公开(公告)号：US08802000B2

公开(公告)日：2014-08-12

申请号：US12511839

申请日：2009-07-29

申请人： Daniel Y. Chu ,  Hui Du

发明人： Daniel Y. Chu ,  Hui Du

IPC分类号： B29C51/10 ,  B29C51/04 ,  B01L3/00 ,  B29C51/02 ,  B29K23/00

CPC分类号： B29C51/04 ,  B01L3/50851 ,  B01L2200/12 ,  B01L2300/0829 ,  B29C51/02 ,  B29C2791/006 ,  B29K2023/06 ,  B29K2023/12

摘要： A multi-well plate with wells having ultra-thin walls and yet with sufficient structural rigidity to allow reliable use of the plate in automated instrumentation is formed by first forming a plate blank by injection molding, the blank being of a thickness that provides the desired rigidity, and then subjecting the blank to vacuum forming to stretch designated areas in the blank to form wells or to extend wells already formed, the stretching resulting in a reduction in thickness of the molded resin at the walls of the wells only.

摘要翻译： 具有超薄壁并且具有足够的结构刚性以允许在自动化仪器中可靠地使用板的多孔板通过首先通过注射成型形成板坯而形成，坯料具有提供期望的厚度 刚性，然后对坯料进行真空成形以拉伸坯料中的指定区域以形成孔或延伸已经形成的孔，拉伸仅导致在孔壁处的模制树脂的厚度减小。

公开(公告)号：US07560075B2

公开(公告)日：2009-07-14

申请号：US11339087

申请日：2006-01-24

申请人： Daniel Y. Chu

发明人： Daniel Y. Chu

IPC分类号： B01L9/00

CPC分类号： B01L9/50 ,  B01L9/523 ,  B01L2300/0829 ,  G01N35/0099 ,  G01N35/028 ,  G01N2035/042 ,  G01N2035/0493

摘要： A multi-well plate such as a microtiter plate is secured from its well side in a manner that corrects or compensates for any deviations of the plate base from a planar configuration. This is achieved by an apparatus that includes an array of posts with exposed tips that define a plane, a plurality of movable collets that, when appropriately actuated, seize the walls of selected wells, and a biasing means to urge the collets in a direction that forces the wells of the microtiter plate against the exposed tips of the posts.

摘要翻译： 诸如微量滴定板的多孔板从孔侧以固定或校正板基与平面构型的任何偏差的方式固定。 这通过一种装置实现，该装置包括具有限定平面的暴露尖端的柱阵列，当适当地致动时抓住选定孔的壁的多个可动夹头，以及偏压装置，以沿着 迫使微量滴定板的孔抵靠柱的露出尖端。

公开(公告)号：US5073246A

公开(公告)日：1991-12-17

申请号：US523786

申请日：1990-05-16

申请人： Daniel Y. Chu ,  John J. Barich

发明人： Daniel Y. Chu ,  John J. Barich

IPC分类号： C25B9/00 ,  B01D57/02 ,  G01N27/26 ,  G01N27/447

CPC分类号： G01N27/44704 ,  B01D57/02 ,  G01N27/44743

摘要： A gel enclosure and buffer tank for vertical slab gel electrophoresis are disclosed. The gel enclosure is formed from two flat plates, one of which contains angled troughs extending off to one side to serve as extensions of the sample wells, thereby increasing the volumetric capacity of each sample well, and improving the ease of loading it with sample. The buffer tank is constructed in such a manner as to hold one flat plate of the gel enclosure in contact with a flat heat transfer wall of the buffer tank, with cooling applied to the outside of the wall by thermoelectric means. Buffer solution below the gel enclosure is also cooled by the cooling wall, and bubbles generated at an electrode, also positioned below the gel enclosure, agitate the cooled buffer solution, extending the cooling effect over the entire surface of the other flat plate of the gel enclosure.

摘要翻译： 公开了用于垂直板状凝胶电泳的凝胶封壳和缓冲罐。 凝胶外壳由两个平板形成，其中一个平板包含一个延伸到一侧的成角度的槽，用作样品孔的延伸部分，从而提高每个样品孔的体积容量，并提高其与样品的相容性。 缓冲罐的构造方式是将凝胶罩的一个平板与缓冲罐的平坦传热壁接触，冷却通过热电装置施加到壁的外部。 凝胶外壳下面的缓冲溶液也被冷却壁冷却，并且在位于凝胶外壳下方的电极处产生的气泡也会搅动冷却的缓冲溶液，从而将冷却效果延伸到凝胶的另一个平板的整个表面上 外壳。

公开(公告)号：US11828084B2

公开(公告)日：2023-11-28

申请号：US17163577

申请日：2021-02-01

申请人： Daniel Y. Chu

发明人： Daniel Y. Chu

IPC分类号： E05B1/00

CPC分类号： E05B1/0053

摘要： A door-unlatching device including a lower actuator including a foot-pad, an upper actuator including a lever-arm and a handle-mount attachable to a handle of door-latch, and a link coupled to the foot-pad and the lever-arm, wherein the lever-arm is movable between a first position and a second position relative to the handle-mount. It can be set to either engaged mode which allows either hand or foot to operate; or disengaged mode to allow only hand to operate which the door can also be locked from entry as by a normal door latch.

