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公开(公告)号:US20060200113A1
公开(公告)日:2006-09-07
申请号:US11353854
申请日:2006-02-13
申请人: David Haffner , Hosheng Tu , Gregory Smedley
发明人: David Haffner , Hosheng Tu , Gregory Smedley
IPC分类号: A61B18/18
CPC分类号: A61F9/00781 , A61M5/14
摘要: Methods of treating glaucoma are described including treatment of an eye with a liquid jet. The liquid jet can be generated by a laser-induced liquid jet instrument which is inserted through an incision in an eye. A stent can also be used, the stent having an inflow portion that is in fluid communication with an outflow portion. The stent can be inserted into the eye and transported from the incision through the anterior chamber of the eye toward the trabecular meshwork of the eye. In some embodiments, the stent can be advanced through the anterior chamber of the eye and provide fluid communication between the anterior chamber and Schlemm's canal. The method includes infusing fluid into an aqueous cavity and increasing the pressure of the fluid within the aqueous cavity.
摘要翻译: 描述治疗青光眼的方法,包括用液体射流治疗眼睛。 液体射流可以通过激光诱导的液体喷射器产生,其通过眼睛中的切口插入。 还可以使用支架,所述支架具有与流出部分流体连通的流入部分。 支架可以插入眼睛,并从切口通过眼睛的前房转移到眼睛的小梁网。 在一些实施例中,支架可以推进穿过眼睛的前房并且在前房和施莱姆氏管之间提供流体连通。 该方法包括将流体输入水腔并增加水腔内的流体的压力。
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公开(公告)号:US08617094B2
公开(公告)日:2013-12-31
申请号:US11332746
申请日:2006-01-12
申请人: Gregory Smedley , David Haffner , Hosheng Tu
发明人: Gregory Smedley , David Haffner , Hosheng Tu
CPC分类号: A61F9/00781 , A61F9/0017 , A61F9/00745 , A61F2009/00891 , A61M5/14 , A61M27/002 , A61M2210/0612
摘要: Methods of treating ocular disorders are disclosed, such as a method that includes inserting an implant in eye tissue, using a delivery instrument, such that an inlet portion of the implant is in an anterior chamber of an eye and an outlet portion of the implant is in a physiological outflow pathway; removing the delivery instrument from the eye without removing the implant; and conducting fluid comprising a therapeutic substance through the implant and into the physiological outflow pathway. Another method includes inserting an instrument into a physiologic outflow pathway through which aqueous humor drains from an anterior chamber of an eye; separating first and second walls of tissues which comprise the physiologic outflow pathway by injecting a fluid comprising a drug from the instrument while the instrument remains in the physiologic outflow pathway; and withdrawing the instrument following the injection with said fluid remaining within the eye such that the drug has a therapeutic effect on the eye.
摘要翻译: 公开了治疗眼部疾病的方法,例如包括使用输送器械将植入物插入眼睛组织中的方法,使得植入物的入口部分在眼睛的前房中并且植入物的出口部分是 在生理流出途径; 在不移除植入物的情况下从眼睛移除输送器械; 以及通过植入物导入包含治疗物质的流体并进入生理流出道。 另一种方法包括将器械插入生理流出通道,通过该生理流出通道从眼睛的前房排出房水; 通过在所述仪器保持在所述生理流出路径中时从所述仪器注入包含药物的流体来分离包括所述生理流出路径的组织的第一和第二壁; 并且在所述注射之后,将所述液体留在眼睛内,使得药物对眼睛具有治疗作用。
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公开(公告)号:US20080183121A2
公开(公告)日:2008-07-31
申请号:US11332746
申请日:2006-01-12
申请人: Gregory Smedley , David Haffner , Hosheng Tu
发明人: Gregory Smedley , David Haffner , Hosheng Tu
IPC分类号: A61M5/00
CPC分类号: A61F9/00781 , A61F9/0017 , A61F9/00745 , A61F2009/00891 , A61M5/14 , A61M27/002 , A61M2210/0612
摘要: Methods of treating ocular disorders are disclosed, such as a method that includes inserting an implant in eye tissue, using a delivery instrument, such that an inlet portion of the implant is in an anterior chamber of an eye and an outlet portion of the implant is in a physiological outflow pathway; removing the delivery instrument from the eye without removing the implant; and conducting fluid comprising a therapeutic substance through the implant and into the physiological outflow pathway. Another method includes inserting an instrument into a physiologic outflow pathway through which aqueous humor drains from an anterior chamber of an eye; separating first and second walls of tissues which comprise the physiologic outflow pathway by injecting a fluid comprising a drug from the instrument while the instrument remains in the physiologic outflow pathway; and withdrawing the instrument following the injection with said fluid remaining within the eye such that the drug has a therapeutic effect on the eye.
