-
11.发明授权Machine-learning approach to modeling biological activity for molecular design and to modeling other characteristics 失效机器学习方法对分子设计的生物活性进行建模，并对其他特征进行建模
公开(公告)号：US6081766A
公开(公告)日：2000-06-27
申请号：US583000
申请日：1996-04-11
申请人： David Chapman , Roger Critchlow , Thomas Glen Dietterich , Ajay N. Jain , Richard H. Lathrop , Tomas Lozano-Perez
发明人： David Chapman , Roger Critchlow , Thomas Glen Dietterich , Ajay N. Jain , Richard H. Lathrop , Tomas Lozano-Perez
CPC分类号： C07K1/00 , G06F19/706 , G06F19/704 , G06F19/707 , Y10S706/92
摘要： Explicit representation of molecular shape of molecules is combined with neural network learning methods to provide models with high predictive ability that generalize to different chemical classes where structurally diverse molecules exhibiting similar surface characteristics are treated as similar. A new machine-learning methodology is disclosed that can accept multiple representations of objects and construct models that predict characteristics of those objects. An extension of this methodology can be applied in cases where the representations of the objects are determined by a set of adjustable parameters. An iterative process applies intermediate models to generate new representations of the objects by adjusting said parameters and repeatedly. retrains the models to obtain better predictive models. This method can be applied to molecules because each molecule can have many orientations and conformations (representations) that are determined by a set of translation, rotation and torsion angle parameters.
摘要翻译： PCT No.PCT / US94 / 05877 Sec。 371日期：1996年4月11日 102（e）日期1996年4月11日PCT 1994年5月20日PCT PCT。 WO94 / 28504 PCT公开号 日期1994年12月8日分子形状的分解形式与神经网络学习方法相结合，提供了具有高预测能力的模型，可以将不同化学类别归结为不同的化学类别，其中表现出相似表面特征的结构多样化分子被相似。 公开了一种新的机器学习方法，其可以接受对象的多个表示并构造预测那些对象的特征的模型。 在通过一组可调参数确定对象的表示的情况下，可以应用该方法的扩展。 迭代过程通过调整所述参数并反复地应用中间模型来生成对象的新表示。 重新模拟模型以获得更好的预测模型。 该方法可以应用于分子，因为每个分子可以具有由一组平移，旋转和扭转角参数确定的许多取向和构象（表示）。
-
12.发明授权Machine-learning approach to modeling biological activity for molecular design and to modeling other characteristics 失效机器学习方法对分子设计的生物活性进行建模，并对其他特征进行建模
公开(公告)号：US5526281A
公开(公告)日：1996-06-11
申请号：US382990
申请日：1994-10-28
申请人： David Chapman , Roger Critchlow , Ajay N. Jain , Rick Lathrop , Tomas L. Perez , Tom Dietterich
发明人： David Chapman , Roger Critchlow , Ajay N. Jain , Rick Lathrop , Tomas L. Perez , Tom Dietterich
CPC分类号： C07K1/00 , G06F19/706 , G06F19/704 , G06F19/707 , Y10S706/92
摘要： Explicit representation of molecular shape of molecules is combined with neural network learning methods to provide models with high predictive ability that generalize to different chemical classes where structurally diverse molecules exhibiting similar surface characteristics are treated as similar. A new machine-learning methodology that can accept multiple representations of objects and construct models that predict characteristics of those objects. An extension of this methodology can be applied in cases where the representations of the objects are determined by a set of adjustable parameters. An iterative process applies intermediate models to generate new representations of the objects by adjusting said parameters and repeatedly retrains the models to obtain better predictive models. This method can be applied to molecules because each molecule can have many orientations and conformations (representations) that are determined by a set of translation, rotation and torsion angle parameters.