公开(公告)号：US08784753B2

公开(公告)日：2014-07-22

申请号：US13551311

申请日：2012-07-17

申请人： Jeffry M. Ceremony ,  Daniel Y. Chu ,  Deepak K. Doshi ,  Rhoel Rumbaoa ,  Dennis W. Loring ,  Paul J. Patt ,  Cliff Baldwin

发明人： Jeffry M. Ceremony ,  Daniel Y. Chu ,  Deepak K. Doshi ,  Rhoel Rumbaoa ,  Dennis W. Loring ,  Paul J. Patt ,  Cliff Baldwin

IPC分类号： B01L3/00 ,  B01L7/00

CPC分类号： B01L7/52 ,  B01L2300/043 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/14 ,  B01L2300/1827

摘要： A thermal cycling instrument for PCR and other reactions performed on multiple samples with temperature changes between sequential stages in the reaction procedure is supplied with a thermal block to provide rapid changes and close control over the temperature in each sample vessel and a pressure plate incorporated into a motorized lid that detects anomalies in the reaction vessels or in their positioning over the thermal block, and automatically adjusts the plate position to achieve an even force distribution over the sample vessels.

摘要翻译： 在多个样品上进行PCR和其他反应的热循环仪器，在反应过程中的顺序阶段之间进行温度变化，提供热块，以提供快速变化并对每个样品容器中的温度进行快速控制， 检测反应容器中的异常或其在热块上的定位的电动盖，并自动调节板的位置以在样品容器上实现均匀的力分布。

公开(公告)号：US08247217B2

公开(公告)日：2012-08-21

申请号：US12370790

申请日：2009-02-13

申请人： Jeffry M. Ceremony ,  Daniel Y. Chu ,  Deepak K. Doshi ,  Rhoel Rumbaoa ,  Dennis W. Loring ,  Paul J. Patt ,  Cliff Baldwin

发明人： Jeffry M. Ceremony ,  Daniel Y. Chu ,  Deepak K. Doshi ,  Rhoel Rumbaoa ,  Dennis W. Loring ,  Paul J. Patt ,  Cliff Baldwin

IPC分类号： C12M1/36 ,  C12M1/02 ,  C12M1/00 ,  C12M3/00 ,  F27D11/00

CPC分类号： B01L7/52 ,  B01L2300/043 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/14 ,  B01L2300/1827

摘要： A thermal cycling instrument for PCR and other reactions performed on multiple samples with temperature changes between sequential stages in the reaction procedure is supplied with a thermal block to provide rapid changes and close control over the temperature in each sample vessel and a pressure plate incorporated into a motorized lid that detects anomalies in the reaction vessels or in their positioning over the thermal block, and automatically adjusts the plate position to achieve an even force distribution over the sample vessels.

摘要翻译： 在多个样品上进行PCR和其他反应的热循环仪器，在反应过程中的顺序阶段之间进行温度变化，提供热块，以提供快速变化并对每个样品容器中的温度进行快速控制， 检测反应容器中的异常或其在热块上的定位的电动盖，并自动调节板的位置以在样品容器上实现均匀的力分布。

公开(公告)号：US07661593B2

公开(公告)日：2010-02-16

申请号：US11291423

申请日：2005-11-30

申请人： Daniel Y. Chu

发明人： Daniel Y. Chu

IPC分类号： G06K7/14

CPC分类号： H02K41/0356

摘要： A moving coil actuator contains a magnet assembly that is movable to shift the range of motion of the coil. The magnet assembly moves between two or more positions along a path of travel that is parallel to the path of travel of the reciprocating motion of the coil. With this feature, the width of an area scanned by a scanning head affixed to the coil can be increased by multiples allowing a simple moving coil actuator to be used for any scanning width.

