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    BIOCOMPATIBLE PACKAGING FOR LONG TERM IMPLANTABLE SENSORS AND ELECTRONICS
    7.
    发明申请
    BIOCOMPATIBLE PACKAGING FOR LONG TERM IMPLANTABLE SENSORS AND ELECTRONICS 审中-公开
    用于长期可植入式传感器和电子产品的生物易燃包装

    公开(公告)号：US20160287101A1

    公开(公告)日：2016-10-06

    申请号：US15076184

    申请日：2016-03-21

    申请人： California Institute of Technology

    发明人： Yu-Chong Tai ,  Yang Liu ,  Aubrey M. Shapero

    IPC分类号： A61B5/0215 ,  A61B5/021

    CPC分类号： A61B5/02156 ,  A61B5/02141 ,  A61B5/0215 ,  A61B2562/0247 ,  A61B2562/12 ,  A61B2562/162 ,  A61B2562/168 ,  G01L9/00

    摘要： An implantable medical device is described. In an example, the implantable medical device includes an electromechanical substrate and sensor, such as a pressure sensor, disposed on the substrate. At least a portion of the sensor is packaged via a liquid encapsulation. The packaging includes a shaped flexible outer membrane that surrounds at least the portion of the sensor. The packaging also includes a hydrophobic liquid disposed between at least the portion of the pressure sensor and the flexible outer membrane. The implantable medical device can be a part of a medical system used for monitoring medical conditions or performing medical operations based on the implantable medical device. Additionally, manufacturing methods are described for packaging the sensor in a liquid encapsulation.

    摘要翻译： 描述了可植入医疗装置。 在一个示例中，可植入医疗装置包括设置在基底上的机电衬底和诸如压力传感器的传感器。 传感器的至少一部分通过液体封装进行封装。 该包装包括至少围绕传感器的该部分的成形的柔性外膜。 该包装还包括设置在压力传感器的至少部分与柔性外膜之间的疏水性液体。 可植入医疗装置可以是用于监视医疗状况或基于可植入医疗装置执行医疗操作的医疗系统的一部分。 另外，描述了用于将传感器封装在液体封装中的制造方法。

    SYSTEM AND METHOD FOR ESTIMATING CARDIAC PRESSURE BASED ON CARDIAC ELECTRICAL CONDUCTION DELAYS USING AN IMPLANTABLE MEDICAL DEVICE
    8.
    发明申请
    SYSTEM AND METHOD FOR ESTIMATING CARDIAC PRESSURE BASED ON CARDIAC ELECTRICAL CONDUCTION DELAYS USING AN IMPLANTABLE MEDICAL DEVICE 审中-公开
    基于使用可植入医疗器械的心脏电导延迟的心脏压力估计系统和方法

    公开(公告)号：US20150025397A1

    公开(公告)日：2015-01-22

    申请号：US13943680

    申请日：2013-07-16

    申请人： Pacesetter, Inc.

    发明人： Brian J. Wenzel ,  Dan E. Gutfinger ,  Mihir Naware ,  Xiaoyi Min ,  Jeffery Siou ,  Anders Bjorling ,  Dorin Panescu

    IPC分类号： A61B5/0215 ,  A61B5/00

    CPC分类号： A61B5/02156 ,  A61B5/0215 ,  A61B5/72 ,  A61N1/365 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/37258

    摘要： Techniques are provided for estimating left atrial pressure (LAP) or other cardiac performance parameters based on measured conduction delays. In particular, LAP is estimated based interventricular conduction delays. Predetermined conversion factors stored within the device are used to convert the various the conduction delays into LAP values or other appropriate cardiac performance parameters. The conversion factors may be, for example, slope and baseline values derived during an initial calibration procedure performed by an external system, such as an external programmer. In some examples, the slope and baseline values may be periodically re-calibrated by the implantable device itself. Techniques are also described for adaptively adjusting pacing parameters based on estimated LAP or other cardiac performance parameters. Still further, techniques are described for estimating conduction delays based on impedance or admittance values and for tracking heart failure therefrom.

    摘要翻译： 提供了基于测量的传导延迟来估计左心房压力（LAP）或其他心脏性能参数的技术。 特别地，LAP是基于室间传导延迟估计的。 存储在装置内的预定转换因子用于将各种导通延迟转换为LAP值或其他适当的心脏性能参数。 转换因子可以是例如由外部系统（诸如外部编程器）执行的初始校准过程期间导出的斜率和基线值。 在一些示例中，可以通过可植入装置本身周期性地重新校准斜率和基线值。 还描述了基于估计的LAP或其他心脏性能参数自适应地调整起搏参数的技术。 此外，描述了用于基于阻抗或导纳值估计导通延迟并用于跟踪其心力衰竭的技术。

    Transducer interface system and method
    9.
    发明授权
    Transducer interface system and method 有权
    传感器接口系统及方法

    公开(公告)号：US08926520B2

    公开(公告)日：2015-01-06

    申请号：US13946646

    申请日：2013-07-19

    申请人： The Board of Regents of the University of Texas System

    发明人： Phillip Douglas Purdy ,  Ronald Bruce Jennings

    IPC分类号： A61B5/0215 ,  G01L9/00 ,  A61B5/03 ,  G01L19/12 ,  G01L27/00 ,  A61B5/00

    CPC分类号： A61B5/02154 ,  A61B5/02156 ,  A61B5/02158 ,  A61B5/024 ,  A61B5/031 ,  A61B5/032 ,  A61B5/6853 ,  A61B5/72 ,  A61B5/7225 ,  A61B5/742 ,  G01L9/00 ,  G01L19/12 ,  G01L27/007

    摘要： A transducer interface system/method allowing conversion from an analog sensor input to a standardized analog output interface is disclosed. In some preferred embodiments the system/method permits a fiber optic pressure sensor to be interfaced to a standard patient care monitor (PCM) system using standardized Wheatstone Bridge analog interface inputs. Within this context the Wheatstone Bridge sensed output is defined by stimulus from the PCM and modulation of bridge element values by the conditioned output of an analog pressure sensor. The use of analog-to-digital-to-analog conversion in this transducer interface permits retrofitting of PCM devices having analog Wheatstone Bridge inputs with advanced patient monitoring sensors without the need for specialized modifications to the baseline PCM data collection framework. Methods disclosed herein include techniques to connect arbitrary types/numbers of analog sensors to traditional PCM systems without the need for PCM system hardware/software modifications.

    摘要翻译： 公开了一种允许从模拟传感器输入到标准化模拟输出接口的转换的传感器接口系统/方法。 在一些优选实施例中，系统/方法允许使用标准化的惠斯通电桥模拟接口输入将光纤压力传感器接口到标准的病人护理监视器（PCM）系统。 在这种情况下，惠斯通电桥感测输出由PCM的激励定义，并通过模拟压力传感器的调节输出调制桥元件值。 在该传感器接口中使用模拟到数模转换可以对具有模拟惠斯通电桥输入的PCM器件进行改进，并具有先进的患者监控传感器，而无需对基线PCM数据采集框架进行专门修改。 本文公开的方法包括将任意类型/数量的模拟传感器连接到传统PCM系统而不需要PCM系统硬件/软件修改的技术。