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公开(公告)号：US06855132B2
公开(公告)日：2005-02-15
申请号：US10342023
申请日：2003-01-14
IPC分类号： C12N15/09 , A61K31/711 , A61K48/00 , A61M5/158 , A61M5/32 , A61M25/00 , A61M31/00 , A61P43/00
CPC分类号： A61M5/3286 , A61M5/3291 , A61M25/0068 , A61M2025/0057 , A61M2025/0073
摘要： The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue. A guidance catheter can be used to direct the invention devices to a remote internal injection site. The invention devices and methods can be used to inject fluids (including those containing nucleic acids for gene therapy) into interior body walls or tissue, such as a beating heart, without substantial loss of fluid and without substantial damage to tissue caused by injectate.
摘要翻译： 本发明提供具有多孔远端部分的手术针头，其中注射的液体将在注射压力下多次地渗漏或渗出，同时针的多孔远端部分插入体表面。 针的多孔远端部分可以由多孔碳，金属，陶瓷或聚合物制成，并且优选地具有减小的流向梯度的流体流向针的位置以补偿注射压力随着流体朝向 这点，从而确保注射过程中注射剂的均匀渗漏。 该针适于附接到导管或注射器。 在另一个实施例中，提供了一种手术组合件，其中具有类似流体流动特征的多孔远侧部分沿着导管的远端定位，并且针尖附接到导管的远端（例如，可导向的导管），用于 刺穿组织。 引导导管可用于将本发明装置引导到远程内部注射部位。 本发明的装置和方法可用于将流体（包括含有用于基因治疗的核酸的那些）注射到内部体壁或组织（例如打浆心脏）中，而没有明显的流体损失，并且对注射造成的组织没有实质的损害。
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公开(公告)号：US06569129B1
公开(公告)日：2003-05-27
申请号：US09661439
申请日：2000-09-13
IPC分类号： A61M2500
CPC分类号： A61B17/3207 , A61B17/22 , A61B18/1477 , A61B18/1492 , A61B2017/00252 , A61B2017/22044 , A61B2017/22067 , A61B2017/22077 , A61B2017/22082 , A61B2017/22084 , A61B2018/1425
摘要： A catheter delivery system for delivering a treatment substance to an occlusion in a lumen of a tubular vessel includes a tubular catheter and a treatment substance. The tubular catheter includes a central lumen passing between a proximal end and a distal end adjacent to an inflatable balloon. The treatment substance is in a form that is configured to be deliverable through the central lumen of the catheter into the lumen of the tubular vessel and to solidify in the vessel.
摘要翻译： 用于将处理物质输送到管状容器的内腔中的闭塞的导管输送系统包括管状导管和处理物质。 管状导管包括中心腔，其通过邻近可膨胀气囊的近端和远端之间。 治疗物质是被构造成可以通过导管的中央腔输送到管状血管的腔中并在血管中固化的形式。
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公开(公告)号：US06547769B2
公开(公告)日：2003-04-15
申请号：US09829022
申请日：2001-04-09
IPC分类号： A61M532
CPC分类号： A61M5/3286 , A61M5/3291 , A61M25/0068 , A61M2025/0057 , A61M2025/0073
摘要： The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue. A guidance catheter can be used to direct the invention devices to a remote internal injection site. The invention devices and methods can be used to inject fluids (including those containing nucleic acids for gene therapy) into interior body walls or tissue, such as a beating heart, without substantial loss of fluid and without substantial damage to tissue caused by injectate.
