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公开(公告)号：US20100047275A1
公开(公告)日：2010-02-25
申请号：US12278728
申请日：2007-02-05
IPC分类号： A61K39/145 , C07K7/08 , C07K14/005 , A61K38/16 , A61K38/10 , C07K1/00 , A61P37/06
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/55566 , A61K2039/57 , A61K2039/572 , A61K2039/70 , C07K7/08 , C07K14/005 , C07K14/11 , C12N2760/16122 , C12N2760/16134 , C12N2760/16171 , C12N2760/16222 , C12N2760/16234 , C12N2760/16271
摘要： Provided is a polypeptide having no more than 100 amino acids, which polypeptide comprises one or more sequences having at least 60% homology with any of SEQ ID 1-6, or comprises two or more epitopes having 7 amino acids or more, each epitope having at least 60% homology with a sub-sequence of any of SEQ ID 1-6 that has the same length as the epitope: SEQ ID 1DLEALMEWLKTRPILSPLTKGILGFVFTLTVP SEQ ID 2LLYCLMVMYLNPGNYSMQVKLGTLCALCEKQASHS SEQ ID 3DLIFLARSALILRGSVAHKSC SEQ ID 4PGIADIEDLTLLARSMVVVRP SEQ ID 5LLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQ SEQ ID 6IIGILHLILWILDRLFFKCIYRLF wherein, the polypeptide is immunogenic in a vertebrate expressing a major histocompatibility complex (MHC) allele, and wherein the polypeptide is not a complete influenza virus protein.
摘要翻译： 提供的多肽具有不超过100个氨基酸，该多肽包含与SEQ ID 1-6中任一个具有至少60％同源性的一个或多个序列，或包含具有7个或更多个氨基酸的两个或多个表位，每个表位具有 与SEQ ID 1-6中任一个具有与表位相同长度的亚序列至少60％的同源性：SEQ ID 1 DLEALMEWLKTRPILSPLTKGILGFVFTLTVP SEQ ID 2 LLYCLMVMYLNPGNYSMQVKLGTLCALCEKQASHS SEQ ID 3 DLIFLARSALILRGSVAHKSC SEQ ID 4 PGIADIEDLTLLARSMVVVRP SEQ ID 5 LLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQ SEQ ID 6 IIGILHLILWILDRLFFKCIYRLF其中，所述多肽在表达主要组织相容性复合体（MHC）等位基因的脊椎动物中是免疫原性的，并且其中所述多肽不是完整的流感病毒蛋白质。
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公开(公告)号：US09056140B2
公开(公告)日：2015-06-16
申请号：US12677701
申请日：2008-09-11
CPC分类号： A61K47/48061 , A61K47/545 , A61K47/6415
摘要： Provided is a compound comprising: (a) a first component capable of binding to ER+ cell receptors; and (b) a second component; wherein the second component is a ribosome inactivating toxin and is conjugated to the first component.
摘要翻译： 提供了一种化合物，其包含：（a）能够结合ER +细胞受体的第一组分; 和（b）第二组分; 其中所述第二组分是核糖体灭活毒素并与第一组分缀合。
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公开(公告)号：US08895537B2
公开(公告)日：2014-11-25
申请号：US13365828
申请日：2012-02-03
申请人： Robin Mark Bannister , John Brew , Suzanne Jane Dilly , Gregory Alan Stoloff , Wilson Caparros-Wanderley
发明人： Robin Mark Bannister , John Brew , Suzanne Jane Dilly , Gregory Alan Stoloff , Wilson Caparros-Wanderley
CPC分类号： A61K31/192 , A61K9/08 , A61K9/2013 , A61K31/19 , A61K31/196 , A61K31/215 , A61K31/216 , A61K31/22 , A61K31/40 , A61K31/60 , A61K47/10 , A61K47/14 , A61K47/34 , A61K47/44 , Y02A50/463
摘要： The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a cardiovascular disease in an individual using such pharmaceutical compositions.
摘要翻译： 本说明书公开了药物组合物，制备这种药物组合物的方法，以及使用这种药物组合物治疗个体心血管疾病的方法和用途。
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公开(公告)号：US20130039937A1
公开(公告)日：2013-02-14
申请号：US13526467
申请日：2012-06-18
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/55544 , C07K14/005 , C07K2319/01 , C12N7/00 , C12N2740/16034 , C12N2740/16071 , C12N2740/16322 , C12N2740/16334
摘要： Provided is a polypeptide having no more than 100 amino acids, which polypeptide comprises one or more sequences having at least 60% homology with any of SEQ ID 1-4, or comprises two or more epitopes having 7 amino acids or more, each epitope having at least 60% homology with a sub-sequence of any of SEQ ID 1-4 that has the same length as the epitope: SEQ ID 1 GDTWAGVEAIIRILQQLLFIHFRIGCQHSR SEQ ID 2 KVGSLQYLALTALITPKKIKPPLPSVKKLTEDRWNKPQKT SEQ ID 3 EPVPLQLPPLERLTLDCSEDCGTSGTQ SEQ ID 4 YKGALDLSHFLKEKGGLEGLIYSQKRQDILDLWVYHTQGYFPD wherein, the polypeptide is immunogenic in a vertebrate expressing a major histocompatibility complex (MHC) allele, and wherein the polypeptide is not a complete HIV virus protein.
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