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11.发明授权Humanized anti-IL 10 antibodies for the treatment of systemic lupus erythematosus (SLE) 有权用于治疗系统性红斑狼疮（SLE）的人源化抗IL 10抗体公开(公告)号：US08956607B2
公开(公告)日：2015-02-17
申请号：US13512712
申请日：2010-11-30
申请人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Peter Röttgen , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth
发明人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Peter Röttgen , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth
CPC分类号： C07K16/244 , A61K2039/505 , C07K2299/00 , C07K2317/14 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2317/92 , G01N33/6869
摘要： Provided is a humanized or chimeric antibody or fragment thereof capable of binding to interleukin-10 (IL-10), wherein said antibody or fragment thereof: (i) binds to the same region of IL-10 as the IL-10 receptor α(IL-I10Ra) and is not capable of binding IL-10 when the IL-10 is bound to the IL- 10 receptor; and (ii) binds to IL-10 in homodimeric form by binding a discontinuous epitope comprising residues of both monomers. Further provided are related products and methods involving the use of the antibody or fragment thereof.
摘要翻译： 提供能够结合白细胞介素-10（IL-10）的人源化或嵌合抗体或其片段，其中所述抗体或其片段：（i）结合与IL-10受体α相同的IL-10区域（ IL-10Ra），并且当IL-10与IL-10受体结合时不能结合IL-10; 和（ii）通过结合包含两个单体的残基的不连续表位与同型二聚体形式的IL-10结合。 进一步提供涉及使用抗体或其片段的相关产物和方法。
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公开(公告)号：US20130004513A1
公开(公告)日：2013-01-03
申请号：US13483280
申请日：2012-05-30
申请人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth , Holger Wallmeier , Kirsten Völp , Gregor Schulz
发明人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth , Holger Wallmeier , Kirsten Völp , Gregor Schulz
IPC分类号： A61K39/395 , C07K16/28 , C40B30/04 , C07K19/00 , C07K9/00 , C07K14/73 , C12N15/13 , C12N15/63 , C12P21/00 , C12N5/0783 , A61P37/06 , C12N1/19 , C12N5/10 , C12N5/12 , H01F1/42 , G06F19/10 , A61M37/00 , G01N23/207 , G01R33/46 , G01N33/53
CPC分类号： G01N33/505 , C07K16/2812 , C07K2299/00 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/75 , G01N2333/70514
摘要： Provided are methods of screening to identify molecules capable of binding to CD4 and capable of activating CD4+CD25+ regulatory T cells. Further provided are antibodies and antibody fragments capable of activating CD4+CD25+ regulatory T cells and methods and uses involving the antibodies and fragments thereof.
摘要翻译： 提供了筛选以鉴定能够结合CD4并能够激活CD4 + CD25 +调节性T细胞的分子的方法。 进一步提供能够激活CD4 + CD25 +调节性T细胞的抗体和抗体片段以及涉及抗体及其片段的方法和用途。
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公开(公告)号：US09995733B2
公开(公告)日：2018-06-12
申请号：US13483280
申请日：2012-05-30
申请人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth , Holger Wallmeier , Kirsten Völp , Gregor Schulz
发明人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth , Holger Wallmeier , Kirsten Völp , Gregor Schulz
CPC分类号： G01N33/505 , C07K16/2812 , C07K2299/00 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/75 , G01N2333/70514
摘要： Provided are methods of screening to identify molecules capable of binding to CD4 and capable of activating CD4+CD25+ regulatory T cells. Further provided are antibodies and antibody fragments capable of activating CD4+CD25+ regulatory T cells and methods and uses involving the antibodies and fragments thereof.
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14.发明申请HUMANIZED ANTI-IL 10 ANTIBODIES FOR THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) 有权用于治疗系统性红斑狼疮（SLE）的人类抗IL10抗体公开(公告)号：US20120321617A1
公开(公告)日：2012-12-20
申请号：US13512712
申请日：2010-11-30
申请人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Peter Röttgen , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth
发明人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Peter Röttgen , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth
IPC分类号： A61K39/395 , C12N15/13 , A61P19/04 , C07K17/00 , G01N33/566 , C12N1/21 , C12N5/10 , C12P21/02 , C12N5/078 , C07K16/24 , C12N15/63
CPC分类号： C07K16/244 , A61K2039/505 , C07K2299/00 , C07K2317/14 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2317/92 , G01N33/6869
摘要： Provided is a humanized or chimeric antibody or fragment thereof capable of binding to interleukin-10 (IL-10), wherein said antibody or fragment thereof: (i) binds to the same region of IL-10 as the 1L-10 receptor α (IL-I10Ra) and is not capable of binding IL-10 when the IL-10 is bound to the IL-10 receptor; and (ii) binds to IL-10 in homodimeric form by binding a discontinuous epitope comprising residues of both monomers. Further provided are related products and methods involving the use of the antibody or fragment thereof.