摘要翻译： 分子分子形状的显式表示与神经网络学习方法相结合，以提供具有高预测能力的模型，将其泛化为不同的化学类别，其中表现出相似表面特征的结构多样的分子被认为是相似的。 一种新的机器学习方法，可以接受对象的多个表示，并构建预测这些对象特征的模型。 在通过一组可调参数确定对象的表示的情况下，可以应用该方法的扩展。 迭代过程通过调整所述参数并重复地重新模拟模型以获得更好的预测模型，应用中间模型来生成对象的新表示。 该方法可以应用于分子，因为每个分子可以具有由一组平移，旋转和扭转角参数确定的许多取向和构象（表示）。
-
公开(公告)号：US4709327A
公开(公告)日：1987-11-24
申请号：US499471
申请日：1983-05-31
申请人： W. Daniel Hillis , Thomas F. Knight, Jr. , Alan Bawden , Brewster L. Kahle , David Chapman , David P. Christman , Cliff A. Lasser , Carl R. Feynman
发明人： W. Daniel Hillis , Thomas F. Knight, Jr. , Alan Bawden , Brewster L. Kahle , David Chapman , David P. Christman , Cliff A. Lasser , Carl R. Feynman
CPC分类号： G06F15/8023
摘要： A parallel processing circuit is disclosed for use as the processor/memory in a highly parallel processor. The circuit comprises an instruction decoder that generates tables of outputs in response to instructions received at the decoder and a plurality of processor/memories each of which comprises a read/write memory and a processor for producing an output depending at least in part on data read from the memory and instruction information received at the instruction decoder. In addition, the circuit provides means for simultaneously addressing at least one cell in each read/write memory to write data thereto or read data therefrom and means for providing to each processor an output table from the decoder, the particular output table depending on instruction information received at the decoder. Further the processing circuit comprises means for selecting from the output table a particular output depending on data input to the processor. Advantageously, each processor/memory also comprises a flag controller for controlling the reading of a plurality of flags and means for simultaneously addressing each flag controller to read a flag for input into the processor associated therewith.Preferably, each processor is a bit-serial processor with three inputs, two from the read/write memory and one from the flag controller, and two outputs, one to the read/write memory and one to the flag controller; and the decoder and the plurality of processor/memories and formed on a single, integrated circuit chip.
摘要翻译： 公开了一种用于高度并行处理器中的处理器/存储器的并行处理电路。 电路包括指令解码器，其响应于在解码器处接收到的指令而生成输出表，以及多个处理器/存储器，每个处理器/存储器包括读/写存储器和用于至少部分地基于数据读取产生输出的处理器 从在指令解码器处接收的存储器和指令信息。 此外，电路提供用于同时寻址每个读/写存储器中的至少一个单元以向其中写入数据或从其读取数据的装置，用于向每个处理器提供来自解码器的输出表的装置，该特定输出表取决于指令信息 在解码器处接收。 此外，处理电路包括用于根据输入到处理器的数据从输出表选择特定输出的装置。 有利地，每个处理器/存储器还包括用于控制多个标志的读取的标志控制器和用于同时寻址每个标志控制器以读取用于输入到与其相关联的处理器的标志的装置。 优选地，每个处理器是具有三个输入的位串行处理器，两个来自读/写存储器和一个来自标志控制器的两个输出，一个输出到读/写存储器，一个输出到该标志控制器; 以及解码器和多个处理器/存储器并形成在单个集成电路芯片上。
-
公开(公告)号：USD256313S
公开(公告)日：1980-08-12
申请号：US901651
申请日：1978-05-01
申请人： David Chapman
设计人： David Chapman
-
公开(公告)号：US08183251B2
公开(公告)日：2012-05-22
申请号：US11946517
申请日：2007-11-28
IPC分类号： C07D403/12 , C07D239/34 , A61K31/506
CPC分类号： C07D403/12 , C07D239/34
摘要： The invention provides compounds of formula (I): wherein R1 and R2 are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy. The compounds are useful as MMP inhibitors.
摘要翻译： 本发明提供式（I）化合物：其中R1和R2如说明书中所定义; 其准备过程; 含有它们的药物组合物; 制备药物组合物的方法; 及其在治疗中的应用。 该化合物可用作MMP抑制剂。
-
公开(公告)号：US20080221139A1
公开(公告)日：2008-09-11
申请号：US11946517
申请日：2007-11-28
IPC分类号： C07D403/12 , A61K31/506 , A61P11/00 , A61P25/00 , A61P19/02
CPC分类号： C07D403/12 , C07D239/34
摘要： The invention provides compounds of formula (I): wherein R1 and R2 are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy. The compounds are useful as MMP inhibitors.
