中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

18 records (took 0.021 seconds)

    SYSTEMS AND METHODS FOR ASSEMBLING A LIPID BILAYER ON A SUBSTANTIALLY PLANAR SOLID SURFACE
    12.
    发明申请
    SYSTEMS AND METHODS FOR ASSEMBLING A LIPID BILAYER ON A SUBSTANTIALLY PLANAR SOLID SURFACE 有权
    用于在大面积平面固体表面上组装脂质双体的系统和方法

    公开(公告)号：US20150056364A1

    公开(公告)日：2015-02-26

    申请号：US14334523

    申请日：2014-07-17

    Applicant: Genia Technologies, Inc.

    Inventor： Roger J.A. Chen ,  Randy Davis

    IPC: C12Q1/68

    CPC classification number: C12Q1/6876 ,  B82Y5/00 ,  G01N33/48721

    Abstract: Techniques for assembling a lipid bilayer on a substantially planar solid surface are described herein. In one example, a lipid material such as a lipid suspension is deposited on a substantially planar solid surface, a bubble filled with fast diffusing gas molecules is formed on the solid surface, and the gas molecules are allowed to diffuse out of the bubble to form a lipid bilayer on the solid surface.

    Abstract translation: 本文描述了在基本上平面的固体表面上组装脂质双层的技术。 在一个实例中，脂质材料如脂质悬浮液沉积在基本上平面的固体表面上，在固体表面上形成填充有快速扩散气体分子的气泡，并使气体分子扩散出气泡形成 固体表面上的脂质双层。

    SYSTEMS AND METHODS FOR FORMING A NANOPORE IN A LIPID BILAYER
    13.
    发明申请
    SYSTEMS AND METHODS FOR FORMING A NANOPORE IN A LIPID BILAYER 有权
    用于形成脂肪双层纳米粒子的系统和方法

    公开(公告)号：US20140203464A1

    公开(公告)日：2014-07-24

    申请号：US14150322

    申请日：2014-01-08

    Applicant: Genia Technologies, Inc.

    Inventor： Roger J.A. Chen ,  Randy Davis

    IPC: C12Q1/68

    CPC classification number: G01N33/48721 ,  B81B1/00 ,  B82Y5/00 ,  G01N15/12

    Abstract: A method of forming a nanopore in a lipid bilayer is disclosed. A nanopore forming solution is deposited over a lipid bilayer. The nanopore forming solution has a concentration level and a corresponding activity level of pore molecules such that nanopores are substantially not formed un-stimulated in the lipid bilayer. Formation of a nanopore in the lipid bilayer is initiated by applying an agitation stimulus level to the lipid bilayer. In some embodiments, the concentration level and the corresponding activity level of pore molecules are at levels such that less than 30 percent of a plurality of available lipid bilayers have nanopores formed un-stimulated therein.

    Abstract translation: 公开了一种在脂质双层中形成纳米孔的方法。 将纳米孔形成溶液沉积在脂质双层上。 形成纳米孔的溶液具有孔分子的浓度水平和相应的活性水平，使得纳米孔在脂双层中基本上未形成未刺激。 脂质双层中的纳米孔的形成是通过向脂质双层施加搅拌刺激水平来引发的。 在一些实施方案中，孔分子的浓度水平和相应的活性水平的水平使得少于30％的多个可用脂质双层具有在其中未被刺激的纳米孔。

    Systems for forming a nanopore in a lipid bilayer
    14.
    发明授权
    Systems for forming a nanopore in a lipid bilayer 有权

    公开(公告)号：US10371692B2

    公开(公告)日：2019-08-06

    申请号：US15488432

    申请日：2017-04-14

    Applicant: Genia Technologies, Inc.

    Inventor： Roger J. A. Chen ,  Randy Davis

    IPC: B81B1/00 ,  B82Y5/00 ,  G01N15/12 ,  C12Q1/6869 ,  G01N33/487

    Abstract: A method of forming a nanopore in a lipid bilayer is disclosed. A nanopore forming solution is deposited over a lipid bilayer. The nanopore forming solution has a concentration level and a corresponding activity level of pore molecules such that nanopores are substantially not formed un-stimulated in the lipid bilayer. Formation of a nanopore in the lipid bilayer is initiated by applying an agitation stimulus level to the lipid bilayer. In some embodiments, the concentration level and the corresponding activity level of pore molecules are at levels such that less than 30 percent of a plurality of available lipid bilayers have nanopores formed un-stimulated therein.

    SYSTEMS AND METHODS FOR FORMING A NANOPORE IN A LIPID BILAYER
    15.
    发明申请
    SYSTEMS AND METHODS FOR FORMING A NANOPORE IN A LIPID BILAYER 审中-公开

    公开(公告)号：US20190070796A1

    公开(公告)日：2019-03-07

    申请号：US16179800

    申请日：2018-11-02

    Applicant: Genia Technologies, Inc.

    Inventor： Roger J.A. Chen ,  Randy Davis

    IPC: B29C67/20 ,  G01N33/487 ,  C12Q1/6869 ,  B82Y5/00 ,  B82Y40/00 ,  B82Y10/00

    Abstract: Techniques for forming a nanopore in a lipid bilayer are described herein. In one example, an agitation stimulus level such as an electrical agitation stimulus is applied to a lipid bilayer wherein the agitation stimulus level tends to facilitate the formation of nanopores in the lipid bilayer. In some embodiments, a change in an electrical property of the lipid bilayer resulting from the formation of the nanopore in the lipid bilayer is detected, and a nanopore has formed in the lipid bilayer is determined based on the detected change in the lipid bilayer electrical property.

    SYSTEMS AND METHODS FOR MANIPULATING A MOLECULE IN A NANOPORE
    18.
    发明申请
    SYSTEMS AND METHODS FOR MANIPULATING A MOLECULE IN A NANOPORE 审中-公开
    在NANOPORE中操作分子的系统和方法

    公开(公告)号：US20140374253A1

    公开(公告)日：2014-12-25

    申请号：US14334110

    申请日：2014-07-17

    Applicant: Genia Technologies, Inc.

    Inventor： Roger J.A. Chen ,  Randy Davis

    IPC: G01N27/447

    CPC classification number: G01N27/447 ,  B82Y5/00 ,  C12Q1/6869 ,  G01N33/48721 ,  C12Q2527/15 ,  C12Q2563/116 ,  C12Q2565/631

    Abstract: Techniques for manipulating a molecule in a nanopore embedded in a lipid bilayer are described. In one example, an acquiring electrical stimulus level is applied across a lipid bilayer wherein a region of the lipid bilayer containing the nanopore is characterized by a resistance and wherein the acquiring electrical stimulus level tends to draw the molecule from a surrounding fluid into the nanopore, a change in the resistance of the lipid bilayer resulting from the acquisition of at least a portion of a molecule into the nanopore is detected, the acquiring electrical stimulus level is changed to a holding electrical stimulus level wherein the portion of the molecule remains in the nanopore upon the changing of the acquiring electrical stimulus level to the holding electrical stimulus level.

    Abstract translation: 描述了在嵌入脂质双层中的纳米孔中操纵分子的技术。 在一个实例中，获得电刺激水平跨越脂质双层施加，其中含有纳米孔的脂质双层的区域的特征在于电阻，并且其中获取电刺激水平倾向于将分子从周围流体吸入纳米孔， 检测到从分子的至少一部分获取到纳米孔中产生的脂质双层的电阻的变化，将获得的电刺激水平改变为保持电刺激水平，其中分子的部分保留在纳米孔中 将获取的电刺激水平改变为保持电刺激水平。

Patent Agency Ranking