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11.发明授权Method and apparatus for controlling concentrations in vivos and in tubing systems 失效用于控制活体和管道系统中浓度的方法和装置
公开(公告)号：US5817042A
公开(公告)日：1998-10-06
申请号：US622642
申请日：1996-03-27
CPC分类号： A61M1/3672 , A61M1/303 , A61M1/30 , A61M1/34 , A61M1/3693
摘要： A method and apparatus for maximizing the total amount of blood processed during an apheresis procedure by optimizing the concentration of anticoagulant in a donor/patient and the associated extracorporeal tubing set is provided. A simplified model of anticoagulant accumulation in a donor/patient's body is used to calculate an optimal anticoagulant infusion rate profile to the donor/patient during a blood processing procedure. A maximum acceptable anticoagulant concentration in the donor/patient acts as an upper limit on the rate at which anticoagulant may be infused to the donor/patient using the optimized infusion rate profile. A minimum acceptable anticoagulant level acts as a lower limit in optimally controlling the anticoagulant concentration in the extracorporeal tubing set. Both the maximum acceptable anticoagulant level in the donor/patient and the minimum acceptable anticoagulant level in the extracorporeal tubing set may be customized for a specific donor/patient thereby allowing the optimized infusion rate profile and the extracorporeal tubing set anticoagulant concentration to be customized for the specific patient.
摘要翻译： 提供了一种通过优化供体/患者和相关体外管组中的抗凝血剂的浓度来最大化在分离术过程中处理的血液总量的方法和装置。 供体/患者体内的抗凝血剂积聚的简化模型用于在血液处理过程中计算给予者/患者的最佳抗凝血剂输注速率曲线。 供体/患者中最大可接受的抗凝血剂浓度作为使用优化的输注速率曲线将抗凝血剂注入供体/患者的速率的上限。 最小可接受的抗凝血剂水平作为最佳控制体外管组中抗凝血剂浓度的下限。 供体/患者中最大可接受的抗凝血剂水平和体外管组中最小可接受的抗凝血剂水平可以针对特定供体/患者定制，从而允许优化的输注速率曲线和体外管道凝固剂浓度定制为 具体病人。
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12.发明授权Method for optimizing spin time in a centrifuge apparatus for biologic fluid 有权用于在生物液体的离心机中优化旋转时间的方法公开(公告)号：US08900112B2
公开(公告)日：2014-12-02
申请号：US13176466
申请日：2011-07-05
CPC分类号： A61M1/3693 , A61M1/0209 , A61M1/3696 , A61M1/3698 , B04B5/0428 , B04B2013/006
摘要： A method for controlling a centrifuge blood component separation system for separating components of a blood product, the separation system comprising a centrifuge and a separation bag and at least one transfer bag. The method comprises selecting a nominal hematocrit value such that an actual hematocrit value is expected to be less than said nominal hematocrit; centrifuging a separation bag containing a volume of composite liquid so as to cause the sedimentation of at least a first component and a second component; transferring some of the first component to a first transfer bag; detecting time of passage of a red blood cell interface at a pre-selected location in the separation bag; and adjusting a predicted processing time based on the time of passage of the red blood cell interface.
摘要翻译： 一种用于控制用于分离血液制品的组分的离心机血液成分分离系统的方法，所述分离系统包括离心机和分离袋以及至少一个转运袋。 该方法包括选择名义血细胞比容值，使得实际血细胞比容值预期小于所述标称血细胞比容; 将含有一定体积的复合液体的分离袋离心，以至少使第一组分和第二组分沉淀; 将一些第一组分转移到第一转运袋中; 检测分离袋中预选位置处红细胞界面通过的时间; 以及基于红细胞接口的通过时间来调整预测的处理时间。
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公开(公告)号：US07497944B2
公开(公告)日：2009-03-03
申请号：US11727550
申请日：2007-03-27
申请人： Niclas Högberg , Emanuel Hällgren , Peter Pihlstedt , Brian M. Holmes , Lars Persson , Lars Strandberg , Geert Van Waeg , Frank Corbin, III
发明人： Niclas Högberg , Emanuel Hällgren , Peter Pihlstedt , Brian M. Holmes , Lars Persson , Lars Strandberg , Geert Van Waeg , Frank Corbin, III
CPC分类号： B04B13/00 , A61M1/0209 , A61M1/0218 , A61M1/025 , A61M1/26 , A61M1/262 , A61M1/3633 , A61M1/3639 , A61M1/3641 , A61M1/3693 , A61M1/3696 , A61M1/3698 , A61M2205/331 , B04B5/0428 , B04B5/0442 , B04B2005/045 , B04B2005/0478 , B04B2013/006
摘要： A system and method are used in connection with processing of blood components. The processing of blood components may involve centrifugal separation and/or filtering of the blood components. In some examples, at least some blood components are centrifugally separated in a chamber and then filtered via a filter rotating along with a centrifuge rotor, wherein the filter is located closer than the chamber to an axis of rotation of the rotor. The filter may include a porous filtration medium configured to filter leukocytes, platelets, and/or red blood cells. Some examples include a pressure sensor sensing pressure of pumped blood components. The sensed pressure may be used in connection with controlling the pumping of the blood products and/or in connection with determining the location of an interface associated with the blood products. Other uses of the sensed pressure are also possible.