摘要翻译: 公开了治疗眼部疾病的方法,例如包括使用输送器械将植入物插入眼睛组织中的方法,使得植入物的入口部分在眼睛的前房中并且植入物的出口部分是 在生理流出途径; 在不移除植入物的情况下从眼睛移除输送器械; 以及通过植入物导入包含治疗物质的流体并进入生理流出道。 另一种方法包括将器械插入生理流出通道,通过该生理流出通道从眼睛的前房排出房水; 通过在所述仪器保持在所述生理流出路径中时从所述仪器注入包含药物的流体来分离包括所述生理流出路径的组织的第一和第二壁; 并且在所述注射之后,将所述液体留在眼睛内,使得药物对眼睛具有治疗作用。
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公开(公告)号:US07186232B1
公开(公告)日:2007-03-06
申请号:US10384912
申请日:2003-03-07
申请人: Gregory Smedley , David Haffner , Hosheng Tu
发明人: Gregory Smedley , David Haffner , Hosheng Tu
CPC分类号: A61F9/00781 , A61F9/0017 , A61F9/00745 , A61F2009/00891 , A61M5/14 , A61M27/002 , A61M2210/0612
摘要: The invention relates to methods of treating glaucoma, such as a method that includes inserting a stent through an incision in an eye; the stent having an inflow portion that is in fluid communication with an outflow portion of the stent; transporting the stent from the incision through the anterior chamber of the eye to an aqueous cavity of the eye, such that the inflow portion of the stent is positioned in the anterior chamber and the outflow portion of the stent is positioned at the aqueous cavity; and infusing fluid from the inflow portion to the outflow portion of the stent.
摘要翻译: 本发明涉及治疗青光眼的方法,例如包括通过切口在眼中插入支架的方法; 支架具有与支架的流出部分流体连通的流入部分; 将支架从切口穿过眼睛的前房运送到眼睛的水腔,使得支架的流入部分位于前房中,并且支架的流出部分位于水腔; 并将流体从流入部分输注到支架的流出部分。
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公开(公告)号:US20100234790A1
公开(公告)日:2010-09-16
申请号:US12772889
申请日:2010-05-03
申请人: Hosheng Tu , Barbara Niksch , David Haffner , Gregory Smedley , Olav B. Bergheim , Morteza (Mory) Gharib
发明人: Hosheng Tu , Barbara Niksch , David Haffner , Gregory Smedley , Olav B. Bergheim , Morteza (Mory) Gharib
IPC分类号: A61M1/00
CPC分类号: A61F9/00781 , A61F9/0017 , A61F2250/0067 , A61L27/54 , A61L2300/258 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/42 , A61L2430/16 , A61M27/002
摘要: Implants and methods for treating ocular disorders are provided. One method involves introducing an implant into an anterior chamber of an eye such that at least a distal end of the implant is temporarily in the anterior chamber. The implant is implanted into eye tissue adjacent the anterior chamber. A therapeutic agent is eluted from the implant into at least one of the anterior chamber, a physiologic outflow pathway of the eye, and a space adjacent a choroid of the eye. The therapeutic agent can be an antiproliferative agent, an anti-inflammatory drug, or a compound for treating glaucoma or ocular hypertension. The therapeutic agent can be contained within the implant or coated on the implant.
摘要翻译: 提供了用于治疗眼部疾病的植入物和方法。 一种方法包括将植入物引入眼睛的前房,使得植入物的至少远端暂时位于前房中。 将植入物植入邻近前房的眼组织。 将治疗剂从植入物洗脱到前房中的至少一个,眼睛的生理流出路径和与眼睛的脉络膜相邻的空间。 治疗剂可以是抗增生剂,抗炎药或治疗青光眼或高眼压症的化合物。 治疗剂可以包含在植入物内或涂覆在植入物上。
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公开(公告)号:US20070118147A1
公开(公告)日:2007-05-24
申请号:US11653815
申请日:2007-01-16
申请人: Gregory Smedley , David Haffner , Barbara Niksch , Hosheng Tu , Thomas Burns
发明人: Gregory Smedley , David Haffner , Barbara Niksch , Hosheng Tu , Thomas Burns
IPC分类号: A61F9/00
CPC分类号: A61F9/00781 , A61F9/0017 , A61F9/00736 , A61F9/00754
摘要: A method is provided for treatment of cataract in combination with a glaucoma procedure while maintaining the intraocular pressure by permitting aqueous to flow out of an anterior chamber of the eye through a surgically stented pathway. A trabecular stent is adapted for implantation within the trabecular meshwork of an eye such that intraocular liquid flows controllably from the anterior chamber of the eye to Schlemm's canal, bypassing the trabecular meshwork. Depending upon the specific treatment contemplated, pharmaceuticals may be utilized in conjunction with the trabecular stent enabling post-cataract healing processes.
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公开(公告)号:US20060047263A1
公开(公告)日:2006-03-02
申请号:US11255625
申请日:2005-10-21
申请人: Hosheng Tu , Gregory Smedley , Barbara Niksch , David Haffner
发明人: Hosheng Tu , Gregory Smedley , Barbara Niksch , David Haffner
IPC分类号: A61M31/00
CPC分类号: A61F2/16 , A61F9/00781 , A61K9/0048
摘要: The invention relates generally medical devices and methods for the treatment of glaucoma in an animal eye and, more particularly, to medical devices and methods for treating tissue of the trabecular meshwork and/or Schlemm's canal of the eye to restore or rejuvenate a portion or all of the normal physiological function of directing aqueous outflow for maintaining a normal intraocular pressure in the eye.
