公开(公告)号：US20220023033A1

公开(公告)日：2022-01-27

申请号：US17496649

申请日：2021-10-07

Applicant: Edwards Lifesciences Corporation

Inventor： David L. Hauser ,  Jan Otto Solem ,  David Alon

IPC: A61F2/24

Abstract: A method of treating a defective heart valve includes inserting a delivery catheter through a small incision in a patient's groin, wherein the delivery catheter has a prosthetic device positioned along a distal end. The prosthetic device includes an insert member and an anchoring member. The insert member self-expands to plug gaps between leaflets of the heart valve. The anchoring member is preferably a stent connected to the insert member by at least one elongate member. The stent is deployed within an adjacent blood vessel for anchoring the insert member. After deployment of the prosthetic device, the leaflets of the heart valve form a tight seal against the insert member for preventing regurgitation when the leaflets are closed and wherein blood passes through the insert member when the leaflets are open.

公开(公告)号：US20200030084A1

公开(公告)日：2020-01-30

申请号：US16593360

申请日：2019-10-04

Applicant: Edwards Lifesciences Corporation

Inventor： David L. Hauser ,  Jan Otto Solem ,  David Alon

IPC: A61F2/24

Abstract: A method of treating a defective mitral valve includes percutaneously advancing a prosthetic device into a patient's heart. The prosthetic device includes an insert member and anchoring member. The prosthetic device is contained within a sheath along a distal end of a delivery catheter during advancement. The anchoring member is secured to a muscular wall of the left ventricle and the insert member self-expands between native leaflets of the mitral valve. The insert member preferably includes a biocompatible fabric outer layer, a passageway, and a valve member disposed within the passageway. After deployment, the native leaflets of the mitral valve form a tight seal against the fabric outer layer of the insert member for preventing regurgitation, while blood passes through the passageway of the insert member for allowing blood to pass from the left atrium to the left ventricle.

公开(公告)号：US20190209322A1

公开(公告)日：2019-07-11

申请号：US16358480

申请日：2019-03-19

Applicant: Edwards Lifesciences Corporation

Inventor： David M. Taylor ,  Tri D. Tran ,  Sean Chow ,  David L. Hauser ,  Pui Tong Ho ,  Alexander H. Cooper

IPC: A61F2/24

CPC classification number: A61F2/2445 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/243 ,  A61F2/2433 ,  A61F2/2448 ,  A61F2/2466 ,  A61F2210/0014 ,  A61F2220/0016 ,  A61F2250/0014

Abstract: Disclosed herein are devices for improving coaption of the mitral valve leaflets to reduce or eliminate mitral valve regurgitation. The devices may be used to perform mitral valve annuloplasty, or to serve as a docking station for a transcatheter prosthetic heart valve. The various embodiments of devices are configured for percutaneous and, in some cases, transvascular delivery. Delivery systems useful for routing the devices to the mitral valve are also disclosed, including catheters, balloons and/or mechanical expansion systems. The devices themselves include at least one tissue penetrating member. Methods of delivery include partially embedding the devices in the mitral valve annulus via at least one tissue penetrating member. Tissue penetrating members may be embedded into the tissue in a simultaneous or a nearly simultaneous fashion. Upon embedding, the devices employ various expansion and/or contraction features to adjust the mitral valve diameter. Adjustments may continue until the leaflets fully coapt and the problem of mitral regurgitation is reduced or eliminated.

公开(公告)号：US20170056176A1

公开(公告)日：2017-03-02

申请号：US15244716

申请日：2016-08-23

Applicant: Edwards Lifesciences Corporation

Inventor： Stanton J. Rowe ,  Jinny Lee ,  Philip P. Corso, JR. ,  Mark Chau ,  David L. Hauser

IPC: A61F2/24

CPC classification number: A61F2/2487 ,  A61B17/0487 ,  A61B2017/00358 ,  A61B2017/0417 ,  A61B2017/0464 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2427 ,  A61F2/2442 ,  A61F2/2454 ,  A61F2/246 ,  A61F2/2463 ,  A61F2/2466 ,  A61F2250/006

Abstract: The present disclosure concerns embodiments of an implantable device that are used to treat an insufficient heart valve that has been previously treated by implantation of a fixation device or an Alfieri stitch that is secured to opposing portions of the native leaflets. In one representative embodiment, an implantable device for remodeling a native mitral valve having two native leaflets and a fixation device or an Alfieri stitch secured to respective free edges of the leaflets is configured to be coupled to the fixation device or Alfieri stitch and apply a remodeling force to the native mitral valve that draws the native leaflets toward each other to promote coaptation of the leaflets.

