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    IMPLANTABLE MEDICAL DEVICE
    12.
    发明申请
    IMPLANTABLE MEDICAL DEVICE 有权
    可植入医疗器械

    公开(公告)号：US20080195162A1

    公开(公告)日：2008-08-14

    申请号：US11970662

    申请日：2008-01-08

    申请人： Michael Lippert ,  Olaf Skerl ,  Stefan Paule ,  Bernhard Fahn ,  Gerald Czygan ,  Heinrich Reinke ,  Albrecht Urbaszek

    发明人： Michael Lippert ,  Olaf Skerl ,  Stefan Paule ,  Bernhard Fahn ,  Gerald Czygan ,  Heinrich Reinke ,  Albrecht Urbaszek

    IPC分类号： A61B5/053 ,  A61N1/362

    CPC分类号： A61B5/053 ,  A61B5/0538 ,  A61B5/14535 ,  A61B5/7207

    摘要： An implantable medical device has an impedance or admittance determination unit, an alternating current or voltage source, a measuring unit, and an analysis unit which is connected to the alternating current or AC voltage source and the measuring unit to calculate an impedance value or an admittance value at different times. The impedance or admittance determination unit may generate measuring current having two different frequencies (preferably below 100 kHz), and the analysis unit may calculate pairs of impedance or admittance values which are chronologically assigned to one another for different frequencies of the measuring current, and calculate a value for a blood impedance or blood admittance component which is independent of the impedance of the body tissue surrounding a particular blood vessel, The analysis unit may also determine trends in this value over time as an indicator for a change of blood hematocrit value.

    摘要翻译： 可植入医疗装置具有阻抗或导纳确定单元，交流或电压源，测量单元和分析单元，其连接到交流电压源或交流电压源和测量单元以计算阻抗值或导纳 价值在不同的时间。 阻抗或导纳确定单元可以产生具有两个不同频率（优选低于100kHz）的测量电流，并且分析单元可以计算针对测量电流的不同频率按时间顺序分配给彼此的阻抗或导纳值对，并且计算 血液阻抗或血液导入分量的值，其独立于围绕特定血管的身体组织的阻抗。分析单元还可以确定该值随时间的趋势作为血液血细胞比容值变化的指标。

    IMPLANT AND SYSTEM FOR PREDICTING DECOMPENSATION
    13.
    发明申请
    IMPLANT AND SYSTEM FOR PREDICTING DECOMPENSATION 有权
    用于预测分解的植入和系统

    公开(公告)号：US20120035453A1

    公开(公告)日：2012-02-09

    申请号：US13186511

    申请日：2011-07-20

    申请人： Olaf Skerl ,  Michael Lippert

    发明人： Olaf Skerl ,  Michael Lippert

    IPC分类号： A61B8/00

    CPC分类号： A61B8/08 ,  A61B8/12 ,  A61B8/4477 ,  A61B8/5223 ,  A61N1/3627 ,  A61N1/3704 ,  A61N1/3925 ,  A61N1/3956

    摘要： An implant predicts decompensation of a patient's heart based on an acoustic pressure measurement. The implant includes first and second acoustic transducers, which are matched to each other and which rest in/on the patient's thorax. The first acoustic transducer emits an acoustic signal which has at least one first signal portion having a first frequency. The second acoustic transducer is designed to receive and re-emit the emitted acoustic signal, or to reflect it, such that the first acoustic transducer receives the emitted acoustic signal. A signal processing unit communicates with at least one of the two acoustic transducers and determines an attenuation value as a function of the attenuation of the received acoustic signal versus the originally emitted acoustic signal, and provides a prediction signal as a function of a comparison of the attenuation value to a threshold value, wherein the prediction signal indicates the development of decompensation.