摘要翻译： 与血液成分的处理有关的系统和方法。 血液成分的处理可能涉及血液成分的离心分离和/或过滤。 在一些实例中，至少一些血液成分在室中离心分离，然后通过与离心机转子一起旋转的过滤器过滤，其中过滤器位于比转筒更靠近转动轴的位置。 过滤器可以包括被配置为过滤白细胞，血小板和/或红细胞的多孔过滤介质。 一些示例包括感测泵送的血液成分的压力的压力传感器。 感测到的压力可以与控制血液制品的泵送和/或与确定与血液制品相关联的界面的位置的结合一起使用。 感测压力的其他用途也是可能的。
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公开(公告)号：US20070255505A1
公开(公告)日：2007-11-01
申请号：US11727550
申请日：2007-03-27
申请人： Niclas Hogberg , Emanuel Hallgren , Peter Pihlstedt , Brian Holmes , Lars Persson , Lars Strandberg , Geert Van Waeg , Frank Corbin
发明人： Niclas Hogberg , Emanuel Hallgren , Peter Pihlstedt , Brian Holmes , Lars Persson , Lars Strandberg , Geert Van Waeg , Frank Corbin
CPC分类号： B04B13/00 , A61M1/0209 , A61M1/0218 , A61M1/025 , A61M1/26 , A61M1/262 , A61M1/3633 , A61M1/3639 , A61M1/3641 , A61M1/3693 , A61M1/3696 , A61M1/3698 , A61M2205/331 , B04B5/0428 , B04B5/0442 , B04B2005/045 , B04B2005/0478 , B04B2013/006
摘要： A system and method are used in connection with processing of blood components. The processing of blood components may involve centrifugal separation and/or filtering of the blood components. In some examples, at least some blood components are centrifugally separated in a chamber and then filtered via a filter rotating along with a centrifuge rotor, wherein the filter is located closer than the chamber to an axis of rotation of the rotor. The filter may include a porous filtration medium configured to filter leukocytes, platelets, and/or red blood cells. Some examples include a pressure sensor sensing pressure of pumped blood components. The sensed pressure may be used in connection with controlling the pumping of the blood products and/or in connection with determining the location of an interface associated with the blood products. Other uses of the sensed pressure are also possible.
摘要翻译： 与血液成分的处理有关的系统和方法。 血液成分的处理可能涉及血液成分的离心分离和/或过滤。 在一些实例中，至少一些血液成分在室中离心分离，然后通过与离心机转子一起旋转的过滤器过滤，其中过滤器位于离转子更靠近转动轴的位置。 过滤器可以包括被配置为过滤白细胞，血小板和/或红细胞的多孔过滤介质。 一些示例包括感测泵送的血液成分的压力的压力传感器。 感测到的压力可以与控制血液制品的泵送和/或与确定与血液制品相关联的界面的位置的结合一起使用。 感测压力的其他用途也是可能的。
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公开(公告)号：US6022306A
公开(公告)日：2000-02-08
申请号：US924787
申请日：1997-09-05
CPC分类号： B04B5/0442 , A61M1/3618 , A61M1/362 , A61M1/3693 , A61M1/3696 , B04B2005/0471
摘要： The instant invention relates to a method and the apparatus for collecting a hyperconcentrated platelet product. A fluid containing platelets and other particles flows into a fluid chamber at a flow rate. The flow rate of the fluid is selected to retain the majority of the platelets in the fluid chamber in a saturated bed. The platelets are collected from the fluid chamber without collecting the other particles to form a hyperconcentrated other particle reduced platelet product.