摘要翻译： 提供能够结合白细胞介素-10（IL-10）的人源化或嵌合抗体或其片段，其中所述抗体或其片段：（i）结合与1L-10受体α相同的IL-10区域（ IL-10Ra），并且当IL-10与IL-10受体结合时不能结合IL-10; 和（ii）通过结合包含两个单体的残基的不连续表位与同型二聚体形式的IL-10结合。 进一步提供涉及使用抗体或其片段的相关产物和方法。
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15.发明申请METHOD OF DECREASING CYTOTOXIC SIDE-EFFECTS AND IMPROVING EFFICACY OF IMMUNOCONJUGATES 有权降低细胞毒副作用的方法和提高免疫球蛋白的效率公开(公告)号：US20090181038A1
公开(公告)日：2009-07-16
申请号：US12342180
申请日：2008-12-23
申请人： Gregor Schulz , Christoph Bruecher , Frank Osterroth , Steffen Zeng , Christoph Uherek , Silke Aigner , Benjamin Daelken , Markus Ruehle , Elmar Kraus
发明人： Gregor Schulz , Christoph Bruecher , Frank Osterroth , Steffen Zeng , Christoph Uherek , Silke Aigner , Benjamin Daelken , Markus Ruehle , Elmar Kraus
IPC分类号： A61K39/44
CPC分类号： C07K16/2896 , A61K39/39558 , A61K47/48561 , A61K47/48569 , A61K47/48723 , A61K47/6849 , A61K47/6851 , A61K47/6891 , A61K2039/505 , A61K2300/00 , B82Y5/00 , C07K2317/24 , C07K2317/34
摘要： Disclosed are methods, compositions and kits for improving targeting, in particular tumor targeting, of immunoconjugates. The method and composition relies on the sequestration of non-target cells that also express the antigen the immunoconjugate targets. Sequestration of those non-target cells in a variety of ways is disclosed. The methods, compositions and kits allow appropriate sequestration of non-target cells while maintaining a high degree of effectiveness of the immunoconjugates against target cells.
摘要翻译： 公开了用于改善免疫缀合物的靶向特别是肿瘤靶向的方法，组合物和试剂盒。 该方法和组合依赖于也表达免疫共轭靶标的非靶细胞的螯合。 公开了以各种方式封存那些非目标细胞。 方法，组合物和试剂盒允许非靶细胞的适当螯合，同时保持免疫缀合物对靶细胞的高度有效性。
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公开(公告)号：US09221914B2
公开(公告)日：2015-12-29
申请号：US12342285
申请日：2008-12-23
申请人： Elmar Kraus , Christoph Bruecher , Benjamin Daelken , Matthias Germer , Steffen Zeng , Frank Osterroth , Christoph Uherek , Silke Aigner , Gregor Schulz
发明人： Elmar Kraus , Christoph Bruecher , Benjamin Daelken , Matthias Germer , Steffen Zeng , Frank Osterroth , Christoph Uherek , Silke Aigner , Gregor Schulz
CPC分类号： C07K16/28 , A61K47/6803 , A61K47/6849 , A61K2039/505 , A61K2039/545 , C07K16/2896 , C07K16/30 , C07K2317/14 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： Disclosed is a human murine chimeric antibody targeting CD138 which substantially retains the antigen binding region of its murine counterpart. The engineered antibody displays improved binding affinities to the antigen and/or more homogenous binding to target cells relative to its murine counterpart. A constant region of the immunoglobulin heavy chain is preferably an IgG4 isotype constant region.
摘要翻译： 公开了靶向CD138的人鼠嵌合抗体，其基本上保留其鼠对应物的抗原结合区。 工程抗体相对于其鼠对应物显示改善的与抗原的结合亲和力和/或与靶细胞更均匀的结合。 免疫球蛋白重链的恒定区优选为IgG4同种型恒定区。
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17.发明授权Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates 有权降低细胞毒性副作用并提高免疫缀合物功效的方法公开(公告)号：US09011864B2
公开(公告)日：2015-04-21
申请号：US12342180
申请日：2008-12-23
申请人： Gregor Schulz , Christoph Bruecher , Frank Osterroth , Steffen Zeng , Christoph Uherek , Silke Aigner , Benjamin Daelken , Markus Ruehle , Elmar Kraus
发明人： Gregor Schulz , Christoph Bruecher , Frank Osterroth , Steffen Zeng , Christoph Uherek , Silke Aigner , Benjamin Daelken , Markus Ruehle , Elmar Kraus
IPC分类号： A61K39/00 , A61K39/395 , A61K47/48 , C07K16/28 , B82Y5/00
CPC分类号： C07K16/2896 , A61K39/39558 , A61K47/48561 , A61K47/48569 , A61K47/48723 , A61K47/6849 , A61K47/6851 , A61K47/6891 , A61K2039/505 , A61K2300/00 , B82Y5/00 , C07K2317/24 , C07K2317/34
摘要： Disclosed are methods, compositions and kits for improving targeting, in particular tumor targeting, of immunoconjugates. The method and composition relies on the sequestration of non-target cells that also express the antigen the immunoconjugate targets. Sequestration of those non-target cells in a variety of ways is disclosed. The methods, compositions and kits allow appropriate sequestration of non-target cells while maintaining a high degree of effectiveness of the immunoconjugates against target cells.
