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公开(公告)号：US08084076B2
公开(公告)日：2011-12-27
申请号：US12027347
申请日：2008-02-07
CPC分类号： A61L31/16 , A61F2/91 , A61F2250/0068 , A61L31/084 , A61L2300/416 , A61L2300/606
摘要： A process for depositing an active substance on selected regions of the surface of a stent, comprising: (i) providing the active substance in at least one form selected from the group consisting of a powder and a paste; and (ii) depositing the active substance on the selected regions of the surface of the stent.Preferably, the active substance comprises or consists essentially of FK506, such as FK506 in the form of a powder with a grain size smaller than 15 micron or a paste with a base of FK506 with a viscosity not lower than 100,000 to 120,000 cps.
摘要翻译： 一种用于在支架表面的选定区域上沉积活性物质的方法，包括：（i）提供活性物质至少一种选自粉末和糊剂的形式; 和（ii）将活性物质沉积在支架表面的选定区域上。 优选地，活性物质包含或基本上由FK506，例如粒度小于15微米的粉末形式的FK506或具有粘度不低于100,000至120,000cps的FK506基料的糊剂组成或组成。
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12.发明申请公开(公告)号：US20110066228A1
公开(公告)日：2011-03-17
申请号：US12951712
申请日：2010-11-22
IPC分类号： A61F2/82
CPC分类号： A61K9/0024 , A61F2250/0068 , A61L31/16 , A61L2300/624
摘要： A carrier for delivering at least one active principle at an intraluminal site. The carrier includes a carrier body, such as a stent. The carrier body is provided with one or more reservoirs. The reservoirs contain nanoparticles which convey at least one active principle. The nanoparticles also comprise a substance having characteristics of preferential affinity attraction to a desired region at the intraluminal site. The nanoparticles can migrate toward the preferred region.
摘要翻译： 用于在管腔内部位输送至少一种活性成分的载体。 载体包括载体如支架。 载体主体设置有一个或多个储存器。 储层包含至少一种有效原理的纳米颗粒。 纳米颗粒还包含具有对腔内部位所需区域的优先亲和力吸引特性的物质。 纳米颗粒可以朝向优选区域迁移。
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公开(公告)号：US20080140186A1
公开(公告)日：2008-06-12
申请号：US12027347
申请日：2008-02-07
CPC分类号： A61L31/16 , A61F2/91 , A61F2250/0068 , A61L31/084 , A61L2300/416 , A61L2300/606
摘要： A process for depositing an active substance on selected regions of the surface of a stent, comprising: (i) providing the active substance in at least one form selected from the group consisting of a powder and a paste; and (ii) depositing the active substance on the selected regions of the surface of the stent.Preferably, the active substance comprises or consists essentially of FK506, such as FK506 in the form of a powder with a grain size smaller than 15 micron or a paste with a base of FK506 with a viscosity not lower than 100,000 to 120,000 cps.
摘要翻译： 一种用于在支架表面的选定区域上沉积活性物质的方法，包括：（i）提供活性物质至少一种选自粉末和糊剂的形式; 和（ii）将活性物质沉积在支架表面的选定区域上。 优选地，活性物质包含或基本上由FK506，例如粒度小于15微米的粉末形式的FK506或具有粘度不低于100,000至120,000cps的FK506基料的糊剂组成或组成。
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公开(公告)号：US20130280315A1
公开(公告)日：2013-10-24
申请号：US13825074
申请日：2011-09-19
IPC分类号： A61L31/16
CPC分类号： A61L31/16 , A61L27/54 , A61L29/16 , A61L2300/41 , A61L2300/412 , A61L2300/416 , A61L2300/426 , A61L2300/43 , A61L2300/432 , A61L2300/602
摘要： Composition for delivery of at least one active principle at the implantation site of an implant device, including: at least one active principle, and at least a first excipient combined with the at least one active principle, wherein the at least a first excipient is selected among fatty acids with a linear or branched, saturated chain, including a number of carbon atoms between 14 and 36.
摘要翻译： 用于在植入装置的植入部位输送至少一种活性成分的组合物，包括：至少一种活性成分，和至少一种与所述至少一种活性成分组合的第一赋形剂，其中至少选择第一赋形剂 在具有直链或支链饱和链的脂肪酸中，包括14至36之间的多个碳原子。
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公开(公告)号：US06645243B2
公开(公告)日：2003-11-11
申请号：US09004376
申请日：1998-01-08
IPC分类号： A61F206
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91516 , A61F2002/91541 , A61F2210/0095 , A61N5/1002
摘要： The stent for angioplasty has a body in the form of a generally tubular casing capable of being dilated in use from a radially-contracted position to a radially-expanded position. The body includes a support structure made from a first material capable of withstanding this dilation without losing its structural integrity. A structure made from a second material which has been rendered radioactive following the exposure of the stent itself to a neutron flux is associated with at least a portion of the carrying structure.
