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公开(公告)号：US10597464B2
公开(公告)日：2020-03-24
申请号：US15414122
申请日：2017-01-24
Applicant: GENMAB A/S
Inventor： Aran Frank Labrijn , Joyce I. Meesters , Ewald T. J. Van Den Bremer , Joost J. Neijssen , Patrick Van Berkel , Bart De Goeij , Tom Vink , Jan Van De Winkel , Janine Schuurman , Paul Parren
Abstract: Novel heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins.
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公开(公告)号：US10407501B2
公开(公告)日：2019-09-10
申请号：US15110414
申请日：2015-01-08
Applicant: GENMAB A/S
Inventor： Edward Norbert Van Den Brink , Joost J. Neijssen , Aran Frank Labrijn , Joyce Meesters , Janine Schuurman , Isil Altintas , Paul Parren , Rik Rademaker
Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.
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公开(公告)号：US09663578B2
公开(公告)日：2017-05-30
申请号：US14317600
申请日：2014-06-27
Applicant: GENMAB A/S
Inventor： Edward Norbert Van Den Brink , Paul Parren , Jan Van De Winkel , Aran Frank Labrijn , Frank Everhardus Martinus Rebers , Esther Cornelia Wilhelmina Breij
IPC: A61K39/395 , C07K16/28 , A61K39/00
CPC classification number: C07K16/283 , A61K2039/505 , C07K2317/21 , C07K2317/30 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/92
Abstract: Isolated monoclonal antibodies which bind to human CD32b and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, and therapeutic and diagnostic methods for using the antibodies.
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公开(公告)号：US20140303356A1
公开(公告)日：2014-10-09
申请号：US14353962
申请日：2012-10-26
Applicant: GENMAB A/S
Inventor： Michael Gramer , Amitava Kundu , Ewald T. J. Van Den Bremer , Muriel Van Kamper , Patrick Priem , Aran Frank Labrijn , Joyce I. Meesters , Joost J. Neijssen , Janine Schuurman , Paul Parren , Patrick Van Berkel , Werner L. Vos , Arnout Gerritsen
CPC classification number: C07K1/1133 , C07K16/2863 , C07K16/2887 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/732 , C07K2317/734 , C07K2317/90
Abstract: The present invention relates to an in vitro method for production of heterodimeric proteins.
Abstract translation: 本发明涉及用于生产异二聚体蛋白质的体外方法。
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公开(公告)号：US20230374131A1
公开(公告)日：2023-11-23
申请号：US18109708
申请日：2023-02-14
Applicant: Genmab A/s
Inventor： Edward Norbert VAN DEN BRINK , Joost J. Neijssen , Aran Frank Labrijn , Joyce Meesters , Janine Schuurman , Isil Altintas , Paul Parren , Rik Rademaker
CPC classification number: C07K16/2809 , C07K16/2887 , C07K16/32 , C07K16/1063 , C07K16/2863 , C07K16/2896 , C07K16/4241 , G01N33/6872 , A61K2039/505
Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.
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Patent Agency Ranking
公开(公告)号：US11046771B2
公开(公告)日：2021-06-29
申请号：US15832366
申请日：2017-12-05
Applicant: GENMAB A/S
Inventor： Bart De Goeij , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , Jan Van De Winkel , David Satijn , Paul Parren , Aran Frank Labrijn , Joyce Meesters , Janine Schuurman , Edward N. Van Den Brink
Abstract: Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
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公开(公告)号：US10906991B2
公开(公告)日：2021-02-02
申请号：US14934956
申请日：2015-11-06
Applicant: GENMAB A/S
Inventor： Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Rob Aalberse , Marijn Van Der Neut Kolfschote , Paul Parren
Abstract: The invention relates to an ex vivo method for the generation of a bispecific antibody, comprising the steps of: a) providing a first antibody having a first binding specificity, wherein said first antibody comprises an IgG4-like CH3 region, b) providing a second antibody having a second binding specificity which differs from said first binding specificity, wherein said second antibody comprises an IgG4-like CH3 region, c) incubating said first and second antibodies together under reducing conditions which allow the cysteines in the core hinge region to undergo disulfide-bond isomerization, and d) obtaining a bispecific antibody. The invention furthermore relates to bispecific antibodies obtainable by the method of the invention.
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公开(公告)号：US20180319888A1
公开(公告)日：2018-11-08
申请号：US15977725
申请日：2018-05-11
Applicant: Genmab A/S
Inventor： Aran Frank Labrijn , Stefan Loverix , Paul Parren , Jan Van De Winkel , Janine Schuurman , Ignace Lasters
IPC: C07K16/28 , C07K16/00 , A61K47/68 , A61K51/10 , A61K39/395
CPC classification number: C07K16/2863 , A61K39/3955 , A61K47/6849 , A61K51/103 , A61K2039/505 , C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/76
Abstract: The present invention relates to positions in the constant region of antibodies, in particular the CH3 region of IgG4, which affect the strength of CH3-CH3 interactions. Mutations that either stabilize or destabilize this interaction are disclosed.
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公开(公告)号：US20150376282A1
公开(公告)日：2015-12-31
申请号：US14739768
申请日：2015-06-15
Applicant: Genmab A/S
Inventor： Aran Frank Labrijn , Stefan Loverix , Paul Parren , Jan Van De Winkel , Janine Schuurman , Ignace Laster
IPC: C07K16/28 , A61K47/48 , A61K51/10 , A61K39/395
CPC classification number: C07K16/2863 , A61K39/3955 , A61K47/6849 , A61K51/103 , A61K2039/505 , C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/76
Abstract: The present invention relates to positions in the constant region of antibodies, in particular the CH3 region of IgG4, which affect the strength of CH3-CH3 interactions. Mutations that either stabilize or destabilize this interaction are disclosed.
Abstract translation: 本发明涉及抗体的恒定区，特别是IgG4的CH3区的位置，其影响了CH3-CH3相互作用的强度。 公开了稳定或不稳定这种相互作用的突变。
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公开(公告)号：US12247065B2
公开(公告)日：2025-03-11
申请号：US17253286
申请日：2019-06-24
Applicant: GENMAB A/S
Inventor： Richard Hibbert , Rob De Jong , Aran Frank Labrijn , Arnout Gerritsen , Janine Schuurman , Paul Parren
Abstract: The present invention relates to a method for controlling the composition of a mixture of two or more different antibodies, such as tow or more different monoclonal antibodies, using chromatography. The mixture is for use as a drug product and the method includes a controlled downstream process for the production of a predetermined ratio of the two or more different antibodies.
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