Abstract translation: 本公开涉及可植入装置的实施例，其用于治疗先前已经通过植入固定在天然传单的相对部分的固定装置或Alfieri针迹来治疗的心脏瓣膜不足。 在一个代表性的实施例中，用于重塑具有两个天然传单的固有二尖瓣的可植入装置和固定到小叶各自的自由边缘上的固定装置或固定装置被配置成联接到固定装置或Alfieri针迹并施加重塑 对原生二尖瓣施加力量，将本地传单彼此拉开，以促进传单的接合。

公开(公告)号：US09579199B2

公开(公告)日：2017-02-28

申请号：US14963149

申请日：2015-12-08

Applicant: Edwards Lifesciences Corporation

Inventor： David L. Hauser ,  Jan O. Solem ,  David Alon

IPC: A61F2/24

CPC classification number: A61F2/246 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2436 ,  A61F2/2445 ,  A61F2/2466 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2220/0016

Abstract: A method of using a device to improve the function of a heart valve is disclosed. In one preferred embodiment, the method includes positioning a prosthetic insert member between leaflets of mitral valve. The insert member has an elongated cross-sectional profile for conforming to gap between leaflets of a mitral valve. The device also includes an anchoring member for attachment to heart tissue for maintaining the insert member in the mitral valve. The insert member is used to plug the gap between the leaflets of the mitral valve and thereby reduce undesirable regurgitation while allowing the leaflets to function in a substantially normal manner. An anchoring member secures the prosthetic insert member to a heart wall. The anchoring member preferably includes a plurality of tissue penetrating hooks or prongs.

Abstract translation: 公开了一种使用装置改善心脏瓣膜功能的方法。 在一个优选实施例中，该方法包括将假体插入件定位在二尖瓣的瓣叶之间。 插入构件具有细长的横截面轮廓，用于与二尖瓣的小叶之间的间隙一致。 该装置还包括用于附接到心脏组织的锚固构件，用于将插入构件保持在二尖瓣中。 插入构件用于堵塞二尖瓣的小叶之间的间隙，从而减少不期望的反流，同时允许小叶以基本正常的方式起作用。 锚定构件将假体插入构件固定到心脏壁。 锚定构件优选地包括多个组织穿透钩或插脚。

公开(公告)号：US20160089239A1

公开(公告)日：2016-03-31

申请号：US14963149

申请日：2015-12-08

Applicant: Edwards Lifesciences Corporation

Inventor： David L. Hauser ,  Jan O. Solem ,  David Alon

IPC: A61F2/24

CPC classification number: A61F2/246 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2436 ,  A61F2/2445 ,  A61F2/2466 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2220/0016

Abstract: A method of using a device to improve the function of a heart valve is disclosed. In one preferred embodiment, the method includes positioning a prosthetic insert member between leaflets of mitral valve. The insert member has an elongated cross-sectional profile for conforming to gap between leaflets of a mitral valve. The device also includes an anchoring member for attachment to heart tissue for maintaining the insert member in the mitral valve. The insert member is used to plug the gap between the leaflets of the mitral valve and thereby reduce undesirable regurgitation while allowing the leaflets to function in a substantially normal manner. An anchoring member secures the prosthetic insert member to a heart wall. The anchoring member preferably includes a plurality of tissue penetrating hooks or prongs.

Abstract translation: 公开了一种使用装置改善心脏瓣膜功能的方法。 在一个优选实施例中，该方法包括将假体插入件定位在二尖瓣的瓣叶之间。 插入构件具有细长的横截面轮廓，用于与二尖瓣的小叶之间的间隙一致。 该装置还包括用于附接到心脏组织的锚固构件，用于将插入构件保持在二尖瓣中。 插入构件用于堵塞二尖瓣的小叶之间的间隙，从而减少不期望的反流，同时允许小叶以基本正常的方式起作用。 锚定构件将假体插入构件固定到心脏壁。 锚定构件优选地包括多个组织穿透钩或插脚。

公开(公告)号：US20150173900A1

公开(公告)日：2015-06-25

申请号：US14636011

申请日：2015-03-02

Applicant: Edwards Lifesciences Corporation

Inventor： David L. Hauser ,  Jan O. Solem ,  David Alon

IPC: A61F2/24

CPC classification number: A61F2/246 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2436 ,  A61F2/2445 ,  A61F2/2466 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2220/0016

Abstract: A method of using a device to improve the function of a heart valve is disclosed. In one preferred embodiment, the method includes positioning a prosthetic insert member between leaflets of mitral valve. The insert member has an elongated cross-sectional profile for conforming to gap between leaflets of a mitral valve. The device also includes an anchoring member for attachment to heart tissue for maintaining the insert member in the mitral valve. The insert member is used to plug the gap between the leaflets of the mitral valve and thereby reduce undesirable regurgitation while allowing the leaflets to function in a substantially normal manner. An anchoring member secures the prosthetic insert member to a heart wall. The anchoring member preferably includes a plurality of tissue penetrating hooks or prongs.