摘要翻译： 本发明涉及用于收集高浓度血小板产品的方法和装置。 含有血小板和其它颗粒的流体以流速流入流体室。 选择流体的流速以将大部分血小板保持在饱和床中的流体室中。 从流体腔室收集血小板而不收集其它颗粒以形成高浓度的其它颗粒还原血小板产物。
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16.发明授权Method and apparatus for controlling concentrations in vivos and in tubing systems 失效用于控制活体和管道系统中浓度的方法和装置
公开(公告)号：US5676645A
公开(公告)日：1997-10-14
申请号：US472931
申请日：1995-06-06
CPC分类号： A61M1/3672 , A61M1/30 , A61M1/34 , A61M1/3693
摘要： A method and apparatus for maximizing the total amount of blood processed during an apheresis procedure by optimizing the concentration of anticoagulant in a donor/patient and the associated extracorporeal tubing set is provided. A simplified model of an anticoagulant accumulation in a donor/patient's body is used to calculate an optimal anticoagulant infusion rate profile to the donor/patient during a blood processing procedure. A maximum acceptable anticoagulant concentration in the donor/patient acts as an upper limit on the rate at which anticoagulant may be infused to the donor/patient using the optimized infusion rate profile. A minimum acceptable anticoagulant level acts as a lower limit in optimally controlling the anticoagulant concentration in the extracorporeal tubing set. Both the maximum acceptable anticoagulant level in the donor/patient and the minimum acceptable anticoagulant level in the extracorporeal tubing set may be customized for a specific donor/patient thereby allowing the optimized infusion rate profile and the extracorporeal tubing set anticoagulant concentration to be customized for the specific patient.
摘要翻译： 提供了一种通过优化供体/患者和相关体外管组中的抗凝血剂的浓度来最大化在分离术过程中处理的血液总量的方法和装置。 在血液处理过程中，使用供体/患者体内抗凝血剂积聚的简化模型来计算供体/患者的最佳抗凝血剂输注速率曲线。 供体/患者中最大可接受的抗凝血剂浓度作为使用优化的输注速率曲线将抗凝血剂注入供体/患者的速率的上限。 最小可接受的抗凝血剂水平作为最佳控制体外管组中抗凝血剂浓度的下限。 供体/患者中最大可接受的抗凝血剂水平和体外管组中最小可接受的抗凝血剂水平可以针对特定供体/患者定制，从而允许优化的输注速率曲线和体外管道凝固剂浓度定制为 具体病人。
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公开(公告)号：US07708889B2
公开(公告)日：2010-05-04
申请号：US12359738
申请日：2009-01-26
申请人： Niclas Högberg , Emanuel Hällgren , Peter Pihlstedt , Brian M. Holmes , Lars Persson , Lars Strandberg , Geert Van Waeg , Frank Corbin, III
发明人： Niclas Högberg , Emanuel Hällgren , Peter Pihlstedt , Brian M. Holmes , Lars Persson , Lars Strandberg , Geert Van Waeg , Frank Corbin, III
CPC分类号： B04B13/00 , A61M1/0209 , A61M1/0218 , A61M1/025 , A61M1/26 , A61M1/262 , A61M1/3633 , A61M1/3639 , A61M1/3641 , A61M1/3693 , A61M1/3696 , A61M1/3698 , A61M2205/331 , B04B5/0428 , B04B5/0442 , B04B2005/045 , B04B2005/0478 , B04B2013/006
摘要： A method used in connection with processing of blood components, wherein blood products are then filtered via a filter rotating along with a centrifuge rotor and the sensed pressure may be used in connection with controlling the pumping of the blood products and/or in connection with determining the location of an interface associated with the blood products.
