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公开(公告)号:US08889847B2
公开(公告)日:2014-11-18
申请号:US13766150
申请日:2013-02-13
Applicant: Genentech, Inc.
Inventor: Mark S. Dennis , Bonnee Rubinfeld , Paul Polakis , Aya Jakobovits
CPC classification number: G01N33/57434 , A61K38/05 , A61K39/39558 , A61K45/06 , A61K47/6851 , A61K47/6869 , A61K47/6871 , A61K49/0002 , A61K49/0058 , A61K51/1045 , A61K51/1072 , A61K2039/505 , C07K16/30 , C07K16/3069 , C07K16/40 , C07K17/00 , C07K2317/24 , C07K2317/31 , C07K2317/515 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/92
Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided.
Abstract translation: 提供抗STEAP-1抗体及其免疫偶联物。 提供了使用抗STEAP-1抗体及其免疫偶联物的方法。
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12.
公开(公告)号:US20140294863A1
公开(公告)日:2014-10-02
申请号:US14063845
申请日:2013-10-25
Applicant: GENENTECH, INC.
Inventor: Mark S. Dennis
CPC classification number: C07K16/3015 , A61K47/6811 , A61K47/6843 , A61K47/6849 , A61K47/6855 , A61K49/0032 , A61K49/0056 , A61K49/0058 , A61K2039/505 , C07K7/08 , C07K16/2863 , C07K16/32 , C07K16/36 , C07K2317/55 , C07K2317/92 , C07K2317/94
Abstract: Peptide ligands having affinity for serum albumin are useful for tumor targeting. Conjugate molecules comprising a serum albumin binding peptide fused to a biologically active molecule demonstrate modified pharmacokinetic properties as compared with the biologically active molecule alone, including tissue (e.g., tumor) uptake, infiltration, and diffusion.
Abstract translation: 对血清白蛋白具有亲和力的肽配体可用于肿瘤靶向。 与生物活性分子融合的包含血清白蛋白结合肽的缀合物分子与单独的生物活性分子(包括组织(例如肿瘤)摄取,浸润和扩散)相比显示出修饰的药代动力学性质。
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公开(公告)号:US20130288302A1
公开(公告)日:2013-10-31
申请号:US13788246
申请日:2013-03-07
Applicant: Genentech, Inc.
Inventor: Sherman Fong , Mark S. Dennis
IPC: C07K16/28
CPC classification number: C07K16/2839 , A61K2039/505 , C07K16/18 , C07K16/2827 , C07K2317/14 , C07K2317/24 , C07K2317/41 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The invention provides therapeutic anti-beta7 antibodies, compositions comprising, and methods of using these antibodies.
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公开(公告)号:US11530275B2
公开(公告)日:2022-12-20
申请号:US16790616
申请日:2020-02-13
Applicant: Genentech, Inc.
Inventor: Xiaocheng Chen , Mark S. Dennis , Allen J. Ebens, Jr. , Teemu T. Junttila , Robert F. Kelley , Mary A. Mathieu
IPC: C07K16/28 , C07K16/32 , A61K39/395 , C07K16/30 , A61K45/06 , A61K31/573 , A61K47/68 , A61K39/00
Abstract: The invention provides anti-cluster of differentiation 3 (CD3) antibodies and methods of using the same.
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公开(公告)号:US11186650B2
公开(公告)日:2021-11-30
申请号:US16144686
申请日:2018-09-27
Applicant: Genentech, Inc.
Inventor: Xiaocheng Chen , Mark S. Dennis , Allen J. Ebens, Jr. , Robert F. Kelley , Mary A. Mathieu , Liping L. Sun
IPC: A61P35/00 , C07K16/32 , C07K16/28 , A61K39/395 , C07K16/30 , A61K45/06 , A61K31/573 , A61K47/68 , A61K39/00
Abstract: The invention provides anti-cluster of differentiation 3 (CD3) antibodies and methods of using the same.
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公开(公告)号:US11007267B2
公开(公告)日:2021-05-18
申请号:US15836107
申请日:2017-12-08
Applicant: Genentech, Inc.
Inventor: Chingwei Vivian Lee , Mark S. Dennis , Germaine Fuh
IPC: A61K39/00 , A61K39/395 , C07K16/28 , C07K16/30 , A61P35/00 , C07K14/725
Abstract: The invention provides anti-cluster of differentiation 3 (CD3) antibodies and methods of using the same.
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公开(公告)号:US09975949B2
公开(公告)日:2018-05-22
申请号:US14960015
申请日:2015-12-04
Applicant: Genentech, Inc.
Inventor: Liping L. Sun , Yvonne Man-Yee Chen , Mark S. Dennis , Allen J. Ebens, Jr. , Andrew Polson
IPC: A61K39/395 , C07K16/28 , A61K47/68 , A61K39/00
CPC classification number: C07K16/2803 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K16/2809 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/622 , C07K2317/92
Abstract: The invention provides anti-CD79b antibodies and methods of using the same.
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公开(公告)号:US20160159906A1
公开(公告)日:2016-06-09
申请号:US14960015
申请日:2015-12-04
Applicant: Genentech, Inc.
Inventor: Liping L. Sun , Yvonne Man-Yee Chen , Mark S. Dennis , Allen J. Ebens, JR. , Andrew Polson
CPC classification number: C07K16/2803 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K16/2809 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/622 , C07K2317/92
Abstract: The invention provides anti-CD79b antibodies and methods of using the same.
Abstract translation: 本发明提供抗CD79b抗体及其使用方法。
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19.
公开(公告)号:US20140051120A1
公开(公告)日:2014-02-20
申请号:US13668054
申请日:2012-11-02
Applicant: Genentech, Inc.
Inventor: Weilan Ye , Mark S. Dennis , Jill Fredrickson
IPC: C07K16/22
CPC classification number: C07K16/22 , A61K31/282 , A61K31/337 , A61K31/513 , A61K31/519 , A61K31/555 , A61K31/56 , A61K38/19 , A61K39/0011 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/46 , C07K16/468 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92
Abstract: The present invention concerns antibodies to EGFL7 and the uses of same.
Abstract translation: 本发明涉及EGFL7的抗体及其用途。
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公开(公告)号:US20130316402A1
公开(公告)日:2013-11-28
申请号:US13766150
申请日:2013-02-13
Applicant: GENENTECH, INC.
Inventor: Mark S. Dennis , Bonnee Rubinfeld , Paul Polakis , Aya Jakobovits
IPC: C07K16/30
CPC classification number: G01N33/57434 , A61K38/05 , A61K39/39558 , A61K45/06 , A61K47/6851 , A61K47/6869 , A61K47/6871 , A61K49/0002 , A61K49/0058 , A61K51/1045 , A61K51/1072 , A61K2039/505 , C07K16/30 , C07K16/3069 , C07K16/40 , C07K17/00 , C07K2317/24 , C07K2317/31 , C07K2317/515 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/92
Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided.
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