摘要翻译： 运动线圈致动器包括可移动以移动线圈的运动范围的磁体组件。 磁体组件沿着平行于线圈的往复运动的行进路径的行进路径在两个或更多个位置之间移动。 利用该特征，由固定到线圈上的扫描头扫描的区域的宽度可以增加多倍，从而允许使用简单的移动线圈致动器用于任何扫描宽度。

公开(公告)号：US20090269835A1

公开(公告)日：2009-10-29

申请号：US12370790

申请日：2009-02-13

申请人： Jeffry M. Ceremony ,  Daniel Y. Chu ,  Deepak K. Doshi ,  Rhoel Rumbaoa ,  Dennis W. Loring ,  Paul J. Patt ,  Cliff Baldwin

发明人： Jeffry M. Ceremony ,  Daniel Y. Chu ,  Deepak K. Doshi ,  Rhoel Rumbaoa ,  Dennis W. Loring ,  Paul J. Patt ,  Cliff Baldwin

IPC分类号： C12M1/36 ,  C12M1/02 ,  F28F3/00

CPC分类号： B01L7/52 ,  B01L2300/043 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/14 ,  B01L2300/1827

摘要： A thermal cycling instrument for PCR and other reactions performed on multiple samples with temperature changes between sequential stages in the reaction procedure is supplied with a thermal block to provide rapid changes and close control over the temperature in each sample vessel and a pressure plate incorporated into a motorized lid that detects anomalies in the reaction vessels or in their positioning over the thermal block, and automatically adjusts the plate position to achieve an even force distribution over the sample vessels.

摘要翻译： 在多个样品上进行PCR和其他反应的热循环仪器，在反应过程中的顺序阶段之间进行温度变化，提供热块，以提供快速变化并对每个样品容器中的温度进行快速控制， 检测反应容器中的异常或其在热块上的定位的电动盖，并自动调节板的位置以在样品容器上实现均匀的力分布。

公开(公告)号：US07516934B2

公开(公告)日：2009-04-14

申请号：US11361411

申请日：2006-02-24

申请人： Daniel Y. Chu ,  Paul J. Patt ,  Jeffry M. Ceremony

发明人： Daniel Y. Chu ,  Paul J. Patt ,  Jeffry M. Ceremony

IPC分类号： F16M13/00

CPC分类号： G01N35/028 ,  B01L9/523 ,  B01L2200/025 ,  B01L2300/0829

摘要： A platform that supports a sample plate such as a microtiter plate, a multi-well plate of any size, or a glass slide with sample spots distributed over its surface, and presents the plate for assay detection by a movable scanning head that has a field depth on the millimeter scale is leveled or otherwise adjusted in a planar orientation by an apparatus that includes a rocker plate, position sensors, and motorized risers arranged on the apparatus to provide the rocker plate with tilting capability along either or both or two orthogonal axes.

摘要翻译： 支撑样品板的平台，例如微量滴定板，任何尺寸的多孔板或具有分布在其表面上的样品斑点的玻片，并且通过具有场的可移动扫描头呈现用于测定检测的板 通过包括设置在设备上的摇臂板，位置传感器和电动立管的装置，平面定位或以其它方式调整深度，以使摇杆具有沿着一个或两个或两个正交轴线的倾斜能力。

公开(公告)号：US5284565A

公开(公告)日：1994-02-08

申请号：US995495

申请日：1992-12-23

申请人： Daniel Y. Chu ,  Elaine R. Mardis

发明人： Daniel Y. Chu ,  Elaine R. Mardis

IPC分类号： B01D57/02 ,  C25B7/00 ,  G01N27/447 ,  G01N27/26

CPC分类号： G01N27/44743

摘要： A comb to be used for holding samples and defining sample lanes in an ultra-thin slab gel in vertical slab gel electrophoresis is constructed with to form tapered or wedged-shaped sample wells, with the narrowest edge of the wedge opening into the upper edge of the gel. In one embodiment, the comb has a wedge-shaped profile along the contact edge to provide an expanded well at each sample location. Notches alternating with grooves are cut into the wedge shape to form teeth which taper along orthogonal axes, the wells being defined by the space between each adjacent pair of teeth. The gel enclosure which holds the slab gel is formed by plates which are shaped along one edge to provide a complementary wedge-shaped opening leading into the gel space. The comb fits snugly into the opening with the teeth of the comb touching or extending a short distance into the upper exposed surface of the gel. In another embodiment, the comb has a rectangular profile, with grooves cut to a varying depth to form the wedge shape.

摘要翻译： 用于在垂直板状凝胶电泳中用于保存样品并在超薄板状凝胶中定义样品通道的梳子被构造成形成锥形或楔形样品样品孔，其中楔形物的最窄边缘开口到 凝胶。 在一个实施例中，梳子具有沿着接触边缘的楔形轮廓，以在每个样品位置处提供扩展的孔。 与沟槽交替的凹槽被切割成楔形，以形成沿着正交轴线逐渐变细的齿，孔由每个相邻齿对之间的空间限定。 保持板状凝胶的凝胶封壳由沿着一个边缘成形的板形成，以提供通向凝胶空间的互补的楔形开口。 梳子紧密地贴合在开口中，梳子的牙齿接触或延伸到凝胶的上暴露表面的短距离。 在另一个实施例中，梳子具有矩形轮廓，其中凹槽切割成不同的深度以形成楔形。