摘要翻译： 一种与血液成分的处理有关的方法，其中血液产物然后通过与离心机转子一起旋转的过滤器过滤，并且感测到的压力可用于控制血液制品的泵送和/或结合确定 与血液制品相关联的界面的位置。
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公开(公告)号：US07413665B2
公开(公告)日：2008-08-19
申请号：US11611567
申请日：2006-12-15
CPC分类号： B04B13/00 , A61M1/0209 , A61M1/0218 , A61M1/025 , A61M1/26 , A61M1/262 , A61M1/3633 , A61M1/3639 , A61M1/3641 , A61M1/3693 , A61M1/3696 , A61M1/3698 , A61M2205/331 , B04B5/0428 , B04B5/0442 , B04B2005/045 , B04B2005/0478 , B04B2013/006
摘要： A system for separating a composite fluid into component parts thereof, including: a centrifuge having a rotor with a separation space and at least two valve members disposed thereon and a container set having a separation container adapted to be disposed in the separation space of the rotor and first and second collection containers connected to the separation container by a first and a second tubes. The tubes are adapted to be disposed in operative relationship with the valve members so that flow through the tubes may be controlled thereby. Three components of the composite fluid may be separated therefrom by the present system and two components may be moved to the collection containers. The container set may further include a third collection container connected to the separation container by a tube, and a third component may thus be moved to this third container.
摘要翻译： 一种将复合流体分离成其组成部分的系统，包括：具有分离空间的转子和设置在其上的至少两个阀构件的离心机和具有适于设置在转子的分离空间中的分离容器的容器组 以及通过第一和第二管连接到分离容器的第一和第二收集容器。 管适于与阀构件成可操作的关系，从而可以控制通过管的流动。 复合流体的三个组分可以通过本系统与其分离，并且两个组分可以移动到收集容器中。 容器组还可以包括通过管连接到分离容器的第三收集容器，并且因此第三组分可以移动到第三容器。
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公开(公告)号：US07396451B2
公开(公告)日：2008-07-08
申请号：US11611682
申请日：2006-12-15
CPC分类号： B04B13/00 , A61M1/0209 , A61M1/0218 , A61M1/025 , A61M1/26 , A61M1/262 , A61M1/3633 , A61M1/3639 , A61M1/3641 , A61M1/3693 , A61M1/3696 , A61M1/3698 , A61M2205/331 , B04B5/0428 , B04B5/0442 , B04B2005/045 , B04B2005/0478 , B04B2013/006
摘要： A system for separating a composite fluid into component parts thereof, including: a centrifuge having a rotor with a separation space and at least two valve members disposed thereon and a container set having a separation container adapted to be disposed in the separation space of the rotor and first and second collection containers connected to the separation container by a first and a second tubes. The tubes are adapted to be disposed in operative relationship with the valve members so that flow through the tubes may be controlled thereby. Three components of the composite fluid may be separated therefrom by the present system and two components may be moved to the collection containers. The container set may further include a third collection container connected to the separation container by a tube, and a third component may thus be moved to this third container.
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20.发明授权Apparatus and method for separating a volume of composite liquid into at least two components 有权将体积的复合液体分离成至少两个组分的装置和方法公开(公告)号：US07347932B2
公开(公告)日：2008-03-25
申请号：US10783831
申请日：2004-02-20
申请人： Brian M. Holmes , Peter Pihlstedt , Geert Van Waeg
发明人： Brian M. Holmes , Peter Pihlstedt , Geert Van Waeg
CPC分类号： A61M1/3693 , A61M1/0209 , A61M1/3696 , A61M1/3698 , A61M2205/331 , B01D21/262 , B01D2221/10 , B04B5/0428 , B04B5/0442 , B04B13/00 , B04B2013/006
摘要： A method for separating a volume of a composite liquid into at least a first component and a second component is performed in a centrifuge cooperating with a separation bag containing the volume of composite liquid. The separation bag is connected to at least a first component bag and a second component bag. The separation bag is spun so as to centrifuge the volume of composite liquid and cause the sedimentation of the at least first and second components. When the at least first and second components have sedimented, the first component is transferred at at least one first transfer flow rate into the first component bag. When the first component has been transferred into the first component bag, the second component is transferred into the intermediate component bag at at least one second transfer flow rate that is different from the at least one first transfer flow rate.
摘要翻译： 在与包含复合液体体积的分离袋配合的离心机中进行将复合液体的体积分离成至少第一成分和第二成分的方法。 分离袋连接到至少第一组分袋和第二组分袋。 旋转分离袋以离心复合液体的体积并引起至少第一和第二组分的沉降。 当至少第一和第二组分沉淀时，第一组分以至少一个第一转移流速转移到第一组分袋中。 当第一组分转移到第一组分袋中时，第二组分以不同于至少一个第一转移流速的至少一个第二转移流速转移到中间组分袋中。
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