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公开(公告)号：US20180064800A9
公开(公告)日：2018-03-08
申请号：US15127537
申请日：2015-03-24
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Fabio BAGNOLI , Luigi FIASCHI , Maria SCARSELLI
IPC: A61K39/085 , C07K14/31
CPC classification number: A61K39/085 , A61K35/74 , A61K2039/55505 , A61K2039/55511 , A61K2039/55577 , A61K2039/645 , A61K2039/70 , C07K14/31 , C07K2319/00 , C07K2319/40
Abstract: Mutant protein A of Staphylococcus aureus (SpA) with decreased affinity for the Fcγ portion of human IgG is provided.
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公开(公告)号：US20170008933A1
公开(公告)日：2017-01-12
申请号：US15120674
申请日：2015-02-27
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Matthew BOTTOMLEY , Enrico MALITO , Manuele MARTINELLI , Maria SCARSELLI
IPC: C07K14/22 , A61K47/48 , A61K39/095
CPC classification number: C07K14/22 , A61K39/095 , A61K2039/523 , A61K2039/55511 , A61K2039/70
Abstract: Modified meningococcal fHbp polypeptides with increased stability.
Abstract translation: 改良的脑膜炎球菌fHbp多肽具有增加的稳定性。
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Patent Agency Ranking
公开(公告)号：US20220257751A1
公开(公告)日：2022-08-18
申请号：US17628667
申请日：2020-07-21
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Massimilliano BIAGINI , Lucia Eleonora FONTANA , Anna GALEA , Nathalie NORAIS , Maria SCARSELLI
IPC: A61K39/385 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/245 , C07K14/31 , C07K14/33 , C12P21/00 , C12Q1/37 , G01N33/68
Abstract: The present invention provides analytical tools for the characterisation of bioconjugates, in particular for the measurement of glycosylation levels, and methods for absolute quantification of glycosylation sequences, as well as sequences and glycosylation sites for use in such methods.
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公开(公告)号：US20170348407A1
公开(公告)日：2017-12-07
申请号：US15679910
申请日：2017-08-17
Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA
Inventor： Vega MASIGNANI , Marirosa MORA , Maria SCARSELLI
IPC: A61K39/085 , C07K14/31 , A61K39/00
CPC classification number: A61K39/085 , A61K2039/70 , C07K14/31
Abstract: The invention provides proteins from Staphylococcus aureus including amino acid sequences and the corresponding nucleotide sequences. The proteins are useful for vaccines, immunogenic compositions, diagnostics, enzymatic studies and also as targets for antibiotics.
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公开(公告)号：US20210277069A1
公开(公告)日：2021-09-09
申请号：US17265610
申请日：2019-08-09
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Maria SCARSELLI , Daniele VEGGI
IPC: C07K14/22 , A61K39/095 , A61P31/04
Abstract: The present invention provides mutated fHbp polypeptides and fusion proteins comprising said mutated fHbp polypeptides that are useful as components of immunogenic compositions for immunizing against Neisseria meningitidis infection.
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公开(公告)号：US20170340720A1
公开(公告)日：2017-11-30
申请号：US15589834
申请日：2017-05-08
Applicant: GlaxoSmithKline Biologicals SA
Inventor： Fabio BAGNOLI , Massimiliano BIAGINI , Luigi FIASCHI , Guido GRANDI , Ravi Pratap Narayan MISHRA , Nathalie NORAIS , Maria SCARSELLI
IPC: A61K39/085 , C07K14/31 , A61K39/00
CPC classification number: A61K39/085 , A61K39/00 , C07K14/31 , C07K2319/00
Abstract: An effective Staphylococcus aureus vaccine may require several antigenic components, and so various combinations of S. aureus antigens are identified for use in immunisation. These polypeptides may optionally be used in combination with S. aureus saccharides.
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公开(公告)号：US20160030545A1
公开(公告)日：2016-02-04
申请号：US14804756
申请日：2015-07-21
Applicant: GlaxoSmithKline Biologicals SA
Inventor： Claire FRASER , Cesira GALEOTTI , Guido GRANDI , Erin HICKEY , Vega MASIGNANI , Marirosa MORA , Jeremy PETERSEN , Mariagrazia PIZZA , Rino RAPPUOLI , Giulio RATTI , Vincenzo SCARLATO , Maria SCARSELLI , Herve TETTELIN , J. Craig VENTER
IPC: A61K39/095 , C07K14/22
CPC classification number: C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
Abstract: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
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