    摘要翻译： 植入物基于声压测量来预测患者心脏的代偿失调。 植入物包括第一和第二声学换能器，它们彼此匹配并且被置于患者胸部中/之上。 第一声​​换能器发射具有至少一个具有第一频率的第一信号部分的声信号。 第二声换能器被设计成接收和重新发射所发射的声信号或反射它，使得第一声换能器接收所发射的声信号。 信号处理单元与两个声换能器中的至少一个通信，并且将衰减值确定为接收的声信号相对于最初发出的声信号的衰减的函数，并且提供预测信号作为 衰减值到阈值，其中预测信号指示发生失代偿。

    IMPLANTABLE MEDICAL DEVICE
    14.
    发明申请
    IMPLANTABLE MEDICAL DEVICE 有权
    可植入医疗器械

    公开(公告)号：US20120245476A1

    公开(公告)日：2012-09-27

    申请号：US13227522

    申请日：2011-09-08

    申请人： Olaf Skerl ,  Michael Lippert ,  Jens Kirchner

    发明人： Olaf Skerl ,  Michael Lippert ,  Jens Kirchner

    IPC分类号： A61B5/029 ,  A61N1/365 ,  A61B5/02

    CPC分类号： A61B5/1102 ,  A61B5/0006 ,  A61N1/36571 ,  A61N1/36578 ,  A61N1/3682 ,  A61N1/3684

    摘要： An implantable medical device includes an integrated or connectable implantable three-dimensional acceleration sensor, and a ballistocardiogram (BCG) capturing unit that is connected or connectable to the acceleration sensor. The BCG evaluation unit processes an acceleration signal provided by the acceleration sensor and derives a BCG from the 3D accelerometer output signal. A BCG evaluation unit is connected to the BCG capturing unit, and is designed to evaluate a BCG provided by the BCG capturing unit and supply an output signal representing stroke volume.

    摘要翻译： 可植入医疗装置包括可组装或可连接的可植入三维加速度传感器，以及连接或连接到加速度传感器的圆心形图（BCG）捕获单元。 BCG评估单元处理由加速度传感器提供的加速度信号，并从3D加速度计输出信号导出BCG。 BCG评估单元连接到BCG捕获单元，并被设计为评估由BCG捕捉单元提供的BCG并提供表示笔画音量的输出信号。

    Implantable medical device
    15.
    发明授权
    Implantable medical device 有权
    植入式医疗器械

    公开(公告)号：US09427176B2

    公开(公告)日：2016-08-30

    申请号：US13227522

    申请日：2011-09-08

    申请人： Olaf Skerl ,  Michael Lippert ,  Jens Kirchner

    发明人： Olaf Skerl ,  Michael Lippert ,  Jens Kirchner

    IPC分类号： A61B5/103 ,  A61B5/11 ,  A61B5/00 ,  A61N1/365 ,  A61N1/368

    CPC分类号： A61B5/1102 ,  A61B5/0006 ,  A61N1/36571 ,  A61N1/36578 ,  A61N1/3682 ,  A61N1/3684

    摘要： An implantable medical device includes an integrated or connectable implantable three-dimensional acceleration sensor, and a ballistocardiogram (BCG) capturing unit that is connected or connectable to the acceleration sensor. The BCG evaluation unit processes an acceleration signal provided by the acceleration sensor and derives a BCG from the 3D accelerometer output signal. A BCG evaluation unit is connected to the BCG capturing unit, and is designed to evaluate a BCG provided by the BCG capturing unit and supply an output signal representing stroke volume.

    摘要翻译： 可植入医疗装置包括可组装或可连接的可植入三维加速度传感器，以及连接或连接到加速度传感器的圆心形图（BCG）捕获单元。 BCG评估单元处理由加速度传感器提供的加速度信号，并从3D加速度计输出信号导出BCG。 BCG评估单元连接到BCG捕获单元，并被设计为评估由BCG捕捉单元提供的BCG并提供表示笔画音量的输出信号。

    Implant and system for predicting decompensation
    16.
    发明授权
    Implant and system for predicting decompensation 有权
    用于预测失代偿的植入物和系统

