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1.发明申请公开(公告)号：US20180051054A1
公开(公告)日：2018-02-22
申请号：US15677888
申请日：2017-08-15
Applicant: Genzyme Corporation
Inventor： Tarl Vetter , Michael Coolbaugh , Veena Warikoo , Konstantin Konstantinov
CPC classification number: C07K1/34 , B01D15/1864 , B01D61/145 , B01D2315/16 , C07K16/00 , C07K2317/21 , C07K2317/31
Abstract: Provided herein are methods of processing a fluid that include the use of one or both of a circuit system including a tangential flow filtration (TFF) unit and a circuit system including a tangential flow virus filtration (TFVF) unit. Also provided are integrated and continuous processes for manufacturing a therapeutic protein drug substance that include a step of processing a fluid including the recombinant therapeutic protein using any of the methods provided herein.
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公开(公告)号：US20240150395A1
公开(公告)日：2024-05-09
申请号：US18416145
申请日：2024-01-18
Applicant: Genzyme Corporation
Inventor： Michael Coolbaugh , Tarl Vetter , Chad Varner , Kevin Brower
Abstract: The present disclosure relates to methods and systems for the continuous production of recombinant proteins. In particular embodiments, the disclosure relates to methods and systems using capture chromatography, post-capture chromatography, virus filtration, and ultrafiltration/diafiltration for the continuous production of recombinant proteins.
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3.发明授权公开(公告)号：US10968252B2
公开(公告)日：2021-04-06
申请号：US15677888
申请日：2017-08-15
Applicant: Genzyme Corporation
Inventor： Tarl Vetter , Michael Coolbaugh , Veena Warikoo , Konstantin Konstantinov
Abstract: Provided herein are methods of processing a fluid that include the use of one or both of a circuit system including a tangential flow filtration (TFF) unit and a circuit system including a tangential flow virus filtration (TFVF) unit. Also provided are integrated and continuous processes for manufacturing a therapeutic protein drug substance that include a step of processing a fluid including the recombinant therapeutic protein using any of the methods provided herein.
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公开(公告)号：US12157873B2
公开(公告)日：2024-12-03
申请号：US18374435
申请日：2023-09-28
Applicant: Genzyme Corporation
Inventor： Kevin Brower , Michael Coolbaugh , Xhorxhi Gjoka , Chad Varner , Jason Walther
Abstract: Systems and devices for producing biological products and methods of using the same are provided. An example universal skid includes a rigid support and a plurality of flow-channel hardware sets. Each flow-channel hardware set couples with a respective flow channel of a plurality of flow channels for unit operations. The flow-channel hardware sets allow the flow channels to operate in parallel or in series for continuous processing over the unit operations. An example modular assembly includes one or more single-use kits for one or more unit operations and a universal skid coupled with the one or more single-use kits. An example manufacturing system includes multiple modular assemblies coupled with each other allowing continuous processing within each modular assembly, in between the modular assemblies, fully continuous processing across multiple unit operations.
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5.发明授权公开(公告)号：US11884703B2
公开(公告)日：2024-01-30
申请号：US17180272
申请日：2021-02-19
Applicant: Genzyme Corporation
Inventor： Tarl Vetter , Michael Coolbaugh , Veena Warikoo , Konstantin Konstantinov
CPC classification number: C07K1/34 , B01D15/1864 , B01D61/145 , B01D61/146 , C07K16/00 , B01D2315/06 , C07K2317/21 , C07K2317/31
Abstract: Provided herein are methods of processing a fluid that include the use of one or both of a circuit system including a tangential flow filtration (TFF) unit and a circuit system including a tangential flow virus filtration (TFVF) unit. Also provided are integrated and continuous processes for manufacturing a therapeutic protein drug substance that include a step of processing a fluid including the recombinant therapeutic protein using any of the methods provided herein.
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Patent Agency Ranking
公开(公告)号：US20250051705A1
公开(公告)日：2025-02-13
申请号：US18930067
申请日：2024-10-29
Applicant: Genzyme Corporation
Inventor： Kevin Brower , Michael Coolbaugh , Xhorxhi Gjoka , Chad Varner , Jason Walther
Abstract: Systems and devices for producing biological products and methods of using the same are provided. An example universal skid includes a rigid support and a plurality of flow-channel hardware sets. Each flow-channel hardware set couples with a respective flow channel of a plurality of flow channels for unit operations. The flow-channel hardware sets allow the flow channels to operate in parallel or in series for continuous processing over the unit operations. An example modular assembly includes one or more single-use kits for one or more unit operations and a universal skid coupled with the one or more single-use kits. An example manufacturing system includes multiple modular assemblies coupled with each other allowing continuous processing within each modular assembly, in between the modular assemblies, fully continuous processing across multiple unit operations.
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公开(公告)号：US20240101945A1
公开(公告)日：2024-03-28
申请号：US18374435
申请日：2023-09-28
Applicant: Genzyme Corporation
Inventor： Kevin Brower , Michael Coolbaugh , Xhorxhi Gjoka , Chad Varner , Jason Walther
CPC classification number: C12M23/44 , B01D15/1821 , B01D15/3804 , C12M47/10 , C12M47/12
Abstract: Systems and devices for producing biological products and methods of using the same are provided. An example universal skid includes a rigid support and a plurality of flow-channel hardware sets. Each flow-channel hardware set couples with a respective flow channel of a plurality of flow channels for unit operations. The flow-channel hardware sets allow the flow channels to operate in parallel or in series for continuous processing over the unit operations. An example modular assembly includes one or more single-use kits for one or more unit operations and a universal skid coupled with the one or more single-use kits. An example manufacturing system includes multiple modular assemblies coupled with each other allowing continuous processing within each modular assembly, in between the modular assemblies, fully continuous processing across multiple unit operations.
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公开(公告)号：US11912741B2
公开(公告)日：2024-02-27
申请号：US16837126
申请日：2020-04-01
Applicant: Genzyme Corporation
Inventor： Michael Coolbaugh , Tarl Vetter , Chad Varner , Kevin Brower
Abstract: The present disclosure relates to methods and systems for the continuous production of recombinant proteins. In particular embodiments, the disclosure relates to methods and systems using capture chromatography, post-capture chromatography, virus filtration, and ultrafiltration/diafiltration for the continuous production of recombinant proteins.
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公开(公告)号：US20230295224A1
公开(公告)日：2023-09-21
申请号：US18174575
申请日：2023-02-24
Applicant: Genzyme Corporation
Inventor： Michael Coolbaugh , Shashi Malladi
CPC classification number: C07K1/36 , B01D61/145 , B01D2315/10
Abstract: Provided herein are methods of processing a fluid comprising a recombinant therapeutic protein that include the use of a bioprocessing system comprising integrated unit operations, including cell removal, cell retention, chromatography, virus inactivation, virus filtration, TFF, and formulation. Also provided are bioprocessing systems that include these unit operations.
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10.发明申请公开(公告)号：US20210171572A1
公开(公告)日：2021-06-10
申请号：US17180272
申请日：2021-02-19
Applicant: Genzyme Corporation
Inventor： Tarl Vetter , Michael Coolbaugh , Veena Warikoo , Konstantin Konstantinov
Abstract: Provided herein are methods of processing a fluid that include the use of one or both of a circuit system including a tangential flow filtration (TFF) unit and a circuit system including a tangential flow virus filtration (TFVF) unit. Also provided are integrated and continuous processes for manufacturing a therapeutic protein drug substance that include a step of processing a fluid including the recombinant therapeutic protein using any of the methods provided herein.
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