Abstract translation: 公开了一种使用装置改善心脏瓣膜功能的方法。 在一个优选实施例中，该方法包括将假体插入件定位在二尖瓣的瓣叶之间。 插入构件具有细长的横截面轮廓，用于与二尖瓣的小叶之间的间隙一致。 该装置还包括用于附接到心脏组织的锚固构件，用于将插入构件保持在二尖瓣中。 插入构件用于堵塞二尖瓣的小叶之间的间隙，从而减少不期望的反流，同时允许小叶以基本正常的方式起作用。 锚定构件将假体插入构件固定到心脏壁。 锚定构件优选地包括多个组织穿透钩或插脚。

公开(公告)号：US20140336702A1

公开(公告)日：2014-11-13

申请号：US14337155

申请日：2014-07-21

Applicant: Edwards Lifesciences Corporation

Inventor： Stanton J. Rowe ,  David L. Hauser ,  Rafael Pintor ,  Richard B. Cates

IPC: A61B17/04 ,  A61B17/06

CPC classification number: A61B17/0487 ,  A61B17/0057 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/0483 ,  A61B17/06166 ,  A61B2017/00243 ,  A61B2017/00575 ,  A61B2017/0061 ,  A61B2017/00654 ,  A61B2017/0445 ,  A61B2017/0456 ,  A61B2017/0464 ,  A61B2017/0488 ,  A61B2017/0496

Abstract: An apparatus, system, and method for repairing openings such as septal defects includes advancing a catheter to the site of the defect, grasping opposing edges of the defect, passing one or more suture lines through the opposing edges, tightening the suture lines, and deploying and expanding a fastener to secure the suture lines and close the defect. The fastener can include tissue-growth-inducing materials to encourage tissue growth onto or into the fastener and/or suture. The fastener includes a locking clip portion and a plug portion, which may be an expandable portion and/or tissue-growth-inducing portion.

Abstract translation: 用于修复诸如间隔缺损的开口的装置，系统和方法包括将导管推进到缺损部位，抓住缺损的相对边缘，使一条或多条缝合线穿过相对边缘，收紧缝合线并展开 并且扩展紧固件以固定缝合线并闭合缺陷。 紧固件可以包括组织生长诱导材料，以促进组织生长到紧固件和/或缝线上。 紧固件包括锁定夹部分和插塞部分，其可以是可扩张部分和/或组织生长诱导部分。

公开(公告)号：US12245940B2

公开(公告)日：2025-03-11

申请号：US17521571

申请日：2021-11-08

Applicant: Edwards Lifesciences Corporation

Inventor： David M. Taylor ,  Tri D. Tran ,  Sean Chow ,  David L. Hauser ,  Pui Tong Ho ,  Alexander H. Cooper

IPC: A61F2/24

Abstract: Certain aspects of the disclosure concern a device for repairing or replacing a native heart valve. The device can include a frame including a first set of struts intersecting with a second set of struts at a plurality of strut connection points. The frame can be radially expandable from a radially collapsed state to a radially expanded state. The device can include at least one expansion feature including a screw head and a screw shaft connected to the screw head. The screw shaft can extend through a first strut connection point and a second strut connection point. The device can further include a plurality of penetrating members extending from a first end of the frame. Rotating the screw shaft in a first direction can radially expand the frame from the radially collapsed state to the radially expanded state.

公开(公告)号：US20220061990A1

公开(公告)日：2022-03-03

申请号：US17521571

申请日：2021-11-08

Applicant: Edwards Lifesciences Corporation

Inventor： David M. Taylor ,  Tri D. Tran ,  Sean Chow ,  David L. Hauser ,  Pui Tong Ho ,  Alexander H. Cooper

IPC: A61F2/24

Abstract: Certain aspects of the disclosure concern a device for repairing or replacing a native heart valve. The device can include a frame including a first set of struts intersecting with a second set of struts at a plurality of strut connection points. The frame can be radially expandable from a radially collapsed state to a radially expanded state. The device can include at least one expansion feature including a screw head and a screw shaft connected to the screw head. The screw shaft can extend through a first strut connection point and a second strut connection point. The device can further include a plurality of penetrating members extending from a first end of the frame. Rotating the screw shaft in a first direction can radially expand the frame from the radially collapsed state to the radially expanded state.