公开(公告)号：US20170238938A1

公开(公告)日：2017-08-24

申请号：US15282186

申请日：2016-09-30

申请人： Genzyme Corporation

发明人： Jean-Marie Vogel ,  James A. Wilkie

IPC分类号： A61B17/12 ,  A61B18/26 ,  A61M5/00 ,  A61B17/22

CPC分类号： A61B17/12186 ,  A61B17/12022 ,  A61B17/12099 ,  A61B17/12109 ,  A61B17/12195 ,  A61B17/22012 ,  A61B18/26 ,  A61B2017/22067 ,  A61M5/007

摘要： One aspect of the present invention provides a method for the treatment of lithiasis, which mitigates the risk of damage to surrounding body tissue when removing a calculi (e.g., biological concretions, such as urinary, biliary, and pancreatic stones) that obstructs or may otherwise be present within a body's anatomical lumen. In one embodiment, the instant invention provides a method of using a polymer plug to occlude a lumen distal to a calculi, whereby calculi fragments resulting from lithotripsy are prevented from traveling up the lumen. In certain embodiments, a dual lumen catheter is utilized to inject two solutions proximal to the calculi, the mixing of said solutions causing a polymer plug to form.

公开(公告)号：US20160338707A1

公开(公告)日：2016-11-24

申请号：US14974398

申请日：2015-12-18

申请人： Genzyme Corporation

发明人： Jean-Marie Vogel ,  William E. Cohn

IPC分类号： A61B17/12 ,  A61B17/08

CPC分类号： A61B17/12195 ,  A61B17/08 ,  A61B17/12031 ,  A61B17/1204 ,  A61B17/12045 ,  A61B17/12109 ,  A61B17/12131 ,  A61B17/12136 ,  A61B17/12186 ,  A61B2017/1205 ,  A61M29/02 ,  A61M2025/1052

摘要： One aspect of the present invention relates to catheters that can be placed in or around bodily conduits to occlude or widen a biological lumen without imparting significant trauma to the lumen. In certain embodiments, the invention particularly relates to the use of a polymer composition which can be made to gel upon insertion into said balloon or skirt. In certain embodiments, the inflating viscous polymer composition is a liquid at room temperature and a gel at mammalian physiological temperature. In certain embodiments, the inflating viscous polymer composition comprises an optionally purified inverse thermosensitive polymer.

公开(公告)号：US20180117211A1

公开(公告)日：2018-05-03

申请号：US15621704

申请日：2017-06-13

申请人： Genzyme Corporation

发明人： Jean-Marie Vogel ,  James A. Wilkie ,  Peter N. Madras

IPC分类号： A61L24/04 ,  A61B17/00

CPC分类号： A61L24/046 ,  A61B17/00491 ,  A61B17/11 ,  A61B17/12022 ,  A61B17/12186 ,  A61B17/12195 ,  A61B2017/00252 ,  A61B2017/1107 ,  A61B2017/1135 ,  A61B2017/12004 ,  A61K31/722 ,  A61K31/728 ,  A61K31/765 ,  A61K45/06 ,  A61K51/06 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/06 ,  A61L2300/406 ,  A61L2400/04 ,  C08L71/02

摘要： Disclosed are compositions, methods and kits to control bleeding through the use of an internal occluder based on polymeric solutions, including use of reverse thermosensitive polymers in nephron-sparing surgeries, which produces a completely bloodless surgical field, allowing speedy resection. In certain embodiments, after a certain amount of time, the flow gradually resumes, with no apparent adverse consequences to the kidney. In certain embodiments, return of blood flow may be accelerated by cooling the kidney. The compositions, methods and kits for perfusive organ hemostasis can also be used to simplify or to enable other organ surgeries or interventional procedures, including liver surgery, prostate surgery, brain surgery, surgery of the uterus, spleen surgery and any surgery on any highly vascularized organs.

公开(公告)号：US20160367261A1

公开(公告)日：2016-12-22

申请号：US15002113

申请日：2016-01-20

申请人： Genzyme Corporation

发明人： Jean-Marie Vogel ,  John A. Merhige

IPC分类号： A61B17/12 ,  A61L24/00 ,  A61L24/04 ,  A61B18/04

CPC分类号： A61B17/12181 ,  A61B18/04 ,  A61K9/0019 ,  A61L24/001 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/046 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/408 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/418 ,  A61L2430/36 ,  A61M37/00

摘要： Precision in thermotherapy is obtained by providing a reverse gelling polymer composition which gels when its temperature is raised towards body temperature. The composition is injected into the blood supply of the tissue being treated, at the beginning of thermotherapy. The temperature increase caused by the heating rapidly gels the composition, which temporarily blocks the flow of blood in the region being treated. This improves the predictability and stability of treatment. On cessation of heating, the composition gradually dissolves, removing the temporary embolization. The use of local heating can also expedite removal of tumors and the like from soft organs, even when the heating itself has no therapeutic effect.