摘要翻译： 用于血管成形术的支架具有大体管状外壳形式的本体，其能够在使用中从径向收缩位置扩张到径向扩张位置。 主体包括由能够承受该膨胀而不失去其结构完整性的第一材料制成的支撑结构。 由支架本身暴露于中子通量后被放射性的第二材料制成的结构与承载结构的至少一部分相关联。
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公开(公告)号：US07607208B2
公开(公告)日：2009-10-27
申请号：US10431557
申请日：2003-05-07
申请人： Maria Curcio , Giovanni Rolando , Franco Vallana
发明人： Maria Curcio , Giovanni Rolando , Franco Vallana
CPC分类号： A61F2/82 , A61F2/0077 , A61F2/86 , A61F2250/0025 , A61F2250/0068 , A61F2310/00574 , A61F2310/0058 , A61L31/022 , A61L31/084 , A61L31/14 , A61L31/16 , A61L33/025 , A61L2300/416 , A61L2300/42 , A61L2400/18 , Y10T29/49885 , Y10T29/49995
摘要： A stent has surface sculpturing, preferably on its outer surface only, having, for example, microspheres, having the function of increasing the actual geometric surface area of the stent, of creating undercuts and roughness to encourage the application of coatings of active or activatable agents, as well as of improving the attachment of the stent to the blood vessel wall.
摘要翻译： 支架具有表面雕刻，优选仅在其外表面上具有例如具有增加支架的实际几何表面积的功能的微球，产生底切和粗糙度以促进施加活性或可激活剂的涂层 ，以及改善支架到血管壁的附着。
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公开(公告)号：US07739781B2
公开(公告)日：2010-06-22
申请号：US11691933
申请日：2007-03-27
申请人： Maria Curcio , Giovanni Rolando , Franco Vallana
发明人： Maria Curcio , Giovanni Rolando , Franco Vallana
CPC分类号： A61F2/82 , A61F2/0077 , A61F2/86 , A61F2250/0025 , A61F2250/0068 , A61F2310/00574 , A61F2310/0058 , A61L31/022 , A61L31/084 , A61L31/14 , A61L31/16 , A61L33/025 , A61L2300/416 , A61L2300/42 , A61L2400/18 , Y10T29/49885 , Y10T29/49995
摘要： A stent has surface sculpturing, preferably on its outer surface only, having, for example, microspheres, having the function of increasing the actual geometric surface area of the stent, of creating undercuts and roughness to encourage the application of coatings of active or activatable agents, as well as of improving the attachment of the stent to the blood vessel wall.
摘要翻译： 支架具有表面雕刻，优选仅在其外表面上具有例如具有增加支架的实际几何表面积的功能的微球，产生底切和粗糙度以促进施加活性或可激活剂的涂层 ，以及改善支架到血管壁的附着。
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公开(公告)号：US20070151093A1
公开(公告)日：2007-07-05
申请号：US11691933
申请日：2007-03-27
申请人： Maria Curcio , Giovanni Rolando , Franco Vallana
发明人： Maria Curcio , Giovanni Rolando , Franco Vallana
IPC分类号： B23P13/04
CPC分类号： A61F2/82 , A61F2/0077 , A61F2/86 , A61F2250/0025 , A61F2250/0068 , A61F2310/00574 , A61F2310/0058 , A61L31/022 , A61L31/084 , A61L31/14 , A61L31/16 , A61L33/025 , A61L2300/416 , A61L2300/42 , A61L2400/18 , Y10T29/49885 , Y10T29/49995
摘要： A stent has surface sculpturing, preferably on its outer surface only, having, for example, microspheres, having the function of increasing the actual geometric surface area of the stent, of creating undercuts and roughness to encourage the application of coatings of active or activatable agents, as well as of improving the attachment of the stent to the blood vessel wall.
摘要翻译： 支架具有表面雕刻，优选仅在其外表面上具有例如具有增加支架的实际几何表面积的功能的微球，产生底切和粗糙度以促进施加活性或可激活剂的涂层 ，以及改善支架到血管壁的附着。
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公开(公告)号：US06638302B1
公开(公告)日：2003-10-28
申请号：US08997597
申请日：1997-12-23
申请人： Maria Curcio , Giovanni Rolando , Franco Vallana
发明人： Maria Curcio , Giovanni Rolando , Franco Vallana
IPC分类号： A61F206
CPC分类号： A61F2/82 , A61F2/0077 , A61F2/86 , A61F2250/0025 , A61F2250/0068 , A61F2310/00574 , A61F2310/0058 , A61L31/022 , A61L31/084 , A61L31/14 , A61L31/16 , A61L33/025 , A61L2300/416 , A61L2300/42 , A61L2400/18 , Y10T29/49885 , Y10T29/49995
摘要： The stent (1) has surface sculpturing, preferably on its outer surface (2) only, constituted, for example, by microspheres (3), having the function of increasing the actual geometric surface area of the stent, of creating undercuts and roughness to encourage the application of coatings of active or activatable agents, as well as of improving the attachment of the stent (1) to the blood vessel wall.
摘要翻译： 支架（1）具有表面雕刻，优选仅在其外表面（2）上构成，例如由微球（3）构成，具有增加支架实际几何表面积的功能，产生底切和粗糙度 鼓励使用活性或可激活剂的涂层，以及改善支架（1）与血管壁的连接。
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20.发明授权公开(公告)号：US06585632B2
公开(公告)日：2003-07-01
申请号：US10236680
申请日：2002-09-06
IPC分类号： A61N500
CPC分类号： A61F2/82 , A61F2/07 , A61F2/91 , A61F2/92 , A61F2210/0095 , A61F2250/0039 , A61K51/1272 , A61N5/1002 , A61N2005/1004
摘要： A device, method, and kit for conveying a radioactive agent to a site of stenosis. The device includes a body portion to be disposed about the surface of a stent. The device comprises a radioactive agent. The device is capable of expanding, thus following the deployment movement of the stent, and is used to counter restenosis.
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