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公开(公告)号：US20180133219A1
公开(公告)日：2018-05-17
申请号：US15868301
申请日：2018-01-11
Applicant: Genentech, Inc.
Inventor： Anthony Estrada , Liting Dong , Kevin X. Chen , Paul Gibbons , Malcolm Huestis , Terry Kellar , Wen Liu , Changyou Ma , Joseph Lyssikatos , Alan Olivero , Snahel Patel , Daniel Shore , Michael Siu
IPC: A61K31/506 , A61K31/444 , A61K35/30 , C07D487/14 , A61K31/553 , C07D417/14 , C07D487/18 , A61K31/55 , C07D401/14 , A61K31/5377 , C07D495/08 , A61K31/4545 , C07D519/00 , A61K31/5386 , A61K45/06 , C07D471/08 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D471/18 , C07D487/08 , C07D491/08
CPC classification number: A61K31/506 , A61K31/444 , A61K31/4545 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/553 , A61K35/30 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D471/18 , C07D487/08 , C07D487/14 , C07D487/18 , C07D491/08 , C07D495/08 , C07D519/00 , A61K2300/00
Abstract: The present invention provides for compounds of Formula I-I and embodiments and salts thereof for the treatment of diseases (e.g., neurodegenerative diseases). R1, R2, R3, X1, X2, A and Cy variable in Formula I-I all have the meaning as defined herein.
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公开(公告)号：US09868720B2
公开(公告)日：2018-01-16
申请号：US14928034
申请日：2015-10-30
Applicant: Genentech, Inc.
Inventor： Frederick Cohen , Snahel Patel
IPC: A61K31/506 , C07D401/14 , C07D405/14 , C07D403/14 , C07D471/04 , C07D493/08 , A61K31/5377 , A61K31/5386 , A61K31/553 , A61K35/30 , C07D409/14 , C07D413/14 , C07D487/04 , C07D491/08 , C07D491/107 , C07D498/08
CPC classification number: C07D401/14 , A61K31/506 , A61K31/5377 , A61K31/5386 , A61K31/553 , A61K35/30 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/08 , C07D491/107 , C07D493/08 , C07D498/08
Abstract: The present invention provides for pyrimidine compounds of Formula I-I and embodiments thereof In Formula I-I in which R1, R2, R3, R4, R5, R6, m, n and the “het” ring are as described herein. Also provided are pharmaceutical compositions comprising compounds of Formula I and methods of using such compounds and compositions.
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公开(公告)号：US09266862B2
公开(公告)日：2016-02-23
申请号：US14267011
申请日：2014-05-01
Applicant: Genentech, Inc.
Inventor： Anthony Estrada , Alan G. Olivero , Snahel Patel , Michael Siu
IPC: C07D403/14 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K35/30 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D471/18 , C07D487/08 , C07D491/08 , C07D495/08 , C07D519/00 , C07D471/08 , A61K45/06 , A61K31/5386
CPC classification number: A61K31/506 , A61K31/444 , A61K31/4545 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/553 , A61K35/30 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D471/18 , C07D487/08 , C07D487/14 , C07D487/18 , C07D491/08 , C07D495/08 , C07D519/00 , A61K2300/00
Abstract: The present invention provides for compounds of Formula I and embodiments and salts thereof for the treatment of diseases (e.g., neurodegenerative diseases). R1, R2, R3, X1, X2, A and Cy variable in Formula all have the meaning as defined herein.
Abstract translation: 本发明提供式I化合物及其实施方案及其盐用于治疗疾病（如神经变性疾病）。 式中的R 1，R 2，R 3，X 1，X 2，A和Cy变量均具有如本文所定义的含义。
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公开(公告)号：US11485745B2
公开(公告)日：2022-11-01
申请号：US16944581
申请日：2020-07-31
Applicant: Valo Health, Inc. , Genentech, Inc.
Inventor： Kenneth W. Bair , Timm R. Baumeister , Peter Dragovich , Xiongcai Liu , Snahel Patel , Po-Wai Yuen , Mark Zak , Guiling Zhao , Yamin Zhang , Xiaozhang Zheng
IPC: C07D519/00 , C07D495/04 , C07D471/04 , C07D487/04 , C07D491/048 , A61K31/438 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , A61K31/444 , A61K31/4545 , A61K31/506 , A61K31/513
Abstract: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
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公开(公告)号：US10975095B2
公开(公告)日：2021-04-13
申请号：US16034207
申请日：2018-07-12
Applicant: Genentech, Inc.
