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    SYSTEM AND METHOD FOR AUTO-RANGING IN OPTICAL COHERENCE TOMOGRAPHY
    1.
    发明申请
    SYSTEM AND METHOD FOR AUTO-RANGING IN OPTICAL COHERENCE TOMOGRAPHY 有权
    用于光学相干坐标自动调节的系统和方法

    公开(公告)号：US20130162948A1

    公开(公告)日：2013-06-27

    申请号：US13335211

    申请日：2011-12-22

    申请人： Siavash Yazdanfar ,  Sora Kim ,  Chulmin Joo

    发明人： Siavash Yazdanfar ,  Sora Kim ,  Chulmin Joo

    IPC分类号： A61B3/15 ,  G01B9/02

    CPC分类号： G01B9/02044 ,  A61B3/102 ,  A61B3/12 ,  G01B9/02048 ,  G01B9/02063 ,  G01B9/02064 ,  G01B9/02091

    摘要： A system, in one embodiment, includes an optical coherence tomography (OCT) imaging system having a light source configured to emit light. The OCT imaging system further includes a beam splitter configured to receive the light from the light source, split the light into a first light portion directed along a sample arm comprising a sample and a second light portion directed along a reference arm comprising a reference mirror, receive a first reflected light portion from the sample arm and a second reflected light portion from the reference arm, combine the first and second reflected light portions to obtain an interference signal. Further, the OCT imaging system includes a controller having logic configured to perform an auto-ranging process to match the reference arm with the sample arm.

    摘要翻译： 在一个实施例中，系统包括具有被配置为发光的光源的光学相干断层摄影（OCT）成像系统。 OCT成像系统还包括分束器，其被配置为接收来自光源的光，将光分成沿着包括样本的样本臂引导的第一光部分和沿着包括参考反射镜的参考臂引导的第二光部分， 从样品臂接收第一反射光部分和从参考臂的第二反射光部分，组合第一和第二反射光部分以获得干涉信号。 此外，OCT成像系统包括具有被配置为执行自动测距过程以使参考臂与样本臂匹配的逻辑的控制器。

    System and method for auto-ranging in optical coherence tomography
    2.
    发明授权
    System and method for auto-ranging in optical coherence tomography 有权
    光学相干断层扫描中自动测距的系统和方法

    公开(公告)号：US09273950B2

    公开(公告)日：2016-03-01

    申请号：US13335211

    申请日：2011-12-22

    申请人： Siavash Yazdanfar ,  Sora Kim ,  Chulmin Joo

    发明人： Siavash Yazdanfar ,  Sora Kim ,  Chulmin Joo

    IPC分类号： A61B3/14 ,  G01B9/02 ,  A61B3/10 ,  A61B3/12

    CPC分类号： G01B9/02044 ,  A61B3/102 ,  A61B3/12 ,  G01B9/02048 ,  G01B9/02063 ,  G01B9/02064 ,  G01B9/02091

    摘要： A system, in one embodiment, includes an optical coherence tomography (OCT) imaging system having a light source configured to emit light. The OCT imaging system further includes a beam splitter configured to receive the light from the light source, split the light into a first light portion directed along a sample arm comprising a sample and a second light portion directed along a reference arm comprising a reference mirror, receive a first reflected light portion from the sample arm and a second reflected light portion from the reference arm, combine the first and second reflected light portions to obtain an interference signal. Further, the OCT imaging system includes a controller having logic configured to perform an auto-ranging process to match the reference arm with the sample arm.

    摘要翻译： 在一个实施例中，系统包括具有被配置为发光的光源的光学相干断层摄影（OCT）成像系统。 OCT成像系统还包括分束器，其被配置为接收来自光源的光，将光分成沿着包括样本的样本臂引导的第一光部分和沿着包括参考反射镜的参考臂引导的第二光部分， 从样品臂接收第一反射光部分和从参考臂的第二反射光部分，组合第一和第二反射光部分以获得干涉信号。 此外，OCT成像系统包括具有被配置为执行自动测距过程以使参考臂与样本臂匹配的逻辑的控制器。

    System and method for auto-focusing in optical coherence tomography
    3.
    发明授权
    System and method for auto-focusing in optical coherence tomography 有权
    光学相干断层扫描中自动聚焦的系统和方法

    公开(公告)号：US08842287B2

    公开(公告)日：2014-09-23

    申请号：US13335175

    申请日：2011-12-22

    申请人： Siavash Yazdanfar ,  Sora Kim ,  Chulmin Joo

    发明人： Siavash Yazdanfar ,  Sora Kim ,  Chulmin Joo

    IPC分类号： G01B9/02

    CPC分类号： G01B9/02091 ,  G01B9/02044 ,  G01B9/02063 ,  G01B9/02064 ,  G01B9/02068

    摘要： A system, in one embodiment, includes an optical coherence tomography (OCT) imaging system having a light source configured to emit light. The OCT imaging system further includes a beam splitter configured to receive the light from the light source, split the light into a first light portion directed along a sample arm comprising a sample and a second light portion directed along a reference arm comprising a reference mirror, receive a first reflected light portion from the sample arm and a second reflected light portion from the reference arm, combine the first and second reflected light portions to obtain an interference signal at a detector. Further, the OCT imaging system includes a controller having logic configured to perform an auto-focusing process to determine the optimal position for a lens in the sample arm in order to bring the sample into focus.

