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    Methods and products related to the improved analysis of carbohydrates
    11.
    发明申请
    Methods and products related to the improved analysis of carbohydrates 审中-公开
    与碳水化合物改进分析有关的方法和产品

    公开(公告)号：US20060127950A1

    公开(公告)日：2006-06-15

    申请号：US11244826

    申请日：2005-10-06

    申请人： Carlos Bosques ,  Nishla Keiser ,  Aravind Srinivasan ,  Rahul Raman ,  Karthik Viswanathan ,  Ram Sasisekharan ,  Pankaj Gandhe ,  Sasi Raguram

    发明人： Carlos Bosques ,  Nishla Keiser ,  Aravind Srinivasan ,  Rahul Raman ,  Karthik Viswanathan ,  Ram Sasisekharan ,  Pankaj Gandhe ,  Sasi Raguram

    IPC分类号： C40B40/10 ,  G01N33/53 ,  C12P21/06

    CPC分类号： G01N33/6851 ,  G01N33/66 ,  G01N33/68 ,  G01N33/6842 ,  G01N33/6848 ,  G01N2400/10 ,  G16C20/20

    摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.

    摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及碳水化合物的分析，例如在蛋白质上发现的N-聚糖和O-聚糖以及与脂质连接的糖。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 来自聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化作用的研究。 还提供了这样的方法。 进一步提供方法以评估生产过程，以评估含有糖缀合物的样品的纯度，并选择具有所需糖基化的糖缀合物。

    METHODS AND PRODUCTS RELATED TO THE IMPROVED ANALYSIS OF CARBOHYDRATES
    12.
    发明申请
    METHODS AND PRODUCTS RELATED TO THE IMPROVED ANALYSIS OF CARBOHYDRATES 审中-公开
    与改进的碳水化合物分析相关的方法和产品

    公开(公告)号：US20120289415A1

    公开(公告)日：2012-11-15

    申请号：US13478662

    申请日：2012-05-23

    申请人： Carlos Bosques ,  Nishla Keiser ,  Aravind Srinivasan ,  Rahul Raman ,  Karthik Viswanathan ,  Ram Sasisekharan ,  Pankaj Gandhe ,  Sasi Raguram

    发明人： Carlos Bosques ,  Nishla Keiser ,  Aravind Srinivasan ,  Rahul Raman ,  Karthik Viswanathan ,  Ram Sasisekharan ,  Pankaj Gandhe ,  Sasi Raguram

    IPC分类号： C40B20/08

    CPC分类号： G01N33/6851 ,  G01N33/66 ,  G01N33/68 ,  G01N33/6842 ,  G01N33/6848 ,  G01N2400/10 ,  G16C20/20

    摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.

    摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及碳水化合物的分析，例如在蛋白质上发现的N-聚糖和O-聚糖以及与脂质连接的糖。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 来自聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化作用的研究。 还提供了这样的方法。 进一步提供方法以评估生产过程，以评估含有糖缀合物的样品的纯度，并选择具有所需糖基化的糖缀合物。

    Methods and products related to the improved analysis of carbohydrates
    13.
    发明授权
    Methods and products related to the improved analysis of carbohydrates 有权
    与碳水化合物改进分析有关的方法和产品

    公开(公告)号：US08209132B2

    公开(公告)日：2012-06-26

    申请号：US12623070

    申请日：2009-11-20

    申请人： Carlos Bosques ,  Nishla Keiser ,  Aravind Srinivasan ,  Rahul Raman ,  Karthik Viswanathan ,  Ram Sasisekharan ,  Pankaj Gandhe ,  Sasi Raguram

    发明人： Carlos Bosques ,  Nishla Keiser ,  Aravind Srinivasan ,  Rahul Raman ,  Karthik Viswanathan ,  Ram Sasisekharan ,  Pankaj Gandhe ,  Sasi Raguram

    IPC分类号： G01N31/00

    CPC分类号： G01N33/6851 ,  G01N33/66 ,  G01N33/68 ,  G01N33/6842 ,  G01N33/6848 ,  G01N2400/10 ,  G06F19/703

    摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.

    摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及碳水化合物的分析，例如在蛋白质上发现的N-聚糖和O-聚糖以及与脂质连接的糖。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 来自聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化作用的研究。 还提供了这样的方法。 进一步提供方法以评估生产过程，以评估含有糖缀合物的样品的纯度，并选择具有所需糖基化的糖缀合物。

    2-O sulfatase compositions and related methods
    16.
    发明授权
    2-O sulfatase compositions and related methods 有权
    2-O硫酸酯酶组合物及相关方法

    公开(公告)号：US07270815B2

    公开(公告)日：2007-09-18

    申请号：US10753761

    申请日：2004-01-07

    申请人： Ram Sasisekharan ,  James R. Myette ,  Zachary Shriver ,  Ganesh Venkataraman

    发明人： Ram Sasisekharan ,  James R. Myette ,  Zachary Shriver ,  Ganesh Venkataraman

    IPC分类号： A61K38/46 ,  C12N9/14

    CPC分类号： C12N9/16 ,  A61K38/00 ,  C12P19/04 ,  G01N33/5041 ,  G01N2400/40

    摘要： The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGs) present in a sample. For instance, 2-O sulfatase may be used for determining the purity, identity, composition and sequence of glycosaminoglycans present in a sample. The invention also relates to methods of inhibiting angiogenesis and cellular proliferation as well as methods for treating cancer, neurodegenerative disease, atherosclerosis and microbial infection using 2-O sulfatase and/or GAG fragments produced by degradation with 2-O sulfatase.

    摘要翻译： 本发明涉及2-O硫酸酯酶及其用途。 特别地，本发明涉及编码这些分子的重组产生的2-O硫酸酯酶，功能变体和核酸分子。 本发明还提供了用于各种目的的2-O硫酸酯酶的方法，包括降解和分析样品中存在的糖胺聚糖（GAG）。 例如，2-O硫酸酯酶可用于测定样品中存在的糖胺聚糖的纯度，同一性，组成和顺序。 本发明还涉及抑制血管生成和细胞增殖的方法以及使用2-O硫酸酯酶降解产生的2- O硫酸酯酶和/或GAG片段来治疗癌症，神经变性疾病，动脉粥样硬化和微生物感染的方法。

    2-O sulfatase nucleic acid compositions
    17.
    发明申请
    2-O sulfatase nucleic acid compositions 有权
    2-O硫酸酯酶核酸组合物

    公开(公告)号：US20060292130A1

    公开(公告)日：2006-12-28

    申请号：US11433224

    申请日：2006-05-11

    申请人： Ram Sasisekharan ,  James Myette ,  Zachary Shriver ,  Ganesh Venkataraman

    发明人： Ram Sasisekharan ,  James Myette ,  Zachary Shriver ,  Ganesh Venkataraman

    IPC分类号： A61K48/00 ,  C07H21/04 ,  C12P21/06 ,  C12N9/16

    CPC分类号： C12N9/16 ,  A61K38/00 ,  C12P19/04 ,  G01N33/5041 ,  G01N2400/40

    摘要： The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGs) present in a sample. For instance, 2-O sulfatase may be used for determining the purity, identity, composition and sequence of glycosaminoglycans present in a sample. The invention also relates to methods of inhibiting angiogenesis and cellular proliferation as well as methods for treating cancer, neurodegenerative disease, atherosclerosis and microbial infection using 2-O sulfatase and/or GAG fragments produced by degradation with 2-O sulfatase.

    摘要翻译： 本发明涉及2-O硫酸酯酶及其用途。 特别地，本发明涉及编码这些分子的重组产生的2-O硫酸酯酶，功能变体和核酸分子。 本发明还提供了用于各种目的的2-O硫酸酯酶的方法，包括降解和分析样品中存在的糖胺聚糖（GAG）。 例如，2-O硫酸酯酶可用于测定样品中存在的糖胺聚糖的纯度，同一性，组成和顺序。 本发明还涉及抑制血管生成和细胞增殖的方法以及使用2-O硫酸酯酶降解产生的2- O硫酸酯酶和/或GAG片段来治疗癌症，神经变性疾病，动脉粥样硬化和微生物感染的方法。