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公开(公告)号：US20180016285A1
公开(公告)日：2018-01-18
申请号：US15718422
申请日：2017-09-28
发明人： Stephen J. Baker , Vincent S. Hernandez , Rashmi Sharma , James A. Nieman , Tsutomu Akama , Yong-Kang Zhang , Jacob J. Plattner , Michael Richard Kevin Alley , Rajeshwar Singh , Fernando Rock
摘要： This invention provides, among other things, novel compounds useful for treating bacterial infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
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公开(公告)号：US20150080342A1
公开(公告)日：2015-03-19
申请号：US14394427
申请日：2013-03-15
IPC分类号： A61K31/69 , A61K31/198
CPC分类号： A61K31/69 , A61K31/198 , Y02A50/473 , A61K2300/00
摘要： Norvaline and/or other amino acids that are capable of being acylated onto tRNALeu by LeuRS, in combination with substituted benzoxaboroles, such as a compound having a structure according to formula III: and methods for decreasing the frequency of resistance and/or reducing the rate of resistance and/or suppressing the emergence of resistance that develops in bacteria exposed to a substituted benzoxaborole or salt thereof by administering a combination of a substituted benzoxaborole such as a compound of formula III or salt thereof and an amino acid or a salt thereof.
摘要翻译： 能够通过LeuRS酰化成tRNALeu的诺瓦宁和/或其它氨基酸与取代的苯并恶唑组合，例如具有根据式III的结构的化合物，以及降低抗性频率和/或降低速率的方法 的抗性和/或抑制暴露于取代的苯并恶唑或其盐的细菌中产生的抗性的出现，其通过给予取代的苯并恶灵如结构式III的化合物或其盐与氨基酸或其盐的组合。
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公开(公告)号：US20140011768A1
公开(公告)日：2014-01-09
申请号：US13915494
申请日：2013-06-11
发明人： Tsutomu Akama , Yong-Kang Zhang , Charles Z. Ding , Jacob J. Plattner , Kirk R. Maples , Yvonne Freund , Virginia Sanders , Yi Xia , Stephen J. Baker , James A. Nieman , Xiaosong Lu , Marcelo Sales , Rashmi Sharma , Rajeshwar Singh , Robert Jacobs , Daitao Chen , Michael Richard Kevin Alley
IPC分类号： C07F5/04
CPC分类号： C07F5/025 , A61K31/69 , C07F5/04 , Y02A50/411
摘要： Compounds and methods of treating anti-inflammatory conditions are disclosed.
摘要翻译： 公开了治疗抗炎症状的化合物和方法。
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公开(公告)号：US11008345B2
公开(公告)日：2021-05-18
申请号：US16526248
申请日：2019-07-30
发明人： Vincent S. Hernandez , Charles Ding , Jacob J. Plattner , Michael Richard Kevin Alley , Fernando Rock , Suoming Zhang , Eric Easom , Xianfeng Li , Ding Zhou
IPC分类号： C07F5/02
摘要： This invention relates to, among other items, benzoxaborole compounds and their use for treating bacterial infections.
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公开(公告)号：US10533021B2
公开(公告)日：2020-01-14
申请号：US15718422
申请日：2017-09-28
发明人： Stephen J. Baker , Vincent S. Hernandez , Rashmi Sharma , James A. Nieman , Tsutomu Akama , Yong-Kang Zhang , Jacob J. Plattner , Michael Richard Kevin Alley , Rajeshwar Singh , Fernando Rock
摘要： This invention provides, among other things, novel compounds useful for treating bacterial infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
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公开(公告)号：US09889146B2
公开(公告)日：2018-02-13
申请号：US15162125
申请日：2016-05-23
IPC分类号： A61K31/69 , A61K31/195 , A61K31/198
CPC分类号： A61K31/69 , A61K31/198 , A61K2300/00
摘要： Norvaline and/or other amino acids that are capable of being acylated onto tRNALeu by LeuRS, in combination with substituted benzoxaboroles, such as a compound having a structure according to formula III: and methods for decreasing the frequency of resistance and/or reducing the rate of resistance and/or suppressing the emergence of resistance that develops in bacteria exposed to a substituted benzoxaborole or salt thereof by administering a combination of a substituted benzoxaborole such as a compound of formula III or salt thereof and an amino acid or a salt thereof.
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公开(公告)号：US09796735B2
公开(公告)日：2017-10-24
申请号：US14536483
申请日：2014-11-07
发明人： Stephen J. Baker , Vincent S. Hernandez , Rashmi Sharma , James A. Nieman , Tsutomu Akama , Yong-Kang Zhang , Jacob J. Plattner , Michael Richard Kevin Alley , Rajeshwar Singh , Fernando Rock
CPC分类号： C07F5/025 , A61K31/69 , Y02A50/387
摘要： The compounds are of the class of 3,7 substituted benzoxaboroles, useful for killing and/or inhibiting the growth of microorganisms.
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公开(公告)号：US09353133B2
公开(公告)日：2016-05-31
申请号：US14201459
申请日：2014-03-07
发明人： Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zegar , Yong-Kang Zhang , Huchen Zhou
IPC分类号： C07F5/04 , C07F5/02 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , A61K31/69 , A61K31/70 , A61K31/7076
CPC分类号： C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
摘要： This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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公开(公告)号：US20140315860A1
公开(公告)日：2014-10-23
申请号：US14221637
申请日：2014-03-21
发明人： Vincent S. HERNANDEZ , Charles Ding , Jacob J. Plattner , Michael Richard Kevin Alley , Fernando Rock , Suoming Zhang , Eric Easom , Xianfeng Li , Ding Zhou
IPC分类号： C07F5/02
CPC分类号： C07F5/025
摘要： This invention relates to, among other items, benzoxaborole compounds and their use for treating bacterial infections.
摘要翻译： 本发明涉及苯并恶唑化合物及其用于治疗细菌感染的用途。
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