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11.
公开(公告)号:US20140337052A1
公开(公告)日:2014-11-13
申请号:US14146742
申请日:2014-01-03
Applicant: FOUNDATION MEDICINE, INC.
Inventor: Michael Pellini , Gary Palmer , Mary P. Lancelotta , Matthew J. Hawryluk , Vincent A. Miller
IPC: G06F19/00
Abstract: Provided are systems and methods for capturing outcome information associated with various cancer treatments. The system facilitates capture and analysis of cancer treatment information and associated outcome information. The treatment and outcome information can include genomic analysis and information on treatment of different cancers. The system can store and analyze any one or more of: tumor type, genomic alterations (e.g., genes and associated alterations, gene sequence mutations, alterations, amplifications, deletions, etc.), and treatment data (including, for example, treatments targeted to specific genes and/or genomic alterations). Users of the outcome system can supply and use the treatment and outcome information to facilitate diagnosis and therapy decisions. User interfaces within the system can be configured to allow users to easily locate outcome information associated with particular treatments of tumors having certain genomic alterations.
Abstract translation: 提供了用于捕获与各种癌症治疗相关的结果信息的系统和方法。 该系统有助于捕获和分析癌症治疗信息和相关的结果信息。 治疗和结果信息可以包括基因组分析和治疗不同癌症的信息。 该系统可以存储和分析以下中的一种或多种:肿瘤类型,基因组改变(例如,基因和相关的改变,基因序列突变,改变,扩增,缺失等)和治疗数据(包括例如靶向治疗 到特定基因和/或基因组改变)。 结果系统的用户可以提供和使用治疗和结果信息来促进诊断和治疗决策。 可以将系统内的用户界面配置为允许用户轻松定位与具有某些基因组改变的肿瘤的特定治疗相关联的结果信息。
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公开(公告)号:US10980804B2
公开(公告)日:2021-04-20
申请号:US14761518
申请日:2014-01-17
Applicant: FOUNDATION MEDICINE, INC.
Inventor: Siraj Mahamed Ali , Matthew J. Hawryluk , Jie He , Doron Lipson , Vincent A. Miller , Jeffrey S. Ross , Philip James Stephens
IPC: A61K31/517 , A61K31/498 , A61K31/19 , A61K31/5025 , C12N9/12 , A61K31/4412 , A61K45/06 , A61K31/47 , A61K31/435 , A61K31/506 , A61K31/519 , A61K31/4439 , A61K31/53 , A61K31/404 , A61K31/5383 , A61K31/496 , C12Q1/6886 , A61K31/553 , C07K14/705 , C07K14/71 , C07K16/40 , C12N15/113 , C12Q1/6883 , G01N33/573
Abstract: Methods and compositions for treating cholangiocarcinoma.
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公开(公告)号:US20200294668A1
公开(公告)日:2020-09-17
申请号:US16793405
申请日:2020-02-18
Applicant: FOUNDATION MEDICINE, INC.
Inventor: Michael Pellini , Gary Palmer , Mary Patricia Lancelotta , Matthew J. Hawryluk , Philip James Stephens
Abstract: Various embodiments provide interfaces to access genomic testing information and incorporate it into daily physician practice. In some embodiments, presentation of genomic alteration data is simplified and/or coupled with contextual applications. Volumes of genomic alterations and associated information (e.g., journal articles, clinical trial information, therapies, etc.) are analyzed and synthesized into actionable information items viewable on an alteration system. According to one embodiment, the system can be configured to focus practitioners on discrete portions of the alteration information on which they can act. According to other aspects, curated information is provided on the system to enable practitioners to make informed decisions regarding the implications of the presence of specific genomic alterations.
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公开(公告)号:US20200281930A1
公开(公告)日:2020-09-10
申请号:US16654582
申请日:2019-10-16
Applicant: FOUNDATION MEDICINE, INC. , UCL Business PLC
Inventor: Chris Hendrik Boshoff , Timothy Robert Fenton , Matthias Alexander Lechner , Philip James Stephens , Matthew J. Hawryluk , Garrett Michael Frampton , Roman Yelensky
IPC: A61K31/519 , C12Q1/70 , A61K31/506 , A61K31/454 , A61K31/52 , A61K31/404 , A61K31/4196 , A61K33/24 , A61K31/282 , A61K31/337 , A61K31/513 , A61K39/395 , A61K31/436 , A61K31/05 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/352 , A61N5/00 , C12Q1/6886 , A61K31/366 , A61K31/505 , A61K31/555 , A61K31/439 , A61K31/4745 , C07K16/28 , C12Q1/6883 , G01N33/571 , A61N5/10
Abstract: Methods of treating a head and neck cancer are disclosed.
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公开(公告)号:US20200211679A1
公开(公告)日:2020-07-02
申请号:US16579496
申请日:2019-09-23
Applicant: FOUNDATION MEDICINE, INC.
Inventor: Michael Pellini , Gary Palmer , Mary Patricia Lancelotta , Matthew J. Hawryluk , Vincent A. Miller
Abstract: A system for tracking and analyzing cancer treatment and outcome information includes a user interface (UI) component for allowing selection of an alteration, an affected gene, an affected pathway, a tumor type, and/or a treatment; a processor configured to receive treatment information and outcome information associated with a patient population; organize the treatment information and the outcome information into at least one tuple; and generate outcome summary information; and an analysis component configured to compare a current patient record for a current patient to existing treatment information for the patient population, identify similar patients in the patient population based on information in the current patient record, and filter a grouping of similar patients; the processor is further configured to display, on the UI component, the outcome summary information; enable navigation within the treatment and outcome information; and identify, based on the outcome information, an appropriate treatment for the current patient.