摘要翻译： 公开了用于改善免疫缀合物的靶向特别是肿瘤靶向的方法，组合物和试剂盒。 该方法和组合依赖于也表达免疫共轭靶标的非靶细胞的螯合。 公开了以各种方式封存那些非目标细胞。 方法，组合物和试剂盒允许非靶细胞的适当螯合，同时保持免疫缀合物对靶细胞的高度有效性。
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公开(公告)号：US20090232810A1
公开(公告)日：2009-09-17
申请号：US12342407
申请日：2008-12-23
申请人： Elmar Kraus , Christoph Bruecher , Benjamin Daelken , Steffen Zeng , Frank Osterroth , Christoph Uherek , Silke Aigner , Matthias Germer
发明人： Elmar Kraus , Christoph Bruecher , Benjamin Daelken , Steffen Zeng , Frank Osterroth , Christoph Uherek , Silke Aigner , Matthias Germer
IPC分类号： A61K39/395 , C07K16/18 , A61P35/00
CPC分类号： C07K16/2896 , A61K45/06 , A61K47/6803 , A61K47/6809 , A61K47/6849 , A61K47/6851 , A61K47/6867 , A61K47/6877 , C07K2317/24 , C07K2317/565 , C07K2317/92
摘要： Disclosed are immunoconjugates having in particular specificity for CD138 expressed on target cells and which display homogenous targeting. The immunoconjugates may be sterially hindered and/or contain a cleavable linker.
摘要翻译： 公开了对目标细胞上表达的CD138具有特异性的免疫偶联物，并且显示出同源靶向。 免疫缀合物可能是空间受阻的和/或含有可切割的接头。
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公开(公告)号：US20090175863A1
公开(公告)日：2009-07-09
申请号：US12342285
申请日：2008-12-23
申请人： Elmar Kraus , Christoph Bruecher , Benjamin Daelken , Matthias Germer , Steffen Zeng , Frank Osterroth , Christoph Uherek , Silke Aigner
发明人： Elmar Kraus , Christoph Bruecher , Benjamin Daelken , Matthias Germer , Steffen Zeng , Frank Osterroth , Christoph Uherek , Silke Aigner
IPC分类号： A61K39/395 , C07K16/18 , C12N5/06 , C12N15/11
CPC分类号： C07K16/28 , A61K47/6803 , A61K47/6849 , A61K2039/505 , A61K2039/545 , C07K16/2896 , C07K16/30 , C07K2317/14 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： Disclosed is a human murine chimeric antibody which substantially retains the antigen binding region of its murine counterpart and displays improved binding affinities to the antigen and/or more homogenous binding to target cells.
摘要翻译： 公开了一种人鼠嵌合抗体，其基本上保留其鼠对应物的抗原结合区，并显示出与抗原的改善的结合亲和力和/或与靶细胞更均匀的结合。
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20.发明授权公开(公告)号：US09446146B2
公开(公告)日：2016-09-20
申请号：US12342815
申请日：2008-12-23
申请人： Benjamin Daelken , Christoph Uherek , Kenneth Anderson , Teru Hideshima , Christoph Bruecher , Frank Osterroth , Silke Aigner , Matthias Germer
发明人： Benjamin Daelken , Christoph Uherek , Kenneth Anderson , Teru Hideshima , Christoph Bruecher , Frank Osterroth , Silke Aigner , Matthias Germer
CPC分类号： A61K47/48561 , A61K47/6803 , A61K47/6809 , A61K47/6849 , A61K47/6851 , A61K47/6867 , A61K2039/505 , C07K16/2896 , C07K2317/34 , C07K2317/73 , C07K2317/92
摘要： Disclosed are immunoconjugates having specificity for CD138 that diminish adhesion of CD138 expressing tumor cells to stroma cells and methods of using the same. This diminished adhesion renders the tumor cells not only susceptible to the immunoconjugate, but also to other agents, in particular cytotoxic agents.
摘要翻译： 公开了对CD138具有特异性的免疫缀合物，其降低表达CD138的肿瘤细胞与基质细胞的粘附性及其使用方法。 这种粘附性降低使得肿瘤细胞不仅对免疫缀合物敏感，而且对其它试剂，特别是细胞毒性剂也是敏感的。
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