公开(公告)号：US09273950B2

公开(公告)日：2016-03-01

申请号：US13335211

申请日：2011-12-22

申请人： Siavash Yazdanfar ,  Sora Kim ,  Chulmin Joo

发明人： Siavash Yazdanfar ,  Sora Kim ,  Chulmin Joo

IPC分类号： A61B3/14 ,  G01B9/02 ,  A61B3/10 ,  A61B3/12

CPC分类号： G01B9/02044 ,  A61B3/102 ,  A61B3/12 ,  G01B9/02048 ,  G01B9/02063 ,  G01B9/02064 ,  G01B9/02091

摘要： A system, in one embodiment, includes an optical coherence tomography (OCT) imaging system having a light source configured to emit light. The OCT imaging system further includes a beam splitter configured to receive the light from the light source, split the light into a first light portion directed along a sample arm comprising a sample and a second light portion directed along a reference arm comprising a reference mirror, receive a first reflected light portion from the sample arm and a second reflected light portion from the reference arm, combine the first and second reflected light portions to obtain an interference signal. Further, the OCT imaging system includes a controller having logic configured to perform an auto-ranging process to match the reference arm with the sample arm.

摘要翻译： 在一个实施例中，系统包括具有被配置为发光的光源的光学相干断层摄影（OCT）成像系统。 OCT成像系统还包括分束器，其被配置为接收来自光源的光，将光分成沿着包括样本的样本臂引导的第一光部分和沿着包括参考反射镜的参考臂引导的第二光部分， 从样品臂接收第一反射光部分和从参考臂的第二反射光部分，组合第一和第二反射光部分以获得干涉信号。 此外，OCT成像系统包括具有被配置为执行自动测距过程以使参考臂与样本臂匹配的逻辑的控制器。

公开(公告)号：US08842287B2

公开(公告)日：2014-09-23

申请号：US13335175

申请日：2011-12-22

申请人： Siavash Yazdanfar ,  Sora Kim ,  Chulmin Joo

发明人： Siavash Yazdanfar ,  Sora Kim ,  Chulmin Joo

IPC分类号： G01B9/02

CPC分类号： G01B9/02091 ,  G01B9/02044 ,  G01B9/02063 ,  G01B9/02064 ,  G01B9/02068

摘要： A system, in one embodiment, includes an optical coherence tomography (OCT) imaging system having a light source configured to emit light. The OCT imaging system further includes a beam splitter configured to receive the light from the light source, split the light into a first light portion directed along a sample arm comprising a sample and a second light portion directed along a reference arm comprising a reference mirror, receive a first reflected light portion from the sample arm and a second reflected light portion from the reference arm, combine the first and second reflected light portions to obtain an interference signal at a detector. Further, the OCT imaging system includes a controller having logic configured to perform an auto-focusing process to determine the optimal position for a lens in the sample arm in order to bring the sample into focus.

摘要翻译： 在一个实施例中，系统包括具有被配置为发光的光源的光学相干断层摄影（OCT）成像系统。 OCT成像系统还包括分束器，其被配置为接收来自光源的光，将光分成沿着包括样本的样本臂引导的第一光部分和沿着包括参考反射镜的参考臂引导的第二光部分， 从采样臂接收第一反射光部分和从参考臂的第二反射光部分，组合第一和第二反射光部分以在检测器处获得干涉信号。 此外，OCT成像系统包括具有被配置为执行自动聚焦处理以确定样本臂中的透镜的最佳位置以便使样本聚焦的逻辑的控制器。

公开(公告)号：US08778682B2

公开(公告)日：2014-07-15

申请号：US13221161

申请日：2011-08-30

申请人： Vasile Bogdan Neculaes ,  Kenneth Roger Conway ,  Allen Lawrence Garner ,  Evelina Roxana Loghin ,  Siavash Yazdanfar ,  Dmitry Vladimirovich Dylov ,  Brian Michael Davis ,  Chulmin Joo

发明人： Vasile Bogdan Neculaes ,  Kenneth Roger Conway ,  Allen Lawrence Garner ,  Evelina Roxana Loghin ,  Siavash Yazdanfar ,  Dmitry Vladimirovich Dylov ,  Brian Michael Davis ,  Chulmin Joo

IPC分类号： C12N15/87 ,  C12N13/00

CPC分类号： C12N13/00 ,  A61K48/0083 ,  C12N15/87

摘要： A method of delivering exogenous molecules, comprising: providing a plurality of cells having a cell membrane; adding a plurality of exogenous molecules to the cells; exposing the cells to a defocused infrared (IR) light to permeabilize the cell membrane of the cells; and delivering the exogenous molecules to the cells through the permeablized cell membrane, wherein an intensity of the IR light at the optical focus is at least greater than or equal to an order of 104 W/cm2.

