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公开(公告)号：US11441240B2
公开(公告)日：2022-09-13
申请号：US16414548
申请日：2019-05-16
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Adam Shultz Adler , Matthew James Spindler , Rena Aviva Mizrahi
IPC: C40B40/08 , C12N15/10 , C12Q1/6888 , C07K16/00 , C07K14/725 , C07K14/74 , C12Q1/6869 , C40B50/06 , C12Q1/6806
Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.
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公开(公告)号：US20220064268A1
公开(公告)日：2022-03-03
申请号：US17469493
申请日：2021-09-08
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Sheila Keating , Adam Shultz Adler , Michael Asensio , Kacy Stadtmiller , Emily Benzie , Ariel Niedecken , Angelica V. Medina-Cucurella , Rena Aviva Mizrahi , Yoong Wearn Lim
Abstract: Provided herein are compositions comprising recombinant polyclonal protein (RPP) derived from mammalian plasma cells and plasmablasts. Specifically, RPPs specific to Zika virus are provided. Also provided are the methods of using the RPP for treatment of viral infection and the methods of making the RPPs.
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公开(公告)号：US20190316118A1
公开(公告)日：2019-10-17
申请号：US16443381
申请日：2019-06-17
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Adam Shultz Adler , Matthew James Spindler , Rena Aviva Mizrahi
IPC: C12N15/10 , C12Q1/6869 , C07K14/74 , C07K14/725 , C12Q1/6806 , C12Q1/6888 , C07K16/00
Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.
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Patent Agency Ranking
公开(公告)号：US20180258422A1
公开(公告)日：2018-09-13
申请号：US15920092
申请日：2018-03-13
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Adam Shultz Adler , Matthew James Spindler , Rena Aviva Mizrahi
IPC: C12N15/10 , C12Q1/6888 , C12Q1/6869 , C07K14/725 , C07K14/74 , C07K16/00
CPC classification number: C12N15/1065 , C07K14/7051 , C07K14/70539 , C07K16/005 , C12N15/1075 , C12Q1/6806 , C12Q1/6869 , C12Q1/6888 , C40B50/06 , C12Q2525/161 , C12Q2535/122 , C12Q2563/159 , C12Q2565/629
Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.
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公开(公告)号：US11718660B2
公开(公告)日：2023-08-08
申请号：US17469493
申请日：2021-09-08
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Sheila Keating , Adam Shultz Adler , Michael Asensio , Kacy Stadtmiller , Emily Benzie , Ariel Niedecken , Angelica V. Medina-Cucurella , Rena Aviva Mizrahi , Yoong Wearn Lim
CPC classification number: C07K16/1081 , A61P31/14 , C07K2317/52 , C07K2317/565 , C07K2317/622
Abstract: Provided herein are compositions comprising recombinant polyclonal protein (RPP) derived from mammalian plasma cells and plasmablasts. Specifically, RPPs specific to Zika virus are provided. Also provided are the methods of using the RPP for treatment of viral infection and the methods of making the RPPs.
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公开(公告)号：US20220064302A1
公开(公告)日：2022-03-03
申请号：US17418764
申请日：2019-12-27
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Adam Shultz Adler , Rena Aviva Mizrahi , Yoong Wearn Lim , Michael Asensio
Abstract: Provided herein are antigen-binding proteins (ABPs) that selectively bind to PD-1 and its isoforms and homologs, and compositions comprising the ABPs. Also provided are methods of using the ABPs, such as therapeutic and diagnostic methods.
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公开(公告)号：US20220056137A1
公开(公告)日：2022-02-24
申请号：US17418768
申请日：2019-12-27
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Adam Shultz Adler , Rena Aviva Mizrahi , Yoong Wearn Lim , Michael Asensio
Abstract: Provided herein are antigen-binding proteins (ABPs) that selectively bind to PD-L1 and its isoforms and homologs, and compositions comprising the ABPs. Also provided are methods of using the ABPs, such as therapeutic and diagnostic methods.
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公开(公告)号：US20190390190A1
公开(公告)日：2019-12-26
申请号：US16414548
申请日：2019-05-16
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Adam Shultz Adler , Matthew James Spindler , Rena Aviva Mizrahi
IPC: C12N15/10 , C12Q1/6806 , C12Q1/6869 , C07K14/74 , C07K14/725 , C07K16/00 , C12Q1/6888
Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.
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