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公开(公告)号：US11498913B2
公开(公告)日：2022-11-15
申请号：US17101018
申请日：2020-11-23
发明人： Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, Jr. , Justin Andrew Caravella , Wei Lu
IPC分类号： C07D401/12 , C07D401/14 , C07D471/04 , A61P35/00 , A61K31/47
摘要： The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, U, W1, W2, W3, R1-R6, and R9 are described herein.
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公开(公告)号：US11254674B2
公开(公告)日：2022-02-22
申请号：US16946159
申请日：2020-06-08
发明人： Shawn E. R. Schiller , Torsten Herbertz , Hongbin Li , Bradford Graves , Steven Mischke , Angela West , Jennifer R. Downing , Anna Ericsson
IPC分类号： C07D471/04
摘要： The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains, and methods of synthesis of these compounds.
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公开(公告)号：US11001588B2
公开(公告)日：2021-05-11
申请号：US16575456
申请日：2019-09-19
发明人： David R. Lancia, Jr. , Gary Gustafson , Neal Green , Lorna Mitchell , Anna Ericsson , David Richard
IPC分类号： C07D401/14 , A61K31/4439 , C07D487/04 , A61K9/00
摘要： The disclosure provides chemical compounds useful as activators of PKR. PKR activating compounds are useful in the treatment of disease and disorders associated with modulation of PKR and/or PKM2, such as pyruvate kinase deficiency (PKD).
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公开(公告)号：US10889567B2
公开(公告)日：2021-01-12
申请号：US16712951
申请日：2019-12-12
发明人： Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, Jr. , Justin Andrew Caravella , Wei Lu
IPC分类号： C07D401/12 , C07D401/14 , C07D471/04 , A61P35/00 , A61K31/47
摘要： The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, U, W1, W2, W3, R1-R6, and R9 are described herein.
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公开(公告)号：US20200253939A1
公开(公告)日：2020-08-13
申请号：US15929436
申请日：2020-05-01
发明人： Anna Ericsson , Neal Green , Gary Gustafson , David R. Lancia , Gary Marshall , Lorna Mitchell , David Richard , Zhongguo Wang
IPC分类号： A61K31/436 , A61K9/00 , A61P7/06
摘要： This disclosure provides compounds and compositions for activating pyruvate kinase R (PKR) and related methods of manufacturing and using these compounds and compositions.
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公开(公告)号：US20180134682A1
公开(公告)日：2018-05-17
申请号：US15712446
申请日：2017-09-22
发明人： Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, Jr. , Justin Andrew Caravella , Wei Lu
IPC分类号： C07D401/12 , C07D405/14 , C07D401/14 , C07D403/12 , C07D471/04 , C07D409/14 , C07D413/14 , C07D417/14
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, W1, W2, W3, and R1-R6 are described herein.
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公开(公告)号：US20180086733A1
公开(公告)日：2018-03-29
申请号：US15677748
申请日：2017-08-15
发明人： Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, JR. , Justin Andrew Caravella , Wei Lu
IPC分类号： C07D401/12 , C07D417/14 , C07D413/14 , C07D405/14 , C07D401/14 , A61K31/4704
CPC分类号： C07D401/12 , A61K31/4704 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, U, V, Z, W1, W2, W3, and R1-R6 are described herein.
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公开(公告)号：US09902728B2
公开(公告)日：2018-02-27
申请号：US14982127
申请日：2015-12-29
发明人： Stephanos Ioannidis , Adam Charles Talbot , Bruce Follows , Alexandre Joseph Buckmelter , Minghua Wang , Ann-Marie Campbell , Darby Rye Schmidt , David Joseph Guerin , Justin A. Caravella , R. Bruce Diebold , Anna Ericsson , David R. Lancia, Jr.
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00 , C07D487/04 , C07D519/00
CPC分类号： C07D487/04 , A61K31/519 , C07D519/00
摘要： The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where m, n, X1, X2, R1-R5, R5′ and R6 are described herein.
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19.发明申请PYRROLO AND PYRAZOLOPYRIMIDINES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS 有权吡咯和吡唑并嘧啶作为UBIQUITIN特异性蛋白酶7抑制剂公开(公告)号：US20160185785A1
公开(公告)日：2016-06-30
申请号：US14982127
申请日：2015-12-29
发明人： Stephanos Ioannidis , Adam Charles Talbot , Bruce Follows , Alexandre Joseph Buckmelter , Minghua Wang , Ann-Marie Campbell , Darby Rye Schmidt , David Joseph Guerin , Justin A. Caravella , R. Bruce Diebold , Anna Ericsson , David Lancia, JR.
IPC分类号： C07D487/04 , C07D519/00
CPC分类号： C07D487/04 , A61K31/519 , C07D519/00
摘要： The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where m, n, X1, X2, R1-R5, R5′ and R6 are described herein.
摘要翻译： 本发明涉及可用于治疗癌症，神经变性疾病，免疫疾病，炎症性疾病，心血管疾病，缺血性疾病，病毒感染和疾病以及细菌感染和疾病的USP7抑制剂的抑制剂，其具有下式：其中m，n， 本文描述了X1，X2，R1-R5，R5'和R6。
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20.发明申请PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS 有权吡啶-2（1H） - 酮喹诺酮衍生物作为突变型脱氢酶抑制剂公开(公告)号：US20160083349A1
公开(公告)日：2016-03-24
申请号：US14858174
申请日：2015-09-18
发明人： Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, JR. , Justin Andrew Caravella , Wei Lu
IPC分类号： C07D215/227 , C07D401/12
CPC分类号： C07D215/227 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要： The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, W1, W2, W3, and R1-R8 are described herein.
摘要翻译： 本发明涉及用于治疗细胞增殖障碍和癌症的具有新形态活性的突变异柠檬酸脱氢酶（mt-IDH）蛋白的抑制剂，其具有下式：其中A，B，W1，W2，W3和R1-R8是 在此描述。
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