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192 条记录 (耗时 0.042 秒)

    Benzothiophene hydroxamic acid derivatives
    13.
    发明授权
    Benzothiophene hydroxamic acid derivatives 有权
    苯并噻吩异羟肟酸衍生物

    公开(公告)号：US07772238B2

    公开(公告)日：2010-08-10

    申请号：US11918912

    申请日：2006-04-14

    申请人： Jed Lee Hubbs ,  Sam Kattar ,  Joey Methot ,  Thomas Miller ,  Phieng Siliphaivanh ,  Matthew Stanton ,  Kevin Wilson ,  David J. Witter

    发明人： Jed Lee Hubbs ,  Sam Kattar ,  Joey Methot ,  Thomas Miller ,  Phieng Siliphaivanh ,  Matthew Stanton ,  Kevin Wilson ,  David J. Witter

    IPC分类号： A61K31/496 ,  A61K31/381 ,  C07D405/04 ,  C07D333/56

    CPC分类号： C07D333/70 ,  A61K31/38 ,  A61K31/381 ,  A61K31/41

    摘要： The present invention relates to a novel class of hydroxamic acid derivatives. The hydroxamic acid compounds can be used to treat cancer. The hydroxamic acid compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.

    摘要翻译： 本发明涉及一类新型异羟肟酸衍生物。 异羟肟酸化合物可用于治疗癌症。 异羟肟酸化合物也可以抑制组蛋白脱乙酰酶，适用于选择性诱导终末分化，阻止肿瘤细胞的细胞生长和/或凋亡，从而抑制这些细胞的增殖。 因此，本发明的化合物可用于治疗具有以肿瘤细胞增殖为特征的肿瘤的患者。 本发明的化合物还可用于预防和治疗TRX介导的疾病，例如自身免疫性，过敏性和炎性疾病，以及预防和/或治疗中枢神经系统（CNS）的疾病，例如神经变性 疾病 本发明进一步提供包含异羟肟酸衍生物和这些药物组合物的安全投药方案的药物组合物，它们易于遵循，并且其在体内导致治疗有效量的异羟肟酸衍生物。

    System and method for updating contact records
    15.
    发明授权
    System and method for updating contact records 有权
    用于更新联系人记录的系统和方法

    公开(公告)号：US07715546B2

    公开(公告)日：2010-05-11

    申请号：US10776775

    申请日：2004-02-09

    申请人： Ezra U. Pagel ,  Daniel N. Duncan ,  Thomas Miller

    发明人： Ezra U. Pagel ,  Daniel N. Duncan ,  Thomas Miller

    IPC分类号： H04M3/00

    CPC分类号： H04M3/5158

    摘要： A system and method for updating contact records automates analysis of contact results for one or more contact devices performing a contact campaign in order to select contact records for skip trace updates to contact information with the updated contact information for real time use by the contact devices. For instance, an update engine analyzes contact records returned by dialers to a distribution module to select contact records to skip trace based on rules, such as where a wrong number code is indicated, or cost analysis, such as where the predicted result of an update has a value greater than the cost of obtaining the update. The distribution model provides the updated contact information for real time use by the dialers of the updated contact numbers.

    摘要翻译： 用于更新联系人记录的系统和方法自动分析执行联系人活动的一个或多个联系人设备的联系人结果，以便选择用于跳过跟踪更新的联系人记录以与所更新的联系人信息联系以供由联系人设备实时使用。 例如，更新引擎将拨号器返回的联系人记录分析到分发模块，以选择联系人记录以基于规则跳过跟踪，例如指示错误的号码代码或成本分析，例如更新的预测结果 具有大于获取更新的成本的值。 分发模型提供更新的联系人信息，供拨号器更新联系电话号码的实时使用。

    Method and apparatus for adjusting the pressure sensor measurement range in a tire pressure monitoring system
    16.
    发明授权
    Method and apparatus for adjusting the pressure sensor measurement range in a tire pressure monitoring system 有权
    用于调整轮胎压力监测系统中的压力传感器测量范围的方法和装置