摘要翻译: 本发明一般涉及用于治疗动物眼睛中的青光眼的医疗装置和方法,更具体地,涉及用于治疗小梁网和/或眼睛的施莱姆氏管的组织以恢复或恢复一部分或全部的医疗装置和方法 引导水流出的正常生理功能,以维持眼中正常的眼内压。
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公开(公告)号:US07708711B2
公开(公告)日:2010-05-04
申请号:US10706300
申请日:2003-11-12
申请人: Hosheng Tu , Barbara Niksch , David Haffner , Gregory Smedley , Olav B. Bergheim , Morteza (Mory) Gharib
发明人: Hosheng Tu , Barbara Niksch , David Haffner , Gregory Smedley , Olav B. Bergheim , Morteza (Mory) Gharib
IPC分类号: A61M19/00
CPC分类号: A61F9/00781 , A61F9/0017 , A61F2250/0067 , A61L27/54 , A61L2300/258 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/42 , A61L2430/16 , A61M27/002
摘要: Devices and methods are provided for the treatment of ocular disorders. An ocular implant has a body comprising material that includes a therapeutic drug. The body has an inlet portion and an outlet portion. The inlet portion is configured to reside in an anterior chamber of an eye when the outlet portion is disposed in a physiological outflow pathway of the eye. The outlet portion has an outflow opening such that the body drains fluid from the anterior chamber to the physiological outflow pathway. One method of treating an ocular disorder involves introducing an implant comprising a therapeutic drug into the eye such that the implant drains aqueous humor into a physiological outflow pathway and the therapeutic drug reaches eye tissue.
摘要翻译: 提供了用于治疗眼部疾病的装置和方法。 眼部植入物具有包含治疗药物的材料的主体。 主体具有入口部分和出口部分。 当出口部分设置在眼睛的生理流出路径中时,入口部分构造成位于眼睛的前房中。 出口部分具有流出开口,使得主体将流体从前房排出到生理流出路径。 治疗眼部疾病的一种方法包括将包含治疗药物的植入物引入眼睛,使得植入物将房水排入生理流出途径,并且治疗药物到达眼组织。
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公开(公告)号:US20070112292A1
公开(公告)日:2007-05-17
申请号:US11598542
申请日:2006-11-13
申请人: Hosheng Tu , Gregory Smedley , David Haffner , Barbara Niksch
发明人: Hosheng Tu , Gregory Smedley , David Haffner , Barbara Niksch
IPC分类号: A61M5/00
CPC分类号: A61M27/00 , A61F9/00781
摘要: The invention relates generally to medical devices and methods for reducing the intraocular pressure in an animal eye and, more particularly, to stent type devices for permitting aqueous outflow from the eye's anterior chamber and associated methods thereof for the treatment of glaucoma. Some aspects provide a self-trephining glaucoma stent and methods thereof which advantageously allow for a “one-step” procedure in which the incision and placement of the stent are accomplished by a single device and operation. This desirably allows for a faster, safer, and less expensive surgical procedure.
摘要翻译: 本发明一般涉及用于降低动物眼睛中的眼内压的医疗装置和方法,更具体地,涉及用于允许水眼从前房的水流出及其相关方法用于治疗青光眼的支架型装置。 一些方面提供了自交叉青光眼支架及其方法,其有利地允许通过单个装置和操作实现支架的切口和放置的“一步”程序。 这理想地允许更快,更安全和更便宜的外科手术。
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公开(公告)号:US20060116626A1
公开(公告)日:2006-06-01
申请号:US11332746
申请日:2006-01-12
申请人: Gregory Smedley , David Haffner , Hosheng Tu
发明人: Gregory Smedley , David Haffner , Hosheng Tu
IPC分类号: A61M5/00
CPC分类号: A61F9/00781 , A61F9/0017 , A61F9/00745 , A61F2009/00891 , A61M5/14 , A61M27/002 , A61M2210/0612
摘要: Methods of treating glaucoma are disclosed, such as a method that includes inserting a stent through an incision in an eye; the stent having an inflow portion that is in fluid communication with an outflow portion of the stent; transporting the stent from the incision through the anterior chamber of the eye to an aqueous cavity of the eye, such that the inflow portion of the stent is positioned in the anterior chamber and the outflow portion of the stent is positioned at the aqueous cavity; and infusing fluid from the inflow portion to the outflow portion of the stent.
摘要翻译: 公开了治疗青光眼的方法,例如包括通过切口在眼中插入支架的方法; 支架具有与支架的流出部分流体连通的流入部分; 将支架从切口穿过眼睛的前房运送到眼睛的水腔,使得支架的流入部分位于前房中,并且支架的流出部分位于水腔; 并将流体从流入部分输注到支架的流出部分。
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