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    Apparatus with weeping tip and method of use
    3.
    发明授权
    Apparatus with weeping tip and method of use 有权
    具有啜饮尖端和使用方法的设备

    公开(公告)号：US07252654B2

    公开(公告)日：2007-08-07

    申请号：US11218700

    申请日：2005-09-02

    申请人： Robert A. VanTassel ,  David R. Holmes, Jr. ,  Robert S. Schwartz

    发明人： Robert A. VanTassel ,  David R. Holmes, Jr. ,  Robert S. Schwartz

    IPC分类号： A61M5/32 ,  A61M25/00

    CPC分类号： A61M5/3286 ,  A61M5/3291 ,  A61M25/0068 ,  A61M2025/0057 ,  A61M2025/0073

    摘要： The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue. A guidance catheter can be used to direct the invention devices to a remote internal injection site. The invention devices and methods can be used to inject fluids (including those containing nucleic acids for gene therapy) into interior body walls or tissue, such as a beating heart, without substantial loss of fluid and without substantial damage to tissue caused by injectate.

    摘要翻译： 本发明提供具有多孔远端部分的手术针头，其中注射的液体将在注射压力下多次地渗漏或渗出，同时针的多孔远端部分插入体表面。 针的多孔远端部分可以由多孔碳，金属，陶瓷或聚合物制成，并且优选地具有减小的流向梯度的流体流向针的位置以补偿注射压力随着流体朝向 这点，从而确保注射过程中注射剂的均匀渗漏。 该针适于附接到导管或注射器。 在另一个实施例中，提供了一种手术组合件，其中具有类似流体流动特征的多孔远侧部分沿着导管的远端定位，并且针尖附接到导管的远端（例如，可导向的导管），用于 刺穿组织。 引导导管可用于将本发明装置引导到远程内部注射部位。 本发明的装置和方法可用于将流体（包括含有用于基因治疗的核酸的那些）注射到内部体壁或组织（例如打浆心脏）中，而没有明显的流体损失，并且对注射造成的组织没有实质的损害。

    Implantable device for promoting repair of a body lumen
    4.
    发明授权
    Implantable device for promoting repair of a body lumen 失效
    用于促进体腔修复的植入式装置

    公开(公告)号：US07235096B1

    公开(公告)日：2007-06-26

    申请号：US09382275

    申请日：1999-08-25

    申请人： Robert A. Van Tassel ,  David R. Holmes, Jr. ,  Robert S. Schwartz

    发明人： Robert A. Van Tassel ,  David R. Holmes, Jr. ,  Robert S. Schwartz

    IPC分类号： A61F2/06

    CPC分类号： A61F2/82 ,  A61B5/0031 ,  A61B5/028 ,  A61B5/6862 ,  A61B5/6876 ,  A61F2/0077 ,  A61F2/91 ,  A61L31/14

    摘要： An implantable stent having surface features adapted to promote an organized growth pattern of infiltrating cells when implanted in a tubular organ is provided. The surface features comprise depressions, pores, projections, pleats, channels or grooves in the stent body and are designed to increase turbulence or stagnation in the flow of a liquid, such as blood through the stent, and/or to promote the growth of infiltrating cells in an organized pattern. Alternatively, the invention stent can be populated with living cells prior to implant and can be heatable from an external source of energy, thereby inducing production of therapeutic bioactive agents from ingrowing cells. The invention also provides an implantable heatable stent for transcutaneously monitoring the flow of fluid through a lumen into which the stent is implanted by measuring the rate at which the heated stent cools in response to blood flow when the source of heat is removed.

    摘要翻译： 提供了一种植入式支架，其具有适于在植入管状器官时促进浸润细胞的有组织生长模式的表面特征。 表面特征包括支架主体中的凹陷，孔，突起，褶皱，通道或凹槽，并且被设计成增加液体如血液通过支架的流动中的湍流或停滞，和/或促进渗透的生长 细胞以有组织的模式。 或者，本发明支架可以在植入之前填充活细胞，并且可以从外部能量源加热，从而从向内生长细胞诱导治疗性生物活性剂的产生。 本发明还提供了一种可植入的可加热支架，用于通过测量当热源移除时响应于血液流动而被加热的支架冷却的速率，通过测量支架植入其中的内腔来经皮监测流体的流动。

    Detecting and Treating Nervous System Disorders
    6.
    发明申请
    Detecting and Treating Nervous System Disorders 有权
    检测和治疗神经系统疾病

    公开(公告)号：US20080312715A1

    公开(公告)日：2008-12-18

    申请号：US12094704

    申请日：2006-11-21

    申请人： Samuel J. Asirvatham ,  Paul A. Friedman ,  Charles J. Bruce ,  David R. Holmes, JR.

    发明人： Samuel J. Asirvatham ,  Paul A. Friedman ,  Charles J. Bruce ,  David R. Holmes, JR.

    IPC分类号： A61N1/05 ,  A61B18/14

    CPC分类号： A61B5/0478 ,  A61B5/4064 ,  A61B5/6851 ,  A61B5/6852 ,  A61B5/6853 ,  A61B18/082 ,  A61B18/1492 ,  A61B18/18 ,  A61B18/24 ,  A61B2018/00214 ,  A61B2018/00446 ,  A61B2018/00577 ,  A61B2018/1467 ,  A61N1/0529

    摘要： Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.

    摘要翻译： 映射设备的一些实施例可以能够通过脑静脉和其他脑血管空间以提供大脑的电生理映射。 该装置的这些实施例还可能能够同时或分开地向目标脑组织提供消融能量或其它治疗。 在这种情况下，可以使用户能够分析患者大脑的电生理图，并且可以在绘制过程之前或之后的同一时间或在短时间内分析可以使用消融能量来治疗中枢神经 系统紊乱 这种治疗可以在不使用侵入性手术的情况下完成，其中脑通过患者颅骨中的开口进入。

    Apparatus with weeping tip and method of use
    7.
    发明授权
    Apparatus with weeping tip and method of use 失效

    公开(公告)号：US06949087B2

    公开(公告)日：2005-09-27

    申请号：US10855026

    申请日：2004-05-26

    申请人： Robert A. VanTassel ,  David R. Holmes, Jr. ,  Robert S. Schwartz

    发明人： Robert A. VanTassel ,  David R. Holmes, Jr. ,  Robert S. Schwartz

    IPC分类号： C12N15/09 ,  A61K31/711 ,  A61K48/00 ,  A61M5/158 ,  A61M5/32 ,  A61M25/00 ,  A61M31/00 ,  A61P43/00

    CPC分类号： A61M5/3286 ,  A61M5/3291 ,  A61M25/0068 ,  A61M2025/0057 ,  A61M2025/0073

    摘要： The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue. A guidance catheter can be used to direct the invention devices to a remote internal injection site. The invention devices and methods can be used to inject fluids (including those containing nucleic acids for gene therapy) into interior body walls or tissue, such as a beating heart, without substantial loss of fluid and without substantial damage to tissue caused by injectate.