    摘要翻译： 在一个实施例中，系统包括具有被配置为发光的光源的光学相干断层摄影（OCT）成像系统。 OCT成像系统还包括分束器，其被配置为接收来自光源的光，将光分成沿着包括样本的样本臂引导的第一光部分和沿着包括参考反射镜的参考臂引导的第二光部分， 从采样臂接收第一反射光部分和从参考臂的第二反射光部分，组合第一和第二反射光部分以在检测器处获得干涉信号。 此外，OCT成像系统包括具有被配置为执行自动聚焦处理以确定样本臂中的透镜的最佳位置以便使样本聚焦的逻辑的控制器。

    SYSTEM AND METHOD FOR AUTO-FOCUSING IN OPTICAL COHERENCE TOMOGRAPHY
    4.
    发明申请
    SYSTEM AND METHOD FOR AUTO-FOCUSING IN OPTICAL COHERENCE TOMOGRAPHY 有权
    用于自动聚焦光学相干坐标测量的系统和方法

    公开(公告)号：US20130162978A1

    公开(公告)日：2013-06-27

    申请号：US13335175

    申请日：2011-12-22

    申请人： Siavash Yazdanfar ,  Sora Kim ,  Chulmin Joo

    发明人： Siavash Yazdanfar ,  Sora Kim ,  Chulmin Joo

    IPC分类号： G01B9/02

    CPC分类号： G01B9/02091 ,  G01B9/02044 ,  G01B9/02063 ,  G01B9/02064 ,  G01B9/02068

    摘要： A system, in one embodiment, includes an optical coherence tomography (OCT) imaging system having a light source configured to emit light. The OCT imaging system further includes a beam splitter configured to receive the light from the light source, split the light into a first light portion directed along a sample arm comprising a sample and a second light portion directed along a reference arm comprising a reference mirror, receive a first reflected light portion from the sample arm and a second reflected light portion from the reference arm, combine the first and second reflected light portions to obtain an interference signal at a detector. Further, the OCT imaging system includes a controller having logic configured to perform an auto-focusing process to determine the optimal position for a lens in the sample arm in order to bring the sample into focus.

    摘要翻译： 在一个实施例中，系统包括具有被配置为发光的光源的光学相干断层摄影（OCT）成像系统。 OCT成像系统还包括分束器，其被配置为接收来自光源的光，将光分成沿着包括样本的样本臂引导的第一光部分和沿着包括参考反射镜的参考臂引导的第二光部分， 从采样臂接收第一反射光部分和从参考臂的第二反射光部分，组合第一和第二反射光部分以在检测器处获得干涉信号。 此外，OCT成像系统包括具有被配置为执行自动聚焦处理以确定样本臂中的透镜的最佳位置以便使样本聚焦的逻辑的控制器。

    SYSTEM FOR OPTICAL BASED DELIVERY OF EXOGENOUS MOLECULES TO CELLS
    5.
    发明申请
    SYSTEM FOR OPTICAL BASED DELIVERY OF EXOGENOUS MOLECULES TO CELLS 审中-公开
    用于基于光源分布的细胞外分泌的系统

    公开(公告)号：US20130052725A1

    公开(公告)日：2013-02-28

    申请号：US13285976

    申请日：2011-10-31

    申请人： Siavash Yazdanfar ,  Vasile Bogdan Neculaes ,  Kenneth Roger Conway ,  Allen Lawrence Garner ,  Evelina Roxana Loghin ,  Dmitry Vladimirovich Dylov ,  Brian Michael Davis ,  Chulmin Joo

    发明人： Siavash Yazdanfar ,  Vasile Bogdan Neculaes ,  Kenneth Roger Conway ,  Allen Lawrence Garner ,  Evelina Roxana Loghin ,  Dmitry Vladimirovich Dylov ,  Brian Michael Davis ,  Chulmin Joo

    IPC分类号： C12M1/42

    CPC分类号： C12M35/02

    摘要： A system for delivering exogenous molecules comprises a support for containing cells and exogenous molecules; an infra-red (IR) light source that generates an IR optical beam with an average power density at least greater than 105 W/cm2; one or more optical elements; an imaging system to image the cells in a field of view; a processor that generates a signal for localization of cells in the field of view; a light pattern shaper for temporal focusing of optical beam to generate wide field illumination on the cells to permeabilise the cell membrane for delivering the exogenous molecules; and a controller that switches optical beam from wide field illumination to a focused illumination. The processor is operatively coupled to the imaging system and the light pattern shaper and transmits the signal for the localization of cells to ensure the temporal focusing of the optical beam on the cells.

