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公开(公告)号:US11752328B2
公开(公告)日:2023-09-12
申请号:US16471473
申请日:2017-12-20
Inventor: Arun Sridhar , Alessandra Giarola , Stephen J. Lewis
CPC classification number: A61N1/0514 , A61N1/3611 , A61N1/36146 , A61B5/4818
Abstract: A neuromodulation apparatus for stimulating neural activity in a renal nerve of a patient is provided, the apparatus comprising a transducer Patient for applying a signal to the renal nerve so as to produce a physiological response. Methods of treating sleep apnoea are also provided, including methods using the neuromodulation apparatus.
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公开(公告)号:US11517754B2
公开(公告)日:2022-12-06
申请号:US16610658
申请日:2018-05-04
Applicant: Galvani Bioelectronics Limited , Centre Nationale de La Recherche Scientifique , Université Côte d'Azur
Inventor: Arun Sridhar , Philippe Blancou , Nicolas Glaichenhaus
Abstract: Modulation of neural signaling of a pancreas-related sympathetic nerve is capable of improving glycaemic control by inhibiting T cell activation or migration to the pancreas, and hence providing a way of treating or preventing type 1 diabetes.
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公开(公告)号:US12157007B2
公开(公告)日:2024-12-03
申请号:US17893924
申请日:2022-08-23
Applicant: Galvani Bioelectronics Limited
Inventor: Gerald Edwin Hunsberger , Arun Sridhar
Abstract: Modulation of neural activity of a ganglion, by applying a signal to a sympathetic nerve adjacent to the ganglion, results in preferential reduction of sympathetic signals to an effector, thereby providing ways of treating and preventing conditions associated with exacerbated sympatho-excitation.
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公开(公告)号:US20230059066A1
公开(公告)日:2023-02-23
申请号:US17782559
申请日:2020-12-09
Applicant: Galvani Bioelectronics Limited , Duke University
Inventor: Arun Sridhar , Philip Milliken , Christopher Lawrence Langdale , Warren Murray Grill , James Arthur Hokanson
IPC: A61N1/36
Abstract: The present disclosure provides an apparatus for stimulating neural activity in a pudendal nerve of a subject, the apparatus comprising of: at least one primary electrode configured to apply a first electrical signal to said nerve; and a controller coupled to said primary electrode (s) and controlling the first electrical signal to be applied thereby, wherein said controller is configured to cause said at least one primary electrode to apply said first electrical signal that stimulates neural activity in the pudendal nerve to improve bladder function, and wherein the first electrical signal is applied in a burst pattern.
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公开(公告)号:US20230030204A1
公开(公告)日:2023-02-02
申请号:US17967436
申请日:2022-10-17
Applicant: Galvani Bioelectronics Limited , Centre Nationale de La Recherche Scientifique , Université Côte d'Azur
Inventor: Arun Sridhar , Philippe Blancou , Nicolas Glaichenhaus
Abstract: Modulation of neural signaling of a pancreas-related sympathetic nerve is capable of improving glycaemic control by inhibiting T cell activation or migration to the pancreas, and hence providing a way of treating or preventing type 1 diabetes.
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公开(公告)号:US20230021801A1
公开(公告)日:2023-01-26
申请号:US17782539
申请日:2020-12-09
Applicant: Galvani Bioelectronics Limited
Inventor: Arun Sridhar , Philip Milliken
IPC: A61N1/36
Abstract: Provided herein is a solution to the problem of stimulation of a target pudendal nerve such that the stimulation applied by the electrode at that position selectively modulates the external urtheral sphincter (EUS), or selectively modulates the external anal sphincter (EAS).
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公开(公告)号:US11464976B2
公开(公告)日:2022-10-11
申请号:US16771441
申请日:2018-12-11
Applicant: Galvani Bioelectronics Limited
Inventor: Gerald Edwin Hunsberger , Arun Sridhar
Abstract: Modulation of neural activity of a ganglion, by applying a signal to a sympathetic nerve adjacent to the ganglion, results in preferential reduction of sympathetic signals to an effector, thereby providing ways of treating and preventing conditions associated with exacerbated sympatho-excitation.
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公开(公告)号:US20220305268A1
公开(公告)日:2022-09-29
申请号:US17619567
申请日:2020-06-17
Inventor: Sarah Faridah Hassan , Stephen J. Lewis , Sheridan McMurray , Arun Sridhar , Ibrahim Salman
Abstract: This invention relates to devices, methods and substances for use in the treatment of hypertension and/or elevated blood pressure in a subject.
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公开(公告)号:US11452872B2
公开(公告)日:2022-09-27
申请号:US16080203
申请日:2017-02-27
Inventor: Alessandra Giarola , Yee-Hsee Hsieh , Stephen J. Lewis , Arun Sridhar
Abstract: This disclosure provides an apparatus or system for the modulation of neural activity in the cervical sympathetic chain (CSC) or superior cervical ganglion (SCG) or SCG post-ganglionic branch(es) and for the treatment of sleep apnoea, as well as methods for their use.
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公开(公告)号:US11369793B2
公开(公告)日:2022-06-28
申请号:US16328090
申请日:2017-08-25
Inventor: Jeffrey Laurence Ardell , Kalyanam Shivkumar , Arun Sridhar
Abstract: Modulation, preferably inhibition, of neurosignaling of a cardiac-related sympathetic nerve in the extracardiac intrathoracic neural circuit is effective in stabilizing cardiac electrical and/or mechanical function, thereby providing ways of treating or preventing cardiac dysfunction such as arrhythmias.
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