Inventor： Snahel Patel , Gregory Hamilton , Guiling Zhao , Huifen Chen , Blake Daniels , Craig Stivala
IPC: C07D498/04 , C07D487/04 , A61P25/16 , A61P25/28 , C07D235/12 , C07D471/04 , A61P17/06 , A61P21/00 , A61P19/02 , A61P1/00
Abstract: The invention provides novel compounds having the general formula I: wherein R1, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.
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Patent Agency Ranking
公开(公告)号：US10933036B2
公开(公告)日：2021-03-02
申请号：US15828271
申请日：2017-11-30
Applicant: Genentech, Inc.
Inventor： Snahel Patel , Gregory Hamilton , Guiling Zhao , Huifen Chen
IPC: C07D471/04 , A61K31/16 , C07D519/00 , C07D487/04 , A61P9/00 , C07D491/048 , C07D491/04 , A61P9/10 , A61P43/00 , A61P29/00 , A61K31/396 , A61K31/397 , A61K31/4025 , A61K31/416 , A61K31/4196 , A61K31/44 , A61K31/5383
Abstract: The invention provides novel compounds having the general formula I: wherein R1, R2, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.
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公开(公告)号：US20190127382A1
公开(公告)日：2019-05-02
申请号：US16175206
申请日：2018-10-30
Applicant: Genentech, Inc.
Inventor： Snahel Patel , Gregory Hamilton , Craig Stivala , Huifen Chen , Blake Daniels
IPC: C07D487/04
Abstract: The invention provides novel compounds having the general formula I: wherein R1, RB1, RB2, n, p, q, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.
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公开(公告)号：US10028954B2
公开(公告)日：2018-07-24
申请号：US15041375
申请日：2016-02-11
Applicant: Genentech, Inc.
Inventor： Anthony Estrada , Alan G Olivero , Snahel Patel , Michael Siu , Joseph Lyssikatos
IPC: A61K31/506 , A61K31/55 , A61K31/5377 , A61K31/444
CPC classification number: A61K31/506 , A61K31/444 , A61K31/4545 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/553 , A61K35/30 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D471/18 , C07D487/08 , C07D487/14 , C07D487/18 , C07D491/08 , C07D495/08 , C07D519/00 , A61K2300/00
Abstract: The present invention provides for compounds of Formula I and embodiments and salts thereof for the treatment of diseases (e.g., neurodegenerative diseases). R1, R2, R3, X1, X2, A and Cy variable in Formula all have the meaning as defined herein.
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公开(公告)号：US20170369510A1
公开(公告)日：2017-12-28
申请号：US15699095
申请日：2017-09-08
Applicant: Genentech, Inc.
Inventor： Anthony Estrada , Snahel Patel , Terry Kellar , Malcolm Huestis , Daniel Shore , Michael Siu
IPC: C07D498/14 , A61K45/06 , A61K31/553 , C07D519/00 , A61K31/5383
CPC classification number: C07D498/14 , A61K31/5383 , A61K31/553 , A61K45/06 , C07D491/14 , C07D519/00
Abstract: The invention relates to compounds of formula (I) and salts thereof: wherein ring A and R1-R2 have any of the values defined in the specification. The compounds and salts are useful for treating DLK mediated disorders. The invention also provides pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable salt thereof, as well as methods of using said compounds, salts, or compositions as DLK inhibitors and for treating neurodegeneration diseases and disorders.
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公开(公告)号：US20170239246A9
公开(公告)日：2017-08-24
申请号：US15041375
申请日：2016-02-11
Applicant: Genentech, Inc.
Inventor： Anthony O. Estrada , Alan G Olivero , Snahel Patel , Michael Siu , Joseph Lyssikatos
IPC: A61K31/506 , A61K31/444 , A61K31/5377 , A61K31/55
CPC classification number: A61K31/506 , A61K31/444 , A61K31/4545 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/553 , A61K35/30 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D471/18 , C07D487/08 , C07D487/14 , C07D487/18 , C07D491/08 , C07D495/08 , C07D519/00 , A61K2300/00
Abstract: The present invention provides for compounds of Formula I and embodiments and salts thereof for the treatment of diseases (e.g., neurodegenerative diseases). R1, R2, R3, X1, X2, A and Cy variable in Formula all have the meaning as defined herein.
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