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公开(公告)号：US20190112364A1
公开(公告)日：2019-04-18
申请号：US16161586
申请日：2018-10-16
Applicant: Eisai R&D Management Co., Ltd. , UCL Business PLC
Inventor： Malcolm Ian Roberts , James Martin Staddon , Hettihewage Alfred Rohan De Silva , Jared Spidel , Hirofumi Aoyagi , Shigeru Akasofu , Yutaka Hashizume , Kishan Agarwala
Abstract: Provided herein are antibodies that specifically bind Tau and methods of using the same.
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公开(公告)号：US20230001004A1
公开(公告)日：2023-01-05
申请号：US17464815
申请日：2021-09-02
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Luigi Grasso , Jared Spidel , James Bradford Kline , Earl Albone
IPC: A61K47/68 , C07K16/28 , C07K16/30 , C07K16/40 , G01N33/533
Abstract: Provided herein are methods for generating conjugated immunoglobulins, the method comprising: decapping a cysteine at amino acid position 80 (“Cys80”) in a light chain variable region of an immunoglobulin, wherein the immunoglobulin comprises a heavy chain variable region and the light chain variable region; and conjugating a thiol-reactive compound to the Cys80, wherein the thiol-reactive compound comprises a thiol-reactive group. Antigen-binding molecules and methods for generating the same, immunoglobulins as well as nucleic acid molecules encoding the immunoglobulins and host cells comprising the nucleic acid molecules, conjugated immunoglobulins, and light chain variable regions for use in a conjugated immunoglobulin are also provided.
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公开(公告)号：US11129904B2
公开(公告)日：2021-09-28
申请号：US16353326
申请日：2019-03-14
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Luigi Grasso , Jared Spidel , James Bradford Kline , Earl Albone
Abstract: Provided herein are methods for generating conjugated immunoglobulins, the method comprising: decapping a cysteine at amino acid position 80 (“Cys80”) in a light chain variable region of an immunoglobulin, wherein the immunoglobulin comprises a heavy chain variable region and the light chain variable region; and conjugating a thiol-reactive compound to the Cys80, wherein the thiol-reactive compound comprises a thiol-reactive group. Antigen-binding molecules and methods for generating the same, immunoglobulins as well as nucleic acid molecules encoding the immunoglobulins and host cells comprising the nucleic acid molecules, conjugated immunoglobulins, and light chain variable regions for use in a conjugated immunoglobulin are also provided.
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公开(公告)号：US10941431B2
公开(公告)日：2021-03-09
申请号：US15662981
申请日：2017-07-28
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Jared Spidel , Earl Albone
Abstract: Provided herein are conjugated immunoglobulins and methods for generating conjugated immunoglobulins using a microbial transglutaminase.
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公开(公告)号：US10358485B2
公开(公告)日：2019-07-23
申请号：US16217360
申请日：2018-12-12
Applicant: Eisai R&D Management Co., Ltd. , UCL Business PLC
Inventor： Malcolm Ian Roberts , James Martin Staddon , Hettihewage Alfred Rohan De Silva , Jared Spidel , Hirofumi Aoyagi , Shigeru Akasofu , Yutaka Hashizume , Kishan Agarwala
Abstract: Provided herein are antibodies that specifically bind Tau and methods of using the same.
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Patent Agency Ranking
公开(公告)号：US20180044711A1
公开(公告)日：2018-02-15
申请号：US15662981
申请日：2017-07-28
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Jared Spidel , Earl Albone
CPC classification number: C12P21/02 , A61K47/68 , A61K47/6803 , A61K47/6811 , C07K16/00 , C07K2317/40 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/53 , C07K2317/55 , C12Y203/02013
Abstract: Provided herein are conjugated immunoglobulins and methods for generating conjugated immunoglobulins using a microbial transglutaminase.
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公开(公告)号：US09809647B2
公开(公告)日：2017-11-07
申请号：US14816989
申请日：2015-08-03
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Toshio Imai , James Bradford Kline , Tetsu Kawano , Luigi Grasso , Yoshimasa Sakamoto , Jared Spidel , Miyuki Nishimura , Kenzo Muramoto , Tatsuo Horizoe
CPC classification number: C07K16/24 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92 , G01N33/6863 , G01N2333/521
Abstract: The present invention relates to novel humanized, chimeric and murine antibodies that have binding specificity for the human CC chemokine ligand 20 (CCL20). The present invention further relates to heavy chains and light chains of said antibodies. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a heavy chain and/or a light chain of said antibodies, and to a method of preparing said antibodies. The anti-CCL20 antibodies of the invention can be used in therapeutic applications to treat, for example, inflammatory and autoimmune disorders and cancer.
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公开(公告)号：US11578120B2
公开(公告)日：2023-02-14
申请号：US17030655
申请日：2020-09-24
Applicant: Eisai R&D Management Co., Ltd. , UCL Business LTD
Inventor： Malcolm Ian Roberts , James Martin Staddon , Hettihewage Alfred Rohan De Silva , Jared Spidel , Hirofumi Aoyagi , Shigeru Akasofu , Yutaka Hashizume , Kishan Agarwala
Abstract: Provided herein are antibodies that specifically bind Tau and methods of using the same.
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公开(公告)号：US11135304B2
公开(公告)日：2021-10-05
申请号：US16062831
申请日：2016-12-16
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Jared Spidel , Earl Albone
Abstract: Provided herein are conjugated immunoglobulins and methods for generating conjugated immunoglobulins using a microbial transglutaminase.
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公开(公告)号：US20210024622A1
公开(公告)日：2021-01-28
申请号：US17030655
申请日：2020-09-24
Applicant: Eisai R&D Management Co., Ltd. , UCL Business LTD
Inventor： Malcolm Ian Roberts , James Martin Staddon , Hettihewage Alfred Rohan De Silva , Jared Spidel , Hirofumi Aoyagi , Shigeru Akasofu , Yutaka Hashizume , Kishan Agarwala
Abstract: Provided herein are antibodies that specifically bind Tau and methods of using the same.
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