摘要翻译： 一种递送外源性分子的方法，包括：提供多个具有细胞膜的细胞; 向细胞中加入多种外源性分子; 将细胞暴露于散焦的红外（IR）光以使细胞的细胞膜透化; 并且通过透过细胞膜将外源性分子递送至细胞，其中所述光学焦点处的IR光的强度至少大于或等于104W / cm 2。

公开(公告)号：US08314399B2

公开(公告)日：2012-11-20

申请号：US12781206

申请日：2010-05-17

申请人： Brent Allen Clothier ,  Adrian Ivan ,  Chulmin Joo ,  Daniel Bruno McDevitt

发明人： Brent Allen Clothier ,  Adrian Ivan ,  Chulmin Joo ,  Daniel Bruno McDevitt

IPC分类号： G01T3/00

CPC分类号： G01T1/202 ,  G01T3/06

摘要： A radiation detector includes a neutron sensing element comprising a neutron scintillating composite material that emits a first photon having a first wavelength and an optical waveguide material having a wavelength-shifting dopant dispersed therein that absorbs the first photon emitted by the neutron scintillating composite material and emits a second photon having a second, different wavelength, and a functionalized reflective layer at an interface between the neutron scintillating composite material and the optical waveguide material. The functionalized reflective layer allows the first photon emitted by the neutron scintillating composite material to pass through and into the optical waveguide material, but prevents the second photon emitted by the optical waveguide material from passing through and into the neutron scintillating composite material. The photons emitted from the neutron sensing element are collected and channeled through the optical waveguide material and into a photosensing element optically coupled to the neutron sensing element.

摘要翻译： 辐射检测器包括中子感测元件，其包括发射具有第一波长的第一光子的中子闪烁复合材料和分散在其中的波长迁移掺杂剂的光波导材料，其吸收由中子闪烁复合材料发射的第一光子并发射 具有第二不同波长的第二光子和在中子闪烁复合材料和光波导材料之间的界面处的官能化反射层。 功能化反射层允许由中子闪烁复合材料发射的第一光子通过并进入光波导材料，但是防止由光波导材料发射的第二光子通过并进入中子闪烁复合材料。 从中子感测元件发射的光子被收集并引导通过光波导材料并且被光耦合到中子感测元件上的光敏元件。

公开(公告)号：US20090219544A1

公开(公告)日：2009-09-03

申请号：US12205277

申请日：2008-09-05

申请人： Chulmin Joo ,  Johannes F. De Boer

发明人： Chulmin Joo ,  Johannes F. De Boer

IPC分类号： G01J3/45 ,  G01B9/02

CPC分类号： G01B9/02044 ,  G01B9/02035 ,  G01B9/02057 ,  G01B9/0209 ,  G01B9/02091 ,  G01B2290/70

摘要： Exemplary arrangement, apparatus, method and computer accessible can be provided. For example, using the exemplary arrangement, apparatus and method, it is possible to configured to propagate at least one electro-magnetic radiation. Indeed, it is possible to receive, using at least one first arrangement, a first portion of the at least one electro-magnetic radiation directed to a sample and a second portion of the least one electro-magnetic radiation directed to a reference, the first arrangement can be structured to at least partially reflect and at least partially allow to transmit the first and second portions. In addition, it is possible to receive, using a second arrangement, (i) a third portion of the electro-magnetic radiation associated with at least one of the transmitted first portion or the reflected first portion from the sample and (ii) a fourth portion of the electro-magnetic radiation associated with at least one of the second transmitted portion of the least one electro-magnetic radiation or the reflected second portion from the reference. The third and fourth portions can travel at least partially along substantially the same path toward the second arrangement, Further, the second arrangement can be configured to receive the reflected first and second portion(s) which interfere with one another, and generate at least one signal which includes information associated with at least one fluctuation in an uncommon path of the first and second portions prior to a receipt thereof by the at least one first arrangement. In addition or alternatively, the second arrangement can be configured to determine information regarding a spectrally resolved interference associated with the third and fourth portions.

摘要翻译： 可以提供示例性布置，装置，方法和可访问的计算机。 例如，使用示例性布置，装置和方法，可以配置成传播至少一个电磁辐射。 实际上，可以使用至少一个第一布置来接收被引导到样本的至少一个电磁辐射的第一部分，以及指向参考的至少一个电磁辐射的第二部分，第一 布置可以构造成至少部分地反射并且至少部分地允许传送第一和第二部分。 此外，可以使用第二布置来接收（i）与来自样品的透射的第一部分或反射的第一部分中的至少一个相关联的电磁辐射的第三部分，以及（ii）第四部分 所述电磁辐射部分与所述至少一个电磁辐射的第二透射部分或所述反射的第二部分中的至少一个相关联。 第三和第四部分可以至少部分地沿着基本上相同的路径行进到第二布置。此外，第二布置可以被配置为接收彼此干涉的反射的第一和第二部分，并且产生至少一个 信号，其包括与由所述至少一个第一布置接收之前的第一和第二部分的不常通路径中的至少一个波动相关联的信息。 另外或替代地，第二布置可以被配置为确定关于与第三和第四部分相关联的光谱解析干扰的信息。

