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    Tangential viral filtration
    5.
    发明授权
    Tangential viral filtration 有权

    公开(公告)号：US11504713B2

    公开(公告)日：2022-11-22

    申请号：US16815657

    申请日：2020-03-11

    Applicant: Genzyme Corporation

    Inventor： Tarl Vetter ,  Kevin Brower

    IPC: B01L3/00 ,  C12M1/00

    Abstract: Viral filters include a filter member featuring a first surface and a second surface and having a thickness extending between the first and second surfaces in a first direction, and a plurality of channels formed in the filter member, each of the channels having a channel axis, where during use, a solution carrying a viral load flows in a direction parallel to the first surface, and at least a portion of the viral load enters the membrane through the first surface and propagates in the first direction, and where for at least 50% of the channels in the filter member, the channel axis is oriented at an angle of between 5 degrees and 85 degrees relative to the first direction.

    Tangential viral filtration
    6.
    发明授权
    Tangential viral filtration 有权

    公开(公告)号：US11440010B2

    公开(公告)日：2022-09-13

    申请号：US17643113

    申请日：2021-12-07

    Applicant: Genzyme Corporation

    Inventor： Tarl Vetter ,  Kevin Brower

    IPC: B01L3/00 ,  C12M1/00

    Abstract: Viral filters include a filter member featuring a first surface and a second surface and having a thickness extending between the first and second surfaces in a first direction, and a plurality of channels formed in the filter member, each of the channels having a channel axis, where during use, a solution carrying a viral load flows in a direction parallel to the first surface, and at least a portion of the viral load enters the membrane through the first surface and propagates in the first direction, and where for at least 50% of the channels in the filter member, the channel axis is oriented at an angle of between 5 degrees and 85 degrees relative to the first direction.

    Affinity-Based Analytical Purification Of Biotherapeutics For Bioprocess Monitoring
    7.
    发明申请
    Affinity-Based Analytical Purification Of Biotherapeutics For Bioprocess Monitoring 审中-公开
    用于生物过程监测的生物治疗剂的基于亲和性的分析纯化

    公开(公告)号：US20140322699A1

    公开(公告)日：2014-10-30

    申请号：US14214105

    申请日：2014-07-08

    Applicant: Genzyme Corporation

    Inventor： Veena Warikoo ,  Kevin Brower

    IPC: C12Q3/00 ,  G01N33/573

    CPC classification number: C12Q3/00 ,  C07K1/22 ,  G01N33/573

    Abstract: The invention as disclosed herein provides a method for purifying a non-antibody protein from solution, comprising a chromatography step wherein the solution is passed over an affinity construct containing an affinity ligand-coupled solid support, wherein the affinity construct is associated with a bioprocess unit operation, and isolating the non-antibody protein from solution.

    Abstract translation: 本文公开的本发明提供了一种从溶液中纯化非抗体蛋白质的方法，包括色谱步骤，其中将溶液通过含有亲和配体偶联固体支持物的亲和构建体，其中亲和构建体与生物过程单元 操作，并从溶液中分离非抗体蛋白。

    SYSTEMS AND DEVICES FOR PRODUCING BIOLOGICAL PRODUCTS AND METHODS OF USING THE SAME
    8.
    发明申请
    SYSTEMS AND DEVICES FOR PRODUCING BIOLOGICAL PRODUCTS AND METHODS OF USING THE SAME 有权

    公开(公告)号：US20250051705A1

    公开(公告)日：2025-02-13

    申请号：US18930067

    申请日：2024-10-29

    Applicant: Genzyme Corporation

    Inventor： Kevin Brower ,  Michael Coolbaugh ,  Xhorxhi Gjoka ,  Chad Varner ,  Jason Walther

    IPC: C12M3/00 ,  B01D15/18 ,  B01D15/38 ,  C12M1/00

    Abstract: Systems and devices for producing biological products and methods of using the same are provided. An example universal skid includes a rigid support and a plurality of flow-channel hardware sets. Each flow-channel hardware set couples with a respective flow channel of a plurality of flow channels for unit operations. The flow-channel hardware sets allow the flow channels to operate in parallel or in series for continuous processing over the unit operations. An example modular assembly includes one or more single-use kits for one or more unit operations and a universal skid coupled with the one or more single-use kits. An example manufacturing system includes multiple modular assemblies coupled with each other allowing continuous processing within each modular assembly, in between the modular assemblies, fully continuous processing across multiple unit operations.

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