    公开(公告)号：US07570157B2

    公开(公告)日：2009-08-04

    申请号：US11163586

    申请日：2005-10-24

    申请人： Thomas Miller ,  Thomas McQuade ,  Greg Swadling ,  Karl Wojcik

    发明人： Thomas Miller ,  Thomas McQuade ,  Greg Swadling ,  Karl Wojcik

    IPC分类号： B60C23/00 ,  G01F23/00

    CPC分类号： B60C23/0408 ,  B60C23/0474

    摘要： A tire pressure monitoring system (12) for a vehicle (10) has a pressure sensor circuit (16A) that includes an ECU (95), a transmitter/receiver (90), and pressure sensor (94). A method of operating a tire pressure monitoring system includes calibrating a tire pressure sensor circuit in a first range and a second range and generating a first calibration data for the first range and second calibration data for the second range. The first calibration data and the second calibration data are stored in a memory of the tire pressure sensing circuit (16A). A data signal corresponding to the pressure is generated. The first or second calibration data is generated in response to the range of the data signal to form a selected calibration. The data signal is calibrated with the selected calibration to form a pressure indicative signal. The pressure indicative signal is transmitted to a receiver (28) within the vehicle (10) with a range status corresponding to the selected calibration. A pressure signal is formed in response to the pressure indicative signal and the range status and the tire pressure monitoring system is operated with the pressure signal.

    摘要翻译： 一种用于车辆（10）的轮胎压力监测系统（12）具有包括ECU（95），发射器/接收器（90）和压力传感器（94）的压力传感器电路（16A）。 一种操作轮胎压力监测系统的方法包括在第一范围和第二范围内校准轮胎压力传感器电路，并且产生用于第一范围的第一校准数据和用于第二范围的第二校准数据。 第一校准数据和第二校准数据被存储在轮胎压力检测电路（16A）的存储器中。 产生与压力对应的数据信号。 响应于数据信号的范围产生第一或第二校准数据以形成选定的校准。 数据信号用所选校准进行校准，以形成压力指示信号。 压力指示信号以对应于所选择的校准的范围状态传送到车辆（10）内的接收器（28）。 响应于压力指示信号形成压力信号，并且使用压力信号来操作范围状态和轮胎压力监测系统。

    Combination Cooking Appliance Including Multiple Microwave Heating Units with Rotatable Antennae
    17.
    发明申请
    Combination Cooking Appliance Including Multiple Microwave Heating Units with Rotatable Antennae 有权
    组合烹饪设备，包括多个可旋转天线的微波加热单元

    公开(公告)号：US20090090707A1

    公开(公告)日：2009-04-09

    申请号：US12248657

    申请日：2008-10-09

    申请人： Robert McNamee ,  Thomas Miller

    发明人： Robert McNamee ,  Thomas Miller

    IPC分类号： H05B6/80

    CPC分类号： H05B6/647 ,  H05B6/725

    摘要： A microwave cooking appliance includes first and second side mounted microwave systems, each including an associated antenna. Drive structure is provided to establish an oscillating operation for each of the antennae, wherein the angles through which the antennae rotate are configured to assure that the cooking appliance operates in favorable mode patterns. In accordance with the invention, the antenna preferably only oscillates through less than or equal to 180° and, most preferably, approximately 150°.

    摘要翻译： 微波烹饪器具包括第一和第二侧面安装的微波系统，每个微波系统包括相关联的天线。 提供驱动结构以建立每个天线的振荡操作，其中天线旋转的角度被配置为确保烹饪器具以有利的模式模式工作。 根据本发明，天线优选地仅振荡小于或等于180°，最优选地大约为150°。

    ELECTROACOUSTIC TRANSDUCER WITH RESISTANCE TO SHOCK-WAVES
    20.
    发明申请
    ELECTROACOUSTIC TRANSDUCER WITH RESISTANCE TO SHOCK-WAVES 有权
    具有抗震波电感传感器

    公开(公告)号：US20070258616A1

    公开(公告)日：2007-11-08

    申请号：US11766461

    申请日：2007-06-21

    申请人： Paris Tsangaris ,  Thomas Longwell ,  Thomas Miller ,  Dennis Kirchhoefer ,  Daniel Warren

    发明人： Paris Tsangaris ,  Thomas Longwell ,  Thomas Miller ,  Dennis Kirchhoefer ,  Daniel Warren

    IPC分类号： H04R1/00

    CPC分类号： H04R11/02 ,  H04R11/00 ,  H04R25/00

    摘要： A transducer comprising a pair of spaced magnets at least partially forming a tunnel having a central axis. A coil having a first and a second side wall and an upper and a lower wall at least partially forms the tunnel. A reed having a central portion extends through the tunnel. The reed has a stationary end, a deflection end, and a tip portion which lies at least partially between the magnets, wherein the reed is mounted for deflection towards or away from the respective magnets.

    摘要翻译： 换能器包括一对间隔开的磁体，至少部分地形成具有中心轴线的隧道。 具有第一和第二侧壁以及至少部分地形成隧道的上壁和下壁的线圈。 具有中心部分的簧片延伸通过隧道。 簧片具有固定的端部，偏转端部和至少部分地位于磁体之间的尖端部分，其中，所述簧片安装成朝向或远离各个磁体偏转。