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公开(公告)号:US09884060B2
公开(公告)日:2018-02-06
申请号:US15045716
申请日:2016-02-17
Applicant: FOUNDATION MEDICINE, INC.
Inventor: Sean R. Downing , Matthew J. Hawryluk , Doron Lipson , Alexander N. Parker , Philip James Stephens
IPC: A61K31/517 , C07K14/82 , C12N9/14 , C12Q1/68 , A61K31/404 , A61K31/4412 , A61K31/444 , A61K31/47 , A61K31/513 , C12N15/113
CPC classification number: A61K31/517 , A61K31/404 , A61K31/4412 , A61K31/444 , A61K31/47 , A61K31/513 , C07K14/82 , C07K2319/00 , C12N9/14 , C12N15/1135 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
Abstract: Novel RET fusion molecules and uses are disclosed. In one embodiment, a KIF5B-RET fusion includes an in-frame fusion of an exon of KIF5B (e.g., one or more exons encoding a kinesin motor domain or a fragment thereof) and an exon of RET (e.g., one or more exons encoding a RET tyrosine kinase domain or a fragment thereof). For example, the KIF5B-RET fusion can include an in-frame fusion of at least exon 15 of KIF5B or a fragment thereof (e.g., exons 1-15 of KIF5B or a fragment thereof) with at least exon 12 of RET or a fragment thereof (e.g., exons 12-20 of RET or a fragment thereof).
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公开(公告)号:US20180000820A1
公开(公告)日:2018-01-04
申请号:US15433646
申请日:2017-02-15
Applicant: FOUNDATION MEDICINE, INC.
Inventor: Siraj Mahamed Ali , Matthew J. Hawryluk , Jeffrey S. Ross , Philip James Stephens
IPC: A61K31/517 , C12Q1/68 , C07K16/32 , C07K14/82 , A61K45/06 , A61K31/475 , A61K47/68 , A61K31/7105 , A61K31/704 , A61K31/5365 , A61K31/519 , A61K31/713 , A61K33/24
CPC classification number: A61K31/517 , A61K31/475 , A61K31/519 , A61K31/5365 , A61K31/704 , A61K31/7105 , A61K31/713 , A61K33/24 , A61K45/06 , A61K47/6803 , A61K47/6851 , A61K47/6855 , C07K14/82 , C07K16/32 , C12Q1/6886 , C12Q2600/106 , A61K2300/00
Abstract: Methods and compositions for treating a urothelial and/or a micropapillary carcinoma, such as a micropapillary urothelial carcinoma are disclosed.
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公开(公告)号:US09297011B2
公开(公告)日:2016-03-29
申请号:US14187280
申请日:2014-02-23
Applicant: FOUNDATION MEDICINE, INC.
Inventor: Sean R. Downing , Matthew J. Hawryluk , Doron Lipson , Alexander N. Parker , Philip James Stephens
IPC: A61K31/47 , A61K31/517 , C12N15/113 , C07K14/82 , C12N9/14 , C12Q1/68 , A61K31/404 , A61K31/4412 , A61K31/444 , A61K31/513
CPC classification number: A61K31/517 , A61K31/404 , A61K31/4412 , A61K31/444 , A61K31/47 , A61K31/513 , C07K14/82 , C07K2319/00 , C12N9/14 , C12N15/1135 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
Abstract: Novel RET fusion molecules and uses are disclosed.
Abstract translation: 公开了新型RET融合分子和用途。
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19.
公开(公告)号:US08673972B2
公开(公告)日:2014-03-18
申请号:US13958502
申请日:2013-08-02
Applicant: Foundation Medicine, Inc. , UCL Business PLC
Inventor: Chris Hendrik Boshoff , Timothy Robert Fenton , Matthias Alexander Lechner , Philip James Stephens , Matthew J. Hawryluk , Roman Yelensky , Garrett Michael Frampton
CPC classification number: A61K31/519 , A61K31/05 , A61K31/282 , A61K31/337 , A61K31/352 , A61K31/366 , A61K31/404 , A61K31/4196 , A61K31/436 , A61K31/439 , A61K31/454 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/52 , A61K31/5377 , A61K31/555 , A61K33/24 , A61K39/39558 , A61K2039/505 , A61N5/00 , A61N5/10 , C07K16/2863 , C12Q1/6883 , C12Q1/6886 , C12Q1/708 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/571 , A61K2300/00
Abstract: Methods of treating a head and neck cancer are disclosed.
Abstract translation: 公开了治疗头颈癌的方法。
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公开(公告)号:US12239648B2
公开(公告)日:2025-03-04
申请号:US17817619
申请日:2022-08-04
Applicant: Foundation Medicine, Inc.
Inventor: Sean R. Downing , Matthew J. Hawryluk , Doron Lipson , Alexander N. Parker , Philip James Stephens
IPC: A61K31/517 , A61K31/404 , A61K31/4412 , A61K31/444 , A61K31/47 , A61K31/513 , C07K14/82 , C12N9/14 , C12N15/113 , C12Q1/6886
Abstract: Novel RET fusion molecules and uses are disclosed.
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