公开(公告)号：US20190201676A1

公开(公告)日：2019-07-04

申请号：US16325325

申请日：2017-08-30

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naoki YAMAMOTO ,  Seiji TOKUMOTO

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61K9/00 ,  A61K47/36 ,  A61M37/00 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053

Abstract: A microneedle sheet is disclosed that comprises a plurality of microneedles formed on a sheet generally along a principal surface of the sheet, wherein the microneedles contain a water-soluble polysaccharide and water, the water content is 1 mass % or more and less than 19 mass % based on the total mass of the microneedles, and the microneedles are raised from the principal surface by bending the sheet.

公开(公告)号：US20190046779A1

公开(公告)日：2019-02-14

申请号：US16078784

申请日：2017-02-15

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Takuya TAJIMA ,  Naoki YAMAMOTO ,  Kazuki KURIYAMA ,  Seiji TOKUMOTO

IPC: A61M37/00

Abstract: An applicator according to one embodiment is an applicator for applying a sheet member to skin, and includes: a bottom plate facing the skin; a top plate facing the bottom plate and configured to be pressed toward the bottom plate; and a bending portion configured to apply the sheet member to the skin by bending the sheet member having advanced thereto in a pressed state in which the top plate has been moved toward the bottom plate.

公开(公告)号：US20190015652A1

公开(公告)日：2019-01-17

申请号：US16134030

申请日：2018-09-18

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kazuya KOMINAMI ,  Shinpei NISHIMURA ,  Seiji TOKUMOTO ,  Makoto OGURA ,  Toshiyuki MATSUDO ,  Naoki YAMAMOTO

IPC: A61M37/00 ,  A61N2/00 ,  A61N1/32

Abstract: A microneedle sheet according to an embodiment comprises a plurality of microneedles formed on a sheet substantially along a principal surface of the sheet. The sheet is bent to raise the microneedles from the principal surface, and the raised microneedles pierce a skin.

公开(公告)号：US20190350840A1

公开(公告)日：2019-11-21

申请号：US16473119

申请日：2017-12-25

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryota HORI ,  Toshihiro KOGURE ,  Seiji TOKUMOTO ,  Shinpei NISHIMURA

IPC: A61K9/00 ,  A61K31/4174 ,  A61K31/135 ,  A61M37/00 ,  A61K47/20 ,  A61K47/02

Abstract: A microneedle device of the present invention comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles, wherein the coating comprising dexmedetomidine or a pharmaceutically acceptable salt thereof and isoproterenol or a pharmaceutically acceptable salt thereof. Using said microneedle device, a fast increase rate of dexmedetomidine concentration in plasma after application of the microneedle device is achieved.

公开(公告)号：US20170348228A1

公开(公告)日：2017-12-07

申请号：US15521101

申请日：2015-10-19

Applicant: HISAMITSU PHARMACEUTICAL CO., INC. ,  ASKA Pharmaceutical Co., Ltd.

Inventor： Shinpei NISHIMURA ,  Seiji TOKUMOTO ,  Takeshi ITO ,  Hajime ASADA

IPC: A61K9/00 ,  A61K47/02 ,  A61K47/10 ,  A61K38/24 ,  A61K47/12 ,  A61K47/18 ,  A61M37/00

CPC classification number: A61K9/0021 ,  A61K9/00 ,  A61K38/24 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/183 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0053

Abstract: The present invention provides a microneedle device comprising: a substrate; a microneedle disposed on the substrate; and a coating layer formed on the microneedle; in which the coating layer comprises a recombinant follicle-stimulating hormone, arginine, and glycerin, in the coating layer, the mass of arginine is 0.07 to 0.75-fold of the mass of the recombinant follicle-stimulating hormone and the mass of glycerin is 0.1 to 2.75-fold of the mass of the recombinant follicle-stimulating hormone.

公开(公告)号：US20160263215A1

公开(公告)日：2016-09-15

申请号：US15032718

申请日：2014-10-30

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Seiji TOKUMOTO ,  Kazuya MACHIDA ,  Nao KUROKAWA ,  Rie NAMIKI

IPC: A61K39/39 ,  A61K39/00

CPC classification number: A61K39/39 ,  A61K9/0014 ,  A61K9/0021 ,  A61K9/08 ,  A61K9/7023 ,  A61K39/0008 ,  A61K47/10 ,  A61K2039/54 ,  A61K2039/55511

Abstract: An adjuvant composition of the present invention contains lauryl alcohol and propylene glycol. Contents of the lauryl alcohol and the propylene glycol are 0.5 to 25% by mass and 8.0 to 99.5% by mass, relative to the total mass of the adjuvant composition, respectively. The lauryl alcohol is dissolved, and the adjuvant composition is used for transdermal or transmucosal administration.

Abstract translation: 本发明的佐剂组合物含有月桂醇和丙二醇。 相对于助剂组合物的总质量，月桂醇和丙二醇的含量分别为0.5〜25质量％，8.0〜99.5质量％。 将月桂醇溶解，将佐剂组合物用于透皮或经粘膜给药。

公开(公告)号：US20160107189A1

公开(公告)日：2016-04-21

申请号：US14894397

申请日：2014-05-29

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Eiji HASHIMOTO ,  Toshiyuki MATSUDO ,  Shinpei NISHIMURA ,  Seiji TOKUMOTO

IPC: B05C15/00 ,  F24F3/16 ,  F24F3/14 ,  B05C21/00 ,  B05C3/00

CPC classification number: B05C15/00 ,  A61M37/0015 ,  A61M2037/0053 ,  B05C3/00 ,  B05C21/00 ,  B05D3/0486 ,  B81B2201/055 ,  B81C99/0025 ,  F24F3/14 ,  F24F3/1603

Abstract: The present invention provides a system for manufacturing a therapeutic microneedle configured to regulate an air environment within a coating chamber for manufacturing a therapeutic microneedle by coating a microneedle with a coating liquid containing a drug, the system for manufacturing a therapeutic microneedle comprising an air compressor, a humidity regulator configured to regulate humidity of air supplied from the air compressor, and an air filter configured to eliminate microorganisms from air to be supplied to the inside of the coating chamber.

Abstract translation: 本发明提供一种用于制造治疗性微针的系统，其构造成通过用含有药物的涂布液涂布微针来调节用于制造治疗性微针的涂布室内的空气环境，该制造用微生物的制造系统包括空气压缩机， 配置为调节从空气压缩机供给的空气的湿度的湿度调节器，以及被配置为从供给到涂布室内部的空气中除去微生物的空气过滤器。