摘要翻译： 通过提供当其温度升高到体温时凝胶化的反胶凝聚合物组合物来获得热疗中的精确度。 在热疗开始时将组合物注射到被治疗组织的血液供应中。 由加热引起的温度升高迅速凝结组合物，这暂时阻止了被处理区域内的血液流动。 这提高了治疗的可预测性和稳定性。 加热停止时，组成逐渐溶解，消除临时栓塞。 即使加热本身没有治疗效果，使用局部加热也可以加速从软体器官中去除肿瘤等。

公开(公告)号：US20160346428A1

公开(公告)日：2016-12-01

申请号：US14982715

申请日：2015-12-29

申请人： Genzyme Corporation

发明人： William E. Cohn ,  Jean-Marie Vogel

IPC分类号： A61L26/00 ,  A61M25/10

CPC分类号： A61L26/0019 ,  A61K31/74 ,  A61K31/765 ,  A61K31/785 ,  A61K45/06 ,  A61L26/0066 ,  A61L26/0095 ,  A61L2400/04 ,  A61L2400/06 ,  A61L2430/36 ,  A61M25/10 ,  A61M29/02

摘要： In certain embodiments, the present invention relates to methods and kits for treating wounds, comprising the step of introducing into said wound a composition comprising at least one optionally purified inverse thermosensitive polymer, wherein said at least one optionally purified inverse thermosensitive polymer forms a gel in said wound, thereby temporarily occluding said wound. In certain embodiments, the present invention relates to the aforementioned method wherein a wound to a blood vessel or a segment of the GI tract is occluded, thereby preventing exsanguination and/or septicemia. In other embodiments, the inventive methods and kits described herein may be used to ameliorate (e.g., fill) temporarily a defect in a biological lumen, thereby strengthening said defect, preventing rupture of, or maintaining, improving or optimizing fluid flow through said lumen.

摘要翻译： 在某些实施方案中，本发明涉及用于治疗伤口的方法和试剂盒，其包括将包含至少一种任选纯化的反相热敏聚合物的组合物引入所述伤口的步骤，其中所述至少一种任选纯化的反相热敏聚合物在 所述伤口，从而暂时封闭所述伤口。 在某些实施方案中，本发明涉及上述方法，其中伤口到血管或胃肠道的一部分被阻塞，从而防止放血和/或败血症。 在其它实施方案中，本文所述的本发明的方法和试剂盒可用于临时改善（例如，填充）生物腔内的缺陷，从而加强所述缺陷，防止破裂或保持，改善或优化通过所述内腔的流体流动。

公开(公告)号：US20160317701A1

公开(公告)日：2016-11-03

申请号：US14951777

申请日：2015-11-25

申请人： Genzyme Corporation

发明人： Jean-Marie Vogel

IPC分类号： A61L24/04 ,  A61K9/00 ,  A61L24/00 ,  A61B17/34

CPC分类号： A61L24/046 ,  A61B17/3478 ,  A61B2017/00269 ,  A61K9/0024 ,  A61K31/765 ,  A61L24/001 ,  A61L24/0031 ,  A61L2400/06 ,  C08L7/02

摘要： One aspect of the invention relates to use of a composition comprising a purified inverse thermosensitive polymer in an endoscopic procedure for gastrointestinal mucosal resectioning in a mammal. Another aspect of the invention relates to a method of 5gastrointestinal mucosal resectioning, comprising administering submucosally to a region of a gastrointestinal mucosa in a mammal an effective amount of a composition comprising a purified inverse thermosensitive polymer; and surgically resecting said region of gastrointestinal mucosa. Yet another aspect of the invention relates to a kit for use in gastrointestinal endoscopic mucosal resectioning in a mammal, comprising a composition 10comprising a purified inverse thermosensitive polymer; a syringe; and instructions for use thereof.

摘要翻译： 本发明的一个方面涉及包含纯化的反相热敏聚合物的组合物在哺乳动物的胃肠粘膜切除术的内窥镜手术中的用途。 本发明的另一方面涉及一种胃肠粘膜切除术的方法，包括向哺乳动物的胃肠粘膜区域施用有效量的包含纯化的反相热敏性聚合物的组合物的粘膜下粘膜; 并手术切除胃肠粘膜的所述区域。 本发明的另一方面涉及用于哺乳动物胃肠内镜粘膜切除术的试剂盒，其包含组合物10，其包含纯化的反相热敏聚合物; 注射器 以及使用说明书。