公开(公告)号：US20130162978A1

公开(公告)日：2013-06-27

申请号：US13335175

申请日：2011-12-22

申请人： Siavash Yazdanfar ,  Sora Kim ,  Chulmin Joo

发明人： Siavash Yazdanfar ,  Sora Kim ,  Chulmin Joo

IPC分类号： G01B9/02

CPC分类号： G01B9/02091 ,  G01B9/02044 ,  G01B9/02063 ,  G01B9/02064 ,  G01B9/02068

摘要： A system, in one embodiment, includes an optical coherence tomography (OCT) imaging system having a light source configured to emit light. The OCT imaging system further includes a beam splitter configured to receive the light from the light source, split the light into a first light portion directed along a sample arm comprising a sample and a second light portion directed along a reference arm comprising a reference mirror, receive a first reflected light portion from the sample arm and a second reflected light portion from the reference arm, combine the first and second reflected light portions to obtain an interference signal at a detector. Further, the OCT imaging system includes a controller having logic configured to perform an auto-focusing process to determine the optimal position for a lens in the sample arm in order to bring the sample into focus.

摘要翻译： 在一个实施例中，系统包括具有被配置为发光的光源的光学相干断层摄影（OCT）成像系统。 OCT成像系统还包括分束器，其被配置为接收来自光源的光，将光分成沿着包括样本的样本臂引导的第一光部分和沿着包括参考反射镜的参考臂引导的第二光部分， 从采样臂接收第一反射光部分和从参考臂的第二反射光部分，组合第一和第二反射光部分以在检测器处获得干涉信号。 此外，OCT成像系统包括具有被配置为执行自动聚焦处理以确定样本臂中的透镜的最佳位置以便使样本聚焦的逻辑的控制器。

公开(公告)号：US20130052738A1

公开(公告)日：2013-02-28

申请号：US13221161

申请日：2011-08-30

申请人： Vasile Bogdan Neculaes ,  Kenneth Roger Conway ,  Allen Lawrence Garner ,  Evelina Roxana Loghin ,  Siavash Yazdanfar ,  Dmitry Vladimirovich Dylov ,  Brian Michael Davis ,  Chulmin Joo

发明人： Vasile Bogdan Neculaes ,  Kenneth Roger Conway ,  Allen Lawrence Garner ,  Evelina Roxana Loghin ,  Siavash Yazdanfar ,  Dmitry Vladimirovich Dylov ,  Brian Michael Davis ,  Chulmin Joo

IPC分类号： C12N13/00 ,  C12N15/63 ,  C12N15/81 ,  C12N15/85 ,  C12N15/82 ,  B82Y5/00

CPC分类号： C12N13/00 ,  A61K48/0083 ,  C12N15/87

摘要： A method of delivering exogenous molecules, comprising: providing a plurality of cells having a cell membrane; adding a plurality of exogenous molecules to the cells; exposing the cells to a defocused infrared (IR) light to permeabilize the cell membrane of the cells; and delivering the exogenous molecules to the cells through the permeablized cell membrane, wherein an intensity of the IR light at the optical focus is at least greater than or equal to an order of 104 W/cm2.

摘要翻译： 一种递送外源性分子的方法，包括：提供多个具有细胞膜的细胞; 向细胞中加入多种外源性分子; 将细胞暴露于散焦的红外（IR）光以使细胞的细胞膜透化; 并且通过透过细胞膜将外源性分子递送至细胞，其中所述光学焦点处的IR光的强度至少大于或等于104W / cm 2。

公开(公告)号：US20100276602A1

公开(公告)日：2010-11-04

申请号：US12781206

申请日：2010-05-17

申请人： Brent Allen Clothier ,  Adrian Ivan ,  Chulmin Joo ,  Daniel Bruno McDevitt

发明人： Brent Allen Clothier ,  Adrian Ivan ,  Chulmin Joo ,  Daniel Bruno McDevitt

IPC分类号： G01T1/20

CPC分类号： G01T1/202 ,  G01T3/06

摘要： A radiation detector includes a neutron sensing element comprising a neutron scintillating composite material that emits a first photon having a first wavelength and an optical waveguide material having a wavelength-shifting dopant dispersed therein that absorbs the first photon emitted by the neutron scintillating composite material and emits a second photon having a second, different wavelength, and a functionalized reflective layer at an interface between the neutron scintillating composite material and the optical waveguide material. The functionalized reflective layer allows the first photon emitted by the neutron scintillating composite material to pass through and into the optical waveguide material, but prevents the second photon emitted by the optical waveguide material from passing through and into the neutron scintillating composite material. The photons emitted from the neutron sensing element are collected and channeled through the optical waveguide material and into a photosensing element optically coupled to the neutron sensing element.

摘要翻译： 辐射检测器包括中子感测元件，其包括发射具有第一波长的第一光子的中子闪烁复合材料和分散在其中的波长迁移掺杂剂的光波导材料，其吸收由中子闪烁复合材料发射的第一光子并发射 具有第二不同波长的第二光子和在中子闪烁复合材料和光波导材料之间的界面处的官能化反射层。 功能化反射层允许由中子闪烁复合材料发射的第一光子通过并进入光波导材料，但是防止由光波导材料发射的第二光子通过并进入中子闪烁复合材料。 从中子感测元件发射的光子被收集并引导通过光波导材料并且被光耦合到中子感测元件上的光敏元件。