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    SYSTEMS AND METHODS FOR FORMING A NANOPORE IN A LIPID BILAYER
    3.
    发明申请
    SYSTEMS AND METHODS FOR FORMING A NANOPORE IN A LIPID BILAYER 审中-公开
    用于形成脂肪双层纳米粒子的系统和方法

    公开(公告)号：US20140374252A1

    公开(公告)日：2014-12-25

    申请号：US14335616

    申请日：2014-07-18

    Applicant: Genia Technologies, Inc.

    Inventor： Roger J.A. Chen ,  Randy Davis

    IPC: C12Q1/68 ,  G01N33/487

    CPC classification number: B29C67/20 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y40/00 ,  C12Q1/6869 ,  G01N33/48721 ,  Y10S977/797 ,  Y10S977/90 ,  Y10S977/942 ,  C12Q2565/631

    Abstract: Techniques for forming a nanopore in a lipid bilayer are described herein. In one example, an agitation stimulus level such as an electrical agitation stimulus is applied to a lipid bilayer wherein the agitation stimulus level tends to facilitate the formation of nanopores in the lipid bilayer. In some embodiments, a change in an electrical property of the lipid bilayer resulting from the formation of the nanopore in the lipid bilayer is detected, and a nanopore has formed in the lipid bilayer is determined based on the detected change in the lipid bilayer electrical property.

    Abstract translation: 本文描述了在脂质双层中形成纳米孔的技术。 在一个实例中，将搅动刺激水平（例如电刺激刺激）施加到脂质双层，其中搅动刺激水平倾向于促进脂质双层中的纳米孔的形成。 在一些实施方案中，检测由在脂质双层中形成纳米孔而导致的脂质双层的电性质的变化，并且基于检测到的脂质双层电性能的变化来确定在脂质双层中形成的纳米孔 。

    Systems and methods for forming a nanopore in a lipid bilayer
    8.
    发明授权
    Systems and methods for forming a nanopore in a lipid bilayer 有权

    公开(公告)号：US10456993B2

    公开(公告)日：2019-10-29

    申请号：US14335616

    申请日：2014-07-18

    Applicant: Genia Technologies, Inc.

    Inventor： Roger J. A. Chen ,  Randy Davis

    IPC: B29C67/20 ,  B82Y5/00 ,  C12Q1/6869 ,  G01N33/487 ,  B82Y10/00 ,  B82Y40/00

    Abstract: Techniques for forming a nanopore in a lipid bilayer are described herein. In one example, an agitation stimulus level such as an electrical agitation stimulus is applied to a lipid bilayer wherein the agitation stimulus level tends to facilitate the formation of nanopores in the lipid bilayer. In some embodiments, a change in an electrical property of the lipid bilayer resulting from the formation of the nanopore in the lipid bilayer is detected, and a nanopore has formed in the lipid bilayer is determined based on the detected change in the lipid bilayer electrical property.

    Methods for forming a nanopore in a lipid bilayer
    10.
    发明授权
    Methods for forming a nanopore in a lipid bilayer 有权

    公开(公告)号：US09678055B2

    公开(公告)日：2017-06-13

    申请号：US14150322

    申请日：2014-01-08

    Applicant: Genia Technologies, Inc.

    Inventor： Roger J. A. Chen ,  Randy Davis

    IPC: G01N33/487 ,  G01N15/12 ,  B81B1/00 ,  B82Y5/00

    CPC classification number: G01N33/48721 ,  B81B1/00 ,  B82Y5/00 ,  G01N15/12

    Abstract: A method of forming a nanopore in a lipid bilayer is disclosed. A nanopore forming solution is deposited over a lipid bilayer. The nanopore forming solution has a concentration level and a corresponding activity level of pore molecules such that nanopores are substantially not formed un-stimulated in the lipid bilayer. Formation of a nanopore in the lipid bilayer is initiated by applying an agitation stimulus level to the lipid bilayer. In some embodiments, the concentration level and the corresponding activity level of pore molecules are at levels such that less than 30 percent of a plurality of available lipid bilayers have nanopores formed un-stimulated therein.

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