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公开(公告)号：US20170008933A1
公开(公告)日：2017-01-12
申请号：US15120674
申请日：2015-02-27
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Matthew BOTTOMLEY , Enrico MALITO , Manuele MARTINELLI , Maria SCARSELLI
IPC: C07K14/22 , A61K47/48 , A61K39/095
CPC classification number: C07K14/22 , A61K39/095 , A61K2039/523 , A61K2039/55511 , A61K2039/70
Abstract: Modified meningococcal fHbp polypeptides with increased stability.
Abstract translation: 改良的脑膜炎球菌fHbp多肽具有增加的稳定性。
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公开(公告)号：US20210253647A1
公开(公告)日：2021-08-19
申请号：US17245681
申请日：2021-04-30
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Matthew BOTTOMLEY , Enrico MALITO , Manuele MARTINELLI , Maria Scarselli
IPC: C07K14/22 , A61K39/095
Abstract: Modified meningococcal fHbp polypeptides with increased stability.
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Patent Agency Ranking
公开(公告)号：US20240327470A1
公开(公告)日：2024-10-03
申请号：US18438870
申请日：2024-02-12
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Matthew BOTTOMLEY , Vega MASIGNANI
IPC: C07K14/22 , A61K39/00 , A61K39/095
CPC classification number: C07K14/22 , A61K39/095 , A61K2039/575 , C07K2319/33
Abstract: The inventors have identified residues within variant 2 and variant 3 of meningococcal fHpb which can be modified to enhance their properties.
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公开(公告)号：US20240218026A1
公开(公告)日：2024-07-04
申请号：US18440212
申请日：2024-02-13
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Matthew BOTTOMLEY , Enrico MALITO , Manuele MARTINELLI , Maria SCARSELLI
IPC: C07K14/22 , A61K39/095 , A61K39/00
CPC classification number: C07K14/22 , A61K39/095 , A61K2039/523 , A61K2039/55511 , A61K2039/70
Abstract: Modified meningococcal fHbp polypeptides with increased stability.
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公开(公告)号：US20250009874A1
公开(公告)日：2025-01-09
申请号：US18650745
申请日：2024-04-30
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Enrico MALITO , Sumana CHANDRAMOULI , Andrea CARFI , Matthew BOTTOMLEY
IPC: A61K39/245 , A61K47/64 , C07K14/005
Abstract: Described are mutant, human cytomegalovirus (HCMV) pentamer complex polypeptides, methods of making them, and their use in HCMV protein complexes and compositions. In particular, the use of the modified HCMV polypeptides to stabilize HCMV complexes or unmask a pentamer epitope is described.
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公开(公告)号：US20220002355A1
公开(公告)日：2022-01-06
申请号：US17346362
申请日：2021-06-14
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Matthew BOTTOMLEY , Vega MASIGNANI
IPC: C07K14/22 , A61K39/095
Abstract: The inventors have identified residues within variant 2 and variant 3 of meningococcal fHpb which can be modified to enhance their properties.
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公开(公告)号：US20190315812A1
公开(公告)日：2019-10-17
申请号：US16458365
申请日：2019-07-01
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Matthew BOTTOMLEY , Enrico MALITO , Manuele MARTINELLI
IPC: C07K14/22 , A61K39/095
Abstract: Modified meningococcal fHbp polypeptides with increased stability.
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