    公开(公告)号：US08652048B2

    公开(公告)日：2014-02-18

    申请号：US13186511

    申请日：2011-07-20

    申请人： Olaf Skerl ,  Michael Lippert

    发明人： Olaf Skerl ,  Michael Lippert

    IPC分类号： A61B8/00

    CPC分类号： A61B8/08 ,  A61B8/12 ,  A61B8/4477 ,  A61B8/5223 ,  A61N1/3627 ,  A61N1/3704 ,  A61N1/3925 ,  A61N1/3956

    摘要： An implant predicts decompensation of a patient's heart based on an acoustic pressure measurement. The implant includes first and second acoustic transducers, which are matched to each other and which rest in/on the patient's thorax. The first acoustic transducer emits an acoustic signal which has at least one first signal portion having a first frequency. The second acoustic transducer is designed to receive and re-emit the emitted acoustic signal, or to reflect it, such that the first acoustic transducer receives the emitted acoustic signal. A signal processing unit communicates with at least one of the two acoustic transducers and determines an attenuation value as a function of the attenuation of the received acoustic signal versus the originally emitted acoustic signal, and provides a prediction signal as a function of a comparison of the attenuation value to a threshold value, wherein the prediction signal indicates the development of decompensation.

    摘要翻译： 植入物基于声压测量来预测患者心脏的代偿失调。 植入物包括第一和第二声学换能器，它们彼此匹配并且被置于患者胸部中/之上。 第一声​​换能器发射具有至少一个具有第一频率的第一信号部分的声信号。 第二声换能器被设计成接收和重新发射所发射的声信号或反射它，使得第一声换能器接收所发射的声信号。 信号处理单元与两个声换能器中的至少一个通信，并且将衰减值确定为接收的声信号相对于最初发出的声信号的衰减的函数，并且提供预测信号作为 衰减值到阈值，其中预测信号指示发生失代偿。

    BLOOD FLOW SENSOR
    17.
    发明申请
    BLOOD FLOW SENSOR 审中-公开
    血液流量传感器

    公开(公告)号：US20120203113A1

    公开(公告)日：2012-08-09

    申请号：US13350855

    申请日：2012-01-16

    申请人： Olaf Skerl ,  Michael Lippert

    发明人： Olaf Skerl ,  Michael Lippert

    IPC分类号： A61B6/00 ,  A61N1/365

    CPC分类号： A61B5/0265 ,  A61B5/027 ,  A61B5/7203 ,  A61B8/06 ,  G01F1/7082 ,  G01F1/7086 ,  G01F1/712

    摘要： A blood flow rate sensor has at least one transmitter for emitting waves into a blood vessel, the propagation of which is deflected by cellular blood components, and at least two receiver units for receiving waves emitted by the transmitter. The receiver units are spaced from each other in the direction of blood flow, and are situated such that each receives waves from a different path through the blood. The output signal of each receiver unit is filtered or otherwise processed to obtain a noise component, and the noise components from the receiver units are cross-correlated to determine a time offset between the output signals. The time offset is inversely proportional to the blood flow rate.

    摘要翻译： 血液流量传感器具有至少一个发射器，用于将波浪发射到血管中，其传播被细胞血液成分偏转，以及至少两个用于接收由发射器发射的波的接收器单元。 接收器单元在血流方向上彼此间隔开，并且被定位成使得每个接收器从接收通过血液的不同路径接收波。 每个接收器单元的输出信号被滤波或以其他方式处理以获得噪声分量，并且来自接收器单元的噪声分量是相互关联的，以确定输出信号之间的时间偏移。 时间偏移与血液流量成反比。

