号：US09504566B2

公开(公告)日：2016-11-29

申请号：US14745287

申请日：2015-06-19

Applicant: Edwards Lifesciences Corporation

Inventor： Jessica Guttenberg ,  Da-Yu Chang ,  Derrick Johnson ,  Brian S. Conklin ,  Qinggang Zeng ,  Myron Howanec, Jr. ,  Grace M. Kim

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2409 ,  A61F2250/0085 ,  A61F2250/0089 ,  A61F2250/0098

Abstract: A prosthetic heart valve configured to replace a native heart valve and for post-implant expansion and having a valve-type indicator thereon visible from outside the body post-implant. The indicator communicates information about the valve, such as the size or orifice diameter of the valve, and/or that the valve has the capacity for post-implant expansion. The indicator can be an alphanumeric symbol or other symbol or combination of symbols that represent information about the characteristics of the valve such as the valve size. The capacity for post-implant expansion facilitates a valve-in-valve procedure, where the valve-type indicator conveys information to the surgeon about whether the implanted valve is suitable for the procedure and informs the choice of the secondary valve.

Abstract translation: 一种假体心脏瓣膜，其构造成代替天然心脏瓣膜并用于植入后扩张，并且在体外植入物后面具有可从其上观察到的瓣膜型指示器。 指示器传达关于阀的信息，例如阀的尺寸或孔直径，和/或阀具有用于植入物扩张的能力。 指示符可以是代表关于阀的特性的信息的字母数字符号或其它符号或符号的组合，例如阀的尺寸。 植入后扩张的能力有利于瓣膜瓣膜手术，其中瓣膜型指示器向外科医生传达关于植入的瓣膜是否适于手术并且通知二次瓣膜的选择的信息。