UMSYMMETRICAL BISAZIDES FOR CHEMOSELECTIVE SEQUENTIAL LIGATION
    13.
    发明申请
    UMSYMMETRICAL BISAZIDES FOR CHEMOSELECTIVE SEQUENTIAL LIGATION 有权
    用于化学连接接头的非对称比酯

    公开(公告)号:US20140018541A1

    公开(公告)日:2014-01-16

    申请号:US13941798

    申请日:2013-07-15

    CPC classification number: C07D403/14 C07D401/06 C07D401/14 C07D403/06

    Abstract: Unsymmetrical bisazides containing chelating and non-chelating azido groups undergo chemoselective three-component copper(I)-catalyzed azide-alkyne conjugation reactions with two different alkyne molecules. In conjunction with the reactivity gap between aromatic and aliphatic alkynes, a bistriazole molecule can be generated with an excellent regioselectivity by mixing two alkynes and a bisazide in a single reaction container. This method is applicable in aqueous solutions at neutral pH, which may lend utilities in bioconjugation applications.

    Abstract translation: 含有螯合和非螯合叠氮基的非对称二叠氮化物通过化学选择性的三组分铜(I) - 与两种不同的炔分子的催化偶氮炔共轭反应。 结合芳族和脂族炔之间的反应性间隙,通过在单个反应容器中混合两个炔和双叠氮化物,可以产生具有优异区域选择性的双三唑分子。 该方法适用于中性pH值的水溶液,这可能在生物共轭应用中有用。

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