    摘要翻译： 用于递送外源分子的系统包括用于含有细胞和外源分子的载体; 红外（IR）光源，其产生平均功率密度至少大于105W / cm2的IR光束; 一个或多个光学元件; 成像系统，用于在视场中对细胞进行成像; 处理器，其在视野中产生用于细胞定位的信号; 用于光束的时间聚焦的光图案整形器以在细胞上产生宽场照明以透过细胞膜以传递外源分子; 以及将光束从宽场照明切换到聚焦照明的控制器。 处理器可操作地耦合到成像系统和光图案整形器，并且传输信号用于细胞的定位，以确保光束在细胞上的时间聚焦。

    Quantitative phase microscopy for high-contrast cell imaging using frequency domain phase shift
    8.
    发明授权
    Quantitative phase microscopy for high-contrast cell imaging using frequency domain phase shift 有权
    定量相位显微镜用于使用频域相移的高对比度细胞成像

    公开(公告)号：US09097900B2

    公开(公告)日：2015-08-04

    申请号：US13523816

    申请日：2012-06-14

    申请人： Evgenia Mikhailovna Kim ,  Robert John Filkins ,  Chulmin Joo

    发明人： Evgenia Mikhailovna Kim ,  Robert John Filkins ,  Chulmin Joo

    IPC分类号： G01B9/02 ,  G02B21/00 ,  G02B21/14 ,  G01B9/04 ,  G02B21/36

    CPC分类号： G02B21/14 ,  G01B9/04 ,  G01B2290/20 ,  G02B21/0088 ,  G02B21/361

    摘要： Some systems described herein include a frequency dependent phase plate for generating multiple phase-contrast images of a sample, each from a different frequency range of light, each phase-contrast image for frequency range of light formed from light diffracted by the sample interfered with undiffracted light that has a frequency-dependent baseline relative phase shift from the phase plate. In some embodiments, the multiple phase-contrast images may be used to generate a quantitative phase image of a sample. The phase-contrast images or the produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei.

    摘要翻译： 本文描述的一些系统包括频率相关相位板，用于产生每个来自不同频率范围的样品的多个相位对比图像，用于由被样品干涉的未衍射的光形成的光的频率范围的每个相位对比度图像 具有频率相关基准的相对于相位板相对相移的光。 在一些实施例中，多个相位对比图像可用于产生样本的定量相位图像。 相位对比图像或产生的定量相位图像可以具有足够的对比度，用于无标记的细胞体和核的自动分割。

    Light-emitting diode backlighting systems
    9.
    发明授权
    Light-emitting diode backlighting systems 有权
    发光二极管背光系统

    公开(公告)号：US08143792B2

    公开(公告)日：2012-03-27

    申请号：US12543722

    申请日：2009-08-19

    申请人： Chulmin Joo ,  Hyunick Shin

    发明人： Chulmin Joo ,  Hyunick Shin

    IPC分类号： H05B37/02

    CPC分类号： H05B33/0827

    摘要： Lighting system embodiments are provided to energize and calibrate strings of light-emitting diodes. These embodiments are particularly useful for calibration of strings of light-emitting diodes that are arranged to provide backlighting of liquid crystal displays. The systems are structured around the use of a single comparator that is multiplexed to facilitate calibration of a plurality of current sources. The systems can be adapted for use in displays in which different techniques (e.g., “analog dimming” and “pulse-width modulation”) are used to vary the brightness of the display. The systems remove the need for special structures (e.g., fuse arrays, special test equipment, and interfaces).

    摘要翻译： 提供照明系统实施例以激励和校准发光二极管串。 这些实施例对于校准布置成提供液晶显示器背光的发光二极管串特别有用。 这些系统围绕使用单个比较器进行结构，该比较器被多路复用以便于多个电流源的校准。 该系统可以适用于其中使用不同技术（例如，“模拟调光”和“脉冲宽度调制”）以改变显示器的亮度的显示器。 该系统消除了对特殊结构（例如，熔丝阵列，特殊测试设备和接口）的需要。

    Quantitative phase microscopy for label-free high-contrast cell imaging
    10.
    发明授权
    Quantitative phase microscopy for label-free high-contrast cell imaging 有权
    用于无标记的高对比度细胞成像的定量相位显微术

    公开(公告)号：US08693000B2

    公开(公告)日：2014-04-08

    申请号：US13335748

    申请日：2011-12-22

    申请人： Evgenia Mikhailovna Kim ,  Robert John Fikins ,  Chulmin Joo

    发明人： Evgenia Mikhailovna Kim ,  Robert John Fikins ,  Chulmin Joo

    IPC分类号： G01B9/02 ,  G02B21/00

    CPC分类号： G02B21/367 ,  G02B21/14

    摘要： Systems and methods described herein employ multiple phase-contrast images with various relative phase shifts between light diffracted by a sample and light not diffracted by the sample to produce a quantitative phase image. The produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei.

    摘要翻译： 本文描述的系统和方法使用多个相差图像，其在由样品衍射的光和不被样品衍射的光之间具有各种相对相移，以产生定量相位图像。 所产生的定量相图可能具有足够的对比度，用于细胞体和细胞核的无标记自动分割。