公开(公告)号：US12157873B2

公开(公告)日：2024-12-03

申请号：US18374435

申请日：2023-09-28

Applicant: Genzyme Corporation

Inventor： Kevin Brower ,  Michael Coolbaugh ,  Xhorxhi Gjoka ,  Chad Varner ,  Jason Walther

IPC: C12M3/00 ,  B01D15/18 ,  B01D15/38 ,  C12M1/00

Abstract: Systems and devices for producing biological products and methods of using the same are provided. An example universal skid includes a rigid support and a plurality of flow-channel hardware sets. Each flow-channel hardware set couples with a respective flow channel of a plurality of flow channels for unit operations. The flow-channel hardware sets allow the flow channels to operate in parallel or in series for continuous processing over the unit operations. An example modular assembly includes one or more single-use kits for one or more unit operations and a universal skid coupled with the one or more single-use kits. An example manufacturing system includes multiple modular assemblies coupled with each other allowing continuous processing within each modular assembly, in between the modular assemblies, fully continuous processing across multiple unit operations.

公开(公告)号：US20220088602A1

公开(公告)日：2022-03-24

申请号：US17643113

申请日：2021-12-07

Applicant: Genzyme Corporation

Inventor： Tarl Vetter ,  Kevin Brower

IPC: B01L3/00 ,  C12M1/00

Abstract: Viral filters include a filter member featuring a first surface and a second surface and having a thickness extending between the first and second surfaces in a first direction, and a plurality of channels formed in the filter member, each of the channels having a channel axis, where during use, a solution carrying a viral load flows in a direction parallel to the first surface, and at least a portion of the viral load enters the membrane through the first surface and propagates in the first direction, and where for at least 50% of the channels in the filter member, the channel axis is oriented at an angle of between 5 degrees and 85 degrees relative to the first direction.

公开(公告)号：US20200290044A1

公开(公告)日：2020-09-17

申请号：US16815657

申请日：2020-03-11

Applicant: Genzyme Corporation

Inventor： Tarl Vetter ,  Kevin Brower

IPC: B01L3/00 ,  C12M1/00

Abstract: Viral filters include a filter member featuring a first surface and a second surface and having a thickness extending between the first and second surfaces in a first direction, and a plurality of channels formed in the filter member, each of the channels having a channel axis, where during use, a solution carrying a viral load flows in a direction parallel to the first surface, and at least a portion of the viral load enters the membrane through the first surface and propagates in the first direction, and where for at least 50% of the channels in the filter member, the channel axis is oriented at an angle of between 5 degrees and 85 degrees relative to the first direction.

公开(公告)号：US20180155801A1

公开(公告)日：2018-06-07

申请号：US15831085

申请日：2017-12-04

Applicant: Genzyme Corporation

Inventor： Veena Warikoo ,  Kevin Brower

IPC: C12Q3/00 ,  C07K1/22 ,  G01N33/573

CPC classification number: C12Q3/00 ,  C07K1/22 ,  G01N33/573

Abstract: The invention as disclosed herein provides a method for purifying a non-antibody protein from solution, comprising a chromatography step wherein the solution is passed over an affinity construct containing an affinity ligand-coupled solid support, wherein the affinity construct is associated with a bioprocess unit operation, and isolating the non-antibody protein from solution.