摘要翻译： 本发明提供具有多孔远端部分的手术针头，其中注射的液体将在注射压力下多次地渗漏或渗出，同时针的多孔远端部分插入体表面。 针的多孔远端部分可以由多孔碳，金属，陶瓷或聚合物制成，并且优选地具有减小的流向梯度的流体流向针的位置以补偿注射压力随着流体朝向 这点，从而确保注射过程中注射剂的均匀渗漏。 该针适于附接到导管或注射器。 在另一个实施例中，提供了一种手术组合件，其中具有类似流体流动特征的多孔远侧部分沿着导管的远端定位，并且针尖附接到导管的远端（例如，可导向的导管），用于 刺穿组织。 引导导管可用于将本发明装置引导到远程内部注射部位。 本发明的装置和方法可用于将流体（包括含有用于基因治疗的核酸的那些）注射到内部体壁或组织（例如打浆心脏）中，而没有明显的流体损失，并且对注射造成的组织没有实质的损害。
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公开(公告)号：US08579955B2
公开(公告)日：2013-11-12
申请号：US11551670
申请日：2006-10-20
IPC分类号： A61F2/82
CPC分类号： A61M29/02 , A61F2/07 , A61F2/24 , A61F2/2481 , A61F2/2487 , A61F2/82 , A61F2/848 , A61F2/90 , A61F2002/821 , A61F2002/8483 , A61F2220/0016 , A61M29/00
摘要： An apparatus and method of use are disclosed for treating, preventing and terminating arrhythmias. In particular, the apparatus is implantable within or on various tissues and structures and is used to prevent or block conduction of aberrant impulses. A variety of methods of the present invention may be used to attack arrhythmias by short-circuiting impulses, inducing fibrosis, ablating tissue or inducing inflammation. In addition, the device and methods may also be used to treat aneurysms. The device may also be used to treat hypertension, and to function as a blood pressure regulator.
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公开(公告)号：US08204600B2
公开(公告)日：2012-06-19
申请号：US12094704
申请日：2006-11-21
IPC分类号： A61N1/05
CPC分类号： A61B5/0478 , A61B5/4064 , A61B5/6851 , A61B5/6852 , A61B5/6853 , A61B18/082 , A61B18/1492 , A61B18/18 , A61B18/24 , A61B2018/00214 , A61B2018/00446 , A61B2018/00577 , A61B2018/1467 , A61N1/0529
摘要： Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.
摘要翻译： 映射设备的一些实施例可以能够通过脑静脉和其他脑血管空间以提供大脑的电生理映射。 该装置的这些实施例还可能能够同时或分开地向目标脑组织提供消融能量或其他治疗。 在这种情况下，可以使用户能够分析患者大脑的电生理图，并且可以在绘制过程之前或之后的同一时间或在短时间内分析可以使用消融能量来治疗中枢神经 系统紊乱 这种治疗可以在不使用侵入性手术的情况下完成，其中脑通过患者颅骨中的开口进入。
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公开(公告)号：US06241710B1
公开(公告)日：2001-06-05
申请号：US09468688
申请日：1999-12-20
IPC分类号： A61M532
CPC分类号： A61M5/3286 , A61M5/3291 , A61M25/0068 , A61M2025/0057 , A61M2025/0073
摘要： The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue. A guidance catheter can be used to direct the invention devices to a remote internal injection site. The invention devices and methods can be used to inject fluids (including those containing nucleic acids for gene therapy) into interior body walls or tissue, such as a beating heart, without substantial loss of fluid and without substantial damage to tissue caused by injectate.
摘要翻译： 本发明提供具有多孔远端部分的手术针头，其中注射的液体将在注射压力下多次渗漏或渗出，同时针的多孔远端部分插入体表面。 针的多孔远端部分可以由多孔碳，金属，陶瓷或聚合物制成，并且优选地具有减小的流向梯度的流体流向针的位置以补偿注射压力随着流体朝向 这点，从而确保注射过程中注射剂的均匀渗漏。 该针适于附接到导管或注射器。 在另一个实施例中，提供了一种手术组合件，其中具有类似流体流动特征的多孔远侧部分沿着导管的远端定位，并且针尖附接到导管的远端（例如，可导向的导管），用于 刺穿组织。 引导导管可用于将本发明装置引导到远程内部注射部位。 本发明的装置和方法可用于将流体（包括含有用于基因治疗的核酸的那些）注射到内部体壁或组织（例如打浆心脏）中，而没有明显的流体损失，并且对注射造成的组织没有实质的损害。
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