摘要翻译： 本发明提供式（I）化合物：其中R 1和R 2如说明书中所定义; 其准备过程; 含有它们的药物组合物 制备药物组合物的方法; 及其在治疗中的应用。 该化合物可用作MMP抑制剂。
-
公开(公告)号：US07330388B1
公开(公告)日：2008-02-12
申请号：US11234411
申请日：2005-09-23
申请人： David Chapman , Richard Parent
发明人： David Chapman , Richard Parent
IPC分类号： G11C7/02
CPC分类号： G11C7/04 , G11C7/065 , G11C7/08 , G11C7/12 , G11C11/4074 , G11C11/4091 , G11C11/4094
摘要： In one arrangement, a semiconductor memory device can include a sense amplifier circuit (300) having drive high transistors (P30/P31), drive low transistors (N31/N32) and equalization transistors (N33-N35). Such transistors can have a body bias (VbiasN, VbiasP) that varies according to the operation conditions of the semiconductor memory device. Such variations can include any of: manufacturing process variations, operating temperature, or operating voltage.
摘要翻译： 在一种布置中，半导体存储器件可以包括具有驱动高晶体管（P 30 / P 31），驱动低晶体管（N 31 / N 32）和均衡晶体管（N 33 -N 35）的读出放大器电路（300）。 这种晶体管可以具有根据半导体存储器件的操作条件而变化的体偏置（VbiasN，VbiasP）。 这种变化可以包括以下任何一种：制造工艺变化，工作温度或工作电压。
-
公开(公告)号：US20060257247A1
公开(公告)日：2006-11-16
申请号：US11130375
申请日：2005-05-16
申请人： William Seidel , David Chapman
发明人： William Seidel , David Chapman
IPC分类号： F01D15/12
CPC分类号： F01D21/006 , F02K7/10
摘要： A brake system for a ram air turbine (RAT) causes the RAT to slow or lock if the RAT achieves an over-speed condition with a centrifugal force operated trigger system that actuates a compression type brake pack to slow or lock the turbine hub
摘要翻译： 用于冲压式空气涡轮机（RAT）的制动系统使得如果RAT利用驱动压缩式制动器组件的离心力操作的触发系统达到超速状态来减慢或锁定RAT，以减慢或锁定涡轮机轮毂
-
公开(公告)号：US20050252152A1
公开(公告)日：2005-11-17
申请号：US10843853
申请日：2004-05-12
申请人： Richard Belinda , David Chapman
发明人： Richard Belinda , David Chapman
CPC分类号： E04C3/11 , F16B5/0275 , F16B25/103 , F16B35/06
摘要： The invention is directed generally toward a fastener for use in assembly of steel truss members which can be installed at an angular orientation relative to the truss member surface. The fastener comprises a shank having a tip and a head. The fastener shank further has threaded portions for engaging truss members and plate elements if present. The tip of the shank can have a self-tapping point. The head of the fastener has a tool engagement surface and a seating surface. The seating surface has a configuration that allows for a wider distribution of force at a truss assembly contact point. In particular, the configuration includes an arcuate contour that is generally convex.
摘要翻译： 本发明总体上涉及用于组装钢桁架构件的紧固件，其可以相对于桁架构件表面以角度方向安装。 紧固件包括具有尖端和头部的柄。 紧固件柄还具有用于接合桁架构件和板构件（如果存在）的螺纹部分。 柄的尖端可以具有自攻点。 紧固件的头部具有工具接合表面和就座表面。 座面具有允许在桁架组件接触点处施加更大的力分配的构造。 特别地，该构造包括通常是凸起的弓形轮廓。
-
公开(公告)号：US20050155311A1
公开(公告)日：2005-07-21
申请号：US11036031
申请日：2005-01-14
申请人： Richard Belinda , David Chapman
发明人： Richard Belinda , David Chapman
CPC分类号： E04C3/12 , F16B5/0275 , F16B25/0015 , F16B25/0089 , F16B25/10 , F16B25/106
摘要： A truss fastener which includes a shaft having a head and a tip. Threading extends along the shaft from the tip end toward the head end of the shaft. The threading is interrupted, abbreviated, and/or otherwise separated by wings projecting from the surface of the shaft. The interrupting projection extends in a generally oblique orientation to the center axis of the fastener.
摘要翻译： 一种桁架紧固件，其包括具有头部和尖端的轴。 螺纹沿着轴从尖端向轴的头端延伸。 通过从轴的表面突出的翼中断，缩写和/或以其它方式分开螺纹。 中断突起以大致倾斜的方式延伸到紧固件的中心轴线。
-
-
-
-
-
-
-
-
-
搜索结果
42 条记录 (耗时 0.024 秒)
