Centrifuge system for separating cells in suspension

    公开(公告)号:US11878311B2

    公开(公告)日:2024-01-23

    申请号:US17587691

    申请日:2022-01-28

    摘要: An apparatus for separating cell suspension material into centrate and concentrate, includes a single use structure (178, 240, 250) releasably positioned in a cavity in a solid wall rotatable centrifuge bowl (172). The bowl and portions of single use structure rotate about an axis (174). A stationary inlet feed tube (184), a centrate discharge tube (212) and a concentrate discharge tube (230) extend along the axis of the rotating single use structure. A centrate centripetal pump (208) is in fluid connection with the centrate discharge tube. A concentrate centripetal pump (216) is in fluid connection with the concentrate discharge tube. A controller (274) operates responsive to sensors (264, 270) in respective centrate and concentrate discharge lines (262, 268), to control flow rates of a concentrate pump (272) and a centrate pump (266) to produce output flows of cell concentrate and generally cell free centrate.

    CENTRIFUGE FOR AUTOMATIC LOADING
    5.
    发明申请

    公开(公告)号:US20220401967A1

    公开(公告)日:2022-12-22

    申请号:US17775723

    申请日:2020-10-09

    IPC分类号: B04B11/04 B04B5/04 B04B7/06

    摘要: The invention relates to a centrifuge (10) for automatic loading, having a drive shaft (44), which is driven in a rotatable manner about a rotor axis (42), having a rotor (46), which is releasably coupled for conjoint rotation to the drive shaft (44) and has mounts for containers for media to be centrifuged, having a housing (12) with lateral outer walls (14, 16, 18, 20) delimiting the centrifuge (10) and with a ceiling (22), wherein at least one outer wall (14) has a sideways directed side opening (28) for loading the rotor (46) as required, and having a safety vessel (50) with at least one partially enclosing protective wall (34), which is adapted at least to the shape of the adjacent outer wall (14) with side opening (28) such that said protective wall closes off the side opening (28).

    AUTOMATIC DISCHARGE SETTING
    7.
    发明申请

    公开(公告)号:US20220250092A1

    公开(公告)日:2022-08-11

    申请号:US17618434

    申请日:2020-07-08

    IPC分类号: B04B11/04 B04B1/14

    摘要: A method of calibrating a centrifugal separator includes retrieving stored data representing a first correlation between different amounts of sediment discharges and rotational speed reductions of the rotatable bowl, generating trigger signals to discharge different amounts of sediment, measuring rotational speed reductions of the rotatable bowl that correspond to the discharges, obtaining values corresponding to the sediment discharges based on the rotational speed reductions and the first correlation, determining data representing a second correlation between the different sediment discharges and trigger signals based on the trigger signals and the values corresponding to the sediment discharges, and obtaining a trigger signal corresponding to a desired discharge amount based on the second correlation.

    CENTRIFUGE SYSTEM FOR SEPARATING CELLS IN SUSPENSION

    公开(公告)号:US20220143627A1

    公开(公告)日:2022-05-12

    申请号:US17587691

    申请日:2022-01-28

    IPC分类号: B04B11/04 B04B11/02 B04B11/08

    摘要: An apparatus for separating cell suspension material into centrate and concentrate, includes a single use structure (178, 240, 250) releasably positioned in a cavity in a solid wall rotatable centrifuge bowl (172). The bowl and portions of single use structure rotate about an axis (174). A stationary inlet feed tube (184), a centrate discharge tube (212) and a concentrate discharge tube (230) extend along the axis of the rotating single use structure. A centrate centripetal pump (208) is in fluid connection with the centrate discharge tube. A concentrate centripetal pump (216) is in fluid connection with the concentrate discharge tube. A controller (274) operates responsive to sensors (264, 270) in respective centrate and concentrate discharge lines (262, 268), to control flow rates of a concentrate pump (272) and a centrate pump (266) to produce output flows of cell concentrate and generally cell free centrate.