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11.发明申请公开(公告)号：US20190322661A1
公开(公告)日：2019-10-24
申请号：US16438135
申请日：2019-06-11
Applicant: Genentech, Inc.
Inventor： Mark Edward Zak , Nicholas Charles Ray , Simon Charles Goodacre , Rohan Mendonca , Terry Kellar , Yun-Xing Cheng , Wei Li , Po-wai Yuen
IPC: C07D471/04 , C07D487/04 , C07D403/14 , A61K31/519 , C07D519/00 , A61P11/06
Abstract: Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.
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公开(公告)号：US20180265515A1
公开(公告)日：2018-09-20
申请号：US15986256
申请日：2018-05-22
Applicant: Genentech, Inc.
Inventor： Yun-Xing Cheng , Paul Gibbons , Terry Kellar , Wei Li , Rohan Mendonca , Po-wai Yuen , Mark Edward Zak , Lei Zhang
IPC: C07D487/04 , C07D519/00
CPC classification number: C07D487/04 , C07D519/00
Abstract: Compounds of Formula (00A) and salts thereof, wherein R1, R2 R3, R4 and n are defined herein, are useful as inhibitors of one or more Janus kinases. Also provided are pharmaceutical compositions that include a compound of Formula (00A) and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.
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13.发明授权公开(公告)号：US09604984B2
公开(公告)日：2017-03-28
申请号：US15139164
申请日：2016-04-26
Applicant: Genentech, Inc.
Inventor： Mark Edward Zak , Nicholas Charles Ray , Simon Charles Goodacre , Rohan Mendonca , Terry Kellar , Yun-Xing Cheng , Wei Li , Po-Wei Yuen
IPC: C07D487/04 , A61K31/519 , A61P11/06 , C07D471/04 , C07D519/00
CPC classification number: C07D471/04 , A61K31/519 , C07D487/04 , C07D519/00
Abstract: Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.
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公开(公告)号：US20200165260A1
公开(公告)日：2020-05-28
申请号：US16777049
申请日：2020-01-30
Applicant: Genentech, Inc.
Inventor： Yun-Xing Cheng , Paul Gibbons , Terry Kellar , Wei Li , Rohan Mendonca , Po-wai Yuen , Mark Edward Zak , Lei Zhang
IPC: C07D487/04 , C07D519/00
Abstract: Compounds of Formula (00A) and salts thereof, wherein R1, R2 R3, R4 and n are defined herein, are useful as inhibitors of one or more Janus kinases. Also provided are pharmaceutical compositions that include a compound of Formula (00A) and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.
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15.发明申请公开(公告)号：US20180305355A1
公开(公告)日：2018-10-25
申请号：US15820515
申请日：2017-11-22
Applicant: Genentech, Inc.
Inventor： Mark Edward Zak , Nicholas Charles Ray , Simon Charles Goodacre , Rohan Mendonca , Terry Kellar , Yun-Xing Cheng , Wei Li , Po-wai Yuen
IPC: C07D471/04 , C07D487/04 , A61K31/519 , C07D519/00
CPC classification number: C07D471/04 , A61K31/519 , C07D487/04 , C07D519/00
Abstract: Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.
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Patent Agency Ranking
公开(公告)号：US20160355606A1
公开(公告)日：2016-12-08
申请号：US14981853
申请日：2015-12-28
Applicant: Genentech, Inc.
Inventor： Yan Wu , Cecilia Pui Chi Chiu , Daniel K. Kirchhofer , Andrew Peterson , Ganesh A. Kolumam , Monica Kong Beltran , Paul Moran , Wei Li , Xanthe Lam , Lin Luis , Ada Hui , Whittemore Tingley , John Douglas Davis , Nageshwar R. Budha
IPC: C07K16/40
CPC classification number: C07K16/40 , A61K39/39591 , A61K2039/505 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: The invention provides anti-PCSK9 antibodies, formulations, dosing regimens, and methods of using the same.
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17.发明授权5-chloro-2-difluoromethoxyphenyl pyrazolopyrimidine compounds, compositions and methods of use thereof 有权5-氯-2-二氟甲氧基苯基吡唑并嘧啶化合物，其组合物及其使用方法公开(公告)号：US09346815B2
公开(公告)日：2016-05-24
申请号：US14720323
申请日：2015-05-22
Applicant: Genentech, Inc.
Inventor： Mark Edward Zak , Nicholas Charles Ray , Simon Charles Goodacre , Rohan Mendonca , Terry Kellar , Yun-Xing Cheng , Wei Li , Po-Wai Yuen
IPC: C07D487/04 , A61K31/519 , A61P11/06 , C07D519/00
CPC classification number: C07D471/04 , A61K31/519 , C07D487/04 , C07D519/00
Abstract: Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.
Abstract translation: 本文描述了式（00A）的化合物和用作Janus激酶抑制剂的方法。
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公开(公告)号：US11731943B2
公开(公告)日：2023-08-22
申请号：US17177356
申请日：2021-02-17
Applicant: Genentech, Inc.
Inventor： James John Crawford , Mark Zak , Terry Kellar , Yun-Xing Cheng , Wei Li , F. Anthony Romero , Paul Gibbons , Guiling Zhao , Gregory Hamilton , Simon Charles Goodacre
IPC: C07D231/40 , C07D401/04 , C07D401/14 , C07D403/08 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
CPC classification number: C07D231/40 , C07D401/04 , C07D401/14 , C07D403/08 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
Abstract: Compounds of Formula (I):
and salts thereof, and methods of use as Janus kinase inhibitors are described herein.-
公开(公告)号：US20210179564A1
公开(公告)日：2021-06-17
申请号：US17177356
申请日：2021-02-17
Applicant: Genentech, Inc.
Inventor： James John Crawford , Mark Zak , Terry Kellar , Yun-Xing Cheng , Wei Li , F. Anthony Romero , Paul Gibbons , Guiling Zhao , Gregory Hamilton , Simon Charles Goodacre
IPC: C07D231/40 , C07D401/14 , C07D401/04 , C07D403/08 , C07D405/04 , C07D405/12 , C07D409/14 , C07D405/14 , C07D417/14 , C07D413/14
Abstract: Compounds of Formula (I): and salts thereof, and methods of use as Janus kinase inhibitors are described herein.
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公开(公告)号：US11034725B2
公开(公告)日：2021-06-15
申请号：US16883552
申请日：2020-05-26
Applicant: Genentech, Inc.
Inventor： Maureen Beresini , Daniel Burdick , Charles Eigenbrot, Jr. , Daniel Kirchhofer , Robert Lazarus , Wei Li , John Quinn , Nicholas Skelton , Mark Ultsch , Yingnan Zhang
IPC: A61K38/00 , C07K7/02 , C12N9/64 , C12Q1/37 , G01N33/573 , G01N33/92 , C40B40/10 , C07K14/00 , A61K47/62 , A61P3/06
Abstract: The invention provides PCSK9 inhibitors, compositions comprising the PCSK9 inhibitors, and methods of identifying and using the PCSK9 inhibitors.
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