    Cardiac pacemaker
    18.
    发明授权
    Cardiac pacemaker 有权
    心脏起搏器

    公开(公告)号：US07702389B2

    公开(公告)日：2010-04-20

    申请号：US11559626

    申请日：2006-11-14

    申请人： Gerald Czygan ,  Michael Lippert

    发明人： Gerald Czygan ,  Michael Lippert

    IPC分类号： A61N1/00

    CPC分类号： A61N1/3627

    摘要： The invention concerns implantable cardiac stimulation devices in general which have at least one stimulation pulse generator (A-STIM; RV-STIM; LV-STIM) to selectively generate a stimulation pulse for delivery to one of at least two different chambers of a heart, said chambers include right and left atria and right and left ventricles, at least one impedance measuring stage (I, U, IMP) being connected to electrodes or connectors for such electrodes to measure an intracardiac impedance when in use, a control unit (CTRL) connected to the stimulation pulse generator and to the impedance measuring unit and being adapted to process a minimum impedance value for a heart cycle to trigger stimulation pulses for two different chambers of the heart with an adjustable time delay (VVD; AVD) and to adjust said time delay depending upon the measured intracardiac impedance minimum value. According to the invention the control unit is adapted to adjust the time delay such that the minimum value of the intracardiac impedance during one heart cycle is minimized or such that the AVD delay is equal to the time interval between an atrial event and the point of time when the minimum impedance value occurs after said atrial contraction.

    摘要翻译： 本发明涉及一般具有至少一个刺激脉冲发生器（A-STIM; RV-STIM; LV-STIM）的可植入心脏刺激装置，以选择性地产生用于递送至心脏的至少两个不同室中的一个的刺激脉冲， 所述腔室包括右心房和左心房以及右心室和左心室，至少一个阻抗测量平台（I，U，IMP）连接到用于这种电极的电极或连接器，用于在使用时测量心内阻抗，控制单元（CTRL） 连接到刺激脉冲发生器和阻抗测量单元，并且适于处理用于心脏周期的最小阻抗值以用可调节的时间延迟（VVD; AVD）触发心脏的两个不同腔室的刺激脉冲，并且调整所述 时间延迟取决于测量的心内阻抗最小值。 根据本发明，控制单元适于调整时间延迟，使得在一个心脏周期期间心内阻抗的最小值被最小化或使得AVD延迟等于心房事件与时间点之间的时间间隔 当在所述心房收缩之后发生最小阻抗值时。

    Device for determining thoracic impedance
    20.
    发明申请
    Device for determining thoracic impedance 有权
    用于确定胸阻抗的装置

    公开(公告)号：US20060135886A1

    公开(公告)日：2006-06-22

    申请号：US11293398

    申请日：2005-12-02

    申请人： Michael Lippert ,  Gerald Czygan

    发明人： Michael Lippert ,  Gerald Czygan

    IPC分类号： A61N1/368

    CPC分类号： A61B5/0031 ,  A61B5/0537

    摘要： An electromedical implant includes a measuring signal generator, an impedance measuring unit to determine the impedance of human or animal tissue, a control unit which, for controlling the measuring signal generator and the impedance measuring unit, is at least indirectly connected to the measuring signal generator and to the impedance measuring unit, as well as an electrode arrangement comprising at least two electrodes which can be directly or indirectly connected or at least temporarily connected to the measuring signal generator and to the impedance measuring unit, or to a connection for such an electrode arrangement. The measuring signal generator is designed to generate and emit a current pulse or a series of current pulses, and the control unit is designed at a specific point in time to cause the measuring signal generator (to generate and emit a current pulse, and to cause the impedance measuring unit to measure the voltage that is present between the electrodes connected to the measuring signal generator and the impedance measuring unit after the passing of at least two time periods of different length that start with commencement of the current pulse being emitted and end before the end of emitting the current pulse, and to issue a voltage value which in each case represents the measured voltage.

    摘要翻译： 电动植入物包括测量信号发生器，用于确定人体或动物组织的阻抗的阻抗测量单元，用于控制测量信号发生器和阻抗测量单元的控制单元至少间接连接到测量信号发生器 和阻抗测量单元，以及包括至少两个电极的电极装置，所述至少两个电极可以直接或间接连接或至少临时连接到测量信号发生器和阻抗测量单元，或者连接到这种电极 安排。 测量信号发生器被设计成产生和发出电流脉冲或一系列电流脉冲，并且控制单元被设计在特定的时间点，以使得测量信号发生器（产生和发射电流脉冲，并引起 所述阻抗测量单元用于测量在连接到所述测量信号发生器的电极和所述阻抗测量单元之间存在的电压，所述电压在经过所述至少两个不同长度的时间段之后，所述至少两个不同长度的时间段从所述当前脉冲的开始开始并被发射 发射电流脉冲的结束，并发出